- Author:
- Dougal Cowan <dj.cowan@auckland.ac.nz>
- Date:
- 2013-02-26 09:41:08+13:00
- Desc:
- initial commit of Niederer 2013 model
- Permanent Source URI:
- https://models.cellml.org/w/dcowan/niederer_2013_PlosOne/rawfile/9484cb65ff6ae375dfe8c7ef60ea651e0b6266fd/passive_model_PlosOne.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 1/23/2013 at 1:20:38 at PM using:
COR (0.9.31.1409)
Copyright 2002-2013 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
<model xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:ns7="http://www.cellml.org/metadata/simulation/1.0#" name="passive" cmeta:id="passive" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<section id="sec_status">
<title>Model Status</title>
<para>
This model is known to run in PCEnv and COR to reproduce the output shown in the publication. A PCEnv session file is also associated with this model.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
This CellML model was based on the June 2007 paper:
</para>
<para>
"A Mathematical Model of the Slow Force Response to Stretch in Rat Ventricular Myocytes" by Steven Niederer and Nicholas Smith
</para>
<para>
The following is the abstract of this paper:
</para>
<para>
We developed a model of the rat ventricular myocyte at room temperature to predict the relative effects of different mechanisms on the cause of the slow increase in force in response to a step change in muscle length. We performed simulations in the presence of stretch-dependent increases in flux through the Na+-H+ exchanger (NHE) and chloride-bicarbonate exchanger (AE), stretch-activated channels (SAC), and the stretch-dependent nitric oxide (NO) induced increased open probability of the ryanodine receptors to estimate the capacity of each mechanism to produce the slow force response (SFR). Inclusion of stretch-dependent NHE & AE, SACs, and stretch-dependent NO effects caused an increase in tension following 15 min of stretch of 0.87%, 32%, and 0%, respectively. Comparing [Ca2+]i dynamics before and after stretch in the presence of combinations of the three stretch-dependent elements, which produced significant SFR values (>20%), showed that the inclusion of stretch-dependent NO effects produced [Ca2+]i transients, which were not consistent with experimental results. Further simulations showed that in the presence of SACs and the absence of stretch-dependent NHE & AE inhibition of NHE attenuated the SFR, such that reduced SFR in the presence of NHE blockers does not indicate a stretch dependence of NHE. Rather, a functioning NHE is responsible for a portion of the SFR. Based on our simulations we estimate that in rat cardiac myocytes at room temperature SACs play a significant role in producing the SFR, potentially in the presence of stretch-dependent NHE & AE and that NO effects, if any, must involve more mechanisms than just increasing the open probability of ryanodine receptors.
</para>
<para>
The complete original publication reference is cited below:
</para>
<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/92/11/4030">A Mathematical Model of the Slow Force Response to Stretch in Rat Ventricular Myocytes</ulink>, Steven Niederer, Nicholas Smith, 2007 <ulink url="http://www.biophysj.org/">
<emphasis>Biophysical Journal</emphasis>
</ulink>, Volume 92(11) pp.4030-4044, PubMed ID: 17369410
</para>
</sect1>
</article>
</documentation>
<rdf:RDF>
<rdf:Seq rdf:about="rdf:#d4b98825-6b98-4c4b-84e9-826e957ecad3">
<rdf:li rdf:resource="rdf:#dcc5fe93-45a1-4350-86cc-6ca9917f49b1"/>
<rdf:li rdf:resource="rdf:#8133a8a2-e4e0-4285-912a-6335c09db267"/>
</rdf:Seq>
<rdf:Description rdf:about="#niederer_smith_2007">
<ns7:simulation rdf:resource="rdf:#$AdsW41"/>
<bqs:reference rdf:resource="rdf:#a8da7b86-37f5-4d12-824f-0a05d63b5562"/>
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#cc750128-f9ce-4f92-9bf9-2a940c0478d8"/>
</rdf:Description>
<rdf:Description rdf:about="">
<dc:publisher>The University of Auckland</dc:publisher>
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#" rdf:resource="rdf:#9ded2dc5-f17d-4c94-8957-f42cd7fcc593"/>
<dcterms:created rdf:resource="rdf:#a9f81b29-2eb4-420c-ac45-755348921ca8"/>
<dc:creator rdf:resource="rdf:#c4dd78a7-bd0a-47df-9911-2a3764aa4667"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a8da7b86-37f5-4d12-824f-0a05d63b5562">
<bqs:Pubmed_id>17369410</bqs:Pubmed_id>
<bqs:JournalArticle rdf:resource="rdf:#39e3a208-d7b8-4f2a-8807-c2f16036aac9"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#dcc5fe93-45a1-4350-86cc-6ca9917f49b1">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#658061ae-c5ea-4ed7-98cc-b4e80e297b85"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#5203a468-d806-4c29-915d-527e542ad818">
<vCard:Given>Nicholas</vCard:Given>
<vCard:Family>Smith</vCard:Family>
<vCard:Other>P</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$BdsW41">
<rdf:rest rdf:resource="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
<rdf:first rdf:resource="rdf:#$CdsW41"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$AdsW41">
<ns7:boundIntervals rdf:resource="rdf:#$BdsW41"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b6744648-1deb-4c9a-9fa1-1adc4b7ffc2c">
<dc:title>Biophysical Journal</dc:title>
</rdf:Description>
<rdf:Description rdf:about="rdf:#b452f26f-8a71-40ff-a7aa-c49e34dfa0eb">
<vCard:FN>James Lawson</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#39e3a208-d7b8-4f2a-8807-c2f16036aac9">
<dc:creator rdf:resource="rdf:#d4b98825-6b98-4c4b-84e9-826e957ecad3"/>
<dc:title>A Mathematical Model of the Slow Force Response to Stretch in Rat Ventricular Myocytes
</dc:title>
<bqs:volume>92</bqs:volume>
<bqs:first_page>4030</bqs:first_page>
<bqs:Journal rdf:resource="rdf:#b6744648-1deb-4c9a-9fa1-1adc4b7ffc2c"/>
<dcterms:issued rdf:resource="rdf:#041ed30e-b295-4050-a267-3fa6d3c6ad92"/>
<bqs:last_page>4044</bqs:last_page>
</rdf:Description>
<rdf:Description rdf:about="rdf:#c4dd78a7-bd0a-47df-9911-2a3764aa4667">
<vCard:ORG rdf:resource="rdf:#a8c07521-fe45-4235-a0e7-321be44efb7c"/>
<vCard:EMAIL rdf:resource="rdf:#d44ff1eb-7cf4-49e2-a7b7-23b8d777d31f"/>
<vCard:N rdf:resource="rdf:#4a1e4131-5d5e-44b8-a852-7a993bc99d4b"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#cc750128-f9ce-4f92-9bf9-2a940c0478d8">
<dc:creator rdf:resource="rdf:#b452f26f-8a71-40ff-a7aa-c49e34dfa0eb"/>
<rdf:value>This cell model provides a descripition of the Electrophysiology, Calcium, pH and Mechanics of the rat ventricular myocte at room temperature.
The model includes representations of length dependent channels NHE & AE and RyR, that can be turned on or off as desired. The model was used to demonstrate the importance of stretch activated channels in regulating the slow force response.
It has also been used in tissue models and can be readily coupled to tissue deformation models (Niederer and Smith Progress in Biophysics and Molecular Biology 2007).
The model uses Hinch 2004 (Biophysical Journal) Ca++ dynamics, Pandit 2001 rat electrophysiology and Niederer 2006 mechanics.
</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#041ed30e-b295-4050-a267-3fa6d3c6ad92">
<dcterms:W3CDTF>2007-06-01 00:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#7a473b8d-92f0-4bea-b9f5-52f829a629f2">
<vCard:FN>Steven Niederer</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="rdf:#4a1e4131-5d5e-44b8-a852-7a993bc99d4b">
<vCard:Given>Steven</vCard:Given>
<vCard:Family>Niederer</vCard:Family>
<vCard:Other/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#9ded2dc5-f17d-4c94-8957-f42cd7fcc593">
<dc:creator rdf:resource="rdf:#7a473b8d-92f0-4bea-b9f5-52f829a629f2"/>
<rdf:value>This CellML model has been created by the author of the paper on which it is based. It has been curated to a high standard and is known to reproduce the published results in PCEnv and COR.</rdf:value>
</rdf:Description>
<rdf:Description rdf:about="rdf:#8133a8a2-e4e0-4285-912a-6335c09db267">
<rdf:type rdf:resource="http://www.cellml.org/bqs/1.0#Person"/>
<vCard:N rdf:resource="rdf:#5203a468-d806-4c29-915d-527e542ad818"/>
</rdf:Description>
<rdf:Description rdf:about="rdf:#$CdsW41">
<ns7:endingValue>10000</ns7:endingValue>
<ns7:nonstandard-pointDensity>10000</ns7:nonstandard-pointDensity>
</rdf:Description>
<rdf:Description rdf:about="rdf:#658061ae-c5ea-4ed7-98cc-b4e80e297b85">
<vCard:Given>Steven</vCard:Given>
<vCard:Family>Niederer</vCard:Family>
<vCard:Other>A</vCard:Other>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a9f81b29-2eb4-420c-ac45-755348921ca8">
<dcterms:W3CDTF>2008-02-02T00:00:00+13:00</dcterms:W3CDTF>
</rdf:Description>
<rdf:Description rdf:about="rdf:#a8c07521-fe45-4235-a0e7-321be44efb7c">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
</rdf:Description>
<rdf:Description rdf:about="rdf:#d44ff1eb-7cf4-49e2-a7b7-23b8d777d31f">
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
<rdf:value>s.niederer@gmail.com</rdf:value>
</rdf:Description>
</rdf:RDF> <units name="micrometre">
<unit units="metre" prefix="micro"/>
</units>
<units name="millimetre">
<unit units="metre" prefix="milli"/>
</units>
<units name="millimetre2">
<unit units="millimetre" exponent="2"/>
</units>
<units name="per_millimetre">
<unit units="millimetre" exponent="-1"/>
</units>
<units name="micrometre3">
<unit units="metre" prefix="micro" exponent="3"/>
</units>
<units name="litre_micrometre3">
<unit units="litre"/>
<unit units="micrometre3" exponent="-1"/>
</units>
<units name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units name="per_millisecond">
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="per_millisecond3">
<unit units="second" prefix="milli" exponent="-3"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="millivolt_square">
<unit units="volt" prefix="milli" exponent="2"/>
</units>
<units name="millisiemens_per_mm2">
<unit units="siemens" prefix="milli"/>
<unit units="millimetre" exponent="-2"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="nanoS_per_picoF">
<unit units="siemens" prefix="nano"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="microF">
<unit units="farad" prefix="micro"/>
</units>
<units name="microFarad_per_millimetre2">
<unit units="microF"/>
<unit units="millimetre2" exponent="-1"/>
</units>
<units name="microA">
<unit units="ampere" prefix="micro"/>
</units>
<units name="picoA_per_picoF">
<unit units="ampere" prefix="pico"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="nanoA_per_millimolar">
<unit units="ampere" prefix="nano"/>
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimetre_per_millisecond">
<unit units="millimetre"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="millimolar_millimetre_per_millisecond">
<unit units="millimolar"/>
<unit units="millimetre"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="millimolar_per_millisecond_per_millivolt">
<unit units="millimolar"/>
<unit units="millisecond" exponent="-1"/>
<unit units="millivolt" exponent="-1"/>
</units>
<units name="per_millimolar">
<unit units="millimolar" exponent="-1"/>
</units>
<units name="millimolar">
<unit units="mole" prefix="milli"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="millimolar2">
<unit units="millimolar" exponent="2"/>
</units>
<units name="millimolar3">
<unit units="millimolar" exponent="3"/>
</units>
<units name="millimolar4">
<unit units="millimolar" exponent="4"/>
</units>
<units name="millimolar_per_millisecond">
<unit units="millimolar"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="millimolar2_per_millisecond">
<unit units="millimolar" exponent="2"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="per_millimolar_per_millisecond">
<unit units="millimolar" exponent="-1"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="per_millimolar2_per_millisecond">
<unit units="millimolar" exponent="-2"/>
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="millijoule_per_mole_kelvin">
<unit units="joule" prefix="milli"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="millimeter_per_millisecond">
<unit units="millimetre"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="coulomb_per_mole">
<unit units="coulomb"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name="uA_per_mm2">
<unit units="microA"/>
<unit units="millimetre2" exponent="-1"/>
</units>
<component name="Ischemia_switch">
<variable name="Resp_Acidosis" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="Met_Acidosis" units="dimensionless" initial_value="0" public_interface="out"/>
<variable name="inhibit_NaK" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="activate_IKb" units="dimensionless" initial_value="0" public_interface="out"/>
</component>
<component name="environment">
<variable name="time" units="millisecond" public_interface="out"/>
<variable name="Rgas" units="millijoule_per_mole_kelvin" initial_value="8314.472" public_interface="out"/>
<variable name="Farad" units="coulomb_per_mole" initial_value="96485.3415" public_interface="out"/>
<variable name="Temp" units="kelvin" initial_value="310" public_interface="out"/>
<variable name="RTF" units="millivolt" public_interface="out"/>
<variable name="Am" units="per_millimetre" initial_value="200" public_interface="out"/>
<variable name="Cm" units="microFarad_per_millimetre2" initial_value="1" public_interface="out"/>
<variable name="alpha_i" units="dimensionless" initial_value="0.8" public_interface="out"/>
<variable name="alpha_fSR" units="dimensionless" initial_value="0.03"/>
<variable name="alpha_SR" units="dimensionless" public_interface="out"/>
<variable name="alpha_fMR" units="dimensionless" initial_value="0.3"/>
<variable name="alpha_MR" units="dimensionless" public_interface="out"/>
<variable name="alpha_cyt" units="dimensionless" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>RTF</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Rgas</ci>
<ci>Temp</ci>
</apply>
<ci>Farad</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_SR</ci>
<apply>
<times/>
<ci>alpha_fSR</ci>
<ci>alpha_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_MR</ci>
<apply>
<times/>
<ci>alpha_fMR</ci>
<ci>alpha_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_cyt</ci>
<apply>
<minus/>
<apply>
<minus/>
<ci>alpha_i</ci>
<ci>alpha_SR</ci>
</apply>
<ci>alpha_MR</ci>
</apply>
</apply>
</math>
</component>
<component name="membrane">
<variable name="Vm" units="millivolt" public_interface="out"/>
<variable name="Farad" units="coulomb_per_mole" public_interface="in"/>
<variable name="zK" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="zNa" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="zCl" units="dimensionless" initial_value="-1" public_interface="out"/>
<variable name="zCa" units="dimensionless" initial_value="2" public_interface="out"/>
<variable name="zHCO3" units="dimensionless" initial_value="-1" public_interface="out"/>
<variable name="zH" units="dimensionless" initial_value="1" public_interface="out"/>
<variable name="zA" units="dimensionless" initial_value="-1" public_interface="out"/>
<variable name="fixed_charge" units="millimolar" initial_value="-1.233254069052028e2" public_interface="out"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="CaiT" units="millimolar" public_interface="in"/>
<variable name="HiT" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<variable name="Ai" units="millimolar" public_interface="in"/>
<variable name="Rgas" units="millijoule_per_mole_kelvin" public_interface="in"/>
<variable name="Temp" units="kelvin" public_interface="in"/>
<variable name="Am" units="per_millimetre" public_interface="in"/>
<variable name="Cm" units="microFarad_per_millimetre2" public_interface="in"/>
<variable name="alpha_cyt" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vm</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_cyt</ci>
<ci>Farad</ci>
</apply>
<apply>
<times/>
<ci>Am</ci>
<ci>Cm</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>zNa</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>zK</ci>
<ci>Ki</ci>
</apply>
<apply>
<times/>
<ci>zCl</ci>
<ci>Cli</ci>
</apply>
<apply>
<times/>
<ci>zCa</ci>
<ci>CaiT</ci>
</apply>
<apply>
<times/>
<ci>zH</ci>
<ci>HiT</ci>
</apply>
<apply>
<times/>
<ci>zHCO3</ci>
<ci>HCO3i</ci>
</apply>
<apply>
<times/>
<ci>Ai</ci>
<ci>zA</ci>
</apply>
<ci>fixed_charge</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="gamma_values">
<variable name="gammaSECRA" units="millimolar_per_millisecond" initial_value="4.75e-5" public_interface="out"/>
<variable name="gammaleak" units="per_millisecond" initial_value="-0.125" public_interface="out"/>
<variable name="gamma_NaK" units="millimolar" initial_value="0.001269187845223" public_interface="out"/>
<variable name="gamma_CO2" units="per_millisecond" initial_value="0.058" public_interface="out"/>
<variable name="gamma_Nab" units="millimolar_per_millisecond_per_millivolt" initial_value="1.428761517726755e-8" public_interface="out"/>
<variable name="gamma_Kb" units="millimolar_per_millisecond_per_millivolt" initial_value="5.378954239918512e-7" public_interface="out"/>
<variable name="gamma_Cab" units="millimolar_per_millisecond_per_millivolt" initial_value="7.676174327141708e-9" public_interface="out"/>
<variable name="gamma_NCX" units="millimolar_per_millisecond" initial_value="4.149438692332562e-5" public_interface="out"/>
<variable name="gamma_NHE" units="millimolar" initial_value="0.087712298303188" public_interface="out"/>
<variable name="gamma_CHE" units="millimolar" initial_value="0.058613874057323" public_interface="out"/>
<variable name="gamma_NBC" units="millimolar" initial_value="6.009784722617906e-6" public_interface="out"/>
<variable name="gamma_AE" units="millimolar" initial_value="6.279454114993227e-5" public_interface="out"/>
<variable name="gamma_Clb" units="millimolar_per_millisecond_per_millivolt" initial_value="1.264015088008236e-7" public_interface="out"/>
</component>
<component name="calc_cai">
<variable name="A" units="millimolar"/>
<variable name="B" units="millimolar2"/>
<variable name="C" units="millimolar3"/>
<variable name="alpha_cai" units="dimensionless"/>
<variable name="alpha_SR" units="dimensionless" public_interface="in"/>
<variable name="alpha_cyt" units="dimensionless" public_interface="in"/>
<variable name="B_ca" units="millimolar"/>
<variable name="gammaSECRA" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="gammaleak" units="per_millisecond" public_interface="in"/>
<variable name="BCai" units="millimolar" initial_value="208.98e-3"/>
<variable name="KCai" units="millimolar" initial_value="0.42e-3"/>
<variable name="CaiT" units="millimolar" public_interface="in"/>
<variable name="Kserca" units="millimolar" initial_value="300e-6"/>
<variable name="Cai" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>B_ca</ci>
<apply>
<divide/>
<ci>gammaSECRA</ci>
<ci>gammaleak</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_cai</ci>
<apply>
<divide/>
<ci>alpha_SR</ci>
<ci>alpha_cyt</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>A</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>B_ca</ci>
</apply>
<ci>KCai</ci>
<ci>Kserca</ci>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>Kserca</ci>
</apply>
</apply>
<ci>CaiT</ci>
</apply>
<ci>BCai</ci>
</apply>
<apply>
<plus/>
<ci>alpha_cai</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>B</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>B_ca</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>KCai</ci>
<ci>CaiT</ci>
</apply>
</apply>
<apply>
<times/>
<ci>CaiT</ci>
<ci>Kserca</ci>
</apply>
</apply>
<apply>
<times/>
<ci>Kserca</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>alpha_cai</ci>
<ci>Kserca</ci>
<ci>KCai</ci>
</apply>
<apply>
<times/>
<ci>BCai</ci>
<ci>Kserca</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>alpha_cai</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>CaiT</ci>
</apply>
<ci>Kserca</ci>
<ci>KCai</ci>
</apply>
<apply>
<plus/>
<ci>alpha_cai</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Cai</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<root/>
<apply>
<minus/>
<apply>
<power/>
<ci>A</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>B</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<cos/>
<apply>
<divide/>
<apply>
<arccos/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">9</cn>
<ci>A</ci>
<ci>B</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<power/>
<ci>A</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">27</cn>
<ci>C</ci>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<apply>
<power/>
<apply>
<minus/>
<apply>
<power/>
<ci>A</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>B</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>A</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calc_cae">
<variable name="bTemp" units="millimolar"/>
<variable name="BCae" units="millimolar" initial_value="2.3"/>
<variable name="KCae" units="millimolar" initial_value="1.1"/>
<variable name="CaeT" units="millimolar" public_interface="in"/>
<variable name="Cae" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>bTemp</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>KCae</ci>
<ci>BCae</ci>
</apply>
<ci>CaeT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Cae</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>bTemp</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>bTemp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>CaeT</ci>
<ci>KCae</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</math>
</component>
<component name="calc_He">
<variable name="bTemp" units="millimolar"/>
<variable name="BHe" units="millimolar" initial_value="350"/>
<variable name="KHe" units="millimolar" initial_value="3.162277660168379e-4"/>
<variable name="HeT" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>bTemp</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>KHe</ci>
<ci>BHe</ci>
</apply>
<ci>HeT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>He</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>bTemp</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>bTemp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>HeT</ci>
<ci>KHe</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</math>
</component>
<component name="calc_Hi">
<variable name="bTemp" units="millimolar"/>
<variable name="BHi" units="millimolar" initial_value="65"/>
<variable name="KHi" units="millimolar" initial_value="3.162277660168379e-4"/>
<variable name="HiT" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>bTemp</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>KHi</ci>
<ci>BHi</ci>
</apply>
<ci>HiT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>Hi</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>bTemp</ci>
</apply>
<apply>
<root/>
<apply>
<plus/>
<apply>
<power/>
<ci>bTemp</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>HiT</ci>
<ci>KHi</ci>
</apply>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</math>
</component>
<component name="J_resp_acidosis">
<variable name="JCO2_resp" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Resp_Acidosis" units="dimensionless" public_interface="in"/>
<variable name="Max_JCO2_res" units="millimolar_per_millisecond" initial_value="0.5e-4"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>JCO2_resp</ci>
<apply>
<times/>
<ci>Resp_Acidosis</ci>
<ci>Max_JCO2_res</ci>
</apply>
</apply>
</math>
</component>
<component name="J_met_acidosis">
<variable name="JH_met" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Met_Acidosis" units="dimensionless" public_interface="in"/>
<variable name="Max_JH_met" units="millimolar_per_millisecond" initial_value="1e-4"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>JH_met</ci>
<apply>
<times/>
<ci>Met_Acidosis</ci>
<ci>Max_JH_met</ci>
</apply>
</apply>
</math>
</component>
<component name="NaK">
<variable name="ADP" units="millimolar" initial_value="0.01"/>
<variable name="cMgATP" units="millimolar" initial_value="9.8"/>
<variable name="cPi_sum" units="millimolar" initial_value="4.2"/>
<variable name="eq_HPi" units="millimolar" initial_value="0.000169"/>
<variable name="eq_KPi" units="millimolar" initial_value="292"/>
<variable name="eq_K_e" units="millimolar" initial_value="0.213"/>
<variable name="eq_K_i" units="millimolar" initial_value="0.5"/>
<variable name="eq_MgATP" units="millimolar" initial_value="2.51"/>
<variable name="eq_NaPi" units="millimolar" initial_value="224"/>
<variable name="eq_Na_base_e" units="millimolar" initial_value="7.75"/>
<variable name="eq_Na_base_i" units="millimolar" initial_value="3.984"/>
<variable name="k1" units="per_millisecond" initial_value="1050"/>
<variable name="k2" units="per_millisecond" initial_value="481"/>
<variable name="k3" units="per_millisecond" initial_value="2000"/>
<variable name="k4" units="per_millisecond" initial_value="320"/>
<variable name="minus_k1" units="per_millimolar_per_millisecond" initial_value="172.1"/>
<variable name="minus_k2" units="per_millisecond" initial_value="40.1"/>
<variable name="minus_k3" units="per_millimolar2_per_millisecond" initial_value="79287.1"/>
<variable name="minus_k4" units="per_millisecond" initial_value="40.1"/>
<variable name="partition_factor" units="dimensionless" initial_value="-0.031"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ke" units="millimolar" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="cPi" units="millimolar"/>
<variable name="dimless_Na_i" units="dimensionless"/>
<variable name="dimless_Na_e" units="dimensionless"/>
<variable name="dimless_K_i" units="dimensionless"/>
<variable name="dimless_K_e" units="dimensionless"/>
<variable name="dimless_MgATP" units="dimensionless"/>
<variable name="alpha1" units="per_millisecond"/>
<variable name="alpha2" units="per_millisecond"/>
<variable name="alpha3" units="per_millisecond"/>
<variable name="alpha4" units="per_millisecond"/>
<variable name="minus_alpha1" units="per_millisecond"/>
<variable name="minus_alpha2" units="per_millisecond"/>
<variable name="minus_alpha3" units="per_millisecond"/>
<variable name="minus_alpha4" units="per_millisecond"/>
<variable name="diagram_sum" units="per_millisecond3"/>
<variable name="s_nak" units="per_millisecond" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>cPi</ci>
<apply>
<divide/>
<ci>cPi_sum</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Ki</ci>
<ci>eq_KPi</ci>
</apply>
<apply>
<divide/>
<ci>Hi</ci>
<ci>eq_HPi</ci>
</apply>
<apply>
<divide/>
<ci>Nai</ci>
<ci>eq_NaPi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_Na_i</ci>
<apply>
<divide/>
<ci>Nai</ci>
<apply>
<times/>
<ci>eq_Na_base_i</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>partition_factor</ci>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>RTF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_Na_e</ci>
<apply>
<divide/>
<ci>Nae</ci>
<apply>
<times/>
<ci>eq_Na_base_e</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>partition_factor</ci>
</apply>
<ci>Vm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>RTF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_K_i</ci>
<apply>
<divide/>
<ci>Ki</ci>
<ci>eq_K_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_K_e</ci>
<apply>
<divide/>
<ci>Ke</ci>
<ci>eq_K_e</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>dimless_MgATP</ci>
<apply>
<divide/>
<ci>cMgATP</ci>
<ci>eq_MgATP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k1</ci>
<apply>
<power/>
<ci>dimless_Na_i</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_i</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha2</ci>
<ci>k2</ci>
</apply>
<apply>
<eq/>
<ci>alpha3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k3</ci>
<apply>
<power/>
<ci>dimless_K_e</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_e</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_e</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha4</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>k4</ci>
<ci>dimless_MgATP</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_MgATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha1</ci>
<apply>
<times/>
<ci>minus_k1</ci>
<ci>ADP</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>minus_k2</ci>
<apply>
<power/>
<ci>dimless_Na_e</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_e</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_e</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha3</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>minus_k3</ci>
<ci>cPi</ci>
<ci>Hi</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_MgATP</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>minus_alpha4</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>minus_k4</ci>
<apply>
<power/>
<ci>dimless_K_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_Na_i</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>dimless_K_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>diagram_sum</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>minus_alpha3</ci>
<ci>minus_alpha2</ci>
<ci>minus_alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>minus_alpha2</ci>
<ci>minus_alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>minus_alpha1</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha3</ci>
<ci>minus_alpha2</ci>
<ci>alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>minus_alpha2</ci>
<ci>alpha1</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>alpha1</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha3</ci>
<ci>alpha1</ci>
<ci>alpha2</ci>
</apply>
<apply>
<times/>
<ci>alpha4</ci>
<ci>alpha1</ci>
<ci>alpha2</ci>
</apply>
<apply>
<times/>
<ci>alpha1</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha3</ci>
<ci>minus_alpha1</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha3</ci>
<ci>alpha2</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha3</ci>
<ci>minus_alpha2</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha1</ci>
<ci>minus_alpha2</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha4</ci>
<ci>minus_alpha1</ci>
<ci>alpha3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_nak</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha1</ci>
<ci>alpha2</ci>
<ci>alpha3</ci>
<ci>alpha4</ci>
</apply>
<apply>
<times/>
<ci>minus_alpha1</ci>
<ci>minus_alpha2</ci>
<ci>minus_alpha3</ci>
<ci>minus_alpha4</ci>
</apply>
</apply>
<ci>diagram_sum</ci>
</apply>
</apply>
</math>
</component>
<component name="s_Nab">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="s_nab" units="millivolt" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_nab</ci>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nae</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="s_Kb">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ke" units="millimolar" public_interface="in"/>
<variable name="s_kb" units="millivolt" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_kb</ci>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ke</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="s_Cab">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Cae" units="millimolar" public_interface="in"/>
<variable name="s_cab" units="millivolt" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_cab</ci>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.5</cn>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cae</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="s_Clb">
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="Cle" units="millimolar" public_interface="in"/>
<variable name="s_clb" units="millivolt" public_interface="out"/>
<variable name="HiRef" units="millimolar" initial_value="7.943282347242821e-5"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="beta_H" units="per_millimolar" initial_value="20000"/>
<variable name="gH" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>gH</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>beta_H</ci>
<apply>
<minus/>
<ci>Hi</ci>
<ci>HiRef</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_clb</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>Vm</ci>
<apply>
<times/>
<ci>RTF</ci>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cli</ci>
<ci>Cle</ci>
</apply>
</apply>
</apply>
</apply>
<ci>gH</ci>
</apply>
</apply>
</math>
</component>
<component name="NCX">
<variable name="KmCai" units="millimolar" initial_value="3.6e-3"/>
<variable name="KmNai" units="millimolar" initial_value="12.3"/>
<variable name="KmCao" units="millimolar" initial_value="1.3"/>
<variable name="KmNao" units="millimolar" initial_value="87.5"/>
<variable name="eta" units="dimensionless" initial_value="0.27"/>
<variable name="kmact" units="millimolar" initial_value="1.25e-6"/>
<variable name="ksat" units="dimensionless" initial_value="0.32"/>
<variable name="nHill" units="dimensionless" initial_value="2"/>
<variable name="dE" units="dimensionless"/>
<variable name="allo" units="dimensionless"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="RTF" units="millivolt" public_interface="in"/>
<variable name="Vm" units="millivolt" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Cae" units="millimolar" public_interface="in"/>
<variable name="edv" units="dimensionless"/>
<variable name="denom1" units="millimolar4"/>
<variable name="denom2" units="millimolar4"/>
<variable name="edv2" units="dimensionless"/>
<variable name="s_ncx" units="dimensionless" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>edv</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RTF</ci>
</apply>
<ci>eta</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>edv2</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<divide/>
<ci>Vm</ci>
<ci>RTF</ci>
</apply>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom1</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>KmCao</ci>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>KmNao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>KmNai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cae</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cai</ci>
<ci>KmCai</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>denom2</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>KmCai</ci>
<apply>
<power/>
<ci>Nae</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>KmNai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cae</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nae</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>allo</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>kmact</ci>
<ci>Cai</ci>
</apply>
<ci>nHill</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>dE</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cae</ci>
<ci>edv</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<ci>Nae</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
<ci>edv2</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>denom1</ci>
<ci>denom2</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>ksat</ci>
<ci>edv2</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_ncx</ci>
<apply>
<times/>
<ci>dE</ci>
<ci>allo</ci>
</apply>
</apply>
</math>
</component>
<component name="NHE">
<variable name="KA" units="millimolar" initial_value="21.4935205515214"/>
<variable name="KB" units="millimolar" initial_value="1.77948608115949e-7"/>
<variable name="K_Hs" units="millimolar" initial_value="0.000416869383470335"/>
<variable name="km1" units="per_millisecond" initial_value="0.14069285629105"/>
<variable name="kp1" units="per_millisecond" initial_value="0.51156085723193"/>
<variable name="kp2" units="per_millisecond" initial_value="0.001698"/>
<variable name="n_Hi" units="dimensionless" initial_value="2"/>
<variable name="km2" units="per_millisecond"/>
<variable name="ap1" units="per_millisecond"/>
<variable name="ap2" units="per_millisecond"/>
<variable name="am1" units="per_millisecond"/>
<variable name="am2" units="per_millisecond"/>
<variable name="reg" units="dimensionless"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="s_nhe" units="per_millisecond" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp1</ci>
<ci>kp2</ci>
</apply>
<ci>km1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ap1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KB</ci>
<ci>Nae</ci>
<ci>kp1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>Nae</ci>
<ci>He</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KB</ci>
<ci>Nai</ci>
<ci>km1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>Nai</ci>
<ci>Hi</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ap2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KA</ci>
<ci>Hi</ci>
<ci>kp2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>Nai</ci>
<ci>Hi</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>KA</ci>
<ci>He</ci>
<ci>km2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>KA</ci>
<ci>KB</ci>
</apply>
<apply>
<times/>
<ci>KB</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>Nae</ci>
<ci>He</ci>
</apply>
<apply>
<times/>
<ci>KA</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<power/>
<ci>K_Hs</ci>
<ci>n_Hi</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_nhe</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>reg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>ap1</ci>
<ci>ap2</ci>
</apply>
<apply>
<times/>
<ci>am1</ci>
<ci>am2</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>ap1</ci>
<ci>ap2</ci>
<ci>am1</ci>
<ci>am2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="CHE">
<variable name="K_Cl_2" units="millimolar" initial_value="5.64"/>
<variable name="K_H" units="millimolar" initial_value="5.105e-5"/>
<variable name="K_a" units="millimolar" initial_value="0.001"/>
<variable name="km12" units="per_millisecond" initial_value="0.0004983"/>
<variable name="kp12" units="per_millisecond" initial_value="0.0012782"/>
<variable name="kp22" units="per_millisecond" initial_value="1.65e-5"/>
<variable name="n_Hi_2" units="dimensionless" initial_value="4"/>
<variable name="km22" units="per_millisecond"/>
<variable name="ap11" units="per_millisecond"/>
<variable name="am11" units="per_millisecond"/>
<variable name="ap21" units="per_millisecond"/>
<variable name="am21" units="per_millisecond"/>
<variable name="reg2" units="dimensionless"/>
<variable name="s_che" units="per_millisecond" public_interface="out"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="Cle" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km22</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp22</ci>
<ci>km12</ci>
</apply>
<ci>kp12</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ap11</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kp12</ci>
<ci>K_H</ci>
</apply>
<ci>Hi</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cli</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am11</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>km12</ci>
<ci>K_H</ci>
</apply>
<ci>He</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cle</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ap21</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>kp22</ci>
<ci>Cle</ci>
</apply>
<ci>K_Cl_2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cle</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am21</ci>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<ci>km22</ci>
<ci>Cli</ci>
</apply>
<ci>K_Cl_2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Cli</ci>
<ci>K_Cl_2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>K_H</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg2</ci>
<apply>
<divide/>
<apply>
<power/>
<ci>K_a</ci>
<ci>n_Hi_2</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi_2</ci>
</apply>
<apply>
<power/>
<ci>K_a</ci>
<ci>n_Hi_2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_che</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>reg2</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>ap11</ci>
<ci>ap21</ci>
</apply>
<apply>
<times/>
<ci>am11</ci>
<ci>am21</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>ap11</ci>
<ci>ap21</ci>
<ci>am11</ci>
<ci>am21</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="NBC">
<variable name="K_HCO3" units="millimolar" initial_value="0.008017"/>
<variable name="K_He" units="millimolar" initial_value="6.53e-5"/>
<variable name="K_Hi" units="millimolar" initial_value="0.000183"/>
<variable name="K_Na" units="millimolar" initial_value="4866.11"/>
<variable name="km13" units="per_millisecond" initial_value="777.92"/>
<variable name="kp13" units="per_millisecond" initial_value="4677"/>
<variable name="kp23" units="per_millisecond" initial_value="6.656"/>
<variable name="km23" units="per_millisecond"/>
<variable name="n_He" units="dimensionless" initial_value="2.18"/>
<variable name="n_Hi" units="dimensionless" initial_value="2.91"/>
<variable name="a" units="dimensionless"/>
<variable name="inb" units="dimensionless"/>
<variable name="inc" units="dimensionless"/>
<variable name="d" units="dimensionless"/>
<variable name="s1" units="dimensionless"/>
<variable name="s6" units="dimensionless"/>
<variable name="reg" units="dimensionless"/>
<variable name="s_nbc" units="per_millisecond" public_interface="out"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Nae" units="millimolar" public_interface="in"/>
<variable name="HCO3e" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km23</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp23</ci>
<ci>km13</ci>
</apply>
<ci>kp13</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>a</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nae</ci>
<ci>K_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Nae</ci>
<ci>HCO3e</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inb</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>Nae</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Nae</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>inc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>Nai</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>d</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<ci>Nai</ci>
<ci>K_Na</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>Nai</ci>
<ci>HCO3i</ci>
</apply>
<apply>
<times/>
<ci>K_Na</ci>
<ci>K_HCO3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s1</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>a</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>d</ci>
<apply>
<plus/>
<ci>kp13</ci>
<apply>
<times/>
<ci>kp23</ci>
<ci>a</ci>
<ci>inb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>km13</ci>
<apply>
<times/>
<ci>km23</ci>
<ci>d</ci>
<ci>inc</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s6</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>d</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>a</ci>
<apply>
<plus/>
<ci>km13</ci>
<apply>
<times/>
<ci>km23</ci>
<ci>d</ci>
<ci>inc</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>kp13</ci>
<apply>
<times/>
<ci>kp23</ci>
<ci>a</ci>
<ci>inb</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<power/>
<ci>K_Hi</ci>
<ci>n_Hi</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
<apply>
<power/>
<ci>K_He</ci>
<ci>n_He</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_nbc</ci>
<apply>
<times/>
<ci>reg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>km13</ci>
<ci>s6</ci>
</apply>
<apply>
<times/>
<ci>kp13</ci>
<ci>s1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="AE">
<variable name="K_Cl" units="millimolar" initial_value="983.5"/>
<variable name="K_HCO3" units="millimolar" initial_value="110.64"/>
<variable name="K_He" units="millimolar" initial_value="0.000312"/>
<variable name="K_Hi" units="millimolar" initial_value="2.67e-5"/>
<variable name="km1" units="per_millisecond" initial_value="21118.2"/>
<variable name="kp1" units="per_millisecond" initial_value="20789.9"/>
<variable name="kp2" units="per_millisecond" initial_value="21256.54"/>
<variable name="n_He" units="dimensionless" initial_value="1.44"/>
<variable name="n_Hi" units="dimensionless" initial_value="5.11"/>
<variable name="km2" units="per_millisecond"/>
<variable name="inva" units="dimensionless"/>
<variable name="invb" units="dimensionless"/>
<variable name="invc" units="dimensionless"/>
<variable name="invd" units="dimensionless"/>
<variable name="s1" units="dimensionless"/>
<variable name="s6" units="dimensionless"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Cli" units="millimolar" public_interface="in"/>
<variable name="Cle" units="millimolar" public_interface="in"/>
<variable name="HCO3e" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<variable name="s_ae" units="per_millisecond" public_interface="out"/>
<variable name="reg" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>km2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>kp2</ci>
<ci>km1</ci>
</apply>
<ci>kp1</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>inva</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3e</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Cle</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>invb</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cle</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>Cle</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>HCO3e</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>invc</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Cli</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>Cli</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>K_HCO3</ci>
</apply>
<apply>
<times/>
<ci>K_Cl</ci>
<ci>HCO3i</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>invd</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>HCO3i</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>K_Cl</ci>
</apply>
<apply>
<times/>
<ci>K_HCO3</ci>
<ci>Cli</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s1</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>inva</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>km1</ci>
<ci>invd</ci>
</apply>
<apply>
<times/>
<ci>km2</ci>
<ci>invc</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kp1</ci>
<ci>inva</ci>
</apply>
<apply>
<times/>
<ci>kp2</ci>
<ci>invb</ci>
</apply>
<apply>
<times/>
<ci>km2</ci>
<ci>invc</ci>
</apply>
<apply>
<times/>
<ci>km1</ci>
<ci>invd</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s6</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>invd</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>kp1</ci>
<ci>inva</ci>
</apply>
<apply>
<times/>
<ci>kp2</ci>
<ci>invb</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kp1</ci>
<ci>inva</ci>
</apply>
<apply>
<times/>
<ci>kp2</ci>
<ci>invb</ci>
</apply>
<apply>
<times/>
<ci>km2</ci>
<ci>invc</ci>
</apply>
<apply>
<times/>
<ci>km1</ci>
<ci>invd</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>reg</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<power/>
<ci>K_Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Hi</ci>
<ci>n_Hi</ci>
</apply>
<apply>
<power/>
<ci>K_Hi</ci>
<ci>n_Hi</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>He</ci>
<ci>n_He</ci>
</apply>
<apply>
<power/>
<ci>K_He</ci>
<ci>n_He</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>s_ae</ci>
<apply>
<times/>
<ci>reg</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>km1</ci>
<ci>s6</ci>
</apply>
<apply>
<times/>
<ci>kp1</ci>
<ci>s1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Fluxes">
<variable name="J_NaK" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nak" units="per_millisecond" public_interface="in"/>
<variable name="gamma_NaK" units="millimolar" public_interface="in"/>
<variable name="inhibit_NaK" units="dimensionless" public_interface="in"/>
<variable name="J_Nab" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nab" units="millivolt" public_interface="in"/>
<variable name="gamma_Nab" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_Kb" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_kb" units="millivolt" public_interface="in"/>
<variable name="gamma_Kb" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_Cab" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_cab" units="millivolt" public_interface="in"/>
<variable name="gamma_Cab" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_NCX" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_ncx" units="dimensionless" public_interface="in"/>
<variable name="gamma_NCX" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NHE" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nhe" units="per_millisecond" public_interface="in"/>
<variable name="gamma_NHE" units="millimolar" public_interface="in"/>
<variable name="J_CHE" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_che" units="per_millisecond" public_interface="in"/>
<variable name="gamma_CHE" units="millimolar" public_interface="in"/>
<variable name="J_NBC" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_nbc" units="per_millisecond" public_interface="in"/>
<variable name="gamma_NBC" units="millimolar" public_interface="in"/>
<variable name="J_AE" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_ae" units="per_millisecond" public_interface="in"/>
<variable name="gamma_AE" units="millimolar" public_interface="in"/>
<variable name="J_Clb" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_clb" units="millivolt" public_interface="in"/>
<variable name="gamma_Clb" units="millimolar_per_millisecond_per_millivolt" public_interface="in"/>
<variable name="J_CO2" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="s_co2" units="millimolar" public_interface="in"/>
<variable name="gamma_CO2" units="per_millisecond" public_interface="in"/>
<variable name="activate_IKb" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_NaK</ci>
<apply>
<times/>
<ci>gamma_NaK</ci>
<ci>s_nak</ci>
<ci>inhibit_NaK</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NCX</ci>
<apply>
<times/>
<ci>gamma_NCX</ci>
<ci>s_ncx</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NHE</ci>
<apply>
<times/>
<ci>gamma_NHE</ci>
<ci>s_nhe</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CHE</ci>
<apply>
<times/>
<ci>gamma_CHE</ci>
<ci>s_che</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC</ci>
<apply>
<times/>
<ci>gamma_NBC</ci>
<ci>s_nbc</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AE</ci>
<apply>
<times/>
<ci>gamma_AE</ci>
<ci>s_ae</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Nab</ci>
<apply>
<times/>
<ci>gamma_Nab</ci>
<ci>s_nab</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Kb</ci>
<apply>
<times/>
<ci>gamma_Kb</ci>
<ci>s_kb</ci>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>activate_IKb</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Cab</ci>
<apply>
<times/>
<ci>gamma_Cab</ci>
<ci>s_cab</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Clb</ci>
<apply>
<times/>
<ci>gamma_Clb</ci>
<ci>s_clb</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_CO2</ci>
<apply>
<times/>
<ci>gamma_CO2</ci>
<ci>s_co2</ci>
</apply>
</apply>
</math>
</component>
<component name="CO2">
<variable name="CO2e" units="millimolar" public_interface="in"/>
<variable name="CO2i" units="millimolar" public_interface="in"/>
<variable name="s_co2" units="millimolar" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>s_co2</ci>
<apply>
<minus/>
<ci>CO2e</ci>
<ci>CO2i</ci>
</apply>
</apply>
</math>
</component>
<component name="AX">
<variable name="KLac" units="millimolar" initial_value="2.24"/>
<variable name="KH" units="millimolar" initial_value="5.223961889991198e-4"/>
<variable name="gamma" units="dimensionless" initial_value="0.157"/>
<variable name="Max_eff" units="millimolar_per_millisecond" initial_value="-4.8e-5"/>
<variable name="Ai" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="Ae" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="J_AX" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="nLaci" units="dimensionless"/>
<variable name="nLaco" units="dimensionless"/>
<variable name="nHi" units="dimensionless"/>
<variable name="nHo" units="dimensionless"/>
<variable name="ap12" units="dimensionless"/>
<variable name="am12" units="dimensionless"/>
<variable name="ap22" units="dimensionless"/>
<variable name="am22" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>nLaci</ci>
<apply>
<divide/>
<ci>Ai</ci>
<ci>KLac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nLaco</ci>
<apply>
<divide/>
<ci>Ae</ci>
<ci>KLac</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nHi</ci>
<apply>
<divide/>
<ci>Hi</ci>
<ci>KH</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>nHo</ci>
<apply>
<divide/>
<ci>He</ci>
<ci>KH</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ap12</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHi</ci>
<apply>
<times/>
<ci>nHi</ci>
<ci>nLaci</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am12</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHo</ci>
<apply>
<times/>
<ci>nHo</ci>
<ci>nLaco</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>ap22</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>nHo</ci>
<ci>nLaco</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHo</ci>
<apply>
<times/>
<ci>nHo</ci>
<ci>nLaco</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>am22</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>nHi</ci>
<ci>nLaci</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nHi</ci>
<apply>
<times/>
<ci>nHi</ci>
<ci>nLaci</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_AX</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Max_eff</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>ap12</ci>
<ci>ap22</ci>
</apply>
<apply>
<times/>
<ci>am12</ci>
<ci>am22</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma</ci>
<apply>
<plus/>
<ci>ap12</ci>
<ci>am12</ci>
</apply>
</apply>
<ci>ap22</ci>
<ci>am22</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="J_co2hyd">
<variable name="HCO3e" units="millimolar" public_interface="in"/>
<variable name="CO2e" units="millimolar" public_interface="in"/>
<variable name="He" units="millimolar" public_interface="in"/>
<variable name="Hi" units="millimolar" public_interface="in"/>
<variable name="HCO3i" units="millimolar" public_interface="in"/>
<variable name="CO2i" units="millimolar" public_interface="in"/>
<variable name="kr_co2hyd" units="per_millimolar_per_millisecond" initial_value="0.481"/>
<variable name="kf_co2hyd" units="per_millisecond" initial_value="0.000365"/>
<variable name="Jco2hydi" units="millimolar_per_millisecond" public_interface="out"/>
<variable name="Jco2hyde" units="millimolar_per_millisecond" public_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Jco2hydi</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_co2hyd</ci>
<ci>CO2i</ci>
</apply>
<apply>
<times/>
<ci>kr_co2hyd</ci>
<ci>HCO3i</ci>
<ci>Hi</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Jco2hyde</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kf_co2hyd</ci>
<ci>CO2e</ci>
</apply>
<apply>
<times/>
<ci>kr_co2hyd</ci>
<ci>HCO3e</ci>
<ci>He</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="concentration">
<variable name="Nai" units="millimolar" initial_value="4" public_interface="out"/>
<variable name="Ki" units="millimolar" initial_value="135" public_interface="out"/>
<variable name="Cli" units="millimolar" initial_value="18" public_interface="out"/>
<variable name="CaiT" units="millimolar" initial_value="0.0335168" public_interface="out"/>
<variable name="HiT" units="millimolar" initial_value="13.049480012175094" public_interface="out"/>
<variable name="HCO3i" units="millimolar" initial_value="11.1004878606748" public_interface="out"/>
<variable name="CO2i" units="millimolar" initial_value="1.1665710344828" public_interface="out"/>
<variable name="Ai" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="Nae" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ke" units="millimolar" initial_value="4" public_interface="out"/>
<variable name="Cle" units="millimolar" initial_value="110" public_interface="out"/>
<variable name="CaeT" units="millimolar" initial_value="2.4" public_interface="out"/>
<variable name="HeT" units="millimolar" initial_value="39.135559233057961" public_interface="out"/>
<variable name="HCO3e" units="millimolar" initial_value="22.471795571390697" public_interface="out"/>
<variable name="CO2e" units="millimolar" initial_value="1.1666" public_interface="out"/>
<variable name="Ae" units="millimolar" initial_value="0" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Jco2hydi" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="Jco2hyde" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NaK" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NCX" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NHE" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_NBC" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_AE" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_CHE" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Nab" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Kb" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Cab" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_Clb" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="JH_met" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_AX" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="JCO2_resp" units="millimolar_per_millisecond" public_interface="in"/>
<variable name="J_CO2" units="millimolar_per_millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>J_NCX</ci>
</apply>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>J_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<ci>J_Nab</ci>
</apply>
<ci>J_NBC</ci>
<ci>J_NHE</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>J_NaK</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<ci>J_Kb</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cli</ci>
</apply>
<apply>
<plus/>
<ci>J_Clb</ci>
<ci>J_CHE</ci>
<ci>J_AE</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaiT</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_Cab</ci>
</apply>
<ci>J_NCX</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HiT</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>J_CHE</ci>
<ci>J_NHE</ci>
</apply>
<ci>J_AX</ci>
</apply>
<ci>Jco2hydi</ci>
<ci>JH_met</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HCO3i</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_NBC</ci>
<ci>J_AE</ci>
</apply>
<ci>Jco2hydi</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CO2i</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>J_CO2</ci>
<ci>Jco2hydi</ci>
</apply>
<ci>JCO2_resp</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ai</ci>
</apply>
<apply>
<plus/>
<ci>J_AX</ci>
<ci>JH_met</ci>
</apply>
</apply>
</math>
</component>
<component name="pH_regulation"/>
<component name="membrane_currents"/>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="concentration">
<component_ref component="calc_Hi"/>
<component_ref component="calc_He"/>
<component_ref component="calc_cai"/>
<component_ref component="calc_cae"/>
</component_ref>
<component_ref component="pH_regulation">
<component_ref component="J_co2hyd"/>
<component_ref component="NBC"/>
<component_ref component="NHE"/>
<component_ref component="CHE"/>
<component_ref component="AE"/>
<component_ref component="AX"/>
<component_ref component="CO2"/>
</component_ref>
<component_ref component="membrane_currents">
<component_ref component="s_Kb"/>
<component_ref component="s_Nab"/>
<component_ref component="s_Cab"/>
<component_ref component="s_Clb"/>
<component_ref component="NCX"/>
<component_ref component="NaK"/>
</component_ref>
</group>
<connection>
<map_components component_1="concentration" component_2="J_co2hyd"/>
<map_variables variable_1="Jco2hydi" variable_2="Jco2hydi"/>
<map_variables variable_1="Jco2hyde" variable_2="Jco2hyde"/>
<map_variables variable_1="HCO3e" variable_2="HCO3e"/>
<map_variables variable_1="CO2e" variable_2="CO2e"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
<map_variables variable_1="CO2i" variable_2="CO2i"/>
</connection>
<connection>
<map_components component_1="J_co2hyd" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="J_co2hyd" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="NBC" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="NBC" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="AE" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="AE" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NBC"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
<map_variables variable_1="HCO3e" variable_2="HCO3e"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="membrane"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="CaiT" variable_2="CaiT"/>
<map_variables variable_1="HiT" variable_2="HiT"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
<map_variables variable_1="Ai" variable_2="Ai"/>
</connection>
<connection>
<map_components component_1="environment" component_2="concentration"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="membrane"/>
<map_variables variable_1="Farad" variable_2="Farad"/>
<map_variables variable_1="Rgas" variable_2="Rgas"/>
<map_variables variable_1="Temp" variable_2="Temp"/>
<map_variables variable_1="Am" variable_2="Am"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="alpha_cyt" variable_2="alpha_cyt"/>
</connection>
<connection>
<map_components component_1="environment" component_2="calc_cai"/>
<map_variables variable_1="alpha_SR" variable_2="alpha_SR"/>
<map_variables variable_1="alpha_cyt" variable_2="alpha_cyt"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_cai"/>
<map_variables variable_1="CaiT" variable_2="CaiT"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_cae"/>
<map_variables variable_1="CaeT" variable_2="CaeT"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_He"/>
<map_variables variable_1="HeT" variable_2="HeT"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="calc_Hi"/>
<map_variables variable_1="HiT" variable_2="HiT"/>
</connection>
<connection>
<map_components component_1="gamma_values" component_2="calc_cai"/>
<map_variables variable_1="gammaSECRA" variable_2="gammaSECRA"/>
<map_variables variable_1="gammaleak" variable_2="gammaleak"/>
</connection>
<connection>
<map_components component_1="J_resp_acidosis" component_2="Ischemia_switch"/>
<map_variables variable_1="Resp_Acidosis" variable_2="Resp_Acidosis"/>
</connection>
<connection>
<map_components component_1="J_met_acidosis" component_2="Ischemia_switch"/>
<map_variables variable_1="Met_Acidosis" variable_2="Met_Acidosis"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NaK"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ke" variable_2="Ke"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="s_Kb"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ke" variable_2="Ke"/>
</connection>
<connection>
<map_components component_1="s_Kb" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Kb" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="s_Nab"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="s_Nab" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Nab" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="s_Clb"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="Cle" variable_2="Cle"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="calc_cai"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="calc_cae"/>
<map_variables variable_1="Cae" variable_2="Cae"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NCX"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="calc_cai"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="calc_cae"/>
<map_variables variable_1="Cae" variable_2="Cae"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="environment"/>
<map_variables variable_1="RTF" variable_2="RTF"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="membrane"/>
<map_variables variable_1="Vm" variable_2="Vm"/>
</connection>
<connection>
<map_components component_1="NHE" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="NHE" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="NHE"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nae" variable_2="Nae"/>
</connection>
<connection>
<map_components component_1="CHE" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="CHE" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="CHE"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="Cle" variable_2="Cle"/>
</connection>
<connection>
<map_components component_1="AX" component_2="calc_He"/>
<map_variables variable_1="He" variable_2="He"/>
</connection>
<connection>
<map_components component_1="AX" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="calc_Hi"/>
<map_variables variable_1="Hi" variable_2="Hi"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="AX"/>
<map_variables variable_1="Ai" variable_2="Ai"/>
<map_variables variable_1="Ae" variable_2="Ae"/>
<map_variables variable_1="J_AX" variable_2="J_AX"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="AE"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
<map_variables variable_1="Cle" variable_2="Cle"/>
<map_variables variable_1="HCO3i" variable_2="HCO3i"/>
<map_variables variable_1="HCO3e" variable_2="HCO3e"/>
</connection>
<connection>
<map_components component_1="NaK" component_2="Fluxes"/>
<map_variables variable_1="s_nak" variable_2="s_nak"/>
</connection>
<connection>
<map_components component_1="gamma_values" component_2="Fluxes"/>
<map_variables variable_1="gamma_NaK" variable_2="gamma_NaK"/>
<map_variables variable_1="gamma_Nab" variable_2="gamma_Nab"/>
<map_variables variable_1="gamma_Kb" variable_2="gamma_Kb"/>
<map_variables variable_1="gamma_Cab" variable_2="gamma_Cab"/>
<map_variables variable_1="gamma_NCX" variable_2="gamma_NCX"/>
<map_variables variable_1="gamma_NHE" variable_2="gamma_NHE"/>
<map_variables variable_1="gamma_CHE" variable_2="gamma_CHE"/>
<map_variables variable_1="gamma_NBC" variable_2="gamma_NBC"/>
<map_variables variable_1="gamma_AE" variable_2="gamma_AE"/>
<map_variables variable_1="gamma_Clb" variable_2="gamma_Clb"/>
<map_variables variable_1="gamma_CO2" variable_2="gamma_CO2"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="Fluxes"/>
<map_variables variable_1="J_NaK" variable_2="J_NaK"/>
<map_variables variable_1="J_Nab" variable_2="J_Nab"/>
<map_variables variable_1="J_Kb" variable_2="J_Kb"/>
<map_variables variable_1="J_Cab" variable_2="J_Cab"/>
<map_variables variable_1="J_Clb" variable_2="J_Clb"/>
<map_variables variable_1="J_NHE" variable_2="J_NHE"/>
<map_variables variable_1="J_NBC" variable_2="J_NBC"/>
<map_variables variable_1="J_AE" variable_2="J_AE"/>
<map_variables variable_1="J_CHE" variable_2="J_CHE"/>
<map_variables variable_1="J_NCX" variable_2="J_NCX"/>
<map_variables variable_1="J_CO2" variable_2="J_CO2"/>
</connection>
<connection>
<map_components component_1="s_Kb" component_2="Fluxes"/>
<map_variables variable_1="s_kb" variable_2="s_kb"/>
</connection>
<connection>
<map_components component_1="s_Clb" component_2="Fluxes"/>
<map_variables variable_1="s_clb" variable_2="s_clb"/>
</connection>
<connection>
<map_components component_1="s_Cab" component_2="Fluxes"/>
<map_variables variable_1="s_cab" variable_2="s_cab"/>
</connection>
<connection>
<map_components component_1="s_Nab" component_2="Fluxes"/>
<map_variables variable_1="s_nab" variable_2="s_nab"/>
</connection>
<connection>
<map_components component_1="CHE" component_2="Fluxes"/>
<map_variables variable_1="s_che" variable_2="s_che"/>
</connection>
<connection>
<map_components component_1="NHE" component_2="Fluxes"/>
<map_variables variable_1="s_nhe" variable_2="s_nhe"/>
</connection>
<connection>
<map_components component_1="NCX" component_2="Fluxes"/>
<map_variables variable_1="s_ncx" variable_2="s_ncx"/>
</connection>
<connection>
<map_components component_1="AE" component_2="Fluxes"/>
<map_variables variable_1="s_ae" variable_2="s_ae"/>
</connection>
<connection>
<map_components component_1="NBC" component_2="Fluxes"/>
<map_variables variable_1="s_nbc" variable_2="s_nbc"/>
</connection>
<connection>
<map_components component_1="Fluxes" component_2="Ischemia_switch"/>
<map_variables variable_1="inhibit_NaK" variable_2="inhibit_NaK"/>
<map_variables variable_1="activate_IKb" variable_2="activate_IKb"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="CO2"/>
<map_variables variable_1="CO2e" variable_2="CO2e"/>
<map_variables variable_1="CO2i" variable_2="CO2i"/>
</connection>
<connection>
<map_components component_1="Fluxes" component_2="CO2"/>
<map_variables variable_1="s_co2" variable_2="s_co2"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="J_resp_acidosis"/>
<map_variables variable_1="JCO2_resp" variable_2="JCO2_resp"/>
</connection>
<connection>
<map_components component_1="concentration" component_2="J_met_acidosis"/>
<map_variables variable_1="JH_met" variable_2="JH_met"/>
</connection>
</model>
