- Author:
- Yong Cheng POH <poh.yongcheng@gmail.com>
- Date:
- 2012-11-05 17:35:06+08:00
- Desc:
- first commit of the core files
- Permanent Source URI:
- https://models.cellml.org/w/yc_poh/poh_2012/rawfile/7ed4e38309a7fe8f9b901be6a95d71681b96a477/poh_2012.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 22/10/2012 at 2:57:14 at PM using:
COR (0.9.31.1409)
Copyright 2002-2012 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk
CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology</title>
<author>
<firstname>Yong Cheng</firstname>
<surname>Poh</surname>
<affiliation>
<shortaffil>NUS Graduate School for Integrative Sciences and Engineering and Department of Bioengineering, National University of Singapore </shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This CellML model represents the human jejunal smooth muscle cell of the small intestine, and describes four slow waves with a 10s period. For more details, please refer to the original paper, visit the <ulink url="http://www.bioeng.nus.edu.sg/compbiolab"> lab's website </ulink> or contact the author <ulink url="mailto:poh.yongcheng@gmail.com?Subject=hJSMC">Yong Cheng</ulink>.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
ABSTRACT: Recently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated.
</para>
<para>
The original paper reference is cited below:
</para>
<para>
A Quantitative Model of Human Jejunal Smooth Muscle Cell Electrophysiology, Yong Cheng Poh, Alberto Corrias, Nicholas Cheng, Martin Lindsay Buist, 2012,
<emphasis>PLoS ONE</emphasis>, 7(8): e42385. <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/">PubMed ID: 22912702 </ulink>
</para>
<informalfigure float="0" id="TODO">
<mediaobject>
<imageobject>
<objectinfo>
<title>Schematic overview of the hJSMC model</title>
</objectinfo>
<imagedata fileref="TODO"/>
</imageobject>
</mediaobject>
<caption>It contains the ionic conductances and sub-cellular mechanisms that shape cellular electrical behaviour and intracellular Ca2+ dynamics.</caption>
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</article>
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<ci>T_correction_Ca</ci>
<cn cellml:units="per_millisecond">0.00232</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">280</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_f</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>xi_f</ci>
<ci>phi_f</ci>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>psi_f</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_s</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>xi_s</ci>
<ci>phi_s</ci>
</apply>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>psi_s</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_sf</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_s</ci>
<ci>psi_f</ci>
</apply>
<ci>xi_f</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>omega_fs</ci>
<ci>psi_s</ci>
</apply>
<apply>
<eq/>
<ci>delta</ci>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="per_millisecond">0.01</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>theta</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>T_correction_Ca</ci>
<cn cellml:units="per_millisecond">4</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="millimolar">1</cn>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>norm</ci>
<apply>
<plus/>
<ci>C3</ci>
<ci>C2</ci>
<ci>C1</ci>
<ci>C0</ci>
<ci>C3Ca</ci>
<ci>C2Ca</ci>
<ci>C1Ca</ci>
<ci>C0Ca</ci>
<ci>O_CaL</ci>
<ci>ICa</ci>
<ci>IVs</ci>
<ci>IVf</ci>
<ci>IVsCa</ci>
<ci>IVfCa</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_3</ci>
<ci>beta_2</ci>
<ci>phi_s</ci>
<ci>phi_f</ci>
<ci>theta</ci>
</apply>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_f</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_s</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_2</ci>
<ci>beta_1</ci>
<ci>theta</ci>
</apply>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_2</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_0</ci>
<ci>C0</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_1</ci>
<ci>beta_0</ci>
<ci>theta</ci>
</apply>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_1</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>alpha_0</ci>
<ci>theta</ci>
</apply>
</apply>
<ci>C0</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_0</ci>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>C0Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_2</ci>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_3</ci>
<ci>beta_2</ci>
<ci>phi_f</ci>
<ci>phi_s</ci>
<ci>delta</ci>
</apply>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_3</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_f</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_s</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_1</ci>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_2</ci>
<ci>beta_1</ci>
<ci>delta</ci>
</apply>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_2</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C1Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C1</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_0</ci>
<ci>C0Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_1</ci>
<ci>beta_0</ci>
<ci>delta</ci>
</apply>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_1</ci>
<ci>C2Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C0Ca</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>C0</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_0</ci>
<ci>delta</ci>
</apply>
<ci>C0Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>beta_0</ci>
<ci>C1Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O_CaL</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>beta_3</ci>
<ci>psi_f</ci>
<ci>psi_s</ci>
<ci>theta</ci>
</apply>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_f</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_s</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ICa</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_3</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>beta_3</ci>
<ci>psi_f</ci>
<ci>psi_s</ci>
<ci>delta</ci>
</apply>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_f</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>xi_s</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVs</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_s</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_s</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_fs</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_s</ci>
<ci>xi_s</ci>
<ci>omega_sf</ci>
<ci>theta</ci>
</apply>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVf</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_f</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_f</ci>
<ci>O_CaL</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_f</ci>
<ci>xi_f</ci>
<ci>omega_fs</ci>
<ci>theta</ci>
</apply>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_sf</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>delta</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVsCa</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>IVs</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_s</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_s</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_fs</ci>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_s</ci>
<ci>xi_s</ci>
<ci>omega_sf</ci>
<ci>delta</ci>
</apply>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IVfCa</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>theta</ci>
<ci>IVf</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>phi_f</ci>
<ci>C3Ca</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>psi_f</ci>
<ci>ICa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci>omega_f</ci>
<ci>xi_f</ci>
<ci>omega_fs</ci>
<ci>delta</ci>
</apply>
<ci>IVfCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>omega_sf</ci>
<ci>IVsCa</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel">
<variable name="i_Ca_T" units="picoA" public_interface="out"/>
<variable name="g_CaT" units="nanoS" initial_value="0.0425"/>
<variable name="E_Ca" units="millivolt" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="d_CaT" units="dimensionless" private_interface="in"/>
<variable name="f_CaT" units="dimensionless" private_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Ca</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Ca_T</ci>
<apply>
<times/>
<ci>g_CaT</ci>
<ci>d_CaT</ci>
<ci>f_CaT</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_d_gate">
<variable name="d_CaT" units="dimensionless" initial_value="0.0791635737410974" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="d_CaT_inf" units="dimensionless"/>
<variable name="tau_d_CaT" units="millisecond"/>
<variable name="T_correction_Ca" units="dimensionless"/>
<variable name="Q10Ca" units="dimensionless" initial_value="2.1"/>
<variable name="T" units="kelvin" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_Ca</ci>
<apply>
<power/>
<ci>Q10Ca</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>d_CaT_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">60.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">5.3</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_d_CaT</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1.9058</cn>
<ci>T_correction_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>d_CaT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>d_CaT_inf</ci>
<ci>d_CaT</ci>
</apply>
<ci>tau_d_CaT</ci>
</apply>
</apply>
</math>
</component>
<component name="T_type_Ca_channel_f_gate">
<variable name="f_CaT" units="dimensionless" initial_value="0.377831534375835" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="f_CaT_inf" units="dimensionless"/>
<variable name="tau_f_CaT" units="millisecond"/>
<variable name="T_correction_Ca" units="dimensionless"/>
<variable name="Q10Ca" units="dimensionless" initial_value="2.1"/>
<variable name="T" units="kelvin" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_Ca</ci>
<apply>
<power/>
<ci>Q10Ca</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_CaT_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">75.5</cn>
</apply>
<cn cellml:units="millivolt">4</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_f_CaT</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="millisecond">0.38117</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">8.6</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">14.7</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">50</cn>
</apply>
</apply>
<cn cellml:units="millivolt2">900</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>T_correction_Ca</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>f_CaT</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>f_CaT_inf</ci>
<ci>f_CaT</ci>
</apply>
<ci>tau_f_CaT</ci>
</apply>
</apply>
</math>
</component>
<component name="voltage_dep_K_channel">
<variable name="i_Kv" units="picoA" public_interface="out"/>
<variable name="g_Kv" units="nanoS" initial_value="1.0217"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="x_Kv" units="dimensionless" private_interface="in"/>
<variable name="y_Kv" units="dimensionless" private_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kv</ci>
<apply>
<times/>
<ci>g_Kv</ci>
<ci>x_Kv</ci>
<ci>y_Kv</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="voltage_dep_K_channel_x_gate">
<variable name="x_Kv" units="dimensionless" initial_value="0.14714161078933" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="x_Kv_inf" units="dimensionless"/>
<variable name="tau_x_Kv" units="millisecond"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="T_correction_K" units="dimensionless"/>
<variable name="Q10K" units="dimensionless" initial_value="3.1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_K</ci>
<apply>
<power/>
<ci>Q10K</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>x_Kv_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">43</cn>
</apply>
</apply>
<cn cellml:units="millivolt">17.36</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_x_Kv</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">4.7803</cn>
<ci>T_correction_K</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>x_Kv</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>x_Kv_inf</ci>
<ci>x_Kv</ci>
</apply>
<ci>tau_x_Kv</ci>
</apply>
</apply>
</math>
</component>
<component name="voltage_dep_K_channel_y_gate">
<variable name="y_Kv" units="dimensionless" initial_value="0.99994773314105" public_interface="out"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="y_Kv_inf" units="dimensionless"/>
<variable name="tau_y_Kv" units="millisecond"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="T_correction_K" units="dimensionless"/>
<variable name="Q10K" units="dimensionless" initial_value="3.1"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>T_correction_K</ci>
<apply>
<power/>
<ci>Q10K</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>T</ci>
<cn cellml:units="kelvin">297</cn>
</apply>
<cn cellml:units="kelvin">10</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_Kv_inf</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">44.9</cn>
</apply>
<cn cellml:units="millivolt">12.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_y_Kv</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">763.7564</cn>
<ci>T_correction_K</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_Kv</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_Kv_inf</ci>
<ci>y_Kv</ci>
</apply>
<ci>tau_y_Kv</ci>
</apply>
</apply>
</math>
</component>
<component name="Calcium_voltage_activated_potassium_channel">
<variable name="i_BK" units="picoA" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="g_BK" units="nanoS" initial_value="80"/>
<variable name="time" units="millisecond" public_interface="in" private_interface="out"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in" private_interface="out"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="O4" units="dimensionless" private_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in" private_interface="out"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_BK</ci>
<apply>
<times/>
<ci>g_BK</ci>
<ci>O4</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Calcium_voltage_activated_potassium_channel_states">
<variable name="C0" units="dimensionless" initial_value="0.48379087935899"/>
<variable name="C1" units="dimensionless" initial_value="0.385183559520031"/>
<variable name="C2" units="dimensionless" initial_value="0.115002824567753"/>
<variable name="C3" units="dimensionless" initial_value="0.0152602714149774"/>
<variable name="C4" units="dimensionless" initial_value="0.000759264410974374"/>
<variable name="O0" units="dimensionless" initial_value="6.94960798375172e-7"/>
<variable name="O1" units="dimensionless" initial_value="5.55636826398253e-8"/>
<variable name="O2" units="dimensionless" initial_value="2.85143702125325e-8"/>
<variable name="O3" units="dimensionless" initial_value="1.59832806123435e-6"/>
<variable name="O4" units="dimensionless" initial_value="1.82113764497095e-6" public_interface="out"/>
<variable name="alpha" units="per_millisecond"/>
<variable name="beta" units="per_millisecond"/>
<variable name="k_on" units="per_millisecond"/>
<variable name="k_off_C" units="per_millisecond"/>
<variable name="k_off_O" units="per_millisecond"/>
<variable name="k_C0O0" units="per_millisecond"/>
<variable name="k_C1O1" units="per_millisecond"/>
<variable name="k_C2O2" units="per_millisecond"/>
<variable name="k_C3O3" units="per_millisecond"/>
<variable name="k_C4O4" units="per_millisecond"/>
<variable name="k_O0C0" units="per_millisecond"/>
<variable name="k_O1C1" units="per_millisecond"/>
<variable name="k_O2C2" units="per_millisecond"/>
<variable name="k_O3C3" units="per_millisecond"/>
<variable name="k_O4C4" units="per_millisecond"/>
<variable name="k_C0C1" units="per_millisecond"/>
<variable name="k_C1C2" units="per_millisecond"/>
<variable name="k_C2C3" units="per_millisecond"/>
<variable name="k_C3C4" units="per_millisecond"/>
<variable name="k_C4C3" units="per_millisecond"/>
<variable name="k_C3C2" units="per_millisecond"/>
<variable name="k_C2C1" units="per_millisecond"/>
<variable name="k_C1C0" units="per_millisecond"/>
<variable name="k_O0O1" units="per_millisecond"/>
<variable name="k_O1O2" units="per_millisecond"/>
<variable name="k_O2O3" units="per_millisecond"/>
<variable name="k_O3O4" units="per_millisecond"/>
<variable name="k_O4O3" units="per_millisecond"/>
<variable name="k_O3O2" units="per_millisecond"/>
<variable name="k_O2O1" units="per_millisecond"/>
<variable name="k_O1O0" units="per_millisecond"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="norm" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt">8.47188</cn>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_kelvin">1</cn>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">7.77556</cn>
</apply>
<ci>V</ci>
</apply>
<apply>
<times/>
<cn cellml:units="per_kelvin">1</cn>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_on</ci>
<cn cellml:units="per_millisecond">40633</cn>
</apply>
<apply>
<eq/>
<ci>k_off_C</ci>
<cn cellml:units="per_millisecond">11</cn>
</apply>
<apply>
<eq/>
<ci>k_off_O</ci>
<cn cellml:units="per_millisecond">1.1</cn>
</apply>
<apply>
<eq/>
<ci>k_C0O0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.02162</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C1O1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000869</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C2O2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0000281</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C3O3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000781</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C4O4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.044324</cn>
<ci>alpha</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O0C0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">318.1084</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O1C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">144.1736</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O2C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">32.6594</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O3C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.095312</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O4C4</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000106</cn>
<ci>beta</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C0C1</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">4</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C1C2</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">3</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C2C3</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">2</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C3C4</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C4C3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C3C2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C2C1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_C1C0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>k_off_C</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O0O1</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">4</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O1O2</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">3</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O2O3</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">2</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O3O4</ci>
<apply>
<times/>
<cn cellml:units="per_millimolar">1</cn>
<ci>k_on</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O4O3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O3O2</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O2O1</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_O1O0</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">1</cn>
<ci>k_off_O</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>norm</ci>
<apply>
<plus/>
<ci>C0</ci>
<ci>C1</ci>
<ci>C2</ci>
<ci>C3</ci>
<ci>C4</ci>
<ci>O0</ci>
<ci>O1</ci>
<ci>O2</ci>
<ci>O3</ci>
<ci>O4</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
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<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>k_C4C3</ci>
<ci>k_C4O4</ci>
</apply>
</apply>
<ci>C4</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_C3C4</ci>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_O4C4</ci>
<ci>O4</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>k_C3C2</ci>
<ci>k_C3O3</ci>
<ci>k_C3C4</ci>
</apply>
</apply>
<ci>C3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_C2C3</ci>
<ci>C2</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_O3C3</ci>
<ci>O3</ci>
</apply>
<ci>norm</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>k_C4C3</ci>
<ci>C4</ci>
</apply>
<ci>norm</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
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<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
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</apply>
</apply>
</math>
</component>
<component name="Na_Ca_exchanger">
<variable name="i_NCX" units="picoA" public_interface="out"/>
<variable name="P_NCX" units="picoA" initial_value="1992.335"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Cai" units="millimolar" public_interface="in"/>
<variable name="Cao" units="millimolar" public_interface="in"/>
<variable name="K_mCa" units="millimolar" initial_value="1.38"/>
<variable name="K_mNai" units="millimolar" initial_value="87.5"/>
<variable name="k_sat" units="dimensionless" initial_value="0.1"/>
<variable name="gamma" units="dimensionless" initial_value="0.35"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NCX</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>P_NCX</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>gamma</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2.5</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Cao</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>gamma</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump">
<variable name="i_NaK" units="picoA" public_interface="out"/>
<variable name="P_NaK" units="picoA" initial_value="9.26"/>
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="K_mK" units="millimolar" initial_value="1"/>
<variable name="K_mNa" units="millimolar" initial_value="40"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>P_NaK</ci>
<ci>Ko</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>Ko</ci>
<ci>K_mK</ci>
</apply>
<apply>
<plus/>
<ci>K_mNa</ci>
<ci>Nai</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0353</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="non_specific_Na_current">
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="i_NsNa" units="picoA" public_interface="out"/>
<variable name="g_NsNa" units="nanoS" initial_value="0.022488"/>
<variable name="Nao" units="millimolar" public_interface="in"/>
<variable name="Nai" units="millimolar" public_interface="in"/>
<variable name="E_Na" units="millivolt" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NsNa</ci>
<apply>
<times/>
<ci>g_NsNa</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="non_specific_K_current">
<variable name="V" units="millivolt" public_interface="in" private_interface="out"/>
<variable name="i_NsK" units="picoA" public_interface="out"/>
<variable name="g_NsK" units="nanoS" initial_value="0.017512"/>
<variable name="Ko" units="millimolar" public_interface="in"/>
<variable name="Ki" units="millimolar" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>i_NsK</ci>
<apply>
<times/>
<ci>g_NsK</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ionic_concentrations">
<variable name="Nai" units="millimolar" initial_value="10.5731241425458" public_interface="out"/>
<variable name="Nao" units="millimolar" initial_value="140" public_interface="out"/>
<variable name="Ki" units="millimolar" initial_value="153.604280337996" public_interface="out"/>
<variable name="Ko" units="millimolar" initial_value="5.4" public_interface="out"/>
<variable name="Cai" units="millimolar" initial_value="5.38843941249284e-5" public_interface="out"/>
<variable name="Cao" units="millimolar" initial_value="2" public_interface="out"/>
<variable name="CRT_total" units="millimolar" initial_value="0.034"/>
<variable name="CaM_total" units="millimolar" initial_value="0.012"/>
<variable name="K_D_CRT" units="millimolar" initial_value="0.0009"/>
<variable name="K_D_CaM" units="millimolar4" initial_value="0.0001"/>
<variable name="n_CRT" units="dimensionless" initial_value="1"/>
<variable name="n_CaM" units="dimensionless" initial_value="4"/>
<variable name="V_myo" units="litre" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="i_Na" units="picoA" public_interface="in"/>
<variable name="i_Kv" units="picoA" public_interface="in"/>
<variable name="i_BK" units="picoA" public_interface="in"/>
<variable name="i_NCX" units="picoA" public_interface="in"/>
<variable name="i_NaK" units="picoA" public_interface="in"/>
<variable name="i_NsK" units="picoA" public_interface="in"/>
<variable name="i_NsNa" units="picoA" public_interface="in"/>
<variable name="i_Ca_L" units="picoA" public_interface="in"/>
<variable name="i_Ca_T" units="picoA" public_interface="in"/>
<variable name="I_stim" units="picoA" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>V_myo</ci>
<cn type="e-notation" cellml:units="litre">3.5 <sep/>
-12</cn>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<divide/>
<cn cellml:units="second">1</cn>
<cn type="e-notation" cellml:units="millisecond">1 <sep/>
15</cn>
</apply>
</apply>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_NsNa</ci>
<apply>
<times/>
<ci>i_NCX</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn type="e-notation" cellml:units="dimensionless">1 <sep/>
-15</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Kv</ci>
<ci>i_BK</ci>
<ci>i_NsK</ci>
<ci>I_stim</ci>
</apply>
<apply>
<times/>
<ci>i_NaK</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<divide/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn type="e-notation" cellml:units="dimensionless">1 <sep/>
-15</cn>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Ca_L</ci>
<ci>i_Ca_T</ci>
</apply>
<apply>
<times/>
<ci>i_NCX</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>V_myo</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>n_CRT</ci>
<ci>CRT_total</ci>
<ci>K_D_CRT</ci>
<apply>
<power/>
<ci>Cai</ci>
<apply>
<minus/>
<ci>n_CRT</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>Cai</ci>
<ci>n_CRT</ci>
</apply>
<ci>K_D_CRT</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>n_CaM</ci>
<ci>CaM_total</ci>
<ci>K_D_CaM</ci>
<apply>
<power/>
<ci>Cai</ci>
<apply>
<minus/>
<ci>n_CaM</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<power/>
<apply>
<plus/>
<apply>
<power/>
<ci>Cai</ci>
<ci>n_CaM</ci>
</apply>
<ci>K_D_CaM</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="I_stim"/>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_states"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_d_gate"/>
<component_ref component="T_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="voltage_dep_K_channel">
<component_ref component="voltage_dep_K_channel_x_gate"/>
<component_ref component="voltage_dep_K_channel_y_gate"/>
</component_ref>
<component_ref component="Calcium_voltage_activated_potassium_channel">
<component_ref component="Calcium_voltage_activated_potassium_channel_states"/>
</component_ref>
<component_ref component="sodium_current">
<component_ref component="Na_channel_states"/>
</component_ref>
<component_ref component="Na_Ca_exchanger"/>
<component_ref component="sodium_potassium_pump"/>
<component_ref component="non_specific_Na_current"/>
<component_ref component="non_specific_K_current"/>
<component_ref component="ionic_concentrations"/>
</component_ref>
</group>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="L_type_Ca_channel">
<component_ref component="L_type_Ca_channel_states"/>
</component_ref>
<component_ref component="T_type_Ca_channel">
<component_ref component="T_type_Ca_channel_d_gate"/>
<component_ref component="T_type_Ca_channel_f_gate"/>
</component_ref>
<component_ref component="voltage_dep_K_channel">
<component_ref component="voltage_dep_K_channel_x_gate"/>
<component_ref component="voltage_dep_K_channel_y_gate"/>
</component_ref>
<component_ref component="Calcium_voltage_activated_potassium_channel">
<component_ref component="Calcium_voltage_activated_potassium_channel_states"/>
</component_ref>
<component_ref component="sodium_current">
<component_ref component="Na_channel_states"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="I_stim" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="Calcium_voltage_activated_potassium_channel" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ionic_concentrations" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="I_stim"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="I_stim" variable_2="I_stim"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="T_type_Ca_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="voltage_dep_K_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Kv" variable_2="i_Kv"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Calcium_voltage_activated_potassium_channel"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_BK" variable_2="i_BK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="Na_Ca_exchanger"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NCX" variable_2="i_NCX"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_specific_Na_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_NsNa" variable_2="i_NsNa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_specific_K_current"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="i_NsK" variable_2="i_NsK"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ionic_concentrations"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="I_stim" component_2="ionic_concentrations"/>
<map_variables variable_1="I_stim" variable_2="I_stim"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_Ca_L" variable_2="i_Ca_L"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_Ca_T" variable_2="i_Ca_T"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_Kv" variable_2="i_Kv"/>
</connection>
<connection>
<map_components component_1="Calcium_voltage_activated_potassium_channel" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="i_BK" variable_2="i_BK"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="ionic_concentrations"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="Na_Ca_exchanger" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="i_NCX" variable_2="i_NCX"/>
</connection>
<connection>
<map_components component_1="sodium_potassium_pump" component_2="ionic_concentrations"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="non_specific_Na_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NsNa" variable_2="i_NsNa"/>
</connection>
<connection>
<map_components component_1="non_specific_K_current" component_2="ionic_concentrations"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="i_NsK" variable_2="i_NsK"/>
</connection>
<connection>
<map_components component_1="L_type_Ca_channel" component_2="L_type_Ca_channel_states"/>
<map_variables variable_1="O_CaL" variable_2="O_CaL"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_d_gate"/>
<map_variables variable_1="d_CaT" variable_2="d_CaT"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="T_type_Ca_channel" component_2="T_type_Ca_channel_f_gate"/>
<map_variables variable_1="f_CaT" variable_2="f_CaT"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="voltage_dep_K_channel_x_gate"/>
<map_variables variable_1="x_Kv" variable_2="x_Kv"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="voltage_dep_K_channel" component_2="voltage_dep_K_channel_y_gate"/>
<map_variables variable_1="y_Kv" variable_2="y_Kv"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="Calcium_voltage_activated_potassium_channel" component_2="Calcium_voltage_activated_potassium_channel_states"/>
<map_variables variable_1="O4" variable_2="O4"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="sodium_current" component_2="Na_channel_states"/>
<map_variables variable_1="O_Na" variable_2="O_Na"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
</model>