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/* There are a total of 8 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 35 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * STATES[0] is Y in component Y (dimensionless). * CONSTANTS[0] is k1 in component Y (first_order_rate_constant). * ALGEBRAIC[6] is k2 in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[1] is k3 in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[0] is C in component C (dimensionless). * STATES[1] is M in component M (dimensionless). * ALGEBRAIC[7] is kwee in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[5] is kcdc25 in component kinetic_parameters (first_order_rate_constant). * STATES[2] is preMPF in component preMPF (dimensionless). * STATES[3] is Cdc25P in component Cdc25P (dimensionless). * CONSTANTS[2] is k25 in component Cdc25P (first_order_rate_constant). * CONSTANTS[3] is Km25 in component Cdc25P (dimensionless). * CONSTANTS[4] is k25r in component Cdc25P (first_order_rate_constant). * CONSTANTS[33] is k25ro in component Cdc25P (first_order_rate_constant). * CONSTANTS[5] is Km25r in component Cdc25P (dimensionless). * CONSTANTS[32] is p in component p (dimensionless). * ALGEBRAIC[2] is Cdc25 in component Cdc25 (dimensionless). * STATES[4] is Wee1 in component Wee1 (dimensionless). * CONSTANTS[6] is kw in component Wee1 (first_order_rate_constant). * CONSTANTS[7] is Kmw in component Wee1 (dimensionless). * CONSTANTS[8] is kwr in component Wee1 (first_order_rate_constant). * CONSTANTS[34] is kwro in component Wee1 (first_order_rate_constant). * CONSTANTS[9] is Kmwr in component Wee1 (dimensionless). * ALGEBRAIC[3] is Wee1P in component Wee1P (dimensionless). * STATES[5] is IEP in component IEP (dimensionless). * CONSTANTS[10] is kie in component IEP (first_order_rate_constant). * CONSTANTS[11] is Kmie in component IEP (dimensionless). * CONSTANTS[12] is kier in component IEP (first_order_rate_constant). * CONSTANTS[13] is Kmier in component IEP (dimensionless). * ALGEBRAIC[1] is IE in component IE (dimensionless). * STATES[6] is APC_ in component APC_ (dimensionless). * CONSTANTS[14] is kap in component APC_ (first_order_rate_constant). * CONSTANTS[15] is Kmap in component APC_ (dimensionless). * CONSTANTS[16] is kapr in component APC_ (first_order_rate_constant). * CONSTANTS[17] is Kmapr in component APC_ (dimensionless). * ALGEBRAIC[4] is APC in component APC (dimensionless). * CONSTANTS[18] is Cdc2tot in component C (dimensionless). * CONSTANTS[19] is Cdc25tot in component Cdc25 (dimensionless). * CONSTANTS[20] is Wee1tot in component Wee1P (dimensionless). * CONSTANTS[21] is IEtot in component IE (dimensionless). * CONSTANTS[22] is APCtot in component APC (dimensionless). * CONSTANTS[23] is R in component p (dimensionless). * CONSTANTS[24] is s in component p (dimensionless). * CONSTANTS[25] is q in component p (dimensionless). * CONSTANTS[26] is V2 in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[27] is V2_ in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[28] is V25 in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[29] is V25_ in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[30] is Vwee in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[31] is Vwee_ in component kinetic_parameters (first_order_rate_constant). * RATES[0] is d/dt Y in component Y (dimensionless). * RATES[1] is d/dt M in component M (dimensionless). * RATES[2] is d/dt preMPF in component preMPF (dimensionless). * RATES[3] is d/dt Cdc25P in component Cdc25P (dimensionless). * RATES[4] is d/dt Wee1 in component Wee1 (dimensionless). * RATES[5] is d/dt IEP in component IEP (dimensionless). * RATES[6] is d/dt APC_ in component APC_ (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.01577552; CONSTANTS[0] = 0.024; CONSTANTS[1] = 1.15; STATES[1] = 0.0142077; STATES[2] = 0.02541723; STATES[3] = 0.4844362; CONSTANTS[2] = 18; CONSTANTS[3] = 0.1; CONSTANTS[4] = 0.8; CONSTANTS[5] = 1; STATES[4] = 0.5155638; CONSTANTS[6] = 18; CONSTANTS[7] = 0.1; CONSTANTS[8] = 0.8; CONSTANTS[9] = 1; STATES[5] = 0.002287817; CONSTANTS[10] = 4.5; CONSTANTS[11] = 0.01; CONSTANTS[12] = 0.34; CONSTANTS[13] = 0.01; STATES[6] = 0.5051103; CONSTANTS[14] = 0.3; CONSTANTS[15] = 0.01; CONSTANTS[16] = 0.3; CONSTANTS[17] = 1; CONSTANTS[18] = 1; CONSTANTS[19] = 1; CONSTANTS[20] = 1; CONSTANTS[21] = 1; CONSTANTS[22] = 1; CONSTANTS[23] = 1; CONSTANTS[24] = 0.021; CONSTANTS[25] = 1; CONSTANTS[26] = 0.01; CONSTANTS[27] = 0.6; CONSTANTS[28] = 0.04; CONSTANTS[29] = 0.4; CONSTANTS[30] = 0.025; CONSTANTS[31] = 2.5; CONSTANTS[32] = CONSTANTS[24]*CONSTANTS[23]+CONSTANTS[25]; CONSTANTS[33] = CONSTANTS[4]/CONSTANTS[32]; CONSTANTS[34] = CONSTANTS[8]/CONSTANTS[32]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[21] - STATES[5]; RATES[5] = ( CONSTANTS[10]*STATES[1]*ALGEBRAIC[1])/(CONSTANTS[11]+ALGEBRAIC[1]) - ( CONSTANTS[12]*STATES[5])/(CONSTANTS[13]+STATES[5]); ALGEBRAIC[2] = CONSTANTS[19] - STATES[3]; RATES[3] = ( CONSTANTS[2]*STATES[1]*ALGEBRAIC[2])/(CONSTANTS[3]+ALGEBRAIC[2]) - ( CONSTANTS[4]*STATES[3])/(CONSTANTS[5]+STATES[3]); ALGEBRAIC[3] = CONSTANTS[20] - STATES[4]; RATES[4] = ( - CONSTANTS[6]*STATES[1]*STATES[4])/(CONSTANTS[7]+STATES[4])+( CONSTANTS[8]*ALGEBRAIC[3])/(CONSTANTS[9]+ALGEBRAIC[3]); ALGEBRAIC[4] = CONSTANTS[22] - STATES[6]; RATES[6] = ( CONSTANTS[14]*STATES[5]*ALGEBRAIC[4])/(CONSTANTS[15]+ALGEBRAIC[4]) - ( CONSTANTS[16]*STATES[6])/(CONSTANTS[17]+STATES[6]); ALGEBRAIC[6] = CONSTANTS[26]*ALGEBRAIC[4]+ CONSTANTS[27]*STATES[6]; ALGEBRAIC[0] = CONSTANTS[18] - (STATES[1]+STATES[2]); RATES[0] = CONSTANTS[0] - ( ALGEBRAIC[6]*STATES[0]+ CONSTANTS[1]*STATES[0]*ALGEBRAIC[0]); ALGEBRAIC[7] = CONSTANTS[30]*ALGEBRAIC[3]+ CONSTANTS[31]*STATES[4]; ALGEBRAIC[5] = CONSTANTS[28]*ALGEBRAIC[2]+ CONSTANTS[29]*STATES[3]; RATES[1] = ( ALGEBRAIC[5]*STATES[2]+ CONSTANTS[1]*STATES[0]*ALGEBRAIC[0]) - ( ALGEBRAIC[6]*STATES[1]+ ALGEBRAIC[7]*STATES[1]); RATES[2] = ALGEBRAIC[7]*STATES[1] - ( ALGEBRAIC[6]*STATES[2]+ ALGEBRAIC[5]*STATES[2]); } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[21] - STATES[5]; ALGEBRAIC[2] = CONSTANTS[19] - STATES[3]; ALGEBRAIC[3] = CONSTANTS[20] - STATES[4]; ALGEBRAIC[4] = CONSTANTS[22] - STATES[6]; ALGEBRAIC[6] = CONSTANTS[26]*ALGEBRAIC[4]+ CONSTANTS[27]*STATES[6]; ALGEBRAIC[0] = CONSTANTS[18] - (STATES[1]+STATES[2]); ALGEBRAIC[7] = CONSTANTS[30]*ALGEBRAIC[3]+ CONSTANTS[31]*STATES[4]; ALGEBRAIC[5] = CONSTANTS[28]*ALGEBRAIC[2]+ CONSTANTS[29]*STATES[3]; }