Location: Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: a Theoretical Study @ cf2ba3333c27 / gall_2000b.cellml

Author:
Hanne Nielsen <hnie010@aucklanduni.ac.nz>
Date:
2011-11-11 13:25:52+13:00
Desc:
Removed error in html
Permanent Source URI:
https://models.cellml.org/w/hnielsen/gall_2000/rawfile/cf2ba3333c2797a9dd1a35cd9316a294b7359b23/gall_2000b.cellml

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This CellML file was generated on 8/18/2011 at 1:28:59 at PM using:

COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

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ABSTRACT: Cytosolic calcium plays a crucial role as a second messenger in cellular signalling. Various cell types, including hepatocytes, display Ca(2+)oscillations when stimulated by an extracellular signal. However, the biological relevance of this temporal organization remains unclear. In this paper, we investigate theoretically the effect of Ca(2+)oscillations on a particular example of cell regulation: the phosphorylation-dephosphorylation cycle controlling the activation of glycogen phosphorylase in hepatocytes. By modelling periodic sinusoidal variations in the intracellular Ca(2+)concentration, we show that Ca(2+)oscillations reduce the threshold for the activation of the enzyme. Furthermore, as the activation of a given enzyme depends on the kinetics of its phosphorylation-dephosphorylation cycle, specificity can be encoded by the oscillation frequency. Finally, using a model for signal-induced Ca(2+)oscillations based on Ca(2+)-induced Ca(2+)release, we show that realistic Ca(2+)oscillations can potentiate the response to a hormonal stimulation. These results indicate that Ca(2+)oscillations in hepatocytes could contribute to increase the efficiency and specificity of cellular signalling, as shown experimentally for gene expression in lymphocytes (Dolmetsch et al., 1998).</para>

        <para>
The complete original paper reference is cited below:
</para>
        <para>
         Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: a Theoretical Study, David Gall et al, 2009, <emphasis>Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: 
a Theoretical Study </emphasis>, 207, 445-454. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/11093832">PubMed ID: 11093832</ulink>
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        <bqs:last_page>454</bqs:last_page>
      </bqs:JournalArticle>
    </bqs:reference>
  </rdf:Description>
</rdf:RDF>

</model>