- Author:
- Hanne Nielsen <hnie010@aucklanduni.ac.nz>
- Date:
- 2011-11-11 13:12:05+13:00
- Desc:
- Added keywords
- Permanent Source URI:
- https://models.cellml.org/w/hnielsen/goldbeter_guilmot_1995/rawfile/2d0f9de452d665a13b891ef86310b5b914a97d58/goldbeter_guilmot_1995.cellml
<?xml version="1.0"?>
<!--
This CellML file was generated on 9/8/2011 at 1:55:43 at PM using:
COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" cmeta:id="goldbeter_guilmot_1995" name="goldbeter_guilmot_1995">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Nielsen</vCard:Family>
<vCard:Given>Hanne</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>hnie010@aucklanduni.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>The University of Auckland</vCard:Orgname>
<vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
</vCard:ORG>
</dc:creator>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2011-09-08</dcterms:W3CDTF>
</dcterms:created>
</rdf:Description>
<rdf:Description rdf:about="#goldbeter_guilmot_1995">
<cmeta:species>Human</cmeta:species>
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>cell cycle</rdf:li>
<rdf:li>oscillation</rdf:li>
<rdf:li>hepatology</rdf:li>
<rdf:li>liver</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
<bqs:reference rdf:parseType="Resource">
<bqs:Pubmed_id> 8631387 </bqs:Pubmed_id>
<bqs:JournalArticle rdf:parseType="Resource">
<dc:creator>
<rdf:Seq>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Goldbeter</vCard:Family>
<vCard:Given>A</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<bqs:Person rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Guilmot</vCard:Family>
<vCard:Given>J</vCard:Given>
</vCard:N>
</bqs:Person>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title>
Arresting the mitotic oscillator and the control of cell proliferation: insights from a cascade model for cdc2 kinase activation
</dc:title>
<dcterms:issued rdf:parseType="Resource">
<dcterms:W3CDTF>1995</dcterms:W3CDTF>
</dcterms:issued>
<bqs:Journal rdf:parseType="Resource">
<dc:title> Experientia </dc:title>
</bqs:Journal>
<bqs:volume>15</bqs:volume>
<bqs:first_page>212</bqs:first_page>
<bqs:last_page>216</bqs:last_page>
</bqs:JournalArticle>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<units name="minute">
<unit multiplier="60" units="second"/>
</units>
<units name="per_minute">
<unit exponent="-1" units="minute"/>
</units>
<units name="micromole">
<unit prefix="micro" units="mole"/>
</units>
<units name="micromolar">
<unit units="micromole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="micromolar_per_minute">
<unit units="micromolar"/>
<unit exponent="-1" units="minute"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="minute"/>
</component>
<component name="C">
<variable cmeta:id="C_C" initial_value="0.1" name="C" public_interface="out" units="micromolar"/>
<variable initial_value="0.05" name="v_i" units="micromolar_per_minute"/>
<variable initial_value="0.25" name="v_d" units="micromolar_per_minute"/>
<variable name="X" public_interface="in" units="micromolar"/>
<variable initial_value="0.02" name="K_d" units="micromolar"/>
<variable initial_value="0.01" name="k_d" units="per_minute"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v_i</ci>
<apply>
<times/>
<ci>v_d</ci>
<ci>X</ci>
<apply>
<divide/>
<ci>C</ci>
<apply>
<plus/>
<ci>K_d</ci>
<ci>C</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>k_d</ci>
<ci>C</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="M">
<variable cmeta:id="M_M" initial_value="0.1" name="M" public_interface="out" units="micromolar"/>
<variable name="V_1" public_interface="in" units="micromolar_per_minute"/>
<variable initial_value="0.01" name="K_1" units="per_minute"/>
<variable initial_value="1.5" name="V_2" units="per_minute"/>
<variable initial_value="0.01" name="K_2" units="per_minute"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>M</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>V_1</ci>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>M</ci>
</apply>
<apply>
<plus/>
<ci>K_1</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>M</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>V_2</ci>
<apply>
<divide/>
<ci>M</ci>
<apply>
<plus/>
<ci>K_2</ci>
<ci>M</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="X">
<variable cmeta:id="X_X" initial_value="0.1" name="X" public_interface="out" units="micromolar"/>
<variable name="V_3" public_interface="in" units="micromolar_per_minute"/>
<variable initial_value="0.01" name="K_3" units="per_minute"/>
<variable initial_value="0.5" name="V_4" units="per_minute"/>
<variable initial_value="0.01" name="K_4" units="per_minute"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>X</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>V_3</ci>
<apply>
<divide/>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>X</ci>
</apply>
<apply>
<plus/>
<ci>K_3</ci>
<apply>
<minus/>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1</cn>
<ci>X</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>V_4</ci>
<apply>
<divide/>
<ci>X</ci>
<apply>
<plus/>
<ci>K_4</ci>
<ci>X</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="V_1">
<variable cmeta:id="V_1_V_1" name="V_1" public_interface="out" units="micromolar_per_minute"/>
<variable name="C" public_interface="in" units="micromolar"/>
<variable initial_value="0.5" name="K_c" units="micromolar"/>
<variable initial_value="3" name="V_M1" units="per_minute"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_1</ci>
<apply>
<times/>
<apply>
<divide/>
<ci>C</ci>
<apply>
<plus/>
<ci>K_c</ci>
<ci>C</ci>
</apply>
</apply>
<ci>V_M1</ci>
</apply>
</apply>
</math>
</component>
<component name="V_3">
<variable cmeta:id="V_3_V_3" name="V_3" public_interface="out" units="micromolar_per_minute"/>
<variable name="M" public_interface="in" units="micromolar"/>
<variable initial_value="1" name="V_M3" units="per_minute"/>
<variable name="time" public_interface="in" units="minute"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_3</ci>
<apply>
<times/>
<ci>M</ci>
<ci>V_M3</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="C"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="M"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="X"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="V_1"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="environment" component_2="V_3"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="C" component_2="X"/>
<map_variables variable_1="X" variable_2="X"/>
</connection>
<connection>
<map_components component_1="C" component_2="V_1"/>
<map_variables variable_1="C" variable_2="C"/>
</connection>
<connection>
<map_components component_1="M" component_2="V_1"/>
<map_variables variable_1="V_1" variable_2="V_1"/>
</connection>
<connection>
<map_components component_1="M" component_2="V_3"/>
<map_variables variable_1="M" variable_2="M"/>
</connection>
<connection>
<map_components component_1="X" component_2="V_3"/>
<map_variables variable_1="V_3" variable_2="V_3"/>
</connection>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"><rdf:Description rdf:about="#goldbeter_guilmot_1995"><simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n1"/></simulation></rdf:Description><rdf:Description rdf:nodeID="n2"><endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en">80</endingValue></rdf:Description><rdf:Description rdf:nodeID="n3"><rdf:rest><rdf:Description rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/></rdf:rest><rdf:first><rdf:Description rdf:nodeID="n2"/></rdf:first></rdf:Description><rdf:Description rdf:nodeID="n1"><boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#"><rdf:Description rdf:nodeID="n3"/></boundIntervals></rdf:Description></rdf:RDF></model>
