Location: Arresting the mitotic oscillator and the control of cell proliferation: insights from a cascade model for cdc2 kinase activation @ 2d0f9de452d6 / goldbeter_guilmot_1995.cellml

Author:
Hanne Nielsen <hnie010@aucklanduni.ac.nz>
Date:
2011-11-11 13:12:05+13:00
Desc:
Added keywords
Permanent Source URI:
https://models.cellml.org/w/hnielsen/goldbeter_guilmot_1995/rawfile/2d0f9de452d665a13b891ef86310b5b914a97d58/goldbeter_guilmot_1995.cellml

<?xml version="1.0"?>
<!--
This CellML file was generated on 9/8/2011 at 1:55:43 at PM using:

COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="goldbeter_guilmot_1995" name="goldbeter_guilmot_1995">


<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
  <rdf:Description rdf:about="">
    <dc:creator rdf:parseType="Resource">
      <vCard:N rdf:parseType="Resource">
        <vCard:Family>Nielsen</vCard:Family>
        <vCard:Given>Hanne</vCard:Given>
       
      </vCard:N>
      <vCard:EMAIL rdf:parseType="Resource">
        <rdf:value>hnie010@aucklanduni.ac.nz</rdf:value>
        <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
      </vCard:EMAIL>
      <vCard:ORG rdf:parseType="Resource">
        <vCard:Orgname>The University of Auckland</vCard:Orgname>
        <vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
      </vCard:ORG>
    </dc:creator>
    <dcterms:created rdf:parseType="Resource">
      <dcterms:W3CDTF>2011-09-08</dcterms:W3CDTF>
    </dcterms:created>
  </rdf:Description>
  <rdf:Description rdf:about="#goldbeter_guilmot_1995">
    <cmeta:species>Human</cmeta:species>
    
    <bqs:reference rdf:parseType="Resource">
      <dc:subject rdf:parseType="Resource">
        <bqs:subject_type>keyword</bqs:subject_type>
        <rdf:value>
          <rdf:Bag>
            <rdf:li>cell cycle</rdf:li>
            <rdf:li>oscillation</rdf:li>
        <rdf:li>hepatology</rdf:li>
        <rdf:li>liver</rdf:li>
          </rdf:Bag>
        </rdf:value>
      </dc:subject>
    </bqs:reference>
    <bqs:reference rdf:parseType="Resource">
      <bqs:Pubmed_id> 8631387 </bqs:Pubmed_id>
      <bqs:JournalArticle rdf:parseType="Resource">
        <dc:creator>
          <rdf:Seq>
            <rdf:li rdf:parseType="Resource">
              <bqs:Person rdf:parseType="Resource">
                <vCard:N rdf:parseType="Resource">
                  <vCard:Family>Goldbeter</vCard:Family>
                  <vCard:Given>A</vCard:Given>
                </vCard:N>
              </bqs:Person>
            </rdf:li>
            
            <rdf:li rdf:parseType="Resource">
              <bqs:Person rdf:parseType="Resource">
                <vCard:N rdf:parseType="Resource">
                  <vCard:Family>Guilmot</vCard:Family>
                  <vCard:Given>J</vCard:Given>
                </vCard:N>
              </bqs:Person>
            </rdf:li>
                      </rdf:Seq>
        </dc:creator>
        <dc:title>
           Arresting the mitotic oscillator and the control of cell proliferation: insights from a cascade model for cdc2 kinase activation
          </dc:title>
        <dcterms:issued rdf:parseType="Resource">
          <dcterms:W3CDTF>1995</dcterms:W3CDTF>
        </dcterms:issued>
        <bqs:Journal rdf:parseType="Resource">
          <dc:title> Experientia </dc:title>
        </bqs:Journal>
        <bqs:volume>15</bqs:volume>
        <bqs:first_page>212</bqs:first_page>
        <bqs:last_page>216</bqs:last_page>
      </bqs:JournalArticle>
    </bqs:reference>
  </rdf:Description>
</rdf:RDF>



   <units name="minute">
      <unit multiplier="60" units="second"/>
   </units>
   <units name="per_minute">
      <unit exponent="-1" units="minute"/>
   </units>
   <units name="micromole">
      <unit prefix="micro" units="mole"/>
   </units>
   <units name="micromolar">
      <unit units="micromole"/>
      <unit exponent="-1" units="litre"/>
   </units>
   <units name="micromolar_per_minute">
      <unit units="micromolar"/>
      <unit exponent="-1" units="minute"/>
   </units>
   <component name="environment">
      <variable cmeta:id="environment_time" name="time" public_interface="out" units="minute"/>
   </component>
   <component name="C">
      <variable cmeta:id="C_C" initial_value="0.1" name="C" public_interface="out" units="micromolar"/>
      <variable initial_value="0.05" name="v_i" units="micromolar_per_minute"/>
      <variable initial_value="0.25" name="v_d" units="micromolar_per_minute"/>
      <variable name="X" public_interface="in" units="micromolar"/>
      <variable initial_value="0.02" name="K_d" units="micromolar"/>
      <variable initial_value="0.01" name="k_d" units="per_minute"/>
      <variable name="time" public_interface="in" units="minute"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>C</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <minus/>
                  <ci>v_i</ci>
                  <apply>
                     <times/>
                     <ci>v_d</ci>
                     <ci>X</ci>
                     <apply>
                        <divide/>
                        <ci>C</ci>
                        <apply>
                           <plus/>
                           <ci>K_d</ci>
                           <ci>C</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>k_d</ci>
                  <ci>C</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="M">
      <variable cmeta:id="M_M" initial_value="0.1" name="M" public_interface="out" units="micromolar"/>
      <variable name="V_1" public_interface="in" units="micromolar_per_minute"/>
      <variable initial_value="0.01" name="K_1" units="per_minute"/>
      <variable initial_value="1.5" name="V_2" units="per_minute"/>
      <variable initial_value="0.01" name="K_2" units="per_minute"/>
      <variable name="time" public_interface="in" units="minute"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>M</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>V_1</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>M</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>K_1</ci>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>M</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>V_2</ci>
                  <apply>
                     <divide/>
                     <ci>M</ci>
                     <apply>
                        <plus/>
                        <ci>K_2</ci>
                        <ci>M</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="X">
      <variable cmeta:id="X_X" initial_value="0.1" name="X" public_interface="out" units="micromolar"/>
      <variable name="V_3" public_interface="in" units="micromolar_per_minute"/>
      <variable initial_value="0.01" name="K_3" units="per_minute"/>
      <variable initial_value="0.5" name="V_4" units="per_minute"/>
      <variable initial_value="0.01" name="K_4" units="per_minute"/>
      <variable name="time" public_interface="in" units="minute"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>X</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>V_3</ci>
                  <apply>
                     <divide/>
                     <apply>
                        <minus/>
                        <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                        <ci>X</ci>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>K_3</ci>
                        <apply>
                           <minus/>
                           <cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
                           <ci>X</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>V_4</ci>
                  <apply>
                     <divide/>
                     <ci>X</ci>
                     <apply>
                        <plus/>
                        <ci>K_4</ci>
                        <ci>X</ci>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="V_1">
      <variable cmeta:id="V_1_V_1" name="V_1" public_interface="out" units="micromolar_per_minute"/>
      <variable name="C" public_interface="in" units="micromolar"/>
      <variable initial_value="0.5" name="K_c" units="micromolar"/>
      <variable initial_value="3" name="V_M1" units="per_minute"/>
      <variable name="time" public_interface="in" units="minute"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_1</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <ci>C</ci>
                  <apply>
                     <plus/>
                     <ci>K_c</ci>
                     <ci>C</ci>
                  </apply>
               </apply>
               <ci>V_M1</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="V_3">
      <variable cmeta:id="V_3_V_3" name="V_3" public_interface="out" units="micromolar_per_minute"/>
      <variable name="M" public_interface="in" units="micromolar"/>
      <variable initial_value="1" name="V_M3" units="per_minute"/>
      <variable name="time" public_interface="in" units="minute"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>V_3</ci>
            <apply>
               <times/>
               <ci>M</ci>
               <ci>V_M3</ci>
            </apply>
         </apply>
      </math>
   </component>
   <connection>
      <map_components component_1="environment" component_2="C"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="M"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="X"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="V_1"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="environment" component_2="V_3"/>
      <map_variables variable_1="time" variable_2="time"/>
   </connection>
   <connection>
      <map_components component_1="C" component_2="X"/>
      <map_variables variable_1="X" variable_2="X"/>
   </connection>
   <connection>
      <map_components component_1="C" component_2="V_1"/>
      <map_variables variable_1="C" variable_2="C"/>
   </connection>
   <connection>
      <map_components component_1="M" component_2="V_1"/>
      <map_variables variable_1="V_1" variable_2="V_1"/>
   </connection>
   <connection>
      <map_components component_1="M" component_2="V_3"/>
      <map_variables variable_1="M" variable_2="M"/>
   </connection>
   <connection>
      <map_components component_1="X" component_2="V_3"/>
      <map_variables variable_1="V_3" variable_2="V_3"/>
   </connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="#goldbeter_guilmot_1995"><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n1"/></simulation></rdf:Description><rdf:Description rdf:nodeID="n2"><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">80</endingValue></rdf:Description><rdf:Description rdf:nodeID="n3"><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest><rdf:first><rdf:Description rdf:nodeID="n2"/></rdf:first></rdf:Description><rdf:Description rdf:nodeID="n1"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n3"/></boundIntervals></rdf:Description></rdf:RDF></model>