/* There are a total of 10 entries in the algebraic variable array. There are a total of 8 entries in each of the rate and state variable arrays. There are a total of 29 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is c in component c (micromolar). * CONSTANTS[0] is delta in component c (dimensionless). * ALGEBRAIC[2] is J_serca in component J_serca (flux). * CONSTANTS[28] is J_in in component J_in (flux). * ALGEBRAIC[4] is J_pm in component J_pm (flux). * ALGEBRAIC[0] is J_IPR in component J_IPR (flux). * STATES[1] is ce in component ce (micromolar). * CONSTANTS[1] is gamma in component ce (dimensionless). * CONSTANTS[2] is p in component p (micromolar). * CONSTANTS[3] is kf in component J_IPR (first_order_rate_constant). * CONSTANTS[4] is g1 in component J_IPR (first_order_rate_constant). * STATES[2] is A in component A (dimensionless). * STATES[3] is O in component O (dimensionless). * STATES[4] is R in component R (dimensionless). * ALGEBRAIC[1] is phi_1 in component IPR_parameters (first_order_rate_constant). * ALGEBRAIC[3] is phi_2 in component IPR_parameters (second_order_rate_constant). * ALGEBRAIC[5] is phi_2_ in component IPR_parameters (first_order_rate_constant). * CONSTANTS[5] is k_1_ in component IPR_parameters (first_order_rate_constant). * CONSTANTS[6] is l_2_ in component IPR_parameters (first_order_rate_constant). * STATES[5] is I_1 in component I_1 (dimensionless). * STATES[6] is S in component S (dimensionless). * ALGEBRAIC[6] is phi_3 in component IPR_parameters (second_order_rate_constant). * ALGEBRAIC[7] is phi_4 in component IPR_parameters (first_order_rate_constant). * ALGEBRAIC[8] is phi_4_ in component IPR_parameters (first_order_rate_constant). * CONSTANTS[7] is k_3_ in component IPR_parameters (first_order_rate_constant). * STATES[7] is I_2 in component I_2 (dimensionless). * ALGEBRAIC[9] is phi_5 in component IPR_parameters (first_order_rate_constant). * CONSTANTS[8] is k_1 in component IPR_parameters (second_order_rate_constant). * CONSTANTS[9] is k_2 in component IPR_parameters (second_order_rate_constant). * CONSTANTS[10] is k_2_ in component IPR_parameters (first_order_rate_constant). * CONSTANTS[11] is k_3 in component IPR_parameters (second_order_rate_constant). * CONSTANTS[12] is k_4 in component IPR_parameters (second_order_rate_constant). * CONSTANTS[13] is k_4_ in component IPR_parameters (first_order_rate_constant). * CONSTANTS[14] is l_2 in component IPR_parameters (first_order_rate_constant). * CONSTANTS[15] is l_4 in component IPR_parameters (second_order_rate_constant). * CONSTANTS[16] is l_4_ in component IPR_parameters (second_order_rate_constant). * CONSTANTS[17] is l_6 in component IPR_parameters (first_order_rate_constant). * CONSTANTS[18] is l_6_ in component IPR_parameters (first_order_rate_constant). * CONSTANTS[19] is L_1 in component IPR_parameters (micromolar). * CONSTANTS[20] is L_3 in component IPR_parameters (micromolar). * CONSTANTS[21] is L_5 in component IPR_parameters (micromolar). * CONSTANTS[22] is Vs in component J_serca (micromolar2_per_second). * CONSTANTS[23] is Ks in component J_serca (micromolar). * CONSTANTS[24] is Vp in component J_pm (flux). * CONSTANTS[25] is Kp in component J_pm (micromolar). * CONSTANTS[26] is alpha1 in component J_in (flux). * CONSTANTS[27] is alpha2 in component J_in (first_order_rate_constant). * RATES[0] is d/dt c in component c (micromolar). * RATES[1] is d/dt ce in component ce (micromolar). * RATES[4] is d/dt R in component R (dimensionless). * RATES[3] is d/dt O in component O (dimensionless). * RATES[5] is d/dt I_1 in component I_1 (dimensionless). * RATES[7] is d/dt I_2 in component I_2 (dimensionless). * RATES[6] is d/dt S in component S (dimensionless). * RATES[2] is d/dt A in component A (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 0.01; CONSTANTS[0] = 0.1; STATES[1] = 0.01; CONSTANTS[1] = 5.4; CONSTANTS[2] = 10.0; CONSTANTS[3] = 0.96; CONSTANTS[4] = 0.002; STATES[2] = 0.16; STATES[3] = 0.01; STATES[4] = 0.16; CONSTANTS[5] = 0.04; CONSTANTS[6] = 0.8; STATES[5] = 0.16; STATES[6] = 0.16; CONSTANTS[7] = 29.8; STATES[7] = 0.16; CONSTANTS[8] = 0.64; CONSTANTS[9] = 37.4; CONSTANTS[10] = 1.4; CONSTANTS[11] = 0.11; CONSTANTS[12] = 4.0; CONSTANTS[13] = 0.54; CONSTANTS[14] = 1.7; CONSTANTS[15] = 1.7; CONSTANTS[16] = 2.5; CONSTANTS[17] = 4707.0; CONSTANTS[18] = 11.4; CONSTANTS[19] = 0.12; CONSTANTS[20] = 0.025; CONSTANTS[21] = 54.7; CONSTANTS[22] = 120.0; CONSTANTS[23] = 0.18; CONSTANTS[24] = 28.0; CONSTANTS[25] = 0.42; CONSTANTS[26] = 0.03; CONSTANTS[27] = 0.2; CONSTANTS[28] = CONSTANTS[26]+ CONSTANTS[27]*CONSTANTS[2]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = ( ( CONSTANTS[8]*CONSTANTS[19]+CONSTANTS[14])*STATES[0])/(CONSTANTS[19]+ STATES[0]*(1.00000+CONSTANTS[19]/CONSTANTS[20])); RATES[5] = ALGEBRAIC[1]*STATES[4] - (CONSTANTS[5]+CONSTANTS[6])*STATES[5]; ALGEBRAIC[2] = (( CONSTANTS[22]*STATES[0])/(CONSTANTS[23]+STATES[0]))*(1.00000/STATES[1]); ALGEBRAIC[0] = ( CONSTANTS[3]*pow( 0.100000*STATES[3]+ 0.900000*STATES[2], 4.00000)+CONSTANTS[4])*(STATES[1] - STATES[0]); RATES[1] = CONSTANTS[1]*(ALGEBRAIC[2] - ALGEBRAIC[0]); ALGEBRAIC[4] = ( CONSTANTS[24]*pow(STATES[0], 2.00000))/(pow(CONSTANTS[25], 2.00000)+pow(STATES[0], 2.00000)); RATES[0] = (ALGEBRAIC[0] - ALGEBRAIC[2])+ CONSTANTS[0]*(CONSTANTS[28] - ALGEBRAIC[4]); ALGEBRAIC[3] = ( CONSTANTS[9]*CONSTANTS[20]+ CONSTANTS[15]*STATES[0])/(CONSTANTS[20]+ STATES[0]*(1.00000+CONSTANTS[20]/CONSTANTS[19])); ALGEBRAIC[5] = (CONSTANTS[10]+ CONSTANTS[16]*STATES[0])/(1.00000+STATES[0]/CONSTANTS[21]); RATES[4] = ( ALGEBRAIC[5]*STATES[3] - ( ALGEBRAIC[3]*CONSTANTS[2]*STATES[4]+ ALGEBRAIC[1]*STATES[4]))+ (CONSTANTS[6]+CONSTANTS[5])*STATES[5]; ALGEBRAIC[6] = ( CONSTANTS[11]*CONSTANTS[21])/(STATES[0]+CONSTANTS[21]); RATES[6] = 1.00000*ALGEBRAIC[6]*STATES[3] - CONSTANTS[7]*STATES[6]; ALGEBRAIC[7] = ( ( CONSTANTS[12]*CONSTANTS[21]+CONSTANTS[17])*STATES[0])/(STATES[0]+CONSTANTS[21]); ALGEBRAIC[8] = ( CONSTANTS[19]*(CONSTANTS[13]+CONSTANTS[18]))/(STATES[0]+CONSTANTS[19]); RATES[3] = ( ALGEBRAIC[3]*CONSTANTS[2]*STATES[4] - (ALGEBRAIC[5]+ALGEBRAIC[7]+ 1.00000*ALGEBRAIC[6])*STATES[3])+ ALGEBRAIC[8]*STATES[2]+ CONSTANTS[7]*STATES[6]; ALGEBRAIC[9] = ( ( CONSTANTS[8]*CONSTANTS[19]+CONSTANTS[14])*STATES[0])/(STATES[0]+CONSTANTS[19]); RATES[7] = ALGEBRAIC[9]*STATES[2] - (CONSTANTS[5]+CONSTANTS[6])*STATES[7]; RATES[2] = ( ALGEBRAIC[7]*STATES[3] - ( ALGEBRAIC[8]*STATES[2]+ ALGEBRAIC[9]*STATES[2]))+ (CONSTANTS[5]+CONSTANTS[6])*STATES[7]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = ( ( CONSTANTS[8]*CONSTANTS[19]+CONSTANTS[14])*STATES[0])/(CONSTANTS[19]+ STATES[0]*(1.00000+CONSTANTS[19]/CONSTANTS[20])); ALGEBRAIC[2] = (( CONSTANTS[22]*STATES[0])/(CONSTANTS[23]+STATES[0]))*(1.00000/STATES[1]); ALGEBRAIC[0] = ( CONSTANTS[3]*pow( 0.100000*STATES[3]+ 0.900000*STATES[2], 4.00000)+CONSTANTS[4])*(STATES[1] - STATES[0]); ALGEBRAIC[4] = ( CONSTANTS[24]*pow(STATES[0], 2.00000))/(pow(CONSTANTS[25], 2.00000)+pow(STATES[0], 2.00000)); ALGEBRAIC[3] = ( CONSTANTS[9]*CONSTANTS[20]+ CONSTANTS[15]*STATES[0])/(CONSTANTS[20]+ STATES[0]*(1.00000+CONSTANTS[20]/CONSTANTS[19])); ALGEBRAIC[5] = (CONSTANTS[10]+ CONSTANTS[16]*STATES[0])/(1.00000+STATES[0]/CONSTANTS[21]); ALGEBRAIC[6] = ( CONSTANTS[11]*CONSTANTS[21])/(STATES[0]+CONSTANTS[21]); ALGEBRAIC[7] = ( ( CONSTANTS[12]*CONSTANTS[21]+CONSTANTS[17])*STATES[0])/(STATES[0]+CONSTANTS[21]); ALGEBRAIC[8] = ( CONSTANTS[19]*(CONSTANTS[13]+CONSTANTS[18]))/(STATES[0]+CONSTANTS[19]); ALGEBRAIC[9] = ( ( CONSTANTS[8]*CONSTANTS[19]+CONSTANTS[14])*STATES[0])/(STATES[0]+CONSTANTS[19]); }