- Author:
- Dewan Sarwar <dsar941@UoA.auckland.ac.nz>
- Date:
- 2019-11-21 18:27:30+13:00
- Desc:
- Modified SEDML models of three prototype protocols and their RDFs
- Permanent Source URI:
- https://models.cellml.org/workspace/267/rawfile/0eebe1382a2cc14b1a897d70fe4e1e739cce1a4c/semgen_annotated_models/Chang_Fujita_2001_Na_H_exchanger.cellml
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<articleinfo>
<title>Mathematical Models of Ionic Transport in the Distal Tubule of the Rat</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Auckland Bioengineering Institute, The University of Auckland</shortaffil>
</affiliation>
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<section id="sec_status">
<title>Model Status</title>
<para>This CellML model is a description of Chang and Fujita's 2001 mathematical model of a Na-H exchanger in the distal tubule of the rat: it is one component of an overall model of acid/base transport in a distal tubule.</para>
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<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: The purpose of this study is to develop a numerical model that simulates acid-base transport in rat distal tubule. We have previously reported a model that deals with transport of Na(+), K(+), Cl(-), and water in this nephron segment (Chang H and Fujita T. Am J Physiol Renal Physiol 276: F931-F951, 1999). In this study, we extend our previous model by incorporating buffer systems, new cell types, and new transport mechanisms. Specifically, the model incorporates bicarbonate, ammonium, and phosphate buffer systems; has cell types corresponding to intercalated cells; and includes the Na/H exchanger, H-ATPase, and anion exchanger. Incorporation of buffer systems has required the following modifications of model equations: new model equations are introduced to represent chemical equilibria of buffer partners [e.g., pH = pK(a) + log(10) (NH(3)/NH(4))], and the formulation of mass conservation is extended to take into account interconversion of buffer partners. Furthermore, finite rates of H(2)CO(3)-CO(2) interconversion are taken into account in modeling the bicarbonate buffer system. Owing to this treatment, the model can simulate the development of disequilibrium pH in the distal tubular fluid. For each new transporter, a state diagram has been constructed to simulate its transport kinetics. With appropriate assignment of maximal transport rates for individual transporters, the model predictions are in agreement with free-flow micropuncture experiments in terms of HCO reabsorption rate in the normal state as well as under the high bicarbonate load. Although the model cannot simulate all of the microperfusion experiments, especially those that showed a flow-dependent increase in HCO reabsorption, the model is consistent with those microperfusion experiments that showed HCO reabsorption rates similar to those in the free-flow micropuncture experiments. We conclude that it is possible to develop a numerical model of the rat distal tubule that simulates acid-base transport, as well as basic solute and water transport, on the basis of tubular geometry, physical principles, and transporter kinetics. Such a model would provide a useful means of integrating detailed kinetic properties of transporters and predicting macroscopic transport characteristics of this nephron segment under physiological and pathophysiological settings.</para>
<para>The original paper reference is cited below:</para>
<para>
A numerical model of acid-base transport in rat distal tubule, Hangil Chang and Toshiro Fujita, 2001,
<emphasis>American Journal of Physiology</emphasis>
, 281, F222-F243.
<ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11457714&dopt=Abstract">PubMed ID: 11457714</ulink>
.
</para>
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<caption>
State diagram of the Na-H exchanger. In this model, the Na-H exchanger has a single binding site (E) to which Na
<superscript>+</superscript>
, H
<superscript>+</superscript>
, and NH
<subscript>4</subscript>
<superscript>+</superscript>
bind competitively. Only the bound forms of the transporter are able to cross the membrane. (Symbols with the asterisk (*) represent conformations facing the cytosol, symbols without indicate conformations facing the extracellular environment.)
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<variable cmeta:id="E_.k11" name="k11" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="E_.time" name="time" public_interface="in" units="second" />
<variable cmeta:id="E_.k10" name="k10" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="E_.k8" name="k8" public_interface="in" units="first_order_rate_constant" />
<variable cmeta:id="E_.k7" name="k7" public_interface="in" units="second_order_rate_constant" />
<variable cmeta:id="E_.ENH4_" name="ENH4_" public_interface="in" units="millimolar" />
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq />
<apply>
<diff />
<bvar>
<ci>time</ci>
</bvar>
<ci>E_</ci>
</apply>
<apply>
<minus />
<apply>
<plus />
<apply>
<times />
<ci>k8</ci>
<ci>ENa_</ci>
</apply>
<apply>
<times />
<ci>k10</ci>
<ci>EH_</ci>
</apply>
<apply>
<times />
<ci>k12</ci>
<ci>ENH4_</ci>
</apply>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>k7</ci>
<ci>Na_</ci>
<ci>E_</ci>
</apply>
<apply>
<times />
<ci>k9</ci>
<ci>H_</ci>
<ci>E_</ci>
</apply>
<apply>
<times />
<ci>k11</ci>
<ci>NH4_</ci>
<ci>E_</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="E_" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="E_" component_2="ENH4_" />
<map_variables variable_1="E_" variable_2="E_" />
</connection>
<connection>
<map_components component_1="E" component_2="ENH4" />
<map_variables variable_1="E" variable_2="E" />
</connection>
<connection>
<map_components component_1="ENa_" component_2="ENa" />
<map_variables variable_1="ENa_" variable_2="ENa_" />
</connection>
<connection>
<map_components component_1="ENH4" component_2="E" />
<map_variables variable_1="ENH4" variable_2="ENH4" />
</connection>
<connection>
<map_components component_1="environment" component_2="ENa" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="E" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="EH" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="environment" component_2="EH_" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="ENa" component_2="E" />
<map_variables variable_1="ENa" variable_2="ENa" />
</connection>
<connection>
<map_components component_1="ENH4_" component_2="ENH4" />
<map_variables variable_1="ENH4_" variable_2="ENH4_" />
</connection>
<connection>
<map_components component_1="ENH4" component_2="ENH4_" />
<map_variables variable_1="ENH4" variable_2="ENH4" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="ENH4_" />
<map_variables variable_1="k17" variable_2="k17" />
<map_variables variable_1="k12" variable_2="k12" />
<map_variables variable_1="k11" variable_2="k11" />
<map_variables variable_1="NH4_" variable_2="NH4_" />
<map_variables variable_1="k18" variable_2="k18" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="E" />
<map_variables variable_1="k6" variable_2="k6" />
<map_variables variable_1="k3" variable_2="k3" />
<map_variables variable_1="NH4" variable_2="NH4" />
<map_variables variable_1="Na" variable_2="Na" />
<map_variables variable_1="k2" variable_2="k2" />
<map_variables variable_1="k4" variable_2="k4" />
<map_variables variable_1="k5" variable_2="k5" />
<map_variables variable_1="H" variable_2="H" />
<map_variables variable_1="k1" variable_2="k1" />
</connection>
<connection>
<map_components component_1="environment" component_2="ENH4_" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="EH" />
<map_variables variable_1="k3" variable_2="k3" />
<map_variables variable_1="k16" variable_2="k16" />
<map_variables variable_1="k15" variable_2="k15" />
<map_variables variable_1="k4" variable_2="k4" />
<map_variables variable_1="H" variable_2="H" />
</connection>
<connection>
<map_components component_1="ENa" component_2="ENa_" />
<map_variables variable_1="ENa" variable_2="ENa" />
</connection>
<connection>
<map_components component_1="ENH4_" component_2="E_" />
<map_variables variable_1="ENH4_" variable_2="ENH4_" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="ENa" />
<map_variables variable_1="k13" variable_2="k13" />
<map_variables variable_1="Na" variable_2="Na" />
<map_variables variable_1="k14" variable_2="k14" />
<map_variables variable_1="k2" variable_2="k2" />
<map_variables variable_1="k1" variable_2="k1" />
</connection>
<connection>
<map_components component_1="ENa_" component_2="E_" />
<map_variables variable_1="ENa_" variable_2="ENa_" />
</connection>
<connection>
<map_components component_1="E" component_2="ENa" />
<map_variables variable_1="E" variable_2="E" />
</connection>
<connection>
<map_components component_1="E_" component_2="ENa_" />
<map_variables variable_1="E_" variable_2="E_" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="ENH4" />
<map_variables variable_1="k6" variable_2="k6" />
<map_variables variable_1="NH4" variable_2="NH4" />
<map_variables variable_1="k17" variable_2="k17" />
<map_variables variable_1="k5" variable_2="k5" />
<map_variables variable_1="k18" variable_2="k18" />
</connection>
<connection>
<map_components component_1="EH" component_2="E" />
<map_variables variable_1="EH" variable_2="EH" />
</connection>
<connection>
<map_components component_1="EH_" component_2="EH" />
<map_variables variable_1="EH_" variable_2="EH_" />
</connection>
<connection>
<map_components component_1="E" component_2="EH" />
<map_variables variable_1="E" variable_2="E" />
</connection>
<connection>
<map_components component_1="E_" component_2="EH_" />
<map_variables variable_1="E_" variable_2="E_" />
</connection>
<connection>
<map_components component_1="environment" component_2="ENH4" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="EH" component_2="EH_" />
<map_variables variable_1="EH" variable_2="EH" />
</connection>
<connection>
<map_components component_1="EH_" component_2="E_" />
<map_variables variable_1="EH_" variable_2="EH_" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="E_" />
<map_variables variable_1="k10" variable_2="k10" />
<map_variables variable_1="k9" variable_2="k9" />
<map_variables variable_1="k12" variable_2="k12" />
<map_variables variable_1="k11" variable_2="k11" />
<map_variables variable_1="k8" variable_2="k8" />
<map_variables variable_1="NH4_" variable_2="NH4_" />
<map_variables variable_1="Na_" variable_2="Na_" />
<map_variables variable_1="H_" variable_2="H_" />
<map_variables variable_1="k7" variable_2="k7" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="EH_" />
<map_variables variable_1="k10" variable_2="k10" />
<map_variables variable_1="k9" variable_2="k9" />
<map_variables variable_1="k16" variable_2="k16" />
<map_variables variable_1="k15" variable_2="k15" />
<map_variables variable_1="H_" variable_2="H_" />
</connection>
<connection>
<map_components component_1="reaction_constants" component_2="ENa_" />
<map_variables variable_1="k13" variable_2="k13" />
<map_variables variable_1="k14" variable_2="k14" />
<map_variables variable_1="k8" variable_2="k8" />
<map_variables variable_1="Na_" variable_2="Na_" />
<map_variables variable_1="k7" variable_2="k7" />
</connection>
<connection>
<map_components component_1="environment" component_2="ENa_" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<rdf:RDF xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:opb="http://bhi.washington.edu/OPB#" xmlns:j.0="http://imc.org/vCard/3.0#">
<rdf:Description rdf:about="#reaction_constants.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_11">
<ro:part_of>
<rdf:Description rdf:about="#entity_8">
<ro:part_of>
<rdf:Description rdf:about="#entity_3">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:17721" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:9672" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29239" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Hydrogen ion concentration in the substrate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH.H">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Hydrogen ion concentration in the substrate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_.EH_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_37">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_5">
<ro:part_of>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<ro:part_of>
<rdf:Description rdf:about="#entity_2">
<ro:part_of rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/cl/CL:0005010" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:66836" />
</rdf:Description>
</ro:part_of>
<dcterms:description>Model Na-H exchanger with a single binding site</dcterms:description>
<semsim:name>Na-H Exchanger</semsim:name>
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29239" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Hydrogen bound Na-H exchanger intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_.k10">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.k12">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_.ENH4_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_12">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:35274" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ammonium bound Na-H exchanger intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENa.time">
<dcterms:description>Time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4.k5">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.NH4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_13">
<ro:part_of rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:35274" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ammonium extracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4_.ENH4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_16">
<ro:part_of>
<rdf:Description rdf:about="#entity_17">
<ro:part_of>
<rdf:Description rdf:about="#entity_18">
<ro:part_of>
<rdf:Description rdf:about="#entity_19">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:9672" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/fma/FMA:9672" />
</rdf:Description>
</ro:part_of>
<dcterms:description>Model Na-H exchanger with a single binding site</dcterms:description>
<semsim:name>Na-H Exchanger</semsim:name>
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:35274" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ammonium bound Na-H exchanger extracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.k13">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH.time">
<dcterms:description>Time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH_.E_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-H exchanger intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH_.k9">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4.k6">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.k10">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4.time">
<dcterms:description>Time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_.k12">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_.time">
<dcterms:description>Time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4_.k18">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.W">
<dcterms:description>Na/H exchanger rate of translocation modification factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENa.k1">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_.k11">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.k11">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH.k16">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENa.k2">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.k16">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.time">
<dcterms:description>Time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENa_.ENa_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_9">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium bound Na-H exchanger intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH.EH">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of>
<rdf:Description rdf:about="#entity_7">
<ro:part_of rdf:resource="#entity_8" />
<dcterms:description>Model Na-H exchanger with a single binding site</dcterms:description>
<semsim:name>Na-H Exchanger</semsim:name>
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29239" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Hydrogen bound Na-H exchanger extracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.NH4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ammonium extracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.ENH4">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf rdf:resource="#entity_16" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ammonium bound Na-H exchanger extracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4_.E_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-H exchanger intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENa.E">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_30">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_15">
<ro:part_of rdf:resource="#entity_8" />
<dcterms:description>Model Na-H exchanger with a single binding site</dcterms:description>
<semsim:name>Na-H Exchanger</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-H exchanger extracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#ENa_" dc:title="ENa_">
<dcterms:alternative>sodium-loaded Na-H exchanger intracellular side</dcterms:alternative>
</rdf:Description>
<rdf:Description rdf:about="#ENa.Na">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_32">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14">
<ro:part_of rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium ion concentration in the substrate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.k17">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4_.k17">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH.k3">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time">
<dcterms:description>Time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.Na">
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium bound Na-H exchanger intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENa_.Na_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular sodium ion concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_.k9">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.EH">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_28">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Hydrogen bound Na-H exchanger extracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENa_.E_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Na-H exchanger intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.NH4_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ammonium intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4.k17">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.k2">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#reaction_constants.k9">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ENH4_.NH4_">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ammonium intracellular concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="http://www.cellml.org/cellml/1.0#E_" dc:title="E_">
<dcterms:alternative>Na-H exchanger intracellular side</dcterms:alternative>
</rdf:Description>
<rdf:Description rdf:about="#ENH4.k18">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#EH_.time">
<dcterms:description>Time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.k3">
<dcterms:description>Anion exchanger rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E.ENa">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf rdf:resource="#entity_10" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Sodium bound Na-H exchanger extracellular concentration</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
