function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =3; end % There are a total of 3 entries in each of the rate and state variable arrays. % There are a total of 8 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (day)'); LEGEND_CONSTANTS(:,1) = strpad('tau in component model_parameters (day)'); LEGEND_CONSTANTS(:,2) = strpad('delta in component model_parameters (cells_per_day)'); LEGEND_CONSTANTS(:,3) = strpad('np in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,4) = strpad('c in component model_parameters (virons_per_day)'); LEGEND_CONSTANTS(:,5) = strpad('k in component model_parameters (ml_per_virons_per_day)'); LEGEND_CONSTANTS(:,6) = strpad('N in component model_parameters (virons_per_cell)'); LEGEND_CONSTANTS(:,7) = strpad('m in component model_parameters (per_day)'); LEGEND_CONSTANTS(:,8) = strpad('T in component uninfected_T_cells (cells_per_ml)'); LEGEND_STATES(:,1) = strpad('T_star in component infected_T_cells (cells_per_ml)'); LEGEND_STATES(:,2) = strpad('VI in component infectious_virus (virons_per_ml)'); LEGEND_ALGEBRAIC(:,1) = strpad('log_VI in component infectious_virus (dimensionless)'); LEGEND_STATES(:,3) = strpad('VNI in component non_infectious_virus (virons_per_ml)'); LEGEND_ALGEBRAIC(:,2) = strpad('virus_total in component total_virus (virons_per_ml)'); LEGEND_ALGEBRAIC(:,3) = strpad('log_virus_total in component total_virus (dimensionless)'); LEGEND_RATES(:,1) = strpad('d/dt T_star in component infected_T_cells (cells_per_ml)'); LEGEND_RATES(:,2) = strpad('d/dt VI in component infectious_virus (virons_per_ml)'); LEGEND_RATES(:,3) = strpad('d/dt VNI in component non_infectious_virus (virons_per_ml)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 1.0; CONSTANTS(:,2) = 0.5; CONSTANTS(:,3) = 1; CONSTANTS(:,4) = 3; CONSTANTS(:,5) = 3.43e-5; CONSTANTS(:,6) = 480; CONSTANTS(:,7) = 0.01; STATES(:,1) = 3.6; STATES(:,2) = 134e3; STATES(:,3) = 0; CONSTANTS(:,8) = 180.000; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,1) = CONSTANTS(:,5).*CONSTANTS(:,8).*STATES(:,2).*(VOI - CONSTANTS(:,1)).*exp( - CONSTANTS(:,7).*CONSTANTS(:,1)).*1.00000 - (CONSTANTS(:,2)./1.00000).*STATES(:,1); RATES(:,2) = ( (1.00000 - CONSTANTS(:,3)).*CONSTANTS(:,6).*CONSTANTS(:,2).*STATES(:,1))./1.00000 - ( CONSTANTS(:,4).*STATES(:,2))./1.00000; RATES(:,3) = ( CONSTANTS(:,3).*CONSTANTS(:,6).*CONSTANTS(:,2).*STATES(:,1))./1.00000 - ( CONSTANTS(:,4).*STATES(:,3))./1.00000; RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = arbitrary_log(STATES(:,2)./1.00000, 10); ALGEBRAIC(:,2) = STATES(:,2)+STATES(:,3); ALGEBRAIC(:,3) = arbitrary_log(ALGEBRAIC(:,2)./1.00000, 10); end % Compute a logarithm to any base" + function x = arbitrary_log(a, base) x = log(a) ./ log(base); end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end