You are here: Home / Exposures / Cortassa, Aon, Marban, Winslow, O'Rourke, 2003 / An Integrated Model of Cardiac Mitrochondrial Energy Metabolism and Calcium Dynamics

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Component: oxidative_phosphorylation

V_O2 = 0.5 rho_res \frac{((ra + rc1 ⅇ^{\frac{6.0 F delta_psi_B}{R T}}) ⅇ^{\frac{Ares F}{R T}} - (ra ⅇ^{\frac{g 6.0 F delta_mu_H}{R T}})) + rc2 ⅇ^{\frac{Ares F}{R T}} ⅇ^{\frac{g 6.0 F delta_mu_H}{R T}}}{(1.0 + r1 ⅇ^{\frac{F Ares}{R T}}) ⅇ^{\frac{6.0 F delta_psi_B}{R T}} + (r2 + r3 ⅇ^{\frac{F Ares}{R T}}) ⅇ^{\frac{g 6.0 F delta_mu_H}{R T}}} V_He = 6.0 rho_res \frac{ra ⅇ^{\frac{F Ares}{R T}} - ((ra + rb) ⅇ^{\frac{g 6.0 F delta_mu_H}{R T}})}{(1.0 + r1 ⅇ^{\frac{F Ares}{R T}}) ⅇ^{\frac{6.0 F delta_psi_B}{R T}} + (r2 + r3 ⅇ^{\frac{F Ares}{R T}}) ⅇ^{\frac{g 6.0 F delta_mu_H}{R T}}} Ares = \frac{R T}{F} \ln (Kres {(\frac{NADH}{NAD})}^{0.5}) V_He_F = 6.0 rho_res_F \frac{ra ⅇ^{\frac{F Ares_F}{R T}} - ((ra + rb) ⅇ^{\frac{g 6.0 F delta_mu_H}{R T}})}{(1.0 + r1 ⅇ^{\frac{F Ares_F}{R T}}) ⅇ^{\frac{6.0 F delta_psi_B}{R T}} + (r2 + r3 ⅇ^{\frac{F Ares_F}{R T}}) ⅇ^{\frac{g 6.0 F delta_mu_H}{R T}}} Ares_F = \frac{R T}{F} \ln (Kres_F {(\frac{FADH2}{FAD})}^{0.5}) V_Hleak = gH delta_mu_H delta_mu_H = \frac{R T}{F} delta_pH + delta_psi_m V_ATPase = (- rho_F1) \frac{(100.0 pa + pc1 ⅇ^{\frac{3.0 F delta_psi_B}{R T}}) ⅇ^{\frac{AF1 F}{R T}} - (pa ⅇ^{\frac{3.0 F delta_mu_H}{R T}} + pc2 ⅇ^{\frac{AF1 F}{R T}} ⅇ^{\frac{3.0 F delta_mu_H}{R T}})}{(1.0 + p1 ⅇ^{\frac{F AF1}{R T}}) ⅇ^{\frac{3.0 F delta_psi_B}{R T}} + (p2 + p3 ⅇ^{\frac{F AF1}{R T}}) ⅇ^{\frac{3.0 F delta_mu_H}{R T}}} V_Hu = (-3.0) rho_F1 \frac{100.0 pa (1.0 + ⅇ^{\frac{F AF1}{R T}}) - ((pa + pb) ⅇ^{\frac{3.0 F delta_mu_H}{R T}})}{(1.0 + p1 ⅇ^{\frac{F AF1}{R T}}) ⅇ^{\frac{3.0 F delta_psi_B}{R T}} + (p2 + p3 ⅇ^{\frac{F AF1}{R T}}) ⅇ^{\frac{3.0 F delta_mu_H}{R T}}} AF1 = \frac{R T}{F} \ln (KF1 \frac{ATP_m}{ADP_m Pi})

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An Integrated Model of Cardiac Mitrochondrial Energy Metabolism and Calcium Dynamics