You are here: Home / Exposures / Riccobene, Omann, Linderman, 1999 / Modeling Activation and Desensitisation of G-Protein Coupled Receptors Provides Insight into Ligand Efficacy

Model Mathematics

Component based math viewer is available

Component: environment

Component: R

\frac{d}{d time} (R) = kr LR + \frac{kfR}{Kact} R_star - (kf L R + kfR R)

Component: R_star

\frac{d}{d time} (R_star) = kr LR_star + kfR R - (alpha kf L R_star + \frac{kfR}{Kact} R_star)

Component: LR

\frac{d}{d time} (LR) = kf L R + \frac{kfR}{alpha Kact} LR_star - (kr LR + kfR LR)

Component: LR_star

\frac{d}{d time} (LR_star) = kfR LR + alpha kf L R_star - (\frac{kfR}{alpha Kact} LR_star + kds LR_star + kr LR_star)

Component: LR_ds

\frac{d}{d time} (LR_ds) = kds LR_star + kf2 L R_ds - (kr2 LR_ds)

Component: R_ds

\frac{d}{d time} (R_ds) = kr2 LR_ds - (kf2 L R_ds)

Component: G_star

\frac{d}{d time} (G_star) = ka G (LR_star + R_star) - (ki G_star)

Component: G

\frac{d}{d time} (G) = ki G_star - (ka G (LR_star + R_star))

Component: L

Component: model_parameters

Source: Derived from workspace Riccobene, Omann, Linderman, 1999 at changeset 70d5b7563585.

Collaboration: To begin collaborating on this work, please use your git client and issue this command:

Downloads

Views Available

Tools

License: This work is licensed under a Creative Commons Attribution 3.0 Unported License.

Modeling Activation and Desensitisation of G-Protein Coupled Receptors Provides Insight into Ligand Efficacy