Journal of Physiology
The Adrian-Chandler-Hodgkin Model of the Skeletal Myocyte Action
Potential, 1970
Mammalia
Skeletal Myocyte
131
Reconstruction of the action potential of frog sartorius muscle
235
103
Lawson
James
Richard
electrophysiology
cardiac
myofilament mechanics
skeletal muscle
5499787
Bioengineering Institute, The University of Auckland
The T-tubular Vt component calculates the voltage in the membrane
of the T-tubular system.
R
H
Adrian
D
Chandler
W
L
Hodgkin
A
Buist
Martin
L
R
Adrian
H
A stimulus protocol (with the same parameters as the Beeler Reuter 97, as the required parameters are unknown) has been added to this model to allow simulation of action potentials.
607
Voltage clamp experiments in striated muscle fibres
644
208
2007-11-12T12:20:00+13:00
This is the CellML description of Adrian, Chandler and Hodgkin's mathematical model of membrane action potentials of mammalian striated skeletal muscle. It describes four ionic currents and uses Hodgkin-Huxley type equations.
Updated curation status
This component contains the differential equations
governing the time dependence of the n gate of the potassium channel.
Altered documentation such that the semicolons are now with the correct comments in the list.
4778131
keyword
The potassium current component contains the differential equations
governing this voltage and time dependent outward current.
The T-tubular current component contains the differential equations
governing the current that occurs as the result of a potential difference
between the cell membrane and the T-tubular system.
The definition of the voltage-dependent activation gating
kinetics for the sodium ion channel (the m gate).
Lawson
Richard
James
Peachey
L
D
1970-01-01
m.buist@auckland.ac.nz
0.001
bdf15
100000
10000
Lloyd
May
Catherine
Bioengineering Institute
The University of Auckland
This component defines the variables that are externally set and
passed into the model along with the variables within the model that
are to be available externally.
Martin Buist
Journal of Physiology
James Lawson
This model has had a stimulus protocol added to it to allow simulation of action potentials. Unfortunately, the details of the stimulation defined in the original paper are not known and as such, the parameters of the stimulus (magnitude, duration, dimensions,) may not be appropriate. Currently, however, the model runs in PCEnv 0.2 and is able to simulate a train of action potentials. COR will not currently run this model.
2007-06-11T13:17:56+12:00
2009-05-05T11:14:24+12:00
The leak current component contains the differential equations
governing the time independent current leakage from the cell.
The sodium current component contains the differential equations
governing the influx of sodium ions through the cell surface
membrane into the cell.
This component defines the calculation of dV/dt, the ordinary differential
equation for the transmembrane potential.
The voltage-dependent inactivation gate for the sodium channel (the
h gate).
2003-10-29T00:00:00+00:00
1973-01-01