C C There are a total of 50 entries in the algebraic variable array. C There are a total of 13 entries in each of the rate and state variable arrays. C There are a total of 53 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is R_cm in component cell (dimensionless). C CONSTS(2) is R in component cell (kilojoule_per_mole_kelvin). C CONSTS(3) is T in component cell (kelvin). C CONSTS(4) is F in component cell (kilojoule_per_mole_millivolt). C CONSTS(51) is S in component cell (kilojoule_per_mole). C CONSTS(52) is Z in component cell (millivolt). C ALGBRC(9) is electric_potential in component cell (millivolt). C CONSTS(5) is protonmotive_force in component cell (millivolt). C ALGBRC(10) is ex_membrane_potential in component cell (millivolt). C ALGBRC(11) is in_membrane_potential in component cell (millivolt). C CONSTS(6) is c_buffi in component cell (molar_proton_per_pH_unit). C CONSTS(7) is c_buffe in component cell (molar_proton_per_pH_unit). C ALGBRC(1) is pH_e in component cell (dimensionless). C ALGBRC(5) is pH_i in component cell (dimensionless). C CONSTS(8) is pKa in component cell (dimensionless). C STATES(1) is He in component He (micromolar). C STATES(2) is Hi in component Hi (micromolar). C ALGBRC(8) is delta_pH in component cell (dimensionless). C CONSTS(9) is dpH in component cell (dimensionless). C ALGBRC(6) is C0_i in component cell (molar_proton_per_pH_unit). C ALGBRC(3) is C0_e in component cell (molar_proton_per_pH_unit). C ALGBRC(7) is r_buffi in component cell (dimensionless). C ALGBRC(4) is r_buffe in component cell (dimensionless). C CONSTS(10) is BN in component cell (dimensionless). C ALGBRC(12) is u in component cell (dimensionless). C ALGBRC(14) is EmN in component redox_potentials (millivolt). C ALGBRC(33) is EmU in component redox_potentials (millivolt). C ALGBRC(30) is Emc in component redox_potentials (millivolt). C ALGBRC(32) is Ema in component redox_potentials (millivolt). C CONSTS(11) is EmN0 in component redox_potentials (millivolt). C CONSTS(12) is EmU0 in component redox_potentials (millivolt). C CONSTS(13) is Emc0 in component redox_potentials (millivolt). C ALGBRC(13) is NAD in component NAD (micromolar). C STATES(3) is NADH in component NADH (micromolar). C ALGBRC(31) is UQ in component UQ (micromolar). C STATES(4) is UQH2 in component UQH2 (micromolar). C STATES(5) is c_2 in component c_2 (micromolar). C ALGBRC(29) is c_3 in component c_3 (micromolar). C CONSTS(14) is Nt in component NAD (micromolar). C ALGBRC(35) is vDH in component vDH (flux). C ALGBRC(37) is vC1 in component vC1 (flux). C STATES(6) is O2 in component O2 (micromolar). C ALGBRC(40) is vC4 in component vC4 (flux). C CONSTS(15) is nA in component vSN (dimensionless). C ALGBRC(39) is vC3 in component vC3 (flux). C ALGBRC(44) is vSN in component vSN (flux). C ALGBRC(45) is vEX in component vEX (flux). C ALGBRC(48) is vPI in component vPI (flux). C CONSTS(53) is vLK in component vLK (flux). C ALGBRC(49) is vCK in component vCK (flux). C ALGBRC(50) is vEFF in component vEFF (flux). C ALGBRC(18) is ADP_mi in component ADP_mi (micromolar). C ALGBRC(15) is ADP_ti in component ADP_ti (micromolar). C ALGBRC(16) is ADP_fi in component ADP_fi (micromolar). C CONSTS(16) is kDDi in component ADP_fi (micromolar). C CONSTS(17) is Mg_fi in component Mg_fi (micromolar). C CONSTS(18) is Ai_SUM in component ADP_ti (micromolar). C STATES(7) is ATP_ti in component ATP_ti (micromolar). C ALGBRC(20) is ATP_mi in component ATP_mi (micromolar). C ALGBRC(17) is ATP_fi in component ATP_fi (micromolar). C CONSTS(19) is kDTi in component ATP_fi (micromolar). C ALGBRC(21) is ADP_me in component ADP_me (micromolar). C STATES(8) is ADP_te in component ADP_te (micromolar). C ALGBRC(19) is ADP_fe in component ADP_fe (micromolar). C CONSTS(20) is kDDe in component ADP_fe (micromolar). C CONSTS(21) is Mg_fe in component Mg_fe (micromolar). C ALGBRC(46) is vUT in component vUT (flux). C ALGBRC(47) is vAK in component vAK (flux). C ALGBRC(23) is ATP_me in component ATP_me (micromolar). C STATES(9) is ATP_te in component ATP_te (micromolar). C ALGBRC(22) is ATP_fe in component ATP_fe (micromolar). C CONSTS(22) is kDTe in component ATP_fe (micromolar). C ALGBRC(24) is AMP_e in component AMP_e (micromolar). C CONSTS(23) is Ae_SUM in component AMP_e (micromolar). C ALGBRC(25) is Cr in component Cr (micromolar). C CONSTS(24) is C_SUM in component Cr (micromolar). C STATES(10) is PCr in component PCr (micromolar). C ALGBRC(27) is Pi_ji in component Pi_ji (micromolar). C STATES(11) is Pi_ti in component Pi_ti (micromolar). C ALGBRC(28) is Pi_je in component Pi_je (micromolar). C STATES(12) is Pi_te in component Pi_te (micromolar). C ALGBRC(26) is P_SUM in component P_SUM (micromolar). C CONSTS(25) is ct in component c_3 (micromolar). C CONSTS(26) is Ut in component UQ (micromolar). C STATES(13) is a_2 in component a_2 (micromolar). C ALGBRC(34) is A3_2 in component a_2 (dimensionless). C CONSTS(27) is Ema0 in component a_2 (millivolt). C CONSTS(28) is at in component a_2 (micromolar). C ALGBRC(2) is a_3 in component a_3 (micromolar). C CONSTS(29) is kDH in component vDH (flux). C CONSTS(30) is KmN in component vDH (micromolar). C CONSTS(31) is pD in component vDH (dimensionless). C CONSTS(32) is kC1 in component vC1 (flux). C ALGBRC(36) is delta_GC1 in component vC1 (millivolt). C CONSTS(33) is kC3 in component vC3 (flux). C ALGBRC(38) is delta_GC3 in component vC3 (millivolt). C CONSTS(34) is kC4 in component vC4 (flux). C CONSTS(35) is KmO in component vC4 (micromolar). C CONSTS(36) is kSN in component vSN (flux). C ALGBRC(42) is delta_GSN in component vSN (millivolt). C ALGBRC(41) is delta_Gp in component vSN (kilojoule_per_mole). C CONSTS(37) is delta_Gp0 in component vSN (kilojoule_per_mole). C ALGBRC(43) is gamma in component vSN (dimensionless). C CONSTS(38) is kEX in component vEX (flux). C CONSTS(39) is km_ADP in component vEX (micromolar). C CONSTS(40) is km_A in component vUT (micromolar). C CONSTS(41) is kUT in component vUT (flux). C CONSTS(42) is kf_AK in component vAK (second_order_rate_constant). C CONSTS(43) is kb_AK in component vAK (second_order_rate_constant). C CONSTS(44) is kL1 in component vLK (flux). C CONSTS(45) is kL2 in component vLK (per_millivolt). C CONSTS(46) is kPI in component vPI (second_order_rate_constant). C CONSTS(47) is kf_CK in component vCK (third_order_rate_constant). C CONSTS(48) is kb_CK in component vCK (second_order_rate_constant). C CONSTS(49) is pH_o in component vEFF (dimensionless). C CONSTS(50) is k_EFF in component vEFF (flux). C RATES(3) is d/dt NADH in component NADH (micromolar). C RATES(6) is d/dt O2 in component O2 (micromolar). C RATES(2) is d/dt Hi in component Hi (micromolar). C RATES(1) is d/dt He in component He (micromolar). C RATES(7) is d/dt ATP_ti in component ATP_ti (micromolar). C RATES(8) is d/dt ADP_te in component ADP_te (micromolar). C RATES(9) is d/dt ATP_te in component ATP_te (micromolar). C RATES(10) is d/dt PCr in component PCr (micromolar). C RATES(11) is d/dt Pi_ti in component Pi_ti (micromolar). C RATES(12) is d/dt Pi_te in component Pi_te (micromolar). C RATES(5) is d/dt c_2 in component c_2 (micromolar). C RATES(4) is d/dt UQH2 in component UQH2 (micromolar). C RATES(13) is d/dt a_2 in component a_2 (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 15.0 CONSTS(2) = 0.0083 CONSTS(3) = 289.0 CONSTS(4) = 0.0965 CONSTS(5) = 190.0 CONSTS(6) = 0.022 CONSTS(7) = 0.025 CONSTS(8) = 6.8 STATES(1) = 1.00 STATES(2) = 1.00 CONSTS(9) = 0.001 CONSTS(10) = 5.0 CONSTS(11) = -320.0 CONSTS(12) = 85.0 CONSTS(13) = 250.0 STATES(3) = 500.0 STATES(4) = 1.00 STATES(5) = 1.00 CONSTS(14) = 2970.0 STATES(6) = 1.00 CONSTS(15) = 2.5 CONSTS(16) = 282 CONSTS(17) = 380.0 CONSTS(18) = 16260.0 STATES(7) = 1.00 CONSTS(19) = 17 STATES(8) = 1.00 CONSTS(20) = 347 CONSTS(21) = 4000.0 STATES(9) = 1.00 CONSTS(22) = 24 CONSTS(23) = 1600.2 CONSTS(24) = 35000.0 STATES(10) = 1.00 STATES(11) = 1.00 STATES(12) = 1.00 CONSTS(25) = 270.0 CONSTS(26) = 1350.0 STATES(13) = 1.00 CONSTS(27) = 540.0 CONSTS(28) = 135.0 CONSTS(29) = 28074 CONSTS(30) = 100.0 CONSTS(31) = 0.8 CONSTS(32) = 238.95 CONSTS(33) = 136.41 CONSTS(34) = 136.41 CONSTS(35) = 120.0 CONSTS(36) = 34316.0 CONSTS(37) = 31.9 CONSTS(38) = 54572 CONSTS(39) = 3.5 CONSTS(40) = 150.0 CONSTS(41) = 686.5 CONSTS(42) = 862.10 CONSTS(43) = 22.747 CONSTS(44) = 2.5 CONSTS(45) = 0.038 CONSTS(46) = 69.421 CONSTS(47) = 1.9258 CONSTS(48) = 0.00087538 CONSTS(49) = 7.0 CONSTS(50) = 1.9258 CONSTS(51) = 2.30300*CONSTS(2)*CONSTS(3) CONSTS(52) = 2.30300*CONSTS(2)*(CONSTS(3)/CONSTS(4)) CONSTS(53) = CONSTS(44)*(EXP( CONSTS(45)*CONSTS(5)) - 1.00000) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = - arbitrary_log(STATES(1)/1.00000e+06, 10) ALGBRC(5) = - arbitrary_log(STATES(2)/1.00000e+06, 10) ALGBRC(8) = CONSTS(52)*(ALGBRC(5) - ALGBRC(1)) ALGBRC(9) = - (CONSTS(5) - ALGBRC(8)) ALGBRC(12) = ALGBRC(9)/CONSTS(5) ALGBRC(29) = CONSTS(25) - STATES(5) ALGBRC(30) = CONSTS(13)+ CONSTS(52)*arbitrary_log(ALGBRC(29)/STATES(5), 10) ALGBRC(32) = ALGBRC(30)+ CONSTS(5)*((2.00000+ 2.00000*ALGBRC(12))/2.00000) ALGBRC(34) = 10.0000 ** (ALGBRC(32) - CONSTS(27))/CONSTS(52) RATES(13) = CONSTS(28)/(1.00000+ALGBRC(34)) ALGBRC(13) = CONSTS(14) - STATES(3) ALGBRC(35) = CONSTS(29)*(1.00000/1.00000+CONSTS(30)/(ALGBRC(13)/STATES(3)) ** CONSTS(31)) ALGBRC(14) = CONSTS(11)+ (CONSTS(52)/2.00000)*arbitrary_log(ALGBRC(13)/STATES(3), 10) ALGBRC(31) = CONSTS(26) - STATES(4) ALGBRC(33) = CONSTS(12)+ (CONSTS(52)/2.00000)*arbitrary_log(ALGBRC(31)/STATES(4), 10) ALGBRC(36) = ALGBRC(33) - (ALGBRC(14)+ CONSTS(5)*(4.00000/2.00000)) ALGBRC(37) = CONSTS(32)*ALGBRC(36) RATES(3) = (ALGBRC(35) - ALGBRC(37))*(CONSTS(1)/CONSTS(10)) ALGBRC(38) = ALGBRC(30) - (ALGBRC(33)+ CONSTS(5)*((4.00000 - 2.00000*ALGBRC(12))/2.00000)) ALGBRC(39) = CONSTS(33)*ALGBRC(38) RATES(4) = CONSTS(1)*(ALGBRC(37) - ALGBRC(39)) ALGBRC(40) = CONSTS(34)*STATES(13)*STATES(5)*(1.00000/(1.00000+CONSTS(35)/STATES(6))) RATES(6) = - ALGBRC(40) RATES(5) = (ALGBRC(39)+ ALGBRC(40)*2.00000)*CONSTS(1)*2.00000 ALGBRC(15) = CONSTS(18) - STATES(7) ALGBRC(41) = CONSTS(37)/(CONSTS(4)+ CONSTS(52)*arbitrary_log( 1.00000e+06*(STATES(7)/( ALGBRC(15)*STATES(11))), 10)) ALGBRC(42) = CONSTS(15)*CONSTS(5) - ALGBRC(41) ALGBRC(43) = 10.0000 ** ALGBRC(42)/CONSTS(52) ALGBRC(44) = CONSTS(36)*((ALGBRC(43) - 1.00000)/(ALGBRC(43)+1.00000)) ALGBRC(11) = 0.650000*ALGBRC(9) ALGBRC(16) = ALGBRC(15)/(1.00000+CONSTS(17)/CONSTS(16)) ALGBRC(17) = STATES(7)/(1.00000+CONSTS(17)/CONSTS(19)) ALGBRC(19) = STATES(8)/(1.00000+CONSTS(21)/CONSTS(20)) ALGBRC(22) = STATES(9)/(1.00000+CONSTS(21)/CONSTS(22)) ALGBRC(45) = CONSTS(38)*(ALGBRC(19)/(ALGBRC(19)+ ALGBRC(22)*10.0000 ** - ALGBRC(11)/CONSTS(52)) - ALGBRC(16)/(ALGBRC(16)+ ALGBRC(17)*10.0000 ** - ALGBRC(11)/CONSTS(52)))*(1.00000/(1.00000+CONSTS(39)/ALGBRC(19))) RATES(7) = (ALGBRC(44) - ALGBRC(45))*CONSTS(1) ALGBRC(6) = (10.0000 ** - ALGBRC(5) - 10.0000 ** - ALGBRC(5) - CONSTS(9))/CONSTS(9) ALGBRC(7) = CONSTS(6)/ALGBRC(6) ALGBRC(27) = STATES(11)/(1.00000+10.0000 ** ALGBRC(5) - CONSTS(8)) ALGBRC(28) = STATES(12)/(1.00000+10.0000 ** ALGBRC(1) - CONSTS(8)) ALGBRC(48) = CONSTS(46)*( STATES(1)*ALGBRC(28) - STATES(2)*ALGBRC(27)) RATES(2) = ( (( (4.00000 - 2.00000*ALGBRC(12))*ALGBRC(39)+ 4.00000*ALGBRC(37)) - ( 2.00000*(2.00000+ 2.00000*ALGBRC(12))*ALGBRC(40)+ CONSTS(15)*ALGBRC(44)+ ALGBRC(12)*ALGBRC(45)+ (1.00000 - ALGBRC(12))*ALGBRC(48)+CONSTS(53)))*CONSTS(1))/ALGBRC(7) RATES(11) = (ALGBRC(48) - ALGBRC(44))*CONSTS(1) ALGBRC(46) = CONSTS(41)*(1.00000/(1.00000+CONSTS(40)/STATES(9))) RATES(12) = ALGBRC(46) - ALGBRC(48) ALGBRC(25) = CONSTS(24) - STATES(10) ALGBRC(49) = CONSTS(47)*STATES(8)*STATES(10)*STATES(1) - CONSTS(48)*STATES(9)*ALGBRC(25) ALGBRC(21) = STATES(8) - ALGBRC(19) ALGBRC(23) = STATES(9) - ALGBRC(22) ALGBRC(24) = CONSTS(23) - (STATES(9)+STATES(8)) ALGBRC(47) = CONSTS(42)*ALGBRC(21)*ALGBRC(19) - CONSTS(43)*ALGBRC(23)*ALGBRC(24) RATES(8) = ALGBRC(46) - (ALGBRC(45)+ 2.00000*ALGBRC(47)+ALGBRC(49)) RATES(9) = (ALGBRC(45)+ALGBRC(47)+ALGBRC(49)) - ALGBRC(46) RATES(10) = - ALGBRC(49) ALGBRC(3) = (10.0000 ** - ALGBRC(1) - 10.0000 ** - ALGBRC(1) - CONSTS(9))/CONSTS(9) ALGBRC(4) = CONSTS(7)/ALGBRC(3) ALGBRC(50) = CONSTS(50)*(CONSTS(49) - ALGBRC(1)) RATES(1) = (( 2.00000*(2.00000+ 2.00000*ALGBRC(12))*ALGBRC(40)+ (4.00000 - 2.00000*ALGBRC(12))*ALGBRC(39)+ 4.00000*ALGBRC(37)) - ( CONSTS(15)*ALGBRC(44)+ ALGBRC(12)*ALGBRC(45)+ (1.00000 - ALGBRC(12))*ALGBRC(48)+CONSTS(53)+ALGBRC(49)+ALGBRC(50)))/ALGBRC(4) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = - arbitrary_log(STATES(1)/1.00000e+06, 10) ALGBRC(5) = - arbitrary_log(STATES(2)/1.00000e+06, 10) ALGBRC(8) = CONSTS(52)*(ALGBRC(5) - ALGBRC(1)) ALGBRC(9) = - (CONSTS(5) - ALGBRC(8)) ALGBRC(12) = ALGBRC(9)/CONSTS(5) ALGBRC(29) = CONSTS(25) - STATES(5) ALGBRC(30) = CONSTS(13)+ CONSTS(52)*arbitrary_log(ALGBRC(29)/STATES(5), 10) ALGBRC(32) = ALGBRC(30)+ CONSTS(5)*((2.00000+ 2.00000*ALGBRC(12))/2.00000) ALGBRC(34) = 10.0000 ** (ALGBRC(32) - CONSTS(27))/CONSTS(52) ALGBRC(13) = CONSTS(14) - STATES(3) ALGBRC(35) = CONSTS(29)*(1.00000/1.00000+CONSTS(30)/(ALGBRC(13)/STATES(3)) ** CONSTS(31)) ALGBRC(14) = CONSTS(11)+ (CONSTS(52)/2.00000)*arbitrary_log(ALGBRC(13)/STATES(3), 10) ALGBRC(31) = CONSTS(26) - STATES(4) ALGBRC(33) = CONSTS(12)+ (CONSTS(52)/2.00000)*arbitrary_log(ALGBRC(31)/STATES(4), 10) ALGBRC(36) = ALGBRC(33) - (ALGBRC(14)+ CONSTS(5)*(4.00000/2.00000)) ALGBRC(37) = CONSTS(32)*ALGBRC(36) ALGBRC(38) = ALGBRC(30) - (ALGBRC(33)+ CONSTS(5)*((4.00000 - 2.00000*ALGBRC(12))/2.00000)) ALGBRC(39) = CONSTS(33)*ALGBRC(38) ALGBRC(40) = CONSTS(34)*STATES(13)*STATES(5)*(1.00000/(1.00000+CONSTS(35)/STATES(6))) ALGBRC(15) = CONSTS(18) - STATES(7) ALGBRC(41) = CONSTS(37)/(CONSTS(4)+ CONSTS(52)*arbitrary_log( 1.00000e+06*(STATES(7)/( ALGBRC(15)*STATES(11))), 10)) ALGBRC(42) = CONSTS(15)*CONSTS(5) - ALGBRC(41) ALGBRC(43) = 10.0000 ** ALGBRC(42)/CONSTS(52) ALGBRC(44) = CONSTS(36)*((ALGBRC(43) - 1.00000)/(ALGBRC(43)+1.00000)) ALGBRC(11) = 0.650000*ALGBRC(9) ALGBRC(16) = ALGBRC(15)/(1.00000+CONSTS(17)/CONSTS(16)) ALGBRC(17) = STATES(7)/(1.00000+CONSTS(17)/CONSTS(19)) ALGBRC(19) = STATES(8)/(1.00000+CONSTS(21)/CONSTS(20)) ALGBRC(22) = STATES(9)/(1.00000+CONSTS(21)/CONSTS(22)) ALGBRC(45) = CONSTS(38)*(ALGBRC(19)/(ALGBRC(19)+ ALGBRC(22)*10.0000 ** - ALGBRC(11)/CONSTS(52)) - ALGBRC(16)/(ALGBRC(16)+ ALGBRC(17)*10.0000 ** - ALGBRC(11)/CONSTS(52)))*(1.00000/(1.00000+CONSTS(39)/ALGBRC(19))) ALGBRC(6) = (10.0000 ** - ALGBRC(5) - 10.0000 ** - ALGBRC(5) - CONSTS(9))/CONSTS(9) ALGBRC(7) = CONSTS(6)/ALGBRC(6) ALGBRC(27) = STATES(11)/(1.00000+10.0000 ** ALGBRC(5) - CONSTS(8)) ALGBRC(28) = STATES(12)/(1.00000+10.0000 ** ALGBRC(1) - CONSTS(8)) ALGBRC(48) = CONSTS(46)*( STATES(1)*ALGBRC(28) - STATES(2)*ALGBRC(27)) ALGBRC(46) = CONSTS(41)*(1.00000/(1.00000+CONSTS(40)/STATES(9))) ALGBRC(25) = CONSTS(24) - STATES(10) ALGBRC(49) = CONSTS(47)*STATES(8)*STATES(10)*STATES(1) - CONSTS(48)*STATES(9)*ALGBRC(25) ALGBRC(21) = STATES(8) - ALGBRC(19) ALGBRC(23) = STATES(9) - ALGBRC(22) ALGBRC(24) = CONSTS(23) - (STATES(9)+STATES(8)) ALGBRC(47) = CONSTS(42)*ALGBRC(21)*ALGBRC(19) - CONSTS(43)*ALGBRC(23)*ALGBRC(24) ALGBRC(3) = (10.0000 ** - ALGBRC(1) - 10.0000 ** - ALGBRC(1) - CONSTS(9))/CONSTS(9) ALGBRC(4) = CONSTS(7)/ALGBRC(3) ALGBRC(50) = CONSTS(50)*(CONSTS(49) - ALGBRC(1)) ALGBRC(2) = CONSTS(28) - STATES(13) ALGBRC(10) = -0.350000*ALGBRC(9) ALGBRC(18) = ALGBRC(15) - ALGBRC(16) ALGBRC(20) = STATES(7) - ALGBRC(17) ALGBRC(26) = STATES(10)+ STATES(9)*3.00000+ STATES(8)*2.00000+ALGBRC(24)+STATES(12)+( STATES(7)*3.00000+ ALGBRC(15)*2.00000+STATES(11))/CONSTS(1) RETURN END