Snyder, Palmer, Moore, 2000

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

The regulation of cytosolic Ca²⁺ concentration, [Ca²⁺]_c, in cardiac myocytes has been recognised to be the predominant determinant of cardiac contraction and relaxation dynamics. Several models have been developed to describe [Ca²⁺]_c regulation in cardiac myocytes and these have evolved to the point where they are able to predict intracellular Ca²⁺ dynamics under experimental conditions.

In their 2000 study, Steven M. Snyder, Bradley M. Palmer and Russell L. Moore published a detailed mathematical model describing cardiocyte Ca²⁺ dynamics with a novel representation of sarcoplasmic reticular Ca²⁺ control (see the figure below). The mathematical representation of the Ca²⁺ regulatory mechanisms of a rat cardiac myocyte included a set of six differential equations.

The complete original paper reference is cited below:

A Mathematical Model of Cardiocyte Ca²⁺ Dynamics with a Novel Representation of Sarcoplasmic Reticular Ca²⁺ Control, Steven M. Snyder, Bradley M. Palmer and Russell L. Moore, 2000, Biophysical Journal , 79, 94-115. (Full text and PDF versions of the article are available for Journal Members on the Biophysical Journal website.) PubMed ID: 10866940

Cell schematic for the model representing three intracellular compartments with buffering, the extracellular space, and the related Ca2+ movement processes.