Hatakeyama, Shirouzu, Yokoyama, Konagaya, Kimura, Naka, Kawasaki, Yumoto, Ichikawa, Kim, Saito, Saeki, 2003

Model Status

This version of the model has been checked in COR and PCEnv and it runs to replicate the published results. The units have been checked and they are consistent.

Model Structure

ErbB receptor tyrosine kinases play an essential role in the proliferation and differentiation of cells. The ErbB receptor family includes ErbB1 - also known as the epidermal growth factor receptor (EGFR) - and the signalling pathways which involve this receptor have been extensively analysed, both experimentally and also via mathematical modelling. ErbB receptors share a common ability to bind a diverse range of ligands, in turn producing a wide range of biological responses. In the study described here, Mariko Hatakeyama et al. examined heregulin (HRG)-induced signal transduction of the ErbB4 receptor, and they produced a mathematical model to capture the features of the signal transduction cascade (described in more detail in the figure below). This model is described here in CellML.

The complete original paper reference is cited below:

A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling, Mariko Hatakeyama, Shuhei Kimura, Takashi Naka, Takuji Kawasaki, Noriko Yumoto, Mio Ichikawa, Jae-Hoon Kim, Kazuki Saito, Mihoro Saeki, Mikako Shirouzu, Shigeyuki Yokoyama, and Akihiko Konagaya, 2003, The Biochemical Journal , 373, 451-463. (Full text and PDF versions of the article are available to journal subscribers on The Biochemical Journal website.) PubMed ID: 12691603

A schematic diagram of the complete signalling network.