Location: semantic-annotation @ 92367a08b2bb / SEDML / eskandari_2005_2.cellml

Author:
Dewan Sarwar <dsar941@UoA.auckland.ac.nz>
Date:
2020-06-25 21:17:52+12:00
Desc:
annotations changed for mackenzie model
Permanent Source URI:
https://models.cellml.org/workspace/267/rawfile/92367a08b2bb9612257ef3f32b6823adf5e0d53b/SEDML/eskandari_2005_2.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model cmeta:id="eskandari_2005" name="eskandari_2005" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
    <units name="umol">
        <unit prefix="micro" units="mole"/>
    </units>
    <units name="C_per_mol">
        <unit units="coulomb"/>
        <unit exponent="-1.0" units="mole"/>
    </units>
    <units name="per_M2_per_second">
        <unit exponent="-2.0" units="M"/>
        <unit exponent="-1.0" units="second"/>
    </units>
    <units name="per_mol">
        <unit exponent="-1.0" units="mole"/>
    </units>
    <units name="per_M3_per_second5">
        <unit exponent="-3.0" units="M"/>
        <unit exponent="-5.0" units="second"/>
    </units>
    <units name="um2">
        <unit exponent="2.0" prefix="micro" units="metre"/>
    </units>
    <units name="umol_per_mol">
        <unit units="umol"/>
        <unit exponent="-1.0" units="mole"/>
    </units>
    <units name="mM">
        <unit prefix="milli" units="mole"/>
        <unit exponent="-1.0" units="litre"/>
    </units>
    <units name="M_per_second">
        <unit exponent="-1.0" units="second"/>
        <unit units="M"/>
    </units>
    <units name="per_second5">
        <unit exponent="-5.0" units="second"/>
    </units>
    <units name="mol_per_um2">
        <unit units="mole"/>
        <unit exponent="-1.0" units="um2"/>
    </units>
    <units name="uA_per_A">
        <unit exponent="-1.0" units="ampere"/>
        <unit units="uA"/>
    </units>
    <units name="per_M_per_second">
        <unit exponent="-1.0" units="M"/>
        <unit exponent="-1.0" units="second"/>
    </units>
    <units name="uA">
        <unit prefix="micro" units="ampere"/>
    </units>
    <units name="pA_per_cm2">
        <unit exponent="-2.0" prefix="centi" units="metre"/>
        <unit prefix="pico" units="ampere"/>
    </units>
    <units name="mV">
        <unit prefix="milli" units="volt"/>
    </units>
    <units name="M">
        <unit exponent="-1.0" units="litre"/>
        <unit units="mole"/>
    </units>
    <units name="per_second">
        <unit exponent="-1.0" units="second"/>
    </units>
    <units name="J_per_K_per_mol">
        <unit exponent="-1.0" units="kelvin"/>
        <unit units="joule"/>
        <unit exponent="-1.0" units="mole"/>
    </units>
    <units name="M3_per_second">
        <unit exponent="-1.0" units="second"/>
        <unit exponent="3.0" units="M"/>
    </units>
    <units name="M3">
        <unit exponent="3.0" units="M"/>
    </units>
    <units name="uA_per_um2">
        <unit units="uA"/>
        <unit exponent="-1.0" units="um2"/>
    </units>
    <units name="volt_per_second">
        <unit units="volt"/>
        <unit exponent="-1.0" units="second"/>
    </units>
    <units name="M2">
        <unit exponent="2.0" units="M"/>
    </units>
    <component name="environment">
        <variable cmeta:id="environment.time" name="time" public_interface="out" units="second"/>
    </component>
    <component name="parameters">
        <variable cmeta:id="parameters.k0_12" initial_value="80000" name="k0_12" public_interface="out" units="per_M2_per_second"/>
        <variable cmeta:id="parameters.k0_21" initial_value="500" name="k0_21" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_23" initial_value="1e5" name="k0_23" public_interface="out" units="per_M_per_second"/>
        <variable cmeta:id="parameters.k0_32" initial_value="20" name="k0_32" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_34" initial_value="50" name="k0_34" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_43" initial_value="50" name="k0_43" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_45" initial_value="800" name="k0_45" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_54" initial_value="1.219e4" name="k0_54" public_interface="out" units="per_M_per_second"/>
        <variable cmeta:id="parameters.k0_25" initial_value="0.3" name="k0_25" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_52" initial_value="9.1e-4" name="k0_52" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_56" initial_value="10" name="k0_56" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_65_f" initial_value="50" name="k0_65_f" units="per_M2_per_second"/>
        <variable cmeta:id="parameters.k0_61_f" initial_value="5" name="k0_61_f" units="per_second"/>
        <variable cmeta:id="parameters.k0_16_f" initial_value="35" name="k0_16_f" units="per_second"/>
        <variable cmeta:id="parameters.k0_65_r" initial_value="4500" name="k0_65_r" units="per_M2_per_second"/>
        <variable cmeta:id="parameters.k0_61_r" initial_value="3" name="k0_61_r" units="per_second"/>
        <variable cmeta:id="parameters.k0_16_r" initial_value="350" name="k0_16_r" units="per_second"/>
        <variable cmeta:id="parameters.k0_65" name="k0_65" public_interface="out" units="per_M2_per_second"/>
        <variable cmeta:id="parameters.k0_61" name="k0_61" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.k0_16" name="k0_16" public_interface="out" units="per_second"/>
        <variable cmeta:id="parameters.delta" initial_value="0.7" name="delta" public_interface="out" units="dimensionless"/>
        <variable cmeta:id="parameters.alpha_p" name="alpha_p" public_interface="out" units="dimensionless"/>
        <variable cmeta:id="parameters.alpha_pp" initial_value="0" name="alpha_pp" public_interface="out" units="dimensionless"/>
        <variable cmeta:id="parameters.N_C" initial_value="3e6" name="N_C" units="dimensionless"/>
        <variable cmeta:id="parameters.N_Avo" initial_value="6.022e23" name="N_Avo" units="per_mol"/>
        <variable cmeta:id="parameters.area" initial_value="1e6" name="area" units="um2"/>
        <variable cmeta:id="parameters.C_T" name="C_T" public_interface="out" units="umol"/>
        <variable cmeta:id="parameters.n" initial_value="2" name="n" public_interface="out" units="dimensionless"/>
        <variable cmeta:id="parameters.z_c" initial_value="-2" name="z_c" public_interface="out" units="dimensionless"/>
        <variable cmeta:id="parameters.z_Na" initial_value="1" name="z_Na" public_interface="out" units="dimensionless"/>
        <variable cmeta:id="parameters.F" initial_value="96485.34" name="F" public_interface="out" units="C_per_mol"/>
        <variable cmeta:id="parameters.R" initial_value="8.314" name="R" public_interface="out" units="J_per_K_per_mol"/>
        <variable cmeta:id="parameters.T" initial_value="310" name="T" public_interface="out" units="kelvin"/>
        <variable cmeta:id="parameters.V" name="V" public_interface="in" units="volt"/>
        <variable cmeta:id="parameters.mu" name="mu" public_interface="out" units="dimensionless"/>
        <variable cmeta:id="parameters.Na_o" name="Na_o" public_interface="in" units="M"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>k0_65</ci>
                <piecewise>
                    <piece>
                        <ci>k0_65_r</ci>
                        <apply>
                            <lt/>
                            <ci>Na_o</ci>
                            <cn cellml:units="M" type="e-notation">100<sep/>-3</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>k0_65_f</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>k0_61</ci>
                <piecewise>
                    <piece>
                        <ci>k0_61_r</ci>
                        <apply>
                            <lt/>
                            <ci>Na_o</ci>
                            <cn cellml:units="M" type="e-notation">100<sep/>-3</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>k0_61_f</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>k0_16</ci>
                <piecewise>
                    <piece>
                        <ci>k0_16_r</ci>
                        <apply>
                            <lt/>
                            <ci>Na_o</ci>
                            <cn cellml:units="M" type="e-notation">100<sep/>-3</cn>
                        </apply>
                    </piece>
                    <otherwise>
                        <ci>k0_16_f</ci>
                    </otherwise>
                </piecewise>
            </apply>
            <apply>
                <eq/>
                <ci>alpha_p</ci>
                <apply>
                    <minus/>
                    <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>delta</ci>
                    </apply>
                    <ci>alpha_pp</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C_T</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="umol_per_mol" type="e-notation">1<sep/>6</cn>
                        <ci>N_C</ci>
                    </apply>
                    <ci>N_Avo</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>mu</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>F</ci>
                        <ci>V</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="ion_concentrations">
        <variable cmeta:id="ion_concentrations.V" initial_value="0e-3" name="V" public_interface="out" units="volt"/>
        <variable cmeta:id="ion_concentrations.Na_i" initial_value="500e-3" name="Na_i" public_interface="out" units="M"/>
        <variable cmeta:id="ion_concentrations.Na_o" initial_value="10e-3" name="Na_o" public_interface="out" units="M"/>
        <variable cmeta:id="ion_concentrations.glucose_i" initial_value="100e-3" name="glucose_i" public_interface="out" units="M"/>
        <variable cmeta:id="ion_concentrations.glucose_o" initial_value="0e-3" name="glucose_o" public_interface="out" units="M"/>
        <variable cmeta:id="ion_concentrations.time" name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>V</ci>
                </apply>
                <cn cellml:units="volt_per_second" type="e-notation">100<sep/>-3</cn>
            </apply>
        </math>
    </component>
    <component name="rate_constants">
        <variable cmeta:id="rate_constants.Na_i" name="Na_i" public_interface="in" units="M"/>
        <variable cmeta:id="rate_constants.Na_o" name="Na_o" public_interface="in" units="M"/>
        <variable cmeta:id="rate_constants.glucose_i" name="glucose_i" public_interface="in" units="M"/>
        <variable cmeta:id="rate_constants.glucose_o" name="glucose_o" public_interface="in" units="M"/>
        <variable cmeta:id="rate_constants.k_12" name="k_12" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_21" name="k_21" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_23" name="k_23" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_32" name="k_32" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_34" name="k_34" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_43" name="k_43" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_45" name="k_45" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_54" name="k_54" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_25" name="k_25" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_52" name="k_52" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_56" name="k_56" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_65" name="k_65" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_61" name="k_61" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k_16" name="k_16" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_12" name="k0_12" public_interface="in" units="per_M2_per_second"/>
        <variable cmeta:id="rate_constants.ks_12" name="ks_12" public_interface="out" units="per_M2_per_second"/>
        <variable cmeta:id="rate_constants.k0_21" name="k0_21" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_23" name="k0_23" public_interface="in" units="per_M_per_second"/>
        <variable cmeta:id="rate_constants.k0_32" name="k0_32" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_34" name="k0_34" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_43" name="k0_43" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_45" name="k0_45" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_54_temp" name="k0_54_temp" public_interface="out" units="per_M_per_second"/>
        <variable cmeta:id="rate_constants.k0_54" name="k0_54" public_interface="in" units="per_M_per_second"/>
        <variable cmeta:id="rate_constants.k0_25" name="k0_25" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k_52_temp" name="k_52_temp" public_interface="out" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_52" name="k0_52" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_56" name="k0_56" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_65" name="k0_65" public_interface="in" units="per_M2_per_second"/>
        <variable cmeta:id="rate_constants.k0_61" name="k0_61" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.k0_16" name="k0_16" public_interface="in" units="per_second"/>
        <variable cmeta:id="rate_constants.delta" name="delta" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="rate_constants.n" name="n" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="rate_constants.z_c" name="z_c" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="rate_constants.z_Na" name="z_Na" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="rate_constants.alpha_p" name="alpha_p" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="rate_constants.alpha_pp" name="alpha_pp" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="rate_constants.C_T" name="C_T" public_interface="in" units="umol"/>
        <variable cmeta:id="rate_constants.mu" name="mu" public_interface="in" units="dimensionless"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>ks_12</ci>
                <apply>
                    <times/>
                    <ci>k0_12</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>n</ci>
                                </apply>
                                <ci>alpha_p</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_12</ci>
                <apply>
                    <times/>
                    <ci>ks_12</ci>
                    <apply>
                        <power/>
                        <ci>Na_o</ci>
                        <ci>n</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_21</ci>
                <apply>
                    <times/>
                    <ci>k0_21</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>n</ci>
                                <ci>z_Na</ci>
                                <ci>alpha_p</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_23</ci>
                <apply>
                    <times/>
                    <ci>k0_23</ci>
                    <ci>glucose_o</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_32</ci>
                <ci>k0_32</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_34</ci>
                <apply>
                    <times/>
                    <ci>k0_34</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>z_c</ci>
                                        <ci>n</ci>
                                    </apply>
                                </apply>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_43</ci>
                <apply>
                    <times/>
                    <ci>k0_43</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <plus/>
                                    <ci>z_c</ci>
                                    <ci>n</ci>
                                </apply>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_45</ci>
                <ci>k0_45</ci>
            </apply>
            <apply>
                <eq/>
                <ci>k_54</ci>
                <apply>
                    <times/>
                    <ci>k0_54_temp</ci>
                    <ci>glucose_i</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_25</ci>
                <apply>
                    <times/>
                    <ci>k0_25</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <apply>
                                        <plus/>
                                        <ci>z_c</ci>
                                        <ci>n</ci>
                                    </apply>
                                </apply>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_52_temp</ci>
                <apply>
                    <times/>
                    <ci>k0_52</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <plus/>
                                    <ci>z_c</ci>
                                    <ci>n</ci>
                                </apply>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_56</ci>
                <apply>
                    <times/>
                    <ci>k0_56</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>n</ci>
                                </apply>
                                <ci>z_Na</ci>
                                <ci>alpha_pp</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_65</ci>
                <apply>
                    <times/>
                    <ci>k0_65</ci>
                    <apply>
                        <power/>
                        <ci>Na_i</ci>
                        <ci>n</ci>
                    </apply>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>n</ci>
                                <ci>z_Na</ci>
                                <ci>alpha_pp</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_61</ci>
                <apply>
                    <times/>
                    <ci>k0_61</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>z_c</ci>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_16</ci>
                <apply>
                    <times/>
                    <ci>k0_16</ci>
                    <apply>
                        <exp/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>z_c</ci>
                                </apply>
                                <ci>delta</ci>
                                <ci>mu</ci>
                            </apply>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k_52</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k0_12</ci>
                        <ci>k_25</ci>
                        <ci>k0_56</ci>
                        <ci>k0_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k0_21</ci>
                        <ci>k0_16</ci>
                        <ci>k0_65</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>k0_54_temp</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_43</ci>
                        <ci>k_32</ci>
                        <ci>k_25</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="kinetic_equations">
        <variable cmeta:id="kinetic_equations.k_12" name="k_12" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_21" name="k_21" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_23" name="k_23" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_32" name="k_32" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_34" name="k_34" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_43" name="k_43" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_45" name="k_45" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_54" name="k_54" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_25" name="k_25" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_52" name="k_52" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_56" name="k_56" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_65" name="k_65" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_61" name="k_61" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.k_16" name="k_16" public_interface="in" units="per_second"/>
        <variable cmeta:id="kinetic_equations.C_1" initial_value="0" name="C_1" public_interface="out" units="umol"/>
        <variable cmeta:id="kinetic_equations.C_2" initial_value="0" name="C_2" public_interface="out" units="umol"/>
        <variable cmeta:id="kinetic_equations.C_3" initial_value="0" name="C_3" public_interface="out" units="umol"/>
        <variable cmeta:id="kinetic_equations.C_4" initial_value="0" name="C_4" public_interface="out" units="umol"/>
        <variable cmeta:id="kinetic_equations.C_5" initial_value="0" name="C_5" public_interface="out" units="umol"/>
        <variable cmeta:id="kinetic_equations.C_6" name="C_6" public_interface="out" units="umol"/>
        <variable cmeta:id="kinetic_equations.C_6_temp" initial_value="0" name="C_6_temp" public_interface="out" units="umol"/>
        <variable cmeta:id="kinetic_equations.C_T" name="C_T" public_interface="in" units="umol"/>
        <variable cmeta:id="kinetic_equations.time" name="time" public_interface="in" units="second"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_1</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>C_2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_61</ci>
                            <ci>C_6</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <ci>k_12</ci>
                            <ci>k_16</ci>
                        </apply>
                        <ci>C_1</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_2</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_12</ci>
                            <ci>C_1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_32</ci>
                            <ci>C_3</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_52</ci>
                            <ci>C_5</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <ci>k_21</ci>
                            <ci>k_23</ci>
                            <ci>k_25</ci>
                        </apply>
                        <ci>C_2</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_3</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_23</ci>
                            <ci>C_2</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_43</ci>
                            <ci>C_4</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <ci>k_32</ci>
                            <ci>k_34</ci>
                        </apply>
                        <ci>C_3</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_4</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_34</ci>
                            <ci>C_3</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_54</ci>
                            <ci>C_5</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <ci>k_45</ci>
                            <ci>k_43</ci>
                        </apply>
                        <ci>C_4</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_5</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_45</ci>
                            <ci>C_4</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_65</ci>
                            <ci>C_6</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_25</ci>
                            <ci>C_2</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <ci>k_54</ci>
                            <ci>k_52</ci>
                            <ci>k_56</ci>
                        </apply>
                        <ci>C_5</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <apply>
                    <diff/>
                    <bvar>
                        <ci>time</ci>
                    </bvar>
                    <ci>C_6_temp</ci>
                </apply>
                <apply>
                    <minus/>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>C_1</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_56</ci>
                            <ci>C_5</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <ci>k_61</ci>
                            <ci>k_65</ci>
                        </apply>
                        <ci>C_6_temp</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C_6</ci>
                <apply>
                    <minus/>
                    <ci>C_T</ci>
                    <apply>
                        <plus/>
                        <ci>C_1</ci>
                        <ci>C_2</ci>
                        <ci>C_3</ci>
                        <ci>C_4</ci>
                        <ci>C_5</ci>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="king_altman_states">
        <variable cmeta:id="king_altman_states.k_12" name="k_12" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_21" name="k_21" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_23" name="k_23" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_32" name="k_32" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_34" name="k_34" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_43" name="k_43" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_45" name="k_45" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_54" name="k_54" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_25" name="k_25" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_52" name="k_52" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_56" name="k_56" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_65" name="k_65" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_61" name="k_61" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.k_16" name="k_16" public_interface="in" units="per_second"/>
        <variable cmeta:id="king_altman_states.C1_sum" name="C1_sum" units="per_second5"/>
        <variable cmeta:id="king_altman_states.C2_sum" name="C2_sum" units="per_second5"/>
        <variable cmeta:id="king_altman_states.C3_sum" name="C3_sum" units="per_second5"/>
        <variable cmeta:id="king_altman_states.C4_sum" name="C4_sum" units="per_second5"/>
        <variable cmeta:id="king_altman_states.C5_sum" name="C5_sum" units="per_second5"/>
        <variable cmeta:id="king_altman_states.C6_sum" name="C6_sum" units="per_second5"/>
        <variable cmeta:id="king_altman_states.C_sum" name="C_sum" units="per_second5"/>
        <variable cmeta:id="king_altman_states.C_T" name="C_T" public_interface="in" units="umol"/>
        <variable cmeta:id="king_altman_states.C1" name="C1" public_interface="out" units="umol"/>
        <variable cmeta:id="king_altman_states.C2" name="C2" public_interface="out" units="umol"/>
        <variable cmeta:id="king_altman_states.C3" name="C3" public_interface="out" units="umol"/>
        <variable cmeta:id="king_altman_states.C4" name="C4" public_interface="out" units="umol"/>
        <variable cmeta:id="king_altman_states.C5" name="C5" public_interface="out" units="umol"/>
        <variable cmeta:id="king_altman_states.C6" name="C6" public_interface="out" units="umol"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>C1_sum</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
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                        <times/>
                        <ci>k_21</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
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                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C2_sum</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
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                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C3_sum</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_23</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_23</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_23</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C4_sum</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
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                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
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                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
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                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C5_sum</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_61</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C6_sum</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_12</ci>
                        <ci>k_25</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>k_16</ci>
                        <ci>k_21</ci>
                        <ci>k_32</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C_sum</ci>
                <apply>
                    <plus/>
                    <ci>C1_sum</ci>
                    <ci>C2_sum</ci>
                    <ci>C3_sum</ci>
                    <ci>C4_sum</ci>
                    <ci>C5_sum</ci>
                    <ci>C6_sum</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C1</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>C_T</ci>
                        <ci>C1_sum</ci>
                    </apply>
                    <ci>C_sum</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C2</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>C_T</ci>
                        <ci>C2_sum</ci>
                    </apply>
                    <ci>C_sum</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C3</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>C_T</ci>
                        <ci>C3_sum</ci>
                    </apply>
                    <ci>C_sum</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C4</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>C_T</ci>
                        <ci>C4_sum</ci>
                    </apply>
                    <ci>C_sum</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C5</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>C_T</ci>
                        <ci>C5_sum</ci>
                    </apply>
                    <ci>C_sum</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>C6</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <ci>C_T</ci>
                        <ci>C6_sum</ci>
                    </apply>
                    <ci>C_sum</ci>
                </apply>
            </apply>
        </math>
    </component>
    <component name="NBC_current">
        <variable cmeta:id="NBC_current.k_12" name="k_12" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_21" name="k_21" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_56" name="k_56" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_65" name="k_65" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_34" name="k_34" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_43" name="k_43" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_25" name="k_25" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_52" name="k_52" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_61" name="k_61" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.k_16" name="k_16" public_interface="in" units="per_second"/>
        <variable cmeta:id="NBC_current.C_1" name="C_1" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C_2" name="C_2" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C_3" name="C_3" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C_4" name="C_4" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C_5" name="C_5" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C_6" name="C_6" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C1" name="C1" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C2" name="C2" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C3" name="C3" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C4" name="C4" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C5" name="C5" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.C6" name="C6" public_interface="in" units="umol"/>
        <variable cmeta:id="NBC_current.delta" name="delta" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="NBC_current.alpha_p" name="alpha_p" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="NBC_current.alpha_pp" name="alpha_pp" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="NBC_current.n" name="n" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="NBC_current.z_c" name="z_c" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="NBC_current.z_Na" name="z_Na" public_interface="in" units="dimensionless"/>
        <variable cmeta:id="NBC_current.F" name="F" public_interface="in" units="C_per_mol"/>
        <variable cmeta:id="NBC_current.I_NaGl_pSS" name="I_NaGl_pSS" public_interface="out" units="uA"/>
        <variable cmeta:id="NBC_current.I_NaGl_SS" name="I_NaGl_SS" public_interface="out" units="uA"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>I_NaGl_pSS</ci>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>n</ci>
                            <ci>z_Na</ci>
                            <ci>alpha_p</ci>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>k_12</ci>
                                    <ci>C_1</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>k_21</ci>
                                    <ci>C_2</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>z_c</ci>
                            <ci>delta</ci>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>k_16</ci>
                                    <ci>C_1</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>k_61</ci>
                                    <ci>C_6</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>n</ci>
                            <ci>z_Na</ci>
                            <ci>alpha_pp</ci>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>k_56</ci>
                                    <ci>C_5</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>k_65</ci>
                                    <ci>C_6</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>I_NaGl_SS</ci>
                <apply>
                    <times/>
                    <apply>
                        <minus/>
                        <ci>F</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>z_c</ci>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>k_16</ci>
                                    <ci>C1</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>k_61</ci>
                                    <ci>C6</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <apply>
                                <plus/>
                                <ci>z_c</ci>
                                <apply>
                                    <times/>
                                    <ci>z_Na</ci>
                                    <ci>n</ci>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>k_25</ci>
                                    <ci>C2</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>k_52</ci>
                                    <ci>C5</ci>
                                </apply>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <apply>
                                <plus/>
                                <ci>z_c</ci>
                                <apply>
                                    <times/>
                                    <ci>z_Na</ci>
                                    <ci>n</ci>
                                </apply>
                            </apply>
                            <apply>
                                <minus/>
                                <apply>
                                    <times/>
                                    <ci>k_34</ci>
                                    <ci>C3</ci>
                                </apply>
                                <apply>
                                    <times/>
                                    <ci>k_43</ci>
                                    <ci>C4</ci>
                                </apply>
                            </apply>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
    <component name="phenomonological_constants">
        <variable cmeta:id="phenomonological_constants.epsilon" name="epsilon" public_interface="out" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.lambda" name="lambda" public_interface="out" units="per_M3_per_second5"/>
        <variable cmeta:id="phenomonological_constants.chi" name="chi" public_interface="out" units="M"/>
        <variable cmeta:id="phenomonological_constants.alpha" name="alpha" public_interface="out" units="M3"/>
        <variable cmeta:id="phenomonological_constants.beta" name="beta" public_interface="out" units="M2"/>
        <variable cmeta:id="phenomonological_constants.gamma" name="gamma" public_interface="out" units="M3_per_second"/>
        <variable cmeta:id="phenomonological_constants.phi" name="phi" public_interface="out" units="M_per_second"/>
        <variable cmeta:id="phenomonological_constants.k_12" name="k_12" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_21" name="k_21" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_23" name="k_23" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_32" name="k_32" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_34" name="k_34" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_43" name="k_43" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_45" name="k_45" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_54" name="k_54" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_25" name="k_25" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_52" name="k_52" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_56" name="k_56" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_65" name="k_65" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_61" name="k_61" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.k_16" name="k_16" public_interface="in" units="per_second"/>
        <variable cmeta:id="phenomonological_constants.ks_12" name="ks_12" public_interface="in" units="per_M2_per_second"/>
        <variable cmeta:id="phenomonological_constants.k0_23" name="k0_23" public_interface="in" units="per_M_per_second"/>
        <variable cmeta:id="phenomonological_constants.C_T" name="C_T" public_interface="in" units="umol"/>
        <variable cmeta:id="phenomonological_constants.F" name="F" public_interface="in" units="C_per_mol"/>
        <variable cmeta:id="phenomonological_constants.Na_o" name="Na_o" public_interface="in" units="M"/>
        <variable cmeta:id="phenomonological_constants.glucose_o" name="glucose_o" public_interface="in" units="M"/>
        <variable cmeta:id="phenomonological_constants.Imax_Na" name="Imax_Na" public_interface="out" units="uA"/>
        <variable cmeta:id="phenomonological_constants.Imax_gluc" name="Imax_gluc" public_interface="out" units="uA"/>
        <variable cmeta:id="phenomonological_constants.Khalf_Na_sq" name="Khalf_Na_sq" public_interface="out" units="M2"/>
        <variable cmeta:id="phenomonological_constants.Khalf_Na" name="Khalf_Na" public_interface="out" units="M"/>
        <variable cmeta:id="phenomonological_constants.Khalf_gluc" name="Khalf_gluc" public_interface="out" units="M"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>lambda</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_52</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_65</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_43</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_56</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_43</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_54</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_45</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_43</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_52</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_61</ci>
                    </apply>
                    <apply>
                        <times/>
                        <ci>ks_12</ci>
                        <ci>k0_23</ci>
                        <ci>k_34</ci>
                        <ci>k_45</ci>
                        <ci>k_56</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>chi</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>lambda</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_54</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_54</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_56</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>beta</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>lambda</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_16</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_16</ci>
                            <ci>k_34</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_16</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_16</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_16</ci>
                            <ci>k_34</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_16</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k0_23</ci>
                            <ci>k_16</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>alpha</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>lambda</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                            <ci>k_61</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_56</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>gamma</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>lambda</ci>
                    </apply>
                    <apply>
                        <plus/>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_54</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_34</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_45</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                        <apply>
                            <times/>
                            <ci>k_16</ci>
                            <ci>k_21</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_52</ci>
                            <ci>k_65</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>phi</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>lambda</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <minus/>
                            <apply>
                                <times/>
                                <apply>
                                    <minus/>
                                    <ci>ks_12</ci>
                                </apply>
                                <ci>k_25</ci>
                                <ci>k_34</ci>
                                <ci>k_45</ci>
                                <ci>k_56</ci>
                                <ci>k_61</ci>
                            </apply>
                            <apply>
                                <times/>
                                <ci>ks_12</ci>
                                <ci>k_25</ci>
                                <ci>k_32</ci>
                                <ci>k_45</ci>
                                <ci>k_56</ci>
                                <ci>k_61</ci>
                            </apply>
                        </apply>
                        <apply>
                            <times/>
                            <ci>ks_12</ci>
                            <ci>k_25</ci>
                            <ci>k_32</ci>
                            <ci>k_43</ci>
                            <ci>k_56</ci>
                            <ci>k_61</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>epsilon</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <cn cellml:units="dimensionless">1</cn>
                        <ci>lambda</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <ci>ks_12</ci>
                    </apply>
                    <ci>k0_23</ci>
                    <ci>k_34</ci>
                    <ci>k_45</ci>
                    <ci>k_56</ci>
                    <ci>k_61</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Imax_gluc</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>F</ci>
                        <ci>C_T</ci>
                        <ci>epsilon</ci>
                        <apply>
                            <power/>
                            <ci>Na_o</ci>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>beta</ci>
                        <apply>
                            <power/>
                            <ci>Na_o</ci>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Imax_Na</ci>
                <apply>
                    <divide/>
                    <apply>
                        <times/>
                        <cn cellml:units="dimensionless">2</cn>
                        <ci>F</ci>
                        <ci>C_T</ci>
                        <apply>
                            <plus/>
                            <ci>phi</ci>
                            <apply>
                                <times/>
                                <ci>epsilon</ci>
                                <ci>glucose_o</ci>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>chi</ci>
                        <ci>glucose_o</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Khalf_gluc</ci>
                <apply>
                    <divide/>
                    <apply>
                        <plus/>
                        <ci>alpha</ci>
                        <apply>
                            <times/>
                            <ci>chi</ci>
                            <apply>
                                <power/>
                                <ci>Na_o</ci>
                                <cn cellml:units="dimensionless">2</cn>
                            </apply>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>beta</ci>
                        <apply>
                            <power/>
                            <ci>Na_o</ci>
                            <cn cellml:units="dimensionless">2</cn>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Khalf_Na_sq</ci>
                <apply>
                    <divide/>
                    <apply>
                        <plus/>
                        <ci>alpha</ci>
                        <apply>
                            <times/>
                            <ci>beta</ci>
                            <ci>glucose_o</ci>
                        </apply>
                    </apply>
                    <apply>
                        <plus/>
                        <ci>chi</ci>
                        <ci>glucose_o</ci>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>Khalf_Na</ci>
                <apply>
                    <root/>
                    <ci>Khalf_Na_sq</ci>
                </apply>
            </apply>
        </math>
    </component>
    <connection>
        <map_components component_1="environment" component_2="kinetic_equations"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="parameters" component_2="rate_constants"/>
        <map_variables variable_1="alpha_pp" variable_2="alpha_pp"/>
        <map_variables variable_1="n" variable_2="n"/>
        <map_variables variable_1="k0_54" variable_2="k0_54"/>
        <map_variables variable_1="k0_43" variable_2="k0_43"/>
        <map_variables variable_1="k0_45" variable_2="k0_45"/>
        <map_variables variable_1="z_c" variable_2="z_c"/>
        <map_variables variable_1="k0_23" variable_2="k0_23"/>
        <map_variables variable_1="k0_12" variable_2="k0_12"/>
        <map_variables variable_1="k0_16" variable_2="k0_16"/>
        <map_variables variable_1="z_Na" variable_2="z_Na"/>
        <map_variables variable_1="k0_21" variable_2="k0_21"/>
        <map_variables variable_1="k0_56" variable_2="k0_56"/>
        <map_variables variable_1="k0_32" variable_2="k0_32"/>
        <map_variables variable_1="k0_65" variable_2="k0_65"/>
        <map_variables variable_1="k0_52" variable_2="k0_52"/>
        <map_variables variable_1="k0_61" variable_2="k0_61"/>
        <map_variables variable_1="k0_25" variable_2="k0_25"/>
        <map_variables variable_1="mu" variable_2="mu"/>
        <map_variables variable_1="k0_34" variable_2="k0_34"/>
        <map_variables variable_1="delta" variable_2="delta"/>
        <map_variables variable_1="C_T" variable_2="C_T"/>
        <map_variables variable_1="alpha_p" variable_2="alpha_p"/>
    </connection>
    <connection>
        <map_components component_1="ion_concentrations" component_2="rate_constants"/>
        <map_variables variable_1="Na_i" variable_2="Na_i"/>
        <map_variables variable_1="glucose_o" variable_2="glucose_o"/>
        <map_variables variable_1="glucose_i" variable_2="glucose_i"/>
        <map_variables variable_1="Na_o" variable_2="Na_o"/>
    </connection>
    <connection>
        <map_components component_1="rate_constants" component_2="kinetic_equations"/>
        <map_variables variable_1="k_16" variable_2="k_16"/>
        <map_variables variable_1="k_34" variable_2="k_34"/>
        <map_variables variable_1="k_25" variable_2="k_25"/>
        <map_variables variable_1="k_23" variable_2="k_23"/>
        <map_variables variable_1="k_32" variable_2="k_32"/>
        <map_variables variable_1="k_65" variable_2="k_65"/>
        <map_variables variable_1="k_54" variable_2="k_54"/>
        <map_variables variable_1="k_61" variable_2="k_61"/>
        <map_variables variable_1="k_43" variable_2="k_43"/>
        <map_variables variable_1="k_45" variable_2="k_45"/>
        <map_variables variable_1="k_21" variable_2="k_21"/>
        <map_variables variable_1="k_12" variable_2="k_12"/>
        <map_variables variable_1="k_56" variable_2="k_56"/>
        <map_variables variable_1="k_52" variable_2="k_52"/>
    </connection>
    <connection>
        <map_components component_1="rate_constants" component_2="phenomonological_constants"/>
        <map_variables variable_1="k_16" variable_2="k_16"/>
        <map_variables variable_1="ks_12" variable_2="ks_12"/>
        <map_variables variable_1="k_34" variable_2="k_34"/>
        <map_variables variable_1="k_25" variable_2="k_25"/>
        <map_variables variable_1="k_23" variable_2="k_23"/>
        <map_variables variable_1="k_32" variable_2="k_32"/>
        <map_variables variable_1="k_65" variable_2="k_65"/>
        <map_variables variable_1="k_54" variable_2="k_54"/>
        <map_variables variable_1="k_61" variable_2="k_61"/>
        <map_variables variable_1="k_43" variable_2="k_43"/>
        <map_variables variable_1="k_45" variable_2="k_45"/>
        <map_variables variable_1="k_21" variable_2="k_21"/>
        <map_variables variable_1="k_12" variable_2="k_12"/>
        <map_variables variable_1="k_56" variable_2="k_56"/>
        <map_variables variable_1="k_52" variable_2="k_52"/>
    </connection>
    <connection>
        <map_components component_1="parameters" component_2="NBC_current"/>
        <map_variables variable_1="alpha_pp" variable_2="alpha_pp"/>
        <map_variables variable_1="n" variable_2="n"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="z_c" variable_2="z_c"/>
        <map_variables variable_1="delta" variable_2="delta"/>
        <map_variables variable_1="z_Na" variable_2="z_Na"/>
        <map_variables variable_1="alpha_p" variable_2="alpha_p"/>
    </connection>
    <connection>
        <map_components component_1="ion_concentrations" component_2="parameters"/>
        <map_variables variable_1="Na_o" variable_2="Na_o"/>
        <map_variables variable_1="V" variable_2="V"/>
    </connection>
    <connection>
        <map_components component_1="parameters" component_2="phenomonological_constants"/>
        <map_variables variable_1="F" variable_2="F"/>
        <map_variables variable_1="k0_23" variable_2="k0_23"/>
        <map_variables variable_1="C_T" variable_2="C_T"/>
    </connection>
    <connection>
        <map_components component_1="environment" component_2="ion_concentrations"/>
        <map_variables variable_1="time" variable_2="time"/>
    </connection>
    <connection>
        <map_components component_1="ion_concentrations" component_2="phenomonological_constants"/>
        <map_variables variable_1="glucose_o" variable_2="glucose_o"/>
        <map_variables variable_1="Na_o" variable_2="Na_o"/>
    </connection>
    <connection>
        <map_components component_1="parameters" component_2="kinetic_equations"/>
        <map_variables variable_1="C_T" variable_2="C_T"/>
    </connection>
    <connection>
        <map_components component_1="rate_constants" component_2="NBC_current"/>
        <map_variables variable_1="k_16" variable_2="k_16"/>
        <map_variables variable_1="k_43" variable_2="k_43"/>
        <map_variables variable_1="k_34" variable_2="k_34"/>
        <map_variables variable_1="k_25" variable_2="k_25"/>
        <map_variables variable_1="k_21" variable_2="k_21"/>
        <map_variables variable_1="k_12" variable_2="k_12"/>
        <map_variables variable_1="k_56" variable_2="k_56"/>
        <map_variables variable_1="k_65" variable_2="k_65"/>
        <map_variables variable_1="k_52" variable_2="k_52"/>
        <map_variables variable_1="k_61" variable_2="k_61"/>
    </connection>
    <connection>
        <map_components component_1="rate_constants" component_2="king_altman_states"/>
        <map_variables variable_1="k_16" variable_2="k_16"/>
        <map_variables variable_1="k_34" variable_2="k_34"/>
        <map_variables variable_1="k_25" variable_2="k_25"/>
        <map_variables variable_1="k_23" variable_2="k_23"/>
        <map_variables variable_1="k_32" variable_2="k_32"/>
        <map_variables variable_1="k_65" variable_2="k_65"/>
        <map_variables variable_1="k_54" variable_2="k_54"/>
        <map_variables variable_1="k_61" variable_2="k_61"/>
        <map_variables variable_1="k_43" variable_2="k_43"/>
        <map_variables variable_1="k_45" variable_2="k_45"/>
        <map_variables variable_1="k_21" variable_2="k_21"/>
        <map_variables variable_1="k_12" variable_2="k_12"/>
        <map_variables variable_1="k_56" variable_2="k_56"/>
        <map_variables variable_1="k_52" variable_2="k_52"/>
    </connection>
    <connection>
        <map_components component_1="kinetic_equations" component_2="NBC_current"/>
        <map_variables variable_1="C_4" variable_2="C_4"/>
        <map_variables variable_1="C_6" variable_2="C_6"/>
        <map_variables variable_1="C_5" variable_2="C_5"/>
        <map_variables variable_1="C_1" variable_2="C_1"/>
        <map_variables variable_1="C_2" variable_2="C_2"/>
        <map_variables variable_1="C_3" variable_2="C_3"/>
    </connection>
    <connection>
        <map_components component_1="parameters" component_2="king_altman_states"/>
        <map_variables variable_1="C_T" variable_2="C_T"/>
    </connection>
    <connection>
        <map_components component_1="king_altman_states" component_2="NBC_current"/>
        <map_variables variable_1="C3" variable_2="C3"/>
        <map_variables variable_1="C6" variable_2="C6"/>
        <map_variables variable_1="C2" variable_2="C2"/>
        <map_variables variable_1="C1" variable_2="C1"/>
        <map_variables variable_1="C4" variable_2="C4"/>
        <map_variables variable_1="C5" variable_2="C5"/>
    </connection>
    <documentation xmlns="http://cellml.org/tmp-documentation">
        <article xmlns="http://cellml.org/tmp-documentation">
            <articleinfo xmlns="http://cellml.org/tmp-documentation">
                <title xmlns="http://cellml.org/tmp-documentation">Kinetics of the Reverse Mode of the Na+/Glucose Cotransporter</title>
                <author xmlns="http://cellml.org/tmp-documentation">
                    <firstname xmlns="http://cellml.org/tmp-documentation">Jonna</firstname>
                    <surname xmlns="http://cellml.org/tmp-documentation">Terkildsen</surname>
                    <affiliation xmlns="http://cellml.org/tmp-documentation">
                        <shortaffil xmlns="http://cellml.org/tmp-documentation">Auckland Bioengineering Institute, University of Auckland</shortaffil>
                    </affiliation>
                </author>
            </articleinfo>
            <sect1 xmlns="http://cellml.org/tmp-documentation" id="sec_status">
                <title xmlns="http://cellml.org/tmp-documentation">Model Status</title>
                <para xmlns="http://cellml.org/tmp-documentation">This CellML model is in the process of being curated, the units are consistent and the model runs in COR and PCEnv. This model does not yet recreate all the published results.</para>
            </sect1>
            <sect1 xmlns="http://cellml.org/tmp-documentation" id="sec_structure">
                <title xmlns="http://cellml.org/tmp-documentation">Model Structure</title>
                <para xmlns="http://cellml.org/tmp-documentation">Abstract: This study investigates the reverse mode of the Na/glucose cotransporter (SGLT1). In giant excised inside-out membrane patches from Xenopus laevis oocytes expressing rabbit SGLT1, application of a-methyl-D-glucopyranoside (aMDG) to the cytoplasmic solution induced an outward current from cytosolic to external membrane surface. The outward current was Na- and sugar-dependent, and was blocked by phlorizin, a specific inhibitor of SGLT1. The current-voltage relationship saturated at positive membrane voltages (30-50 mV), and approached zero at -150 mV. The half-maximal concentration for aMDG-evoked outward current (K_0.5_aMDG) was 35 mM (at 0 mV). In comparison, K_0.5_aMDG for forward sugar transport was 0.15 mM (at 0 mV). K_0.5_Na was similar for forward and reverse transport (~ 35mM at 0 mV). Specificity of SGLT1 for reverse transport was: aMDG (1.0) > D-galactose (0.84) > 3-O-methyl-glucose (0.55) > D-glucose (0.38), whereas for forward transport, specificity was: aMDG ~ D-glucose ~ D-galactose > 3-O-methylglucose. Thus there is an asymmetry in sugar kinetics and specificity between forward and reverse modes. Computer simulations showed that a 6-state kinetic model for SGLT1 can account for Na/sugar cotransport and its voltage dependence in both the forward and reverse modes at saturating sodium concentrations. Our data indicate that under physiological conditions, the transporter is poised to accumulate sugar efficiently in the enterocyte.</para>
                <para xmlns="http://cellml.org/tmp-documentation">The original paper reference is cited below:</para>
                <para xmlns="http://cellml.org/tmp-documentation">&#xd;
          Kinetics of the Reverse Mode of the Na+/Glucose Cotransporter, S.Eskandari, E.M. Wright and D.D.F. Loo, 2005,&#xd;
          <emphasis xmlns="http://cellml.org/tmp-documentation">Journal of Membrane Biology</emphasis>&#xd;
          , 204, 23-32.&#xd;
          <ulink xmlns="http://cellml.org/tmp-documentation" url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&amp;cmd=Retrieve&amp;dopt=AbstractPlus&amp;list_uids=16007500&amp;query_hl=1&amp;itool=pubmed_docsum">PubMed ID: 16007500</ulink>
                </para>
                <informalfigure xmlns="http://cellml.org/tmp-documentation" float="0" id="fig_reaction_diagram">
                    <mediaobject xmlns="http://cellml.org/tmp-documentation">
                        <imageobject xmlns="http://cellml.org/tmp-documentation">
                            <objectinfo xmlns="http://cellml.org/tmp-documentation">
                                <title xmlns="http://cellml.org/tmp-documentation">model diagram</title>
                            </objectinfo>
                            <imagedata xmlns="http://cellml.org/tmp-documentation" fileref="eskandari_2005.png"/>
                        </imageobject>
                    </mediaobject>
                    <caption xmlns="http://cellml.org/tmp-documentation">Schematic diagram of the Eskandari et al 2005 SGLT1 model. C' represents the external-facing carrier. C'' represents the internal-facing carrier.</caption>
                </informalfigure>
            </sect1>
        </article>
    </documentation>
</model>