/* There are a total of 30 entries in the algebraic variable array. There are a total of 14 entries in each of the rate and state variable arrays. There are a total of 93 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * STATES[0] is CycA in component CycA (dimensionless). * CONSTANTS[0] is k_assa in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[1] is k_dissa in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[20] is V_di in component V_di (first_order_rate_constant). * ALGEBRAIC[21] is V_sa in component V_sa (first_order_rate_constant). * ALGEBRAIC[14] is V_da in component V_da (first_order_rate_constant). * STATES[1] is Tri_A in component Tri_A (dimensionless). * STATES[2] is CKI in component CKI (dimensionless). * STATES[3] is CycB in component CycB (dimensionless). * CONSTANTS[2] is k_assb in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[3] is k_dissb in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[24] is V_sb in component V_sb (first_order_rate_constant). * ALGEBRAIC[25] is V_db in component V_db (first_order_rate_constant). * ALGEBRAIC[29] is V_25 in component V_25 (first_order_rate_constant). * ALGEBRAIC[27] is V_wee in component V_wee (first_order_rate_constant). * STATES[4] is pB in component pB (dimensionless). * STATES[5] is BCKI in component BCKI (dimensionless). * STATES[6] is CycE in component CycE (dimensionless). * CONSTANTS[4] is k_disse in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[5] is k_asse in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[23] is V_se in component V_se (first_order_rate_constant). * ALGEBRAIC[13] is V_de in component V_de (first_order_rate_constant). * STATES[7] is Tri_E in component Tri_E (dimensionless). * ALGEBRAIC[1] is CycD in component CycD (dimensionless). * CONSTANTS[6] is CycD_0 in component CycD (dimensionless). * STATES[8] is mass in component mass (dimensionless). * STATES[9] is Cdc20_A in component Cdc20_A (dimensionless). * CONSTANTS[7] is k_a20 in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[8] is k_i20 in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[9] is k_d20 in component kinetic_parameters (first_order_rate_constant). * STATES[10] is APCP in component APCP (dimensionless). * STATES[11] is Cdc20_i in component Cdc20_i (dimensionless). * CONSTANTS[10] is J_a20 in component Cdc20_A (dimensionless). * CONSTANTS[11] is J_i20 in component Cdc20_A (dimensionless). * CONSTANTS[12] is k_s20p in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[13] is k_s20pp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[14] is n20 in component Cdc20_i (dimensionless). * CONSTANTS[15] is J_20 in component Cdc20_i (dimensionless). * CONSTANTS[16] is J_a20 in component Cdc20_i (dimensionless). * CONSTANTS[17] is J_i20 in component Cdc20_i (dimensionless). * ALGEBRAIC[0] is APC in component APC (dimensionless). * CONSTANTS[18] is APC_T in component APC (dimensionless). * CONSTANTS[19] is k_aie in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[20] is k_iie in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[21] is J_aie in component APCP (dimensionless). * CONSTANTS[22] is J_iie in component APCP (dimensionless). * STATES[12] is pBCKI in component pBCKI (dimensionless). * ALGEBRAIC[18] is V_si in component V_si (first_order_rate_constant). * ALGEBRAIC[9] is Cdh1_i in component Cdh1_i (dimensionless). * CONSTANTS[23] is Cdh1_T in component Cdh1_i (dimensionless). * STATES[13] is Cdh1 in component Cdh1 (dimensionless). * ALGEBRAIC[17] is V_ah1 in component V_ah1 (first_order_rate_constant). * ALGEBRAIC[19] is V_ih1 in component V_ih1 (first_order_rate_constant). * CONSTANTS[24] is J_ah1 in component Cdh1 (dimensionless). * CONSTANTS[25] is J_ih1 in component Cdh1 (dimensionless). * CONSTANTS[26] is mu in component mass (first_order_rate_constant). * CONSTANTS[27] is maxmass in component mass (dimensionless). * ALGEBRAIC[10] is V_atf in component V_atf (first_order_rate_constant). * CONSTANTS[28] is k_atfp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[29] is k_atfapp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[30] is k_atfepp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[31] is k_atfdpp in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[11] is V_itf in component V_itf (first_order_rate_constant). * CONSTANTS[32] is k_itfp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[33] is k_itfapp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[34] is k_itfbpp in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[12] is TF_E in component TF_E (dimensionless). * CONSTANTS[35] is J_itf in component TF_E (dimensionless). * CONSTANTS[36] is J_atf in component TF_E (dimensionless). * CONSTANTS[37] is k_dep in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[38] is k_deepp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[39] is k_deapp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[40] is k_debpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[41] is k_dap in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[42] is k_dapp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[43] is k_dappp in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[16] is TF_I in component TF_I (dimensionless). * CONSTANTS[44] is k_afi in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[45] is k_ifip in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[46] is k_ifibpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[47] is J_ifi in component TF_I (dimensionless). * CONSTANTS[48] is J_afi in component TF_I (dimensionless). * ALGEBRAIC[15] is Cdc14 in component TF_I (dimensionless). * CONSTANTS[49] is k_ah1p in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[50] is k_ah1pp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[51] is k_ih1p in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[52] is k_ih1app in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[53] is k_ih1bpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[54] is k_ih1epp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[55] is k_ih1dpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[56] is k_sip in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[57] is k_sipp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[58] is k_dip in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[59] is k_diapp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[60] is k_diepp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[61] is k_didpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[62] is k_dibpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[63] is k_14di in component kinetic_parameters (dimensionless). * ALGEBRAIC[2] is preMPF in component preMPF (dimensionless). * ALGEBRAIC[3] is CycBT in component CycBT (dimensionless). * ALGEBRAIC[4] is CycAT in component CycAT (dimensionless). * ALGEBRAIC[5] is CycET in component CycET (dimensionless). * ALGEBRAIC[6] is Tri_B in component Tri_B (dimensionless). * ALGEBRAIC[7] is CKIT in component CKIT (dimensionless). * ALGEBRAIC[8] is Cdc20_T in component Cdc20_T (dimensionless). * ALGEBRAIC[22] is TF_B in component TF_B (dimensionless). * CONSTANTS[64] is k_afb in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[65] is k_ifb in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[66] is J_ifb in component TF_B (dimensionless). * CONSTANTS[67] is J_afb in component TF_B (dimensionless). * CONSTANTS[68] is k_sbp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[69] is k_sbpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[70] is k_sap in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[71] is k_sapp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[72] is k_sep in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[73] is k_sepp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[74] is k_dbp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[75] is k_dbhpp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[76] is k_dbcpp in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[26] is Wee1 in component Wee1 (dimensionless). * CONSTANTS[77] is k_aweep in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[78] is k_aweepp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[79] is k_iweep in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[80] is k_iweepp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[81] is J_iwee in component Wee1 (dimensionless). * CONSTANTS[82] is J_awee in component Wee1 (dimensionless). * CONSTANTS[83] is k_weep in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[84] is k_weepp in component kinetic_parameters (first_order_rate_constant). * ALGEBRAIC[28] is Cdc25 in component Cdc25 (dimensionless). * CONSTANTS[85] is k_a25p in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[86] is k_a25pp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[87] is k_i25p in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[88] is k_i25pp in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[89] is J_i25 in component Cdc25 (dimensionless). * CONSTANTS[90] is J_a25 in component Cdc25 (dimensionless). * CONSTANTS[91] is k_25p in component kinetic_parameters (first_order_rate_constant). * CONSTANTS[92] is k_25pp in component kinetic_parameters (first_order_rate_constant). * RATES[0] is d/dt CycA in component CycA (dimensionless). * RATES[3] is d/dt CycB in component CycB (dimensionless). * RATES[6] is d/dt CycE in component CycE (dimensionless). * RATES[9] is d/dt Cdc20_A in component Cdc20_A (dimensionless). * RATES[11] is d/dt Cdc20_i in component Cdc20_i (dimensionless). * RATES[10] is d/dt APCP in component APCP (dimensionless). * RATES[4] is d/dt pB in component pB (dimensionless). * RATES[5] is d/dt BCKI in component BCKI (dimensionless). * RATES[12] is d/dt pBCKI in component pBCKI (dimensionless). * RATES[1] is d/dt Tri_A in component Tri_A (dimensionless). * RATES[7] is d/dt Tri_E in component Tri_E (dimensionless). * RATES[2] is d/dt CKI in component CKI (dimensionless). * RATES[13] is d/dt Cdh1 in component Cdh1 (dimensionless). * RATES[8] is d/dt mass in component mass (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.09450308233499527; CONSTANTS[0] = 50; CONSTANTS[1] = 0.06; STATES[1] = 0.3492224216461182; STATES[2] = 0.02882070094347; STATES[3] = 0.1903585940599442; CONSTANTS[2] = 60; CONSTANTS[3] = 0.05; STATES[4] = 0.01234426256269217; STATES[5] = 0.679449200630188; STATES[6] = 0.2092024385929108; CONSTANTS[4] = 0; CONSTANTS[5] = 0; STATES[7] = 0; CONSTANTS[6] = 0.108; STATES[8] = 1.338267803192139; STATES[9] = 0.3572723865509033; CONSTANTS[7] = 1; CONSTANTS[8] = 0.16; CONSTANTS[9] = 0.05; STATES[10] = 0.07591402530670166; STATES[11] = 0.7702387571334839; CONSTANTS[10] = 1; CONSTANTS[11] = 1; CONSTANTS[12] = 0.001; CONSTANTS[13] = 1; CONSTANTS[14] = 1; CONSTANTS[15] = 10; CONSTANTS[16] = 1; CONSTANTS[17] = 1; CONSTANTS[18] = 1; CONSTANTS[19] = 0.1; CONSTANTS[20] = 0.15; CONSTANTS[21] = 0.1; CONSTANTS[22] = 0.1; STATES[12] = 0.04795938357710838; CONSTANTS[23] = 1; STATES[13] = 0.7189393639564514; CONSTANTS[24] = 0.03; CONSTANTS[25] = 0.03; CONSTANTS[26] = 0.005776; CONSTANTS[27] = 10000; CONSTANTS[28] = 0; CONSTANTS[29] = 1.5; CONSTANTS[30] = 0.38; CONSTANTS[31] = 3; CONSTANTS[32] = 0.75; CONSTANTS[33] = 0; CONSTANTS[34] = 8; CONSTANTS[35] = 0.01; CONSTANTS[36] = 0.01; CONSTANTS[37] = 0.12; CONSTANTS[38] = 0; CONSTANTS[39] = 0; CONSTANTS[40] = 0; CONSTANTS[41] = 0.01; CONSTANTS[42] = 0.16; CONSTANTS[43] = 0; CONSTANTS[44] = 6; CONSTANTS[45] = 0.008; CONSTANTS[46] = 0.05; CONSTANTS[47] = 2; CONSTANTS[48] = 1; CONSTANTS[49] = 0.02; CONSTANTS[50] = 0.8; CONSTANTS[51] = 0.001; CONSTANTS[52] = 0.35; CONSTANTS[53] = 0.1; CONSTANTS[54] = 0.06; CONSTANTS[55] = 0.005; CONSTANTS[56] = 0.018; CONSTANTS[57] = 0.18; CONSTANTS[58] = 0.02; CONSTANTS[59] = 0.1; CONSTANTS[60] = 0.12; CONSTANTS[61] = 0.1; CONSTANTS[62] = 0.8; CONSTANTS[63] = 12; CONSTANTS[64] = 1; CONSTANTS[65] = 0.15; CONSTANTS[66] = 0.1; CONSTANTS[67] = 0.1; CONSTANTS[68] = 0.004; CONSTANTS[69] = 0.04; CONSTANTS[70] = 0.0015; CONSTANTS[71] = 0.01; CONSTANTS[72] = 0; CONSTANTS[73] = 0.15; CONSTANTS[74] = 0.003; CONSTANTS[75] = 0.4; CONSTANTS[76] = 0.15; CONSTANTS[77] = 0.3; CONSTANTS[78] = 0; CONSTANTS[79] = 0; CONSTANTS[80] = 1; CONSTANTS[81] = 0.05; CONSTANTS[82] = 0.05; CONSTANTS[83] = 0.02; CONSTANTS[84] = 0.2; CONSTANTS[85] = 0; CONSTANTS[86] = 1; CONSTANTS[87] = 0.3; CONSTANTS[88] = 0; CONSTANTS[89] = 0.1; CONSTANTS[90] = 0.1; CONSTANTS[91] = 0.01; CONSTANTS[92] = 5; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[9] = (( CONSTANTS[7]*STATES[10]*STATES[11])/(CONSTANTS[10]+STATES[11]) - ( STATES[9]*CONSTANTS[8])/(CONSTANTS[11]+STATES[9])) - STATES[9]*CONSTANTS[9]; RATES[11] = (((CONSTANTS[12]+ CONSTANTS[13]*pow(STATES[3], CONSTANTS[14]))/(pow(CONSTANTS[15], CONSTANTS[14])+pow(STATES[3], CONSTANTS[14]))+( STATES[9]*CONSTANTS[8])/(CONSTANTS[17]+STATES[9])) - CONSTANTS[9]*STATES[11]) - ( CONSTANTS[7]*STATES[10]*STATES[11])/(CONSTANTS[16]+STATES[11]); RATES[8] = CONSTANTS[26]*STATES[8]*(1.00000 - STATES[8]/CONSTANTS[27]); ALGEBRAIC[0] = (CONSTANTS[18] - STATES[10])/1.00000; RATES[10] = ( CONSTANTS[19]*STATES[3]*ALGEBRAIC[0])/(CONSTANTS[21]+ALGEBRAIC[0]) - ( CONSTANTS[20]*STATES[10])/(CONSTANTS[22]+STATES[10]); ALGEBRAIC[9] = (CONSTANTS[23] - STATES[13])/1.00000; ALGEBRAIC[15] = STATES[9]; ALGEBRAIC[17] = CONSTANTS[49]+ CONSTANTS[50]*ALGEBRAIC[15]; ALGEBRAIC[1] = CONSTANTS[6]*STATES[8]; ALGEBRAIC[19] = CONSTANTS[51]+ CONSTANTS[52]*STATES[0]+ CONSTANTS[53]*STATES[3]+ CONSTANTS[54]*STATES[6]+ CONSTANTS[55]*ALGEBRAIC[1]; RATES[13] = ( ALGEBRAIC[9]*ALGEBRAIC[17])/(CONSTANTS[24]+ALGEBRAIC[9]) - ( STATES[13]*ALGEBRAIC[19])/(CONSTANTS[25]+STATES[13]); ALGEBRAIC[20] = (CONSTANTS[58]+ CONSTANTS[59]*STATES[0]+ CONSTANTS[62]*STATES[3]+ CONSTANTS[60]*STATES[6]+ CONSTANTS[61]*ALGEBRAIC[1])/(1.00000+ CONSTANTS[63]*ALGEBRAIC[15]); ALGEBRAIC[14] = CONSTANTS[41]+ (CONSTANTS[42]+CONSTANTS[43])*STATES[9]+ CONSTANTS[43]*STATES[11]; RATES[1] = (( CONSTANTS[0]*STATES[2]*STATES[0] - CONSTANTS[1]*STATES[1]) - ALGEBRAIC[20]*STATES[1]) - ALGEBRAIC[14]*STATES[1]; ALGEBRAIC[13] = CONSTANTS[37]+ CONSTANTS[38]*STATES[6]+ CONSTANTS[39]*STATES[0]+ CONSTANTS[40]*STATES[3]; RATES[7] = (( CONSTANTS[5]*STATES[2]*STATES[6] - CONSTANTS[4]*STATES[7]) - ALGEBRAIC[20]*STATES[7]) - ALGEBRAIC[13]*STATES[7]; ALGEBRAIC[10] = CONSTANTS[28]+ CONSTANTS[29]*STATES[0]+ CONSTANTS[30]*STATES[6]+ CONSTANTS[31]*ALGEBRAIC[1]; ALGEBRAIC[11] = CONSTANTS[32]+ CONSTANTS[33]*STATES[0]+ CONSTANTS[34]*STATES[3]; ALGEBRAIC[12] = ( 2.00000*ALGEBRAIC[10]*CONSTANTS[35])/((ALGEBRAIC[11] - ALGEBRAIC[10])+ CONSTANTS[36]*ALGEBRAIC[11]+ CONSTANTS[35]*ALGEBRAIC[10]+ pow((pow((ALGEBRAIC[11] - ALGEBRAIC[10])+ CONSTANTS[36]*ALGEBRAIC[11]+ CONSTANTS[35]*ALGEBRAIC[10], 2.00000) - 4.00000*(ALGEBRAIC[11] - ALGEBRAIC[10])*CONSTANTS[35]*ALGEBRAIC[10]), 1.0 / 2)); ALGEBRAIC[21] = STATES[8]*(CONSTANTS[70]+ CONSTANTS[71]*ALGEBRAIC[12]); RATES[0] = (( CONSTANTS[1]*STATES[1]+ ALGEBRAIC[20]*STATES[1]+ALGEBRAIC[21]) - ALGEBRAIC[14]*STATES[0]) - CONSTANTS[0]*STATES[2]*STATES[0]; ALGEBRAIC[23] = STATES[8]*(CONSTANTS[72]+ CONSTANTS[73]*ALGEBRAIC[12]); RATES[6] = (( CONSTANTS[4]*STATES[7]+ ALGEBRAIC[20]*STATES[7]+ALGEBRAIC[23]) - ALGEBRAIC[13]*STATES[6]) - CONSTANTS[5]*STATES[2]*STATES[6]; ALGEBRAIC[25] = CONSTANTS[74]+ CONSTANTS[75]*STATES[13]+ CONSTANTS[76]*STATES[9]; ALGEBRAIC[16] = ( 2.00000*CONSTANTS[44]*ALGEBRAIC[15]*CONSTANTS[47])/(((CONSTANTS[45]+ CONSTANTS[46]*STATES[3]) - CONSTANTS[44]*ALGEBRAIC[15])+ CONSTANTS[48]*(CONSTANTS[45]+ CONSTANTS[46]*STATES[3])+ CONSTANTS[47]*CONSTANTS[44]*ALGEBRAIC[15]+ pow((pow(((CONSTANTS[45]+ CONSTANTS[46]*STATES[3]) - CONSTANTS[44]*ALGEBRAIC[15])+ CONSTANTS[48]*(CONSTANTS[45]+ CONSTANTS[46]*STATES[3])+ CONSTANTS[47]*CONSTANTS[44]*ALGEBRAIC[15], 2.00000) - 4.00000*((CONSTANTS[45]+ CONSTANTS[46]*STATES[3]) - CONSTANTS[44]*ALGEBRAIC[15])*CONSTANTS[47]*CONSTANTS[44]*ALGEBRAIC[15]), 1.0 / 2)); ALGEBRAIC[18] = CONSTANTS[56]+ CONSTANTS[57]*ALGEBRAIC[16]; RATES[2] = ((((((( - CONSTANTS[2]*STATES[3]*STATES[2]+ CONSTANTS[3]*STATES[5]) - CONSTANTS[2]*STATES[4]*STATES[2])+ CONSTANTS[3]*STATES[12]+ ALGEBRAIC[25]*STATES[5]+ ALGEBRAIC[25]*STATES[12]+ALGEBRAIC[18]) - ALGEBRAIC[20]*STATES[2]) - CONSTANTS[0]*STATES[2]*STATES[0])+ CONSTANTS[1]*STATES[1]+ ALGEBRAIC[14]*STATES[1]) - CONSTANTS[5]*STATES[2]*STATES[6])+ CONSTANTS[4]*STATES[7]+ ALGEBRAIC[13]*STATES[7]; ALGEBRAIC[22] = ( 2.00000*CONSTANTS[64]*STATES[3]*CONSTANTS[66])/((CONSTANTS[65] - CONSTANTS[64]*STATES[3])+ CONSTANTS[67]*CONSTANTS[65]+ CONSTANTS[66]*CONSTANTS[64]*STATES[3]+ pow((pow((CONSTANTS[65] - CONSTANTS[64]*STATES[3])+ CONSTANTS[67]*CONSTANTS[65]+ CONSTANTS[66]*CONSTANTS[64]*STATES[3], 2.00000) - 4.00000*(CONSTANTS[65] - CONSTANTS[64]*STATES[3])*CONSTANTS[64]*STATES[3]*CONSTANTS[66]), 1.0 / 2)); ALGEBRAIC[24] = STATES[8]*(CONSTANTS[68]+ CONSTANTS[69]*ALGEBRAIC[22]); ALGEBRAIC[28] = ( 2.00000*(CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89])/(((CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15]) - (CONSTANTS[85]+ CONSTANTS[86]*STATES[3]))+ CONSTANTS[90]*(CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15])+ (CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89]+ pow((pow(((CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15]) - (CONSTANTS[85]+ CONSTANTS[86]*STATES[3]))+ CONSTANTS[90]*(CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15])+ (CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89], 2.00000) - 4.00000*((CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15]) - (CONSTANTS[85]+ CONSTANTS[86]*STATES[3]))*(CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89]), 1.0 / 2)); ALGEBRAIC[29] = CONSTANTS[91]+ CONSTANTS[92]*ALGEBRAIC[28]; ALGEBRAIC[26] = ( 2.00000*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15])*CONSTANTS[81])/(((CONSTANTS[79]+ CONSTANTS[80]*STATES[3]) - (CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]))+ CONSTANTS[82]*(CONSTANTS[79]+ CONSTANTS[80]*STATES[3])+ CONSTANTS[81]*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15])+ pow((pow(((CONSTANTS[79]+ CONSTANTS[80]*STATES[3]) - (CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]))+ CONSTANTS[82]*(CONSTANTS[79]+ CONSTANTS[80]*STATES[3])+ CONSTANTS[81]*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]), 2.00000) - 4.00000*((CONSTANTS[79]+ CONSTANTS[80]*STATES[3]) - (CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]))*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15])*CONSTANTS[81]), 1.0 / 2)); ALGEBRAIC[27] = CONSTANTS[83]+ CONSTANTS[84]*ALGEBRAIC[26]; RATES[3] = ((((ALGEBRAIC[24] - ALGEBRAIC[25]*STATES[3])+ ALGEBRAIC[29]*STATES[4]) - ALGEBRAIC[27]*STATES[3]) - CONSTANTS[2]*STATES[3]*STATES[2])+ CONSTANTS[3]*STATES[5]+ ALGEBRAIC[20]*STATES[5]; RATES[4] = ((( ALGEBRAIC[27]*STATES[3] - ALGEBRAIC[25]*STATES[4]) - CONSTANTS[2]*STATES[4]*STATES[2])+ CONSTANTS[3]*STATES[12]+ ALGEBRAIC[20]*STATES[12]) - ALGEBRAIC[29]*STATES[4]; RATES[5] = (((( CONSTANTS[2]*STATES[3]*STATES[2] - CONSTANTS[3]*STATES[5])+ ALGEBRAIC[29]*STATES[12]) - ALGEBRAIC[27]*STATES[5]) - ALGEBRAIC[25]*STATES[5]) - ALGEBRAIC[20]*STATES[5]; RATES[12] = (((( CONSTANTS[2]*STATES[4]*STATES[2] - CONSTANTS[3]*STATES[12]) - ALGEBRAIC[29]*STATES[12])+ ALGEBRAIC[27]*STATES[5]) - ALGEBRAIC[25]*STATES[12]) - ALGEBRAIC[20]*STATES[12]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONSTANTS[18] - STATES[10])/1.00000; ALGEBRAIC[9] = (CONSTANTS[23] - STATES[13])/1.00000; ALGEBRAIC[15] = STATES[9]; ALGEBRAIC[17] = CONSTANTS[49]+ CONSTANTS[50]*ALGEBRAIC[15]; ALGEBRAIC[1] = CONSTANTS[6]*STATES[8]; ALGEBRAIC[19] = CONSTANTS[51]+ CONSTANTS[52]*STATES[0]+ CONSTANTS[53]*STATES[3]+ CONSTANTS[54]*STATES[6]+ CONSTANTS[55]*ALGEBRAIC[1]; ALGEBRAIC[20] = (CONSTANTS[58]+ CONSTANTS[59]*STATES[0]+ CONSTANTS[62]*STATES[3]+ CONSTANTS[60]*STATES[6]+ CONSTANTS[61]*ALGEBRAIC[1])/(1.00000+ CONSTANTS[63]*ALGEBRAIC[15]); ALGEBRAIC[14] = CONSTANTS[41]+ (CONSTANTS[42]+CONSTANTS[43])*STATES[9]+ CONSTANTS[43]*STATES[11]; ALGEBRAIC[13] = CONSTANTS[37]+ CONSTANTS[38]*STATES[6]+ CONSTANTS[39]*STATES[0]+ CONSTANTS[40]*STATES[3]; ALGEBRAIC[10] = CONSTANTS[28]+ CONSTANTS[29]*STATES[0]+ CONSTANTS[30]*STATES[6]+ CONSTANTS[31]*ALGEBRAIC[1]; ALGEBRAIC[11] = CONSTANTS[32]+ CONSTANTS[33]*STATES[0]+ CONSTANTS[34]*STATES[3]; ALGEBRAIC[12] = ( 2.00000*ALGEBRAIC[10]*CONSTANTS[35])/((ALGEBRAIC[11] - ALGEBRAIC[10])+ CONSTANTS[36]*ALGEBRAIC[11]+ CONSTANTS[35]*ALGEBRAIC[10]+ pow((pow((ALGEBRAIC[11] - ALGEBRAIC[10])+ CONSTANTS[36]*ALGEBRAIC[11]+ CONSTANTS[35]*ALGEBRAIC[10], 2.00000) - 4.00000*(ALGEBRAIC[11] - ALGEBRAIC[10])*CONSTANTS[35]*ALGEBRAIC[10]), 1.0 / 2)); ALGEBRAIC[21] = STATES[8]*(CONSTANTS[70]+ CONSTANTS[71]*ALGEBRAIC[12]); ALGEBRAIC[23] = STATES[8]*(CONSTANTS[72]+ CONSTANTS[73]*ALGEBRAIC[12]); ALGEBRAIC[25] = CONSTANTS[74]+ CONSTANTS[75]*STATES[13]+ CONSTANTS[76]*STATES[9]; ALGEBRAIC[16] = ( 2.00000*CONSTANTS[44]*ALGEBRAIC[15]*CONSTANTS[47])/(((CONSTANTS[45]+ CONSTANTS[46]*STATES[3]) - CONSTANTS[44]*ALGEBRAIC[15])+ CONSTANTS[48]*(CONSTANTS[45]+ CONSTANTS[46]*STATES[3])+ CONSTANTS[47]*CONSTANTS[44]*ALGEBRAIC[15]+ pow((pow(((CONSTANTS[45]+ CONSTANTS[46]*STATES[3]) - CONSTANTS[44]*ALGEBRAIC[15])+ CONSTANTS[48]*(CONSTANTS[45]+ CONSTANTS[46]*STATES[3])+ CONSTANTS[47]*CONSTANTS[44]*ALGEBRAIC[15], 2.00000) - 4.00000*((CONSTANTS[45]+ CONSTANTS[46]*STATES[3]) - CONSTANTS[44]*ALGEBRAIC[15])*CONSTANTS[47]*CONSTANTS[44]*ALGEBRAIC[15]), 1.0 / 2)); ALGEBRAIC[18] = CONSTANTS[56]+ CONSTANTS[57]*ALGEBRAIC[16]; ALGEBRAIC[22] = ( 2.00000*CONSTANTS[64]*STATES[3]*CONSTANTS[66])/((CONSTANTS[65] - CONSTANTS[64]*STATES[3])+ CONSTANTS[67]*CONSTANTS[65]+ CONSTANTS[66]*CONSTANTS[64]*STATES[3]+ pow((pow((CONSTANTS[65] - CONSTANTS[64]*STATES[3])+ CONSTANTS[67]*CONSTANTS[65]+ CONSTANTS[66]*CONSTANTS[64]*STATES[3], 2.00000) - 4.00000*(CONSTANTS[65] - CONSTANTS[64]*STATES[3])*CONSTANTS[64]*STATES[3]*CONSTANTS[66]), 1.0 / 2)); ALGEBRAIC[24] = STATES[8]*(CONSTANTS[68]+ CONSTANTS[69]*ALGEBRAIC[22]); ALGEBRAIC[28] = ( 2.00000*(CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89])/(((CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15]) - (CONSTANTS[85]+ CONSTANTS[86]*STATES[3]))+ CONSTANTS[90]*(CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15])+ (CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89]+ pow((pow(((CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15]) - (CONSTANTS[85]+ CONSTANTS[86]*STATES[3]))+ CONSTANTS[90]*(CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15])+ (CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89], 2.00000) - 4.00000*((CONSTANTS[87]+ CONSTANTS[88]*ALGEBRAIC[15]) - (CONSTANTS[85]+ CONSTANTS[86]*STATES[3]))*(CONSTANTS[85]+ CONSTANTS[86]*STATES[3])*CONSTANTS[89]), 1.0 / 2)); ALGEBRAIC[29] = CONSTANTS[91]+ CONSTANTS[92]*ALGEBRAIC[28]; ALGEBRAIC[26] = ( 2.00000*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15])*CONSTANTS[81])/(((CONSTANTS[79]+ CONSTANTS[80]*STATES[3]) - (CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]))+ CONSTANTS[82]*(CONSTANTS[79]+ CONSTANTS[80]*STATES[3])+ CONSTANTS[81]*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15])+ pow((pow(((CONSTANTS[79]+ CONSTANTS[80]*STATES[3]) - (CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]))+ CONSTANTS[82]*(CONSTANTS[79]+ CONSTANTS[80]*STATES[3])+ CONSTANTS[81]*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]), 2.00000) - 4.00000*((CONSTANTS[79]+ CONSTANTS[80]*STATES[3]) - (CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15]))*(CONSTANTS[77]+ CONSTANTS[78]*ALGEBRAIC[15])*CONSTANTS[81]), 1.0 / 2)); ALGEBRAIC[27] = CONSTANTS[83]+ CONSTANTS[84]*ALGEBRAIC[26]; ALGEBRAIC[2] = STATES[4]+STATES[5]; ALGEBRAIC[3] = STATES[3]+STATES[4]+STATES[5]+STATES[12]; ALGEBRAIC[4] = STATES[0]+STATES[1]; ALGEBRAIC[5] = STATES[6]+STATES[7]; ALGEBRAIC[6] = STATES[5]+STATES[12]; ALGEBRAIC[7] = STATES[2]+STATES[5]+STATES[12]+STATES[1]+STATES[7]; ALGEBRAIC[8] = STATES[11]+STATES[9]; }