- Author:
- Dougal Cowan <dj.cowan@auckland.ac.nz>
- Date:
- 2013-02-26 10:00:35+13:00
- Desc:
- stripped out old documentation
re-added PMR keywords
- Permanent Source URI:
- https://models.cellml.org/w/dcowan/niederer_2013_PlosOne/rawfile/106616bbe7c1aba3a91eef61a1d449bdcb77374c/passive_model_PlosOne.cellml
<?xml version="1.0" encoding="utf-8"?>
<model
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"
xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#"
name="passive"
cmeta:id="passive"
xmlns="http://www.cellml.org/cellml/1.0#"
xmlns:cellml="http://www.cellml.org/cellml/1.0#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
</rdf:RDF> <units name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units name="millimetre">
<unit units="metre" prefix="milli"/>
</units>
<units name="millimetre2">
<unit units="millimetre" exponent="2"/>
</units>
<units name="per_millimetre">
<unit units="millimetre" exponent="-1"/>
</units>
<units name="micrometre3">
<unit units="metre" prefix="micro" exponent="3"/>
</units>
<units name="litre_micrometre3">
<unit units="litre"/>
<unit units="micrometre3" exponent="-1"/>
</units>
<units name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units name="per_millisecond">
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="per_millisecond3">
<unit units="second" prefix="milli" exponent="-3"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="millivolt_square">
<unit units="volt" prefix="milli" exponent="2"/>
</units>
<units name="millisiemens_per_mm2">
<unit units="siemens" prefix="milli"/>
<unit units="millimetre" exponent="-2"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="nanoS_per_picoF">
<unit units="siemens" prefix="nano"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="microFarad_per_millimetre2">
<unit units="microF"/>
<unit units="millimetre2" exponent="-1"/>
</units>
<units name="microA">
<unit units="ampere" prefix="micro"/>
</units>
<units name="picoA_per_picoF">
<unit units="ampere" prefix="pico"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="nanoA_per_millimolar">
<unit units="ampere" prefix="nano"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimetre_per_millisecond">
<unit units="millimetre"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="millimolar_millimetre_per_millisecond">
<unit units="millimolar"/>
<unit units="millimetre"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="millimolar_per_millisecond_per_millivolt">
<unit units="millimolar"/>
<unit units="millisecond" exponent="-1"/>
<unit units="millivolt" exponent="-1"/>
</units>
<units name="per_millimolar">
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar2">
<unit units="millimolar" exponent="2"/>
</units>
<units name="millimolar3">
<unit units="millimolar" exponent="3"/>
</units>
<units name="millimolar4">
<unit units="millimolar" exponent="4"/>
</units>
<units name="millimolar_per_millisecond">
<unit units="millimolar"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="millimolar2_per_millisecond">
<unit units="millimolar" exponent="2"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="per_millimolar_per_millisecond">
<unit units="millimolar" exponent="-1"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="per_millimolar2_per_millisecond">
<unit units="millimolar" exponent="-2"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="millijoule_per_mole_kelvin">
<unit units="joule" prefix="milli"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="millimeter_per_millisecond">
<unit units="millimetre"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name="uA_per_mm2">
<unit units="microA"/>
<unit units="millimetre2" exponent="-1"/>
</units>
<component name="Ischemia_switch">
<variable name="Resp_Acidosis" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="Met_Acidosis" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="inhibit_NaK" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="activate_IKb" units="dimensionless" initial_value="0" public_interface="out"/>
</component>
<component name="environment">
<variable name="time" units="millisecond" public_interface="out"/>
<variable name="Rgas" units="millijoule_per_mole_kelvin" initial_value="8314.472" public_interface="out"/>
<variable name="Farad" units="coulomb_per_mole" initial_value="96485.3415" public_interface="out"/>
<variable name="Temp" units="kelvin" initial_value="310" public_interface="out"/>
<variable name="RTF" units="millivolt" public_interface="out"/>
<variable name="Am" units="per_millimetre" initial_value="200" public_interface="out"/>
<variable name="Cm" units="microFarad_per_millimetre2" initial_value="1" public_interface="out"/>
<variable name="alpha_i" units="dimensionless" initial_value="0.8" public_interface="out"/>
<variable name="alpha_fSR" units="dimensionless" initial_value="0.03"/>
<variable name="alpha_SR" units="dimensionless" public_interface="out"/>
<variable name="alpha_fMR" units="dimensionless" initial_value="0.3"/>
<variable name="alpha_MR" units="dimensionless" public_interface="out"/>
<variable name="alpha_cyt" units="dimensionless" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RTF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Rgas</ci>
<ci>Temp</ci>
</apply>
<ci>Farad</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_SR</ci>
<apply>
<times/>
<ci>alpha_fSR</ci>
<ci>alpha_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_MR</ci>
<apply>
<times/>
<ci>alpha_fMR</ci>
<ci>alpha_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_cyt</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>alpha_i</ci>
<ci>alpha_SR</ci>
</apply>
<ci>alpha_MR</ci>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable name="Vm" units="millivolt" public_interface="out"/>
<variable name="Farad" units="coulomb_per_mole" public_interface="in"/>
<variable name="zK" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="zNa" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="zCl" units="dimensionless" initial_value="-1" public_interface="out"/>
<variable name="zCa" units="dimensionless" initial_value="2" public_interface="out"/>
<variable name="zHCO3" units="dimensionless" initial_value="-1" public_interface="out"/>
<variable name="zH" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="zA" units="dimensionless" initial_value="-1" public_interface="out"/>
<variable name="fixed_charge" units="millimolar" initial_value="-1.233254069052028e2" public_interface="out"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="CaiT" units="millimolar" public_interface="in"/>
<variable name="HiT" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<variable name="Ai" units="millimolar" public_interface="in"/>
<variable name="Rgas" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="Temp" units="kelvin" public_interface="in"/>
<variable name="Am" units="per_millimetre" public_interface="in"/>
<variable name="Cm" units="microFarad_per_millimetre2" public_interface="in"/>
<variable name="alpha_cyt" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vm</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_cyt</ci>
<ci>Farad</ci>
</apply>
<apply>
<times/>
<ci>Am</ci>
<ci>Cm</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>zNa</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>zK</ci>
<ci>Ki</ci>
</apply>
<apply>
<times/>
<ci>zCl</ci>
<ci>Cli</ci>
</apply>
<apply>
<times/>
<ci>zCa</ci>
<ci>CaiT</ci>
</apply>
<apply>
<times/>
<ci>zH</ci>
<ci>HiT</ci>
</apply>
<apply>
<times/>
<ci>zHCO3</ci>
<ci>HCO3i</ci>
</apply>
<apply>
<times/>
<ci>Ai</ci>
<ci>zA</ci>
</apply>
<ci>fixed_charge</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="gamma_values">
<variable name="gammaSECRA" units="millimolar_per_millisecond" initial_value="4.75e-5" public_interface="out"/>
<variable name="gammaleak" units="per_millisecond" initial_value="-0.125" public_interface="out"/>
<variable name="gamma_NaK" units="millimolar" initial_value="0.001269187845223" public_interface="out"/>
<variable name="gamma_CO2" units="per_millisecond" initial_value="0.058" public_interface="out"/>
<variable name="gamma_Nab" units="millimolar_per_millisecond_per_millivolt" initial_value="1.428761517726755e-8" public_interface="out"/>
<variable name="gamma_Kb" units="millimolar_per_millisecond_per_millivolt" initial_value="5.378954239918512e-7" public_interface="out"/>
<variable name="gamma_Cab" units="millimolar_per_millisecond_per_millivolt" initial_value="7.676174327141708e-9" public_interface="out"/>
<variable name="gamma_NCX" units="millimolar_per_millisecond" initial_value="4.149438692332562e-5" public_interface="out"/>
<variable name="gamma_NHE" units="millimolar" initial_value="0.087712298303188" public_interface="out"/>
<variable name="gamma_CHE" units="millimolar" initial_value="0.058613874057323" public_interface="out"/>
<variable name="gamma_NBC" units="millimolar" initial_value="6.009784722617906e-6" public_interface="out"/>
<variable name="gamma_AE" units="millimolar" initial_value="6.279454114993227e-5" public_interface="out"/>
<variable name="gamma_Clb" units="millimolar_per_millisecond_per_millivolt" initial_value="1.264015088008236e-7" public_interface="out"/>
</component>
<component name="calc_cai">
<variable name="A" units="millimolar"/>
<variable name="B" units="millimolar2"/>
<variable name="C" units="millimolar3"/>
<variable name="alpha_cai" units="dimensionless"/>
<variable name="alpha_SR" units="dimensionless" public_interface="in"/>
<variable name="alpha_cyt" units="dimensionless" public_interface="in"/>
<variable name="B_ca" units="millimolar"/>
<variable name="gammaSECRA" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="gammaleak" units="per_millisecond" public_interface="in"/>
<variable name="BCai" units="millimolar" initial_value="208.98e-3"/>
<variable name="KCai" units="millimolar" initial_value="0.42e-3"/>
<variable name="CaiT" units="millimolar" public_interface="in"/>
<variable name="Kserca" units="millimolar" initial_value="300e-6"/>
<variable name="Cai" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>B_ca</ci>
<apply>
<divide/>
<ci>gammaSECRA</ci>
<ci>gammaleak</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_cai</ci>
<apply>
<divide/>
<ci>alpha_SR</ci>
<ci>alpha_cyt</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>A</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>B_ca</ci>
</apply>
<ci>KCai</ci>
<ci>Kserca</ci>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>Kserca</ci>
</apply>
</apply>
<ci>CaiT</ci>
</apply>
<ci>BCai</ci>
</apply>
<apply>
<plus/>
<ci>alpha_cai</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>B</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>B_ca</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>KCai</ci>
<ci>CaiT</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CaiT</ci>
<ci>Kserca</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Kserca</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>Kserca</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>BCai</ci>
<ci>Kserca</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>alpha_cai</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>CaiT</ci>
</apply>
<ci>Kserca</ci>
<ci>KCai</ci>
</apply>
<apply>
<plus/>
<ci>alpha_cai</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cai</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<ci>A</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>B</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<cos/>
<apply>
<divide/>
<apply>
<arccos/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">9</cn>
<ci>A</ci>
<ci>B</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<power/>
<ci>A</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">27</cn>
<ci>C</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<ci>A</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>B</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>A</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calc_cae">
<variable name="bTemp" units="millimolar"/>
<variable name="BCae" units="millimolar" initial_value="2.3"/>
<variable name="KCae" units="millimolar" initial_value="1.1"/>
<variable name="CaeT" units="millimolar" public_interface="in"/>
<variable name="Cae" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>bTemp</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>KCae</ci>
<ci>BCae</ci>
</apply>
<ci>CaeT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Cae</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>bTemp</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>bTemp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>CaeT</ci>
<ci>KCae</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</math>
</component>
<component name="calc_He">
<variable name="bTemp" units="millimolar"/>
<variable name="BHe" units="millimolar" initial_value="350"/>
<variable name="KHe" units="millimolar" initial_value="3.162277660168379e-4"/>
<variable name="HeT" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>bTemp</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>KHe</ci>
<ci>BHe</ci>
</apply>
<ci>HeT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>He</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>bTemp</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>bTemp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>HeT</ci>
<ci>KHe</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</math>
</component>
<component name="calc_Hi">
<variable name="bTemp" units="millimolar"/>
<variable name="BHi" units="millimolar" initial_value="65"/>
<variable name="KHi" units="millimolar" initial_value="3.162277660168379e-4"/>
<variable name="HiT" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>bTemp</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>KHi</ci>
<ci>BHi</ci>
</apply>
<ci>HiT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Hi</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>bTemp</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>bTemp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>HiT</ci>
<ci>KHi</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</math>
</component>
<component name="J_resp_acidosis">
<variable name="JCO2_resp" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Resp_Acidosis" units="dimensionless" public_interface="in"/>
<variable name="Max_JCO2_res" units="millimolar_per_millisecond" initial_value="0.5e-4"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>JCO2_resp</ci>
<apply>
<times/>
<ci>Resp_Acidosis</ci>
<ci>Max_JCO2_res</ci>
</apply>
</apply>
</math>
</component>
<component name="J_met_acidosis">
<variable name="JH_met" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Met_Acidosis" units="dimensionless" public_interface="in"/>
<variable name="Max_JH_met" units="millimolar_per_millisecond" initial_value="1e-4"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>JH_met</ci>
<apply>
<times/>
<ci>Met_Acidosis</ci>
<ci>Max_JH_met</ci>
</apply>
</apply>
</math>
</component>
<component name="NaK">
<variable name="ADP" units="millimolar" initial_value="0.01"/>
<variable name="cMgATP" units="millimolar" initial_value="9.8"/>
<variable name="cPi_sum" units="millimolar" initial_value="4.2"/>
<variable name="eq_HPi" units="millimolar" initial_value="0.000169"/>
<variable name="eq_KPi" units="millimolar" initial_value="292"/>
<variable name="eq_K_e" units="millimolar" initial_value="0.213"/>
<variable name="eq_K_i" units="millimolar" initial_value="0.5"/>
<variable name="eq_MgATP" units="millimolar" initial_value="2.51"/>
<variable name="eq_NaPi" units="millimolar" initial_value="224"/>
<variable name="eq_Na_base_e" units="millimolar" initial_value="7.75"/>
<variable name="eq_Na_base_i" units="millimolar" initial_value="3.984"/>
<variable name="k1" units="per_millisecond" initial_value="1050"/>
<variable name="k2" units="per_millisecond" initial_value="481"/>
<variable name="k3" units="per_millisecond" initial_value="2000"/>
<variable name="k4" units="per_millisecond" initial_value="320"/>
<variable name="minus_k1" units="per_millimolar_per_millisecond" initial_value="172.1"/>
<variable name="minus_k2" units="per_millisecond" initial_value="40.1"/>
<variable name="minus_k3" units="per_millimolar2_per_millisecond" initial_value="79287.1"/>
<variable name="minus_k4" units="per_millisecond" initial_value="40.1"/>
<variable name="partition_factor" units="dimensionless" initial_value="-0.031"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ke" units="millimolar" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="cPi" units="millimolar"/>
<variable name="dimless_Na_i" units="dimensionless"/>
<variable name="dimless_Na_e" units="dimensionless"/>
<variable name="dimless_K_i" units="dimensionless"/>
<variable name="dimless_K_e" units="dimensionless"/>
<variable name="dimless_MgATP" units="dimensionless"/>
<variable name="alpha1" units="per_millisecond"/>
<variable name="alpha2" units="per_millisecond"/>
<variable name="alpha3" units="per_millisecond"/>
<variable name="alpha4" units="per_millisecond"/>
<variable name="minus_alpha1" units="per_millisecond"/>
<variable name="minus_alpha2" units="per_millisecond"/>
<variable name="minus_alpha3" units="per_millisecond"/>
<variable name="minus_alpha4" units="per_millisecond"/>
<variable name="diagram_sum" units="per_millisecond3"/>
<variable name="s_nak" units="per_millisecond" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>cPi</ci>
<apply>
<divide/>
<ci>cPi_sum</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ki</ci>
<ci>eq_KPi</ci>
</apply>
<apply>
<divide/>
<ci>Hi</ci>
<ci>eq_HPi</ci>
</apply>
<apply>
<divide/>
<ci>Nai</ci>
<ci>eq_NaPi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_Na_i</ci>
<apply>
<divide/>
<ci>Nai</ci>
<apply>
<times/>
<ci>eq_Na_base_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>partition_factor</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>RTF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_Na_e</ci>
<apply>
<divide/>
<ci>Nae</ci>
<apply>
<times/>
<ci>eq_Na_base_e</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>partition_factor</ci>
</apply>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>RTF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_K_i</ci>
<apply>
<divide/>
<ci>Ki</ci>
<ci>eq_K_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_K_e</ci>
<apply>
<divide/>
<ci>Ke</ci>
<ci>eq_K_e</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_MgATP</ci>
<apply>
<divide/>
<ci>cMgATP</ci>
<ci>eq_MgATP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>dimless_Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_i</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha2</ci>
<ci>k2</ci>
</apply>
<apply>
<eq/>
<ci>alpha3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k3</ci>
<apply>
<power/>
<ci>dimless_K_e</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_e</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_e</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha4</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k4</ci>
<ci>dimless_MgATP</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_MgATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha1</ci>
<apply>
<times/>
<ci>minus_k1</ci>
<ci>ADP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>minus_k2</ci>
<apply>
<power/>
<ci>dimless_Na_e</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_e</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_e</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>minus_k3</ci>
<ci>cPi</ci>
<ci>Hi</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_MgATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha4</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>minus_k4</ci>
<apply>
<power/>
<ci>dimless_K_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_i</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>diagram_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>minus_alpha3</ci>
<ci>minus_alpha2</ci>
<ci>minus_alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>minus_alpha2</ci>
<ci>minus_alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>minus_alpha1</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha3</ci>
<ci>minus_alpha2</ci>
<ci>alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>minus_alpha2</ci>
<ci>alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>alpha1</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha3</ci>
<ci>alpha1</ci>
<ci>alpha2</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>alpha1</ci>
<ci>alpha2</ci>
</apply>
<apply>
<times/>
<ci>alpha1</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha3</ci>
<ci>minus_alpha1</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha3</ci>
<ci>alpha2</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha3</ci>
<ci>minus_alpha2</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha1</ci>
<ci>minus_alpha2</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha1</ci>
<ci>alpha3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_nak</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha1</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
<ci>alpha4</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha1</ci>
<ci>minus_alpha2</ci>
<ci>minus_alpha3</ci>
<ci>minus_alpha4</ci>
</apply>
</apply>
<ci>diagram_sum</ci>
</apply>
</apply>
</math>
</component>
<component name="s_Nab">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="s_nab" units="millivolt" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_nab</ci>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nae</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="s_Kb">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ke" units="millimolar" public_interface="in"/>
<variable name="s_kb" units="millivolt" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_kb</ci>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ke</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="s_Cab">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Cae" units="millimolar" public_interface="in"/>
<variable name="s_cab" units="millivolt" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_cab</ci>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cae</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="s_Clb">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="Cle" units="millimolar" public_interface="in"/>
<variable name="s_clb" units="millivolt" public_interface="out"/>
<variable name="HiRef" units="millimolar" initial_value="7.943282347242821e-5"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="beta_H" units="per_millimolar" initial_value="20000"/>
<variable name="gH" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>gH</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta_H</ci>
<apply>
<minus/>
<ci>Hi</ci>
<ci>HiRef</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_clb</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cli</ci>
<ci>Cle</ci>
</apply>
</apply>
</apply>
</apply>
<ci>gH</ci>
</apply>
</apply>
</math>
</component>
<component name="NCX">
<variable name="KmCai" units="millimolar" initial_value="3.6e-3"/>
<variable name="KmNai" units="millimolar" initial_value="12.3"/>
<variable name="KmCao" units="millimolar" initial_value="1.3"/>
<variable name="KmNao" units="millimolar" initial_value="87.5"/>
<variable name="eta" units="dimensionless" initial_value="0.27"/>
<variable name="kmact" units="millimolar" initial_value="1.25e-6"/>
<variable name="ksat" units="dimensionless" initial_value="0.32"/>
<variable name="nHill" units="dimensionless" initial_value="2"/>
<variable name="dE" units="dimensionless"/>
<variable name="allo" units="dimensionless"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Cae" units="millimolar" public_interface="in"/>
<variable name="edv" units="dimensionless"/>
<variable name="denom1" units="millimolar4"/>
<variable name="denom2" units="millimolar4"/>
<variable name="edv2" units="dimensionless"/>
<variable name="s_ncx" units="dimensionless" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>edv</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RTF</ci>
</apply>
<ci>eta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>edv2</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RTF</ci>
</apply>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>KmCao</ci>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>KmNao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>KmNai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cae</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cai</ci>
<ci>KmCai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>KmCai</ci>
<apply>
<power/>
<ci>Nae</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>KmNai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cae</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nae</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>allo</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>kmact</ci>
<ci>Cai</ci>
</apply>
<ci>nHill</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dE</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cae</ci>
<ci>edv</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nae</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
<ci>edv2</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>denom1</ci>
<ci>denom2</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<ci>edv2</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_ncx</ci>
<apply>
<times/>
<ci>dE</ci>
<ci>allo</ci>
</apply>
</apply>
</math>
</component>
<component name="NHE">
<variable name="KA" units="millimolar" initial_value="21.4935205515214"/>
<variable name="KB" units="millimolar" initial_value="1.77948608115949e-7"/>
<variable name="K_Hs" units="millimolar" initial_value="0.000416869383470335"/>
<variable name="km1" units="per_millisecond" initial_value="0.14069285629105"/>
<variable name="kp1" units="per_millisecond" initial_value="0.51156085723193"/>
<variable name="kp2" units="per_millisecond" initial_value="0.001698"/>
<variable name="n_Hi" units="dimensionless" initial_value="2"/>
<variable name="km2" units="per_millisecond"/>
<variable name="ap1" units="per_millisecond"/>
<variable name="ap2" units="per_millisecond"/>
<variable name="am1" units="per_millisecond"/>
<variable name="am2" units="per_millisecond"/>
<variable name="reg" units="dimensionless"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="s_nhe" units="per_millisecond" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp1</ci>
<ci>kp2</ci>
</apply>
<ci>km1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ap1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KB</ci>
<ci>Nae</ci>
<ci>kp1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>Nae</ci>
<ci>He</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KB</ci>
<ci>Nai</ci>
<ci>km1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>Nai</ci>
<ci>Hi</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ap2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KA</ci>
<ci>Hi</ci>
<ci>kp2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>Nai</ci>
<ci>Hi</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KA</ci>
<ci>He</ci>
<ci>km2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>Nae</ci>
<ci>He</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<power/>
<ci>K_Hs</ci>
<ci>n_Hi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_nhe</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>reg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>ap1</ci>
<ci>ap2</ci>
</apply>
<apply>
<times/>
<ci>am1</ci>
<ci>am2</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>ap1</ci>
<ci>ap2</ci>
<ci>am1</ci>
<ci>am2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CHE">
<variable name="K_Cl_2" units="millimolar" initial_value="5.64"/>
<variable name="K_H" units="millimolar" initial_value="5.105e-5"/>
<variable name="K_a" units="millimolar" initial_value="0.001"/>
<variable name="km12" units="per_millisecond" initial_value="0.0004983"/>
<variable name="kp12" units="per_millisecond" initial_value="0.0012782"/>
<variable name="kp22" units="per_millisecond" initial_value="1.65e-5"/>
<variable name="n_Hi_2" units="dimensionless" initial_value="4"/>
<variable name="km22" units="per_millisecond"/>
<variable name="ap11" units="per_millisecond"/>
<variable name="am11" units="per_millisecond"/>
<variable name="ap21" units="per_millisecond"/>
<variable name="am21" units="per_millisecond"/>
<variable name="reg2" units="dimensionless"/>
<variable name="s_che" units="per_millisecond" public_interface="out"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="Cle" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km22</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp22</ci>
<ci>km12</ci>
</apply>
<ci>kp12</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ap11</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kp12</ci>
<ci>K_H</ci>
</apply>
<ci>Hi</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cli</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am11</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>km12</ci>
<ci>K_H</ci>
</apply>
<ci>He</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cle</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ap21</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kp22</ci>
<ci>Cle</ci>
</apply>
<ci>K_Cl_2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cle</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am21</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>km22</ci>
<ci>Cli</ci>
</apply>
<ci>K_Cl_2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cli</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg2</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>K_a</ci>
<ci>n_Hi_2</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi_2</ci>
</apply>
<apply>
<power/>
<ci>K_a</ci>
<ci>n_Hi_2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_che</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>reg2</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>ap11</ci>
<ci>ap21</ci>
</apply>
<apply>
<times/>
<ci>am11</ci>
<ci>am21</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>ap11</ci>
<ci>ap21</ci>
<ci>am11</ci>
<ci>am21</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NBC">
<variable name="K_HCO3" units="millimolar" initial_value="0.008017"/>
<variable name="K_He" units="millimolar" initial_value="6.53e-5"/>
<variable name="K_Hi" units="millimolar" initial_value="0.000183"/>
<variable name="K_Na" units="millimolar" initial_value="4866.11"/>
<variable name="km13" units="per_millisecond" initial_value="777.92"/>
<variable name="kp13" units="per_millisecond" initial_value="4677"/>
<variable name="kp23" units="per_millisecond" initial_value="6.656"/>
<variable name="km23" units="per_millisecond"/>
<variable name="n_He" units="dimensionless" initial_value="2.18"/>
<variable name="n_Hi" units="dimensionless" initial_value="2.91"/>
<variable name="a" units="dimensionless"/>
<variable name="inb" units="dimensionless"/>
<variable name="inc" units="dimensionless"/>
<variable name="d" units="dimensionless"/>
<variable name="s1" units="dimensionless"/>
<variable name="s6" units="dimensionless"/>
<variable name="reg" units="dimensionless"/>
<variable name="s_nbc" units="per_millisecond" public_interface="out"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="HCO3e" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km23</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp23</ci>
<ci>km13</ci>
</apply>
<ci>kp13</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nae</ci>
<ci>K_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Nae</ci>
<ci>HCO3e</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inb</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>Nae</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>Nai</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>d</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Nai</ci>
<ci>HCO3i</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>a</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>d</ci>
<apply>
<plus/>
<ci>kp13</ci>
<apply>
<times/>
<ci>kp23</ci>
<ci>a</ci>
<ci>inb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>km13</ci>
<apply>
<times/>
<ci>km23</ci>
<ci>d</ci>
<ci>inc</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s6</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>d</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>a</ci>
<apply>
<plus/>
<ci>km13</ci>
<apply>
<times/>
<ci>km23</ci>
<ci>d</ci>
<ci>inc</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>kp13</ci>
<apply>
<times/>
<ci>kp23</ci>
<ci>a</ci>
<ci>inb</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<power/>
<ci>K_Hi</ci>
<ci>n_Hi</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
<apply>
<power/>
<ci>K_He</ci>
<ci>n_He</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_nbc</ci>
<apply>
<times/>
<ci>reg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>km13</ci>
<ci>s6</ci>
</apply>
<apply>
<times/>
<ci>kp13</ci>
<ci>s1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="AE">
<variable name="K_Cl" units="millimolar" initial_value="983.5"/>
<variable name="K_HCO3" units="millimolar" initial_value="110.64"/>
<variable name="K_He" units="millimolar" initial_value="0.000312"/>
<variable name="K_Hi" units="millimolar" initial_value="2.67e-5"/>
<variable name="km1" units="per_millisecond" initial_value="21118.2"/>
<variable name="kp1" units="per_millisecond" initial_value="20789.9"/>
<variable name="kp2" units="per_millisecond" initial_value="21256.54"/>
<variable name="n_He" units="dimensionless" initial_value="1.44"/>
<variable name="n_Hi" units="dimensionless" initial_value="5.11"/>
<variable name="km2" units="per_millisecond"/>
<variable name="inva" units="dimensionless"/>
<variable name="invb" units="dimensionless"/>
<variable name="invc" units="dimensionless"/>
<variable name="invd" units="dimensionless"/>
<variable name="s1" units="dimensionless"/>
<variable name="s6" units="dimensionless"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="Cle" units="millimolar" public_interface="in"/>
<variable name="HCO3e" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<variable name="s_ae" units="per_millisecond" public_interface="out"/>
<variable name="reg" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp2</ci>
<ci>km1</ci>
</apply>
<ci>kp1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>inva</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Cle</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>invb</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cle</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>Cle</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>HCO3e</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>invc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cli</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>Cli</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>HCO3i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>invd</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Cli</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>inva</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>km1</ci>
<ci>invd</ci>
</apply>
<apply>
<times/>
<ci>km2</ci>
<ci>invc</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kp1</ci>
<ci>inva</ci>
</apply>
<apply>
<times/>
<ci>kp2</ci>
<ci>invb</ci>
</apply>
<apply>
<times/>
<ci>km2</ci>
<ci>invc</ci>
</apply>
<apply>
<times/>
<ci>km1</ci>
<ci>invd</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s6</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>invd</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>kp1</ci>
<ci>inva</ci>
</apply>
<apply>
<times/>
<ci>kp2</ci>
<ci>invb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kp1</ci>
<ci>inva</ci>
</apply>
<apply>
<times/>
<ci>kp2</ci>
<ci>invb</ci>
</apply>
<apply>
<times/>
<ci>km2</ci>
<ci>invc</ci>
</apply>
<apply>
<times/>
<ci>km1</ci>
<ci>invd</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<power/>
<ci>K_Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<power/>
<ci>K_Hi</ci>
<ci>n_Hi</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
<apply>
<power/>
<ci>K_He</ci>
<ci>n_He</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_ae</ci>
<apply>
<times/>
<ci>reg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>km1</ci>
<ci>s6</ci>
</apply>
<apply>
<times/>
<ci>kp1</ci>
<ci>s1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Fluxes">
<variable name="J_NaK" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nak" units="per_millisecond" public_interface="in"/>
<variable name="gamma_NaK" units="millimolar" public_interface="in"/>
<variable name="inhibit_NaK" units="dimensionless" public_interface="in"/>
<variable name="J_Nab" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nab" units="millivolt" public_interface="in"/>
<variable name="gamma_Nab" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_Kb" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_kb" units="millivolt" public_interface="in"/>
<variable name="gamma_Kb" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_Cab" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_cab" units="millivolt" public_interface="in"/>
<variable name="gamma_Cab" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_NCX" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_ncx" units="dimensionless" public_interface="in"/>
<variable name="gamma_NCX" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NHE" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nhe" units="per_millisecond" public_interface="in"/>
<variable name="gamma_NHE" units="millimolar" public_interface="in"/>
<variable name="J_CHE" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_che" units="per_millisecond" public_interface="in"/>
<variable name="gamma_CHE" units="millimolar" public_interface="in"/>
<variable name="J_NBC" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nbc" units="per_millisecond" public_interface="in"/>
<variable name="gamma_NBC" units="millimolar" public_interface="in"/>
<variable name="J_AE" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_ae" units="per_millisecond" public_interface="in"/>
<variable name="gamma_AE" units="millimolar" public_interface="in"/>
<variable name="J_Clb" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_clb" units="millivolt" public_interface="in"/>
<variable name="gamma_Clb" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_CO2" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_co2" units="millimolar" public_interface="in"/>
<variable name="gamma_CO2" units="per_millisecond" public_interface="in"/>
<variable name="activate_IKb" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_NaK</ci>
<apply>
<times/>
<ci>gamma_NaK</ci>
<ci>s_nak</ci>
<ci>inhibit_NaK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NCX</ci>
<apply>
<times/>
<ci>gamma_NCX</ci>
<ci>s_ncx</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NHE</ci>
<apply>
<times/>
<ci>gamma_NHE</ci>
<ci>s_nhe</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CHE</ci>
<apply>
<times/>
<ci>gamma_CHE</ci>
<ci>s_che</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC</ci>
<apply>
<times/>
<ci>gamma_NBC</ci>
<ci>s_nbc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AE</ci>
<apply>
<times/>
<ci>gamma_AE</ci>
<ci>s_ae</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Nab</ci>
<apply>
<times/>
<ci>gamma_Nab</ci>
<ci>s_nab</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Kb</ci>
<apply>
<times/>
<ci>gamma_Kb</ci>
<ci>s_kb</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>activate_IKb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Cab</ci>
<apply>
<times/>
<ci>gamma_Cab</ci>
<ci>s_cab</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Clb</ci>
<apply>
<times/>
<ci>gamma_Clb</ci>
<ci>s_clb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CO2</ci>
<apply>
<times/>
<ci>gamma_CO2</ci>
<ci>s_co2</ci>
</apply>
</apply>
</math>
</component>
<component name="CO2">
<variable name="CO2e" units="millimolar" public_interface="in"/>
<variable name="CO2i" units="millimolar" public_interface="in"/>
<variable name="s_co2" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_co2</ci>
<apply>
<minus/>
<ci>CO2e</ci>
<ci>CO2i</ci>
</apply>
</apply>
</math>
</component>
<component name="AX">
<variable name="KLac" units="millimolar" initial_value="2.24"/>
<variable name="KH" units="millimolar" initial_value="5.223961889991198e-4"/>
<variable name="gamma" units="dimensionless" initial_value="0.157"/>
<variable name="Max_eff" units="millimolar_per_millisecond" initial_value="-4.8e-5"/>
<variable name="Ai" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="Ae" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="J_AX" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="nLaci" units="dimensionless"/>
<variable name="nLaco" units="dimensionless"/>
<variable name="nHi" units="dimensionless"/>
<variable name="nHo" units="dimensionless"/>
<variable name="ap12" units="dimensionless"/>
<variable name="am12" units="dimensionless"/>
<variable name="ap22" units="dimensionless"/>
<variable name="am22" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>nLaci</ci>
<apply>
<divide/>
<ci>Ai</ci>
<ci>KLac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nLaco</ci>
<apply>
<divide/>
<ci>Ae</ci>
<ci>KLac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nHi</ci>
<apply>
<divide/>
<ci>Hi</ci>
<ci>KH</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nHo</ci>
<apply>
<divide/>
<ci>He</ci>
<ci>KH</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ap12</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHi</ci>
<apply>
<times/>
<ci>nHi</ci>
<ci>nLaci</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am12</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHo</ci>
<apply>
<times/>
<ci>nHo</ci>
<ci>nLaco</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ap22</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>nHo</ci>
<ci>nLaco</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHo</ci>
<apply>
<times/>
<ci>nHo</ci>
<ci>nLaco</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am22</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>nHi</ci>
<ci>nLaci</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHi</ci>
<apply>
<times/>
<ci>nHi</ci>
<ci>nLaci</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AX</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Max_eff</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>ap12</ci>
<ci>ap22</ci>
</apply>
<apply>
<times/>
<ci>am12</ci>
<ci>am22</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<plus/>
<ci>ap12</ci>
<ci>am12</ci>
</apply>
</apply>
<ci>ap22</ci>
<ci>am22</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_co2hyd">
<variable name="HCO3e" units="millimolar" public_interface="in"/>
<variable name="CO2e" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<variable name="CO2i" units="millimolar" public_interface="in"/>
<variable name="kr_co2hyd" units="per_millimolar_per_millisecond" initial_value="0.481"/>
<variable name="kf_co2hyd" units="per_millisecond" initial_value="0.000365"/>
<variable name="Jco2hydi" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Jco2hyde" units="millimolar_per_millisecond" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Jco2hydi</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_co2hyd</ci>
<ci>CO2i</ci>
</apply>
<apply>
<times/>
<ci>kr_co2hyd</ci>
<ci>HCO3i</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jco2hyde</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_co2hyd</ci>
<ci>CO2e</ci>
</apply>
<apply>
<times/>
<ci>kr_co2hyd</ci>
<ci>HCO3e</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="concentration">
<variable name="Nai" units="millimolar" initial_value="4" public_interface="out"/>
<variable name="Ki" units="millimolar" initial_value="135" public_interface="out"/>
<variable name="Cli" units="millimolar" initial_value="18" public_interface="out"/>
<variable name="CaiT" units="millimolar" initial_value="0.0335168" public_interface="out"/>
<variable name="HiT" units="millimolar" initial_value="13.049480012175094" public_interface="out"/>
<variable name="HCO3i" units="millimolar" initial_value="11.1004878606748" public_interface="out"/>
<variable name="CO2i" units="millimolar" initial_value="1.1665710344828" public_interface="out"/>
<variable name="Ai" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="Nae" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ke" units="millimolar" initial_value="4" public_interface="out"/>
<variable name="Cle" units="millimolar" initial_value="110" public_interface="out"/>
<variable name="CaeT" units="millimolar" initial_value="2.4" public_interface="out"/>
<variable name="HeT" units="millimolar" initial_value="39.135559233057961" public_interface="out"/>
<variable name="HCO3e" units="millimolar" initial_value="22.471795571390697" public_interface="out"/>
<variable name="CO2e" units="millimolar" initial_value="1.1666" public_interface="out"/>
<variable name="Ae" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Jco2hydi" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="Jco2hyde" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NaK" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NCX" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NHE" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NBC" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_AE" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_CHE" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Nab" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Kb" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Cab" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Clb" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="JH_met" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_AX" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="JCO2_resp" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_CO2" units="millimolar_per_millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>J_NCX</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>J_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>J_Nab</ci>
</apply>
<ci>J_NBC</ci>
<ci>J_NHE</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>J_NaK</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>J_Kb</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cli</ci>
</apply>
<apply>
<plus/>
<ci>J_Clb</ci>
<ci>J_CHE</ci>
<ci>J_AE</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaiT</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_Cab</ci>
</apply>
<ci>J_NCX</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HiT</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_CHE</ci>
<ci>J_NHE</ci>
</apply>
<ci>J_AX</ci>
</apply>
<ci>Jco2hydi</ci>
<ci>JH_met</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HCO3i</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_NBC</ci>
<ci>J_AE</ci>
</apply>
<ci>Jco2hydi</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CO2i</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_CO2</ci>
<ci>Jco2hydi</ci>
</apply>
<ci>JCO2_resp</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ai</ci>
</apply>
<apply>
<plus/>
<ci>J_AX</ci>
<ci>JH_met</ci>
</apply>
</apply>
</math>
</component>
<component name="pH_regulation"/>
<component name="membrane_currents"/>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="concentration">
<component_ref component="calc_Hi"/>
<component_ref component="calc_He"/>
<component_ref component="calc_cai"/>
<component_ref component="calc_cae"/>
</component_ref>
<component_ref component="pH_regulation">
<component_ref component="J_co2hyd"/>
<component_ref component="NBC"/>
<component_ref component="NHE"/>
<component_ref component="CHE"/>
<component_ref component="AE"/>
<component_ref component="AX"/>
<component_ref component="CO2"/>
</component_ref>
<component_ref component="membrane_currents">
<component_ref component="s_Kb"/>
<component_ref component="s_Nab"/>
<component_ref component="s_Cab"/>
<component_ref component="s_Clb"/>
<component_ref component="NCX"/>
<component_ref component="NaK"/>
</component_ref>
</group>
<connection>
<map_components component_1="concentration" component_2="J_co2hyd"/>
<map_variables variable_1="Jco2hydi" variable_2="Jco2hydi"/>
<map_variables variable_1="Jco2hyde" variable_2="Jco2hyde"/>
<map_variables variable_1="HCO3e" variable_2="HCO3e"/>
<map_variables variable_1="CO2e" variable_2="CO2e"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
<map_variables variable_1="CO2i" variable_2="CO2i"/>
</connection>
<connection>
<map_components component_1="J_co2hyd" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="J_co2hyd" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="NBC" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="NBC" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="AE" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="AE" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NBC"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
<map_variables variable_1="HCO3e" variable_2="HCO3e"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="membrane"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="CaiT" variable_2="CaiT"/>
<map_variables variable_1="HiT" variable_2="HiT"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
<map_variables variable_1="Ai" variable_2="Ai"/>
</connection>
<connection>
<map_components component_1="environment" component_2="concentration"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="membrane"/>
<map_variables variable_1="Farad" variable_2="Farad"/>
<map_variables variable_1="Rgas" variable_2="Rgas"/>
<map_variables variable_1="Temp" variable_2="Temp"/>
<map_variables variable_1="Am" variable_2="Am"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="alpha_cyt" variable_2="alpha_cyt"/>
</connection>
<connection>
<map_components component_1="environment" component_2="calc_cai"/>
<map_variables variable_1="alpha_SR" variable_2="alpha_SR"/>
<map_variables variable_1="alpha_cyt" variable_2="alpha_cyt"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_cai"/>
<map_variables variable_1="CaiT" variable_2="CaiT"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_cae"/>
<map_variables variable_1="CaeT" variable_2="CaeT"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_He"/>
<map_variables variable_1="HeT" variable_2="HeT"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_Hi"/>
<map_variables variable_1="HiT" variable_2="HiT"/>
</connection>
<connection>
<map_components component_1="gamma_values" component_2="calc_cai"/>
<map_variables variable_1="gammaSECRA" variable_2="gammaSECRA"/>
<map_variables variable_1="gammaleak" variable_2="gammaleak"/>
</connection>
<connection>
<map_components component_1="J_resp_acidosis" component_2="Ischemia_switch"/>
<map_variables variable_1="Resp_Acidosis" variable_2="Resp_Acidosis"/>
</connection>
<connection>
<map_components component_1="J_met_acidosis" component_2="Ischemia_switch"/>
<map_variables variable_1="Met_Acidosis" variable_2="Met_Acidosis"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NaK"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ke" variable_2="Ke"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="s_Kb"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ke" variable_2="Ke"/>
</connection>
<connection>
<map_components component_1="s_Kb" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Kb" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="s_Nab"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="s_Nab" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Nab" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="s_Clb"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="Cle" variable_2="Cle"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="calc_cai"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="calc_cae"/>
<map_variables variable_1="Cae" variable_2="Cae"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NCX"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="calc_cai"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="calc_cae"/>
<map_variables variable_1="Cae" variable_2="Cae"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="NHE" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="NHE" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NHE"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="CHE" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="CHE" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="CHE"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="Cle" variable_2="Cle"/>
</connection>
<connection>
<map_components component_1="AX" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="AX" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="AX"/>
<map_variables variable_1="Ai" variable_2="Ai"/>
<map_variables variable_1="Ae" variable_2="Ae"/>
<map_variables variable_1="J_AX" variable_2="J_AX"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="AE"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="Cle" variable_2="Cle"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
<map_variables variable_1="HCO3e" variable_2="HCO3e"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="Fluxes"/>
<map_variables variable_1="s_nak" variable_2="s_nak"/>
</connection>
<connection>
<map_components component_1="gamma_values" component_2="Fluxes"/>
<map_variables variable_1="gamma_NaK" variable_2="gamma_NaK"/>
<map_variables variable_1="gamma_Nab" variable_2="gamma_Nab"/>
<map_variables variable_1="gamma_Kb" variable_2="gamma_Kb"/>
<map_variables variable_1="gamma_Cab" variable_2="gamma_Cab"/>
<map_variables variable_1="gamma_NCX" variable_2="gamma_NCX"/>
<map_variables variable_1="gamma_NHE" variable_2="gamma_NHE"/>
<map_variables variable_1="gamma_CHE" variable_2="gamma_CHE"/>
<map_variables variable_1="gamma_NBC" variable_2="gamma_NBC"/>
<map_variables variable_1="gamma_AE" variable_2="gamma_AE"/>
<map_variables variable_1="gamma_Clb" variable_2="gamma_Clb"/>
<map_variables variable_1="gamma_CO2" variable_2="gamma_CO2"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="Fluxes"/>
<map_variables variable_1="J_NaK" variable_2="J_NaK"/>
<map_variables variable_1="J_Nab" variable_2="J_Nab"/>
<map_variables variable_1="J_Kb" variable_2="J_Kb"/>
<map_variables variable_1="J_Cab" variable_2="J_Cab"/>
<map_variables variable_1="J_Clb" variable_2="J_Clb"/>
<map_variables variable_1="J_NHE" variable_2="J_NHE"/>
<map_variables variable_1="J_NBC" variable_2="J_NBC"/>
<map_variables variable_1="J_AE" variable_2="J_AE"/>
<map_variables variable_1="J_CHE" variable_2="J_CHE"/>
<map_variables variable_1="J_NCX" variable_2="J_NCX"/>
<map_variables variable_1="J_CO2" variable_2="J_CO2"/>
</connection>
<connection>
<map_components component_1="s_Kb" component_2="Fluxes"/>
<map_variables variable_1="s_kb" variable_2="s_kb"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="Fluxes"/>
<map_variables variable_1="s_clb" variable_2="s_clb"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="Fluxes"/>
<map_variables variable_1="s_cab" variable_2="s_cab"/>
</connection>
<connection>
<map_components component_1="s_Nab" component_2="Fluxes"/>
<map_variables variable_1="s_nab" variable_2="s_nab"/>
</connection>
<connection>
<map_components component_1="CHE" component_2="Fluxes"/>
<map_variables variable_1="s_che" variable_2="s_che"/>
</connection>
<connection>
<map_components component_1="NHE" component_2="Fluxes"/>
<map_variables variable_1="s_nhe" variable_2="s_nhe"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="Fluxes"/>
<map_variables variable_1="s_ncx" variable_2="s_ncx"/>
</connection>
<connection>
<map_components component_1="AE" component_2="Fluxes"/>
<map_variables variable_1="s_ae" variable_2="s_ae"/>
</connection>
<connection>
<map_components component_1="NBC" component_2="Fluxes"/>
<map_variables variable_1="s_nbc" variable_2="s_nbc"/>
</connection>
<connection>
<map_components component_1="Fluxes" component_2="Ischemia_switch"/>
<map_variables variable_1="inhibit_NaK" variable_2="inhibit_NaK"/>
<map_variables variable_1="activate_IKb" variable_2="activate_IKb"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="CO2"/>
<map_variables variable_1="CO2e" variable_2="CO2e"/>
<map_variables variable_1="CO2i" variable_2="CO2i"/>
</connection>
<connection>
<map_components component_1="Fluxes" component_2="CO2"/>
<map_variables variable_1="s_co2" variable_2="s_co2"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="J_resp_acidosis"/>
<map_variables variable_1="JCO2_resp" variable_2="JCO2_resp"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="J_met_acidosis"/>
<map_variables variable_1="JH_met" variable_2="JH_met"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="#passive">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>category 1</rdf:li>
<rdf:li>category 2, etc.</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
</model>
