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Switching from Simple to Complex Oscillations in Calcium Signaling

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Description
We present a new model for calcium oscillations based on experiments in hepatocytes. The model considers feedback inhibition on the initial agonist receptor complex by calcium and activated phospholipase C, as well as receptor type-dependent self-enhanced behavior of the activated G(alpha) subunit. It is able to show simple periodic oscillations and periodic bursting, and it is the first model to display chaotic bursting in response to agonist stimulations. Moreover, our model offers a possible explanation for the differences in dynamic behavior observed in response to different agonists in hepatocytes.
Owner
Hanne Nielsen <hnie010@aucklanduni.ac.nz>
URI for git clone/pull/push
https://models.cellml.org/w/hnielsen/kummer_2000

Files

Filename Size Date Options
.DS_Store 6148 2011-08-23 [browse]
kummer_2000.ai 1145214 2011-08-23 [browse]
kummer_2000.html 1636 2011-08-23 [browse]
kummer_2000.png 57304 2011-08-23 [browse]
kummer_2000.svg 224012 2011-08-23 [browse]
kummer_2000.xul 231385 2011-08-23 [browse]
kummer_2000_1a.cellml 20427 2011-08-23 [browse]
kummer_2000_1a.session.xml 15048 2011-08-23 [browse] [run]
kummer_2000_1b.cellml 27212 2011-08-23 [browse]
kummer_2000_1b.session.xml 14397 2011-08-23 [browse] [run]
kummer_2000_1c.cellml 22208 2011-08-23 [browse]
kummer_2000_1c.session.xml 13363 2011-08-23 [browse] [run]