function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =6; end % There are a total of 3 entries in each of the rate and state variable arrays. % There are a total of 9 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (day)'); LEGEND_STATES(:,1) = strpad('x1 in component x1 (cell)'); LEGEND_CONSTANTS(:,1) = strpad('alpha1 in component model_parameters (flux)'); LEGEND_CONSTANTS(:,2) = strpad('beta1 in component model_parameters (first_order_rate_constant)'); LEGEND_CONSTANTS(:,3) = strpad('g11 in component model_parameters (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('g21 in component model_parameters (dimensionless)'); LEGEND_STATES(:,2) = strpad('x2 in component x2 (cell)'); LEGEND_CONSTANTS(:,4) = strpad('alpha2 in component model_parameters (first_order_rate_constant)'); LEGEND_CONSTANTS(:,5) = strpad('beta2 in component model_parameters (first_order_rate_constant)'); LEGEND_CONSTANTS(:,6) = strpad('g12 in component model_parameters (dimensionless)'); LEGEND_CONSTANTS(:,7) = strpad('g22 in component model_parameters (dimensionless)'); LEGEND_STATES(:,3) = strpad('z in component z (percent)'); LEGEND_CONSTANTS(:,8) = strpad('k1 in component model_parameters (percent_per_cell_per_day)'); LEGEND_CONSTANTS(:,9) = strpad('k2 in component model_parameters (percent_per_cell_per_day)'); LEGEND_ALGEBRAIC(:,4) = strpad('y1 in component y1 (cell)'); LEGEND_ALGEBRAIC(:,6) = strpad('y2 in component y2 (cell)'); LEGEND_ALGEBRAIC(:,3) = strpad('x1_bar in component x1_bar (cell)'); LEGEND_ALGEBRAIC(:,5) = strpad('x2_bar in component x2_bar (cell)'); LEGEND_ALGEBRAIC(:,2) = strpad('gamma in component model_parameters (dimensionless)'); LEGEND_RATES(:,1) = strpad('d/dt x1 in component x1 (cell)'); LEGEND_RATES(:,2) = strpad('d/dt x2 in component x2 (cell)'); LEGEND_RATES(:,3) = strpad('d/dt z in component z (percent)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; STATES(:,1) = 10.06066; CONSTANTS(:,1) = 3; CONSTANTS(:,2) = 0.2; CONSTANTS(:,3) = 0.5; STATES(:,2) = 212.132; CONSTANTS(:,4) = 4; CONSTANTS(:,5) = 0.02; CONSTANTS(:,6) = 1; CONSTANTS(:,7) = 0; STATES(:,3) = 100.0; CONSTANTS(:,8) = 0.24; CONSTANTS(:,9) = 0.0017; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end RATES(:,2) = CONSTANTS(:,4).*power(STATES(:,1), CONSTANTS(:,6)).*power(STATES(:,2), CONSTANTS(:,7)) - CONSTANTS(:,5).*STATES(:,2); ALGEBRAIC(:,1) = piecewise({VOI>=1.00000&VOI<2.00000, 0.150000 }, -0.500000); RATES(:,1) = CONSTANTS(:,1).*power(STATES(:,1), CONSTANTS(:,3)).*power(STATES(:,2), ALGEBRAIC(:,1)) - CONSTANTS(:,2).*STATES(:,1); ALGEBRAIC(:,2) = CONSTANTS(:,6).*ALGEBRAIC(:,1) - (1.00000 - CONSTANTS(:,3)).*(1.00000 - CONSTANTS(:,7)); ALGEBRAIC(:,3) = power(CONSTANTS(:,2)./CONSTANTS(:,1), (1.00000 - CONSTANTS(:,7))./ALGEBRAIC(:,2)).*power(CONSTANTS(:,5)./CONSTANTS(:,4), ALGEBRAIC(:,1)./ALGEBRAIC(:,2)); ALGEBRAIC(:,4) = piecewise({STATES(:,1)>ALGEBRAIC(:,3), STATES(:,1) - ALGEBRAIC(:,3) }, 0.00000); ALGEBRAIC(:,5) = power(CONSTANTS(:,2)./CONSTANTS(:,1), CONSTANTS(:,6)./ALGEBRAIC(:,2)).*power(CONSTANTS(:,5)./CONSTANTS(:,4), (1.00000 - CONSTANTS(:,3))./ALGEBRAIC(:,2)); ALGEBRAIC(:,6) = piecewise({STATES(:,2)>ALGEBRAIC(:,5), STATES(:,2) - ALGEBRAIC(:,5) }, 0.00000); RATES(:,3) = CONSTANTS(:,9).*ALGEBRAIC(:,6) - CONSTANTS(:,8).*ALGEBRAIC(:,4); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,1) = piecewise({VOI>=1.00000&VOI<2.00000, 0.150000 }, -0.500000); ALGEBRAIC(:,2) = CONSTANTS(:,6).*ALGEBRAIC(:,1) - (1.00000 - CONSTANTS(:,3)).*(1.00000 - CONSTANTS(:,7)); ALGEBRAIC(:,3) = power(CONSTANTS(:,2)./CONSTANTS(:,1), (1.00000 - CONSTANTS(:,7))./ALGEBRAIC(:,2)).*power(CONSTANTS(:,5)./CONSTANTS(:,4), ALGEBRAIC(:,1)./ALGEBRAIC(:,2)); ALGEBRAIC(:,4) = piecewise({STATES(:,1)>ALGEBRAIC(:,3), STATES(:,1) - ALGEBRAIC(:,3) }, 0.00000); ALGEBRAIC(:,5) = power(CONSTANTS(:,2)./CONSTANTS(:,1), CONSTANTS(:,6)./ALGEBRAIC(:,2)).*power(CONSTANTS(:,5)./CONSTANTS(:,4), (1.00000 - CONSTANTS(:,3))./ALGEBRAIC(:,2)); ALGEBRAIC(:,6) = piecewise({STATES(:,2)>ALGEBRAIC(:,5), STATES(:,2) - ALGEBRAIC(:,5) }, 0.00000); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end