C C There are a total of 9 entries in the algebraic variable array. C There are a total of 22 entries in each of the rate and state variable arrays. C There are a total of 45 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is T2 in component T2 (micromolar). C ALGBRC(1) is Vmax in component T2 (flux). C CONSTS(38) is KR in component T2 (molar). C STATES(2) is LT2 in component LT2 (micromolar). C STATES(3) is T2R in component T2R (micromolar). C CONSTS(1) is R in component R (micromolar). C STATES(4) is T3 in component T3 (micromolar). C CONSTS(2) is L in component L (micromolar). C STATES(5) is Bp in component Bp (micromolar). C STATES(6) is T2p in component T2p (micromolar). C CONSTS(3) is Y0 in component Y0 (micromolar). C STATES(7) is Yp in component Yp (micromolar). C CONSTS(4) is B0 in component B0 (micromolar). C CONSTS(5) is k5 in component model_parameters (second_order_rate_constant). C CONSTS(6) is k_5 in component model_parameters (first_order_rate_constant). C CONSTS(7) is k8 in component model_parameters (first_order_rate_constant). C CONSTS(8) is k_1 in component model_parameters (second_order_rate_constant). C CONSTS(9) is ky in component model_parameters (second_order_rate_constant). C CONSTS(10) is kb in component model_parameters (second_order_rate_constant). C CONSTS(11) is k1a in component model_parameters (first_order_rate_constant). C CONSTS(12) is k1b in component model_parameters (second_order_rate_constant). C CONSTS(13) is k1c in component model_parameters (first_order_rate_constant). C ALGBRC(2) is Vmax in component T3 (flux). C CONSTS(39) is KR in component T3 (molar). C STATES(8) is LT3 in component LT3 (micromolar). C STATES(9) is T3R in component T3R (micromolar). C STATES(10) is T4 in component T4 (micromolar). C STATES(11) is T3p in component T3p (micromolar). C CONSTS(14) is k6 in component model_parameters (second_order_rate_constant). C CONSTS(15) is k_6 in component model_parameters (first_order_rate_constant). C CONSTS(16) is k9 in component model_parameters (first_order_rate_constant). C CONSTS(17) is k_2 in component model_parameters (second_order_rate_constant). C CONSTS(18) is k2a in component model_parameters (first_order_rate_constant). C CONSTS(19) is k2b in component model_parameters (second_order_rate_constant). C CONSTS(20) is k2c in component model_parameters (first_order_rate_constant). C STATES(12) is LT4 in component LT4 (micromolar). C STATES(13) is T4p in component T4p (micromolar). C CONSTS(21) is k7 in component model_parameters (second_order_rate_constant). C CONSTS(22) is k_7 in component model_parameters (first_order_rate_constant). C CONSTS(23) is k10 in component model_parameters (first_order_rate_constant). C ALGBRC(3) is Vmax in component T2p (flux). C CONSTS(40) is KR in component T2p (molar). C STATES(14) is LT2p in component LT2p (micromolar). C STATES(15) is T2pR in component T2pR (micromolar). C ALGBRC(4) is Vmax in component T3p (flux). C CONSTS(41) is KR in component T3p (molar). C STATES(16) is LT3p in component LT3p (micromolar). C STATES(17) is T3pR in component T3pR (micromolar). C STATES(18) is LT4p in component LT4p (micromolar). C ALGBRC(5) is Vmax in component LT2 (flux). C CONSTS(42) is KR in component LT2 (molar). C STATES(19) is LT2R in component LT2R (micromolar). C CONSTS(24) is k11 in component model_parameters (first_order_rate_constant). C CONSTS(25) is k_3 in component model_parameters (second_order_rate_constant). C CONSTS(26) is k3a in component model_parameters (first_order_rate_constant). C CONSTS(27) is k3b in component model_parameters (second_order_rate_constant). C CONSTS(28) is k3c in component model_parameters (first_order_rate_constant). C ALGBRC(6) is Vmax in component LT3 (flux). C CONSTS(43) is KR in component LT3 (molar). C STATES(20) is LT3R in component LT3R (micromolar). C CONSTS(29) is k12 in component model_parameters (first_order_rate_constant). C CONSTS(30) is k_4 in component model_parameters (second_order_rate_constant). C CONSTS(31) is k4a in component model_parameters (first_order_rate_constant). C CONSTS(32) is k4b in component model_parameters (second_order_rate_constant). C CONSTS(33) is k4c in component model_parameters (first_order_rate_constant). C CONSTS(34) is k13 in component model_parameters (first_order_rate_constant). C ALGBRC(7) is Vmax in component LT2p (flux). C CONSTS(44) is KR in component LT2p (molar). C STATES(21) is LT2pR in component LT2pR (micromolar). C ALGBRC(8) is Vmax in component LT3p (flux). C CONSTS(45) is KR in component LT3p (molar). C STATES(22) is LT3pR in component LT3pR (micromolar). C ALGBRC(9) is P in component P (micromolar). C CONSTS(35) is Z in component Z (micromolar). C CONSTS(36) is k_y in component model_parameters (second_order_rate_constant). C CONSTS(37) is k_b in component model_parameters (first_order_rate_constant). C RATES(1) is d/dt T2 in component T2 (micromolar). C RATES(4) is d/dt T3 in component T3 (micromolar). C RATES(10) is d/dt T4 in component T4 (micromolar). C RATES(6) is d/dt T2p in component T2p (micromolar). C RATES(11) is d/dt T3p in component T3p (micromolar). C RATES(13) is d/dt T4p in component T4p (micromolar). C RATES(2) is d/dt LT2 in component LT2 (micromolar). C RATES(8) is d/dt LT3 in component LT3 (micromolar). C RATES(12) is d/dt LT4 in component LT4 (micromolar). C RATES(14) is d/dt LT2p in component LT2p (micromolar). C RATES(16) is d/dt LT3p in component LT3p (micromolar). C RATES(18) is d/dt LT4p in component LT4p (micromolar). C RATES(7) is d/dt Yp in component Yp (micromolar). C RATES(5) is d/dt Bp in component Bp (micromolar). C RATES(3) is d/dt T2R in component T2R (micromolar). C RATES(9) is d/dt T3R in component T3R (micromolar). C RATES(15) is d/dt T2pR in component T2pR (micromolar). C RATES(17) is d/dt T3pR in component T3pR (micromolar). C RATES(19) is d/dt LT2R in component LT2R (micromolar). C RATES(20) is d/dt LT3R in component LT3R (micromolar). C RATES(21) is d/dt LT2pR in component LT2pR (micromolar). C RATES(22) is d/dt LT3pR in component LT3pR (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.01 STATES(2) = 0.01 STATES(3) = 0.01 CONSTS(1) = 0.3 STATES(4) = 0.01 CONSTS(2) = 3.0 STATES(5) = 0.01 STATES(6) = 0.01 CONSTS(3) = 20.0 STATES(7) = 0.01 CONSTS(4) = 1.7 CONSTS(5) = 7E7 CONSTS(6) = 70.0 CONSTS(7) = 15.0 CONSTS(8) = 4E5 CONSTS(9) = 3E7 CONSTS(10) = 8E5 CONSTS(11) = 10 CONSTS(12) = 17 CONSTS(13) = 0.17 STATES(8) = 0.01 STATES(9) = 0.01 STATES(10) = 0.01 STATES(11) = 0.01 CONSTS(14) = 7E7 CONSTS(15) = 70.0 CONSTS(16) = 45.0 CONSTS(17) = 3E4 CONSTS(18) = 10 CONSTS(19) = 17 CONSTS(20) = 0.017 STATES(12) = 0.01 STATES(13) = 0.01 CONSTS(21) = 7E7 CONSTS(22) = 70.0 CONSTS(23) = 48.0 STATES(14) = 0.01 STATES(15) = 0.01 STATES(16) = 0.01 STATES(17) = 0.01 STATES(18) = 0.01 STATES(19) = 0.01 CONSTS(24) = 0.0 CONSTS(25) = 4E5 CONSTS(26) = 10 CONSTS(27) = 17 CONSTS(28) = 5.1 STATES(20) = 0.01 CONSTS(29) = 16.5 CONSTS(30) = 3E4 CONSTS(31) = 10 CONSTS(32) = 17 CONSTS(33) = 0.51 CONSTS(34) = 34.56 STATES(21) = 0.01 STATES(22) = 0.01 CONSTS(35) = 40.0 CONSTS(36) = 5E5 CONSTS(37) = 0.35 CONSTS(38) = (CONSTS(11)+CONSTS(13))/CONSTS(12) CONSTS(39) = (CONSTS(18)+CONSTS(20))/CONSTS(19) CONSTS(40) = (CONSTS(11)+CONSTS(13))/CONSTS(12) CONSTS(41) = (CONSTS(18)+CONSTS(20))/CONSTS(19) CONSTS(42) = (CONSTS(26)+CONSTS(28))/CONSTS(27) CONSTS(43) = (CONSTS(31)+CONSTS(33))/CONSTS(32) CONSTS(44) = (CONSTS(26)+CONSTS(28))/CONSTS(27) CONSTS(45) = (CONSTS(31)+CONSTS(33))/CONSTS(32) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(10) = ( CONSTS(22)*STATES(12)+ CONSTS(9)*STATES(13)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(13)*(CONSTS(4) - STATES(5))) - ( CONSTS(21)*CONSTS(2)*STATES(10)+ CONSTS(23)*STATES(10)) RATES(13) = ( CONSTS(22)*STATES(18)+ CONSTS(9)*STATES(10)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(10)*(CONSTS(4) - STATES(5))) - ( CONSTS(21)*CONSTS(2)*STATES(13)+ CONSTS(23)*STATES(13)) RATES(12) = ( CONSTS(22)*STATES(10)+ CONSTS(9)*STATES(18)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(18)*(CONSTS(4) - STATES(5))) - ( CONSTS(21)*CONSTS(2)*STATES(12)+ CONSTS(34)*STATES(12)) RATES(18) = ( CONSTS(22)*STATES(13)+ CONSTS(9)*STATES(18)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(18)*(CONSTS(4) - STATES(5))) - ( CONSTS(21)*CONSTS(2)*STATES(18)+ CONSTS(34)*STATES(18)) RATES(3) = CONSTS(12)*STATES(1)*CONSTS(1) - ( CONSTS(11)*STATES(3)+ CONSTS(13)*STATES(3)) RATES(9) = CONSTS(19)*STATES(4)*CONSTS(1) - ( CONSTS(18)*STATES(9)+ CONSTS(20)*STATES(9)) RATES(15) = CONSTS(12)*STATES(6)*CONSTS(1) - ( CONSTS(11)*STATES(15)+ CONSTS(13)*STATES(15)) RATES(17) = CONSTS(19)*STATES(11)*CONSTS(1) - ( CONSTS(18)*STATES(17)+ CONSTS(20)*STATES(17)) RATES(19) = CONSTS(27)*STATES(2)*CONSTS(1) - ( CONSTS(26)*STATES(19)+ CONSTS(28)*STATES(19)) RATES(20) = CONSTS(32)*STATES(8)*CONSTS(1) - ( CONSTS(31)*STATES(20)+ CONSTS(33)*STATES(20)) RATES(21) = CONSTS(27)*STATES(14)*CONSTS(1) - ( CONSTS(26)*STATES(21)+ CONSTS(28)*STATES(21)) RATES(22) = CONSTS(32)*STATES(16)*CONSTS(1) - ( CONSTS(31)*STATES(22)+ CONSTS(33)*STATES(22)) ALGBRC(1) = CONSTS(13)*(CONSTS(1)+STATES(3)) RATES(1) = ( CONSTS(6)*STATES(2)+ CONSTS(8)*STATES(5)*STATES(4)+ CONSTS(9)*STATES(6)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(6)*(CONSTS(4) - STATES(5))) - ( CONSTS(5)*CONSTS(2)*STATES(1)+ CONSTS(7)*STATES(1)+ ALGBRC(1)*(STATES(1)/(CONSTS(38)+STATES(1)))) ALGBRC(2) = CONSTS(20)*(CONSTS(1)+STATES(9)) RATES(4) = ( CONSTS(15)*STATES(8)+ CONSTS(17)*STATES(5)*STATES(10)+ CONSTS(9)*STATES(11)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(11)*(CONSTS(4) - STATES(5))) - ( CONSTS(14)*CONSTS(2)*STATES(4)+ CONSTS(16)*STATES(4)+ ALGBRC(2)*(STATES(4)/(CONSTS(39)+STATES(4)))) ALGBRC(3) = CONSTS(13)*(CONSTS(1)+STATES(15)) RATES(6) = ( CONSTS(6)*STATES(14)+ CONSTS(8)*STATES(5)*STATES(11)+ CONSTS(9)*STATES(1)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(1)*(CONSTS(4) - STATES(5))) - ( CONSTS(5)*CONSTS(2)*STATES(6)+ CONSTS(7)*STATES(6)+ ALGBRC(3)*(STATES(6)/(CONSTS(40)+STATES(6)))) ALGBRC(4) = CONSTS(20)*(CONSTS(1)+STATES(17)) RATES(11) = ( CONSTS(15)*STATES(16)+ CONSTS(17)*STATES(5)*STATES(13)+ CONSTS(9)*STATES(4)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(4)*(CONSTS(4) - STATES(5))) - ( CONSTS(14)*CONSTS(2)*STATES(11)+ CONSTS(16)*STATES(11)+ ALGBRC(4)*(STATES(11)/(CONSTS(41)+STATES(11)))) ALGBRC(5) = CONSTS(28)*(CONSTS(1)+STATES(19)) RATES(2) = ( CONSTS(6)*STATES(1)+ CONSTS(25)*STATES(5)*STATES(8)+ CONSTS(9)*STATES(14)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(14)*(CONSTS(4) - STATES(5))) - ( CONSTS(5)*CONSTS(2)*STATES(2)+ CONSTS(24)*STATES(2)+ ALGBRC(5)*(STATES(2)/(CONSTS(42)+STATES(2)))) ALGBRC(6) = CONSTS(33)*(CONSTS(1)+STATES(20)) RATES(8) = ( CONSTS(15)*STATES(4)+ CONSTS(30)*STATES(5)*STATES(12)+ CONSTS(9)*STATES(16)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(16)*(CONSTS(4) - STATES(5))) - ( CONSTS(14)*CONSTS(2)*STATES(8)+ CONSTS(29)*STATES(8)+ ALGBRC(6)*(STATES(8)/(CONSTS(43)+STATES(8)))) ALGBRC(7) = CONSTS(28)*(CONSTS(1)+STATES(21)) RATES(14) = ( CONSTS(6)*STATES(6)+ CONSTS(25)*STATES(5)*STATES(16)+ CONSTS(9)*STATES(2)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(2)*(CONSTS(4) - STATES(5))) - ( CONSTS(5)*CONSTS(2)*STATES(14)+ CONSTS(24)*STATES(14)+ ALGBRC(7)*(STATES(14)/(CONSTS(44)+STATES(14)))) ALGBRC(8) = CONSTS(33)*(CONSTS(1)+STATES(22)) RATES(16) = ( CONSTS(15)*STATES(11)+ CONSTS(30)*STATES(5)*STATES(18)+ CONSTS(9)*STATES(8)*(CONSTS(3) - STATES(7))+ CONSTS(10)*STATES(8)*(CONSTS(4) - STATES(5))) - ( CONSTS(14)*CONSTS(2)*STATES(16)+ CONSTS(29)*STATES(16)+ ALGBRC(8)*(STATES(16)/(CONSTS(45)+STATES(16)))) ALGBRC(9) = STATES(6)+STATES(14)+STATES(11)+STATES(16)+STATES(13)+STATES(18) RATES(7) = CONSTS(9)*ALGBRC(9)*(CONSTS(3) - STATES(7)) - CONSTS(36)*CONSTS(35)*STATES(7) RATES(5) = CONSTS(10)*ALGBRC(9)*(CONSTS(4) - STATES(5)) - CONSTS(37)*STATES(5) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(13)*(CONSTS(1)+STATES(3)) ALGBRC(2) = CONSTS(20)*(CONSTS(1)+STATES(9)) ALGBRC(3) = CONSTS(13)*(CONSTS(1)+STATES(15)) ALGBRC(4) = CONSTS(20)*(CONSTS(1)+STATES(17)) ALGBRC(5) = CONSTS(28)*(CONSTS(1)+STATES(19)) ALGBRC(6) = CONSTS(33)*(CONSTS(1)+STATES(20)) ALGBRC(7) = CONSTS(28)*(CONSTS(1)+STATES(21)) ALGBRC(8) = CONSTS(33)*(CONSTS(1)+STATES(22)) ALGBRC(9) = STATES(6)+STATES(14)+STATES(11)+STATES(16)+STATES(13)+STATES(18) RETURN END