/* There are a total of 9 entries in the algebraic variable array. There are a total of 1 entries in each of the rate and state variable arrays. There are a total of 6 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * CONSTANTS[0] is BFN in component non_muscle_O2_delivery (L_per_minute). * CONSTANTS[1] is OVA in component non_muscle_O2_delivery (mL_per_L). * CONSTANTS[2] is HM in component non_muscle_O2_delivery (dimensionless). * CONSTANTS[3] is AOM in component non_muscle_O2_delivery (dimensionless). * CONSTANTS[5] is O2ARTN in component NM_O2_blood_supply (mL_per_minute). * ALGEBRAIC[4] is DOB in component delivery_of_O2_to_NM_tissues (mL_per_minute). * ALGEBRAIC[5] is POV in component NM_venous_O2_content (mmHg). * ALGEBRAIC[6] is OSV in component NM_venous_O2_content (dimensionless). * ALGEBRAIC[1] is POT in component pressure_of_O2_in_NM_tissue_cells (mmHg). * ALGEBRAIC[3] is MO2 in component O2_consumption_by_NM_tissue (mL_per_minute). * CONSTANTS[4] is O2M in component parameter_values (mL_per_minute). * ALGEBRAIC[2] is P1O in component O2_consumption_by_NM_tissue (mmHg). * ALGEBRAIC[0] is QO2 in component volume_of_O2_in_NM_tissue (mL). * ALGEBRAIC[8] is DO2N in component volume_of_O2_in_NM_tissue (mL_per_minute). * ALGEBRAIC[7] is DO2N1 in component volume_of_O2_in_NM_tissue (mL_per_minute). * STATES[0] is QO2T in component volume_of_O2_in_NM_tissue (mL). * RATES[0] is d/dt QO2T in component volume_of_O2_in_NM_tissue (mL). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 2.79521; CONSTANTS[1] = 204.497; CONSTANTS[2] = 40.0381; CONSTANTS[3] = 1.00002; CONSTANTS[4] = 164; STATES[0] = 72.2362; CONSTANTS[5] = CONSTANTS[1]*CONSTANTS[0]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (STATES[0]<0.00000 ? 0.00000 : STATES[0]); ALGEBRAIC[1] = ALGEBRAIC[0]*0.486110; rootfind_0(VOI, CONSTANTS, RATES, STATES, ALGEBRAIC, pret); ALGEBRAIC[2] = (ALGEBRAIC[1]>35.0000 ? 35.0000 : ALGEBRAIC[1]); ALGEBRAIC[3] = CONSTANTS[3]*CONSTANTS[4]*(1.00000 - pow(35.0001 - ALGEBRAIC[2], 3.00000)/42875.0); ALGEBRAIC[7] = ALGEBRAIC[4] - ALGEBRAIC[3]; ALGEBRAIC[8] = (ALGEBRAIC[0]<6.00000&&ALGEBRAIC[7]<0.00000 ? ALGEBRAIC[7]*0.100000 : ALGEBRAIC[7]); RATES[0] = ALGEBRAIC[8]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (STATES[0]<0.00000 ? 0.00000 : STATES[0]); ALGEBRAIC[1] = ALGEBRAIC[0]*0.486110; ALGEBRAIC[2] = (ALGEBRAIC[1]>35.0000 ? 35.0000 : ALGEBRAIC[1]); ALGEBRAIC[3] = CONSTANTS[3]*CONSTANTS[4]*(1.00000 - pow(35.0001 - ALGEBRAIC[2], 3.00000)/42875.0); ALGEBRAIC[7] = ALGEBRAIC[4] - ALGEBRAIC[3]; ALGEBRAIC[8] = (ALGEBRAIC[0]<6.00000&&ALGEBRAIC[7]<0.00000 ? ALGEBRAIC[7]*0.100000 : ALGEBRAIC[7]); } void objfunc_0(double *p, double *hx, int m, int n, void *adata) { struct rootfind_info* rfi = (struct rootfind_info*)adata; #define VOI rfi->aVOI #define CONSTANTS rfi->aCONSTANTS #define RATES rfi->aRATES #define STATES rfi->aSTATES #define ALGEBRAIC rfi->aALGEBRAIC #define pret rfi->aPRET ALGEBRAIC[4] = p[0]; ALGEBRAIC[5] = p[1]; ALGEBRAIC[6] = p[2]; hx[0] = ALGEBRAIC[6] - (CONSTANTS[5] - ALGEBRAIC[4])/( CONSTANTS[2]*5.25000*CONSTANTS[0]); hx[1] = ALGEBRAIC[5] - ALGEBRAIC[6]*57.1400; hx[2] = ALGEBRAIC[4] - (ALGEBRAIC[5] - ALGEBRAIC[1])*12.8570*CONSTANTS[0]; #undef VOI #undef CONSTANTS #undef RATES #undef STATES #undef ALGEBRAIC #undef pret } void rootfind_0(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC, int* pret) { static double p[3] = {0.1,0.1,0.1}; double bp[3], work[LM_DIF_WORKSZ(3, 3)]; struct rootfind_info rfi; rfi.aVOI = VOI; rfi.aCONSTANTS = CONSTANTS; rfi.aRATES = RATES; rfi.aSTATES = STATES; rfi.aALGEBRAIC = ALGEBRAIC; rfi.aPRET = pret; do_levmar(objfunc_0, p, bp, work, pret, 3, &rfi); ALGEBRAIC[4] = p[0]; ALGEBRAIC[5] = p[1]; ALGEBRAIC[6] = p[2]; }