Model Mathematics

Component: environment

Component: G_o

Component: G

ddtimeG=V_IN-V_HK

Component: G6P

ddtimeG6P=V_HK-V_PFK+V_G6PDH

Component: FDP

ddtimeFDP=V_PFK-V_ALD

Component: G3P

ddtimeG3P=2V_ALD-V_GAPDH

Component: DPG

ddtimeDPG=V_GAPDH-V_PGK

Component: PEP

ddtimePEP=V_PGK-V_PK

Component: Py

ddtimePy=V_PK-V_TCA+V_ADH

Component: ATP

ddtimeATP=V_PGK+V_PK+POV_TCA-V_HK+V_PFK+V_ATPase

Component: ADP

ADP=Cn-ATP+AMP

Component: AMP

Component: GTP

Component: GDP

Component: H

Component: NADP

Component: NADH

Component: NAD

Component: CD

CD=CMTP-CT+CP

Component: CT

ddtimeCT=-kpolCTCP2+kfCD+kbCTGDP

Component: CP

ddtimeCP=kpolCTCP2-kdpCP

Component: PKp

ddtimePKp=0.1kp2PKtCP-kp3PKp+k4PKpGTP

Component: PKt

PKt=C_PK-PKp

Component: V_IN

V_IN=V_IN_maxG_oKG_in+G_o1+G6PKe_in-GKG_in+G1+G6PKe_in

Component: V_HK

V_HK=V_HK_max11+KG_sKATP_mGATP+KG_mG+KATP_mATP

Component: V_PFK

V_PFK=V_PFK_maxgrG6PKG6P_rATPKATP_r1+G6PKG6P_r+ATPKATP_r+grG6PKG6P_rATPKATP_rn1-11+G6PKG6P_r+ATPKATP_r+grG6PKG6P_rATPKATP_rn1+Lo1+cAMPAMPKAMP_r1+AMPKAMP_rn11+cG6PG6PKG6P_r+cATPATPKATP_r+grcG6PG6PKG6P_rcATPATPKATP_rn1

Component: V_G6PDH

V_G6PDH=V_G6PDH_maxKG6PKNADPG6PNADP+KG6PG6P+KNADPNADP+1+V_G6PDH_max_IIKG6PKNADP_KTUBG6PNADPTUB+KG6PKNADP_G6PNADP+KNADP_KTUBNADPTUB+KG6PKTUBG6PTUB+KTUBTUB+KG6PG6P+KNADP_NADP+1 TUB=CT+CD

Component: V_ALD

V_ALD=V_ALD_maxFDPKFDP_m-V_ALD_max_rG3PKG3P_m1+FDPKFDP_m+G3PKG3P_m

Component: V_GAPDH

V_GAPDH=V_GAPDH_max1+KG3PG3P+KNADNAD1+AMPK1+ADPK2+ATPK3+KG3PKNADG3PNAD1+NADHKNADH_i+1+AMPK1+ADPK2+ATPK3

Component: V_PGK

V_PGK=V_PGK_maxDPGKDPG_m+DPG

Component: V_PK

V_PK=V_PK_max1+KpHHgr_PKPEPKPEP_rADPKADP_rRn-1+Lo_PK1+cFDPFDPKFDP_r1+FDPKFDP_rnFDPKFDP_rgt_PKcPEPPEPKPEP_rcADPADPKADP_rTn-1Rn+Lo_PK1+cFDPFDPKFDP_r1+FDPKFDP_rnTn R=1+PEPKPEP_r+ADPKADP_r+gr_PKPEPKPEP_rADPKADP_r T=1+cPEPPEPKPEP_r+cADPADPKADP_r+gt_PKcPEPPEPKPEP_rcADPADPKADP_r V_PK_max=V_PKt_max+V_PKp_max-V_PKt_maxPKpC_PK n=4+PKpC_PK

Component: V_TCA

V_TCA=V_TCA_maxPy2KPy_m2+Py2

Component: V_ADH

V_ADH=V_ADH_maxPyKPy__m+Py

Component: V_ATPase

V_ATPase=KATPATP