- Author:
- Dewan Sarwar <sarwarcse@gmail.com>
- Date:
- 2019-03-12 17:33:26+13:00
- Desc:
- replaced with 74550 luminal id in weinstein_1995.cellml and chang_fujita_b_1999.cellml model
- Permanent Source URI:
- https://models.cellml.org/workspace/267/rawfile/de66cf6e0104ef68b668c901c2a2a4b8d9cceb13/moss_2009.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="moss_2009" cmeta:id="moss_2009">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<section id="sec_status">
<title>Model Status</title>
<para>This CellML model cannot be opened in COR and it cannot be run in PCEnv due to the use of vectors - something which may be included in the CellML 1.2 specification. The way this model is written it is not ideally suited for expression in CellML. However, we have attempted to describe the model in CellML with the hope that in the future it may be further validated and curated.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: In this paper, concepts from network automata are adapted and extended to model complex biological systems. Specifically, systems of nephrons, the operational units of the kidney, are modelled and the dynamics of such systems are explored. Nephron behaviour can fluctuate widely and, under certain conditions, become chaotic. However, the behaviour of the whole kidney remains remarkably stable and blood solute levels are maintained under a wide range of conditions even when many nephrons are damaged or lost. A network model is used to investigate the stability of systems of nephrons and interactions between nephrons. More sophisticated dynamics are explored including the observed oscillations in single nephron filtration rates and the development of stable ionic and osmotic gradients in the inner medulla which contribute to the countercurrent exchange mechanism. We have used the model to explore the effects of changes in input parameters including hydrostatic and osmotic pressures and concentrations of ions, such as sodium and chloride. The intrinsic nephron control, tubuloglomerular feedback, is included and the effects of coupling between nephrons are explored in two-, eight- and 72-nephron models.</para>
<para>The original paper reference is cited below:</para>
<para>
A computational model for emergent dynamics in the kidney, Moss R, Kazmierczak E, Kirley M, and Harris P, 2009,
<emphasis>Philosophical Transactions of the Royal Society A</emphasis>
, 367, 2125-40.
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/19414449">PubMed ID: 19414449</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram">
<mediaobject>
<imageobject>
<imagedata fileref="moss_2009.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram representing the model for the single-nephron tubule as a network automata, showing the edges that capture fluid flow, solute transport and tubulo-glomerular feedback.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<units name="mmHg">
<unit units="pascal" />
</units>
<units name="g_per_L">
<unit exponent="-1.0" units="litre" />
<unit units="gram" />
</units>
<units name="nanoL_per_minute_mmHg">
<unit prefix="nano" units="litre" />
<unit exponent="-1.0" units="mmHg" />
<unit exponent="-1.0" units="minute" />
</units>
<units name="mmHg_minute_per_nanoL">
<unit units="minute" />
<unit exponent="-1.0" prefix="nano" units="litre" />
<unit units="mmHg" />
</units>
<units name="mmHg_L_per_gram">
<unit units="litre" />
<unit units="mmHg" />
<unit exponent="-1.0" units="gram" />
</units>
<units name="mmHg_L2_per_gram2">
<unit units="mmHg" />
<unit exponent="-2.0" units="gram" />
<unit exponent="2.0" units="litre" />
</units>
<units name="nanoL_per_minute">
<unit prefix="nano" units="litre" />
<unit exponent="-1.0" units="minute" />
</units>
<units name="millimolar">
<unit prefix="milli" units="mole" />
<unit exponent="-1.0" units="litre" />
</units>
<units name="radian_per_second">
<unit exponent="-1.0" units="second" />
<unit units="radian" />
</units>
<units name="minute">
<unit units="second" />
</units>
<units name="nanoL_per_minute_cm">
<unit exponent="-1.0" units="minute" />
<unit exponent="-1.0" prefix="centi" units="metre" />
<unit prefix="nano" units="litre" />
</units>
<component name="environment">
<variable cmeta:id="environment.time" name="time" public_interface="out" units="minute" />
</component>
<component name="model_parameters">
<variable cmeta:id="model_parameters.C_A" initial_value="57.0" name="C_A" public_interface="out" units="g_per_L" />
<variable cmeta:id="model_parameters.C_E" initial_value="5.8" name="C_E" public_interface="out" units="g_per_L" />
<variable cmeta:id="model_parameters.t" name="t" public_interface="out" units="minute" />
<variable cmeta:id="model_parameters.delta_t" name="delta_t" public_interface="out" units="minute" />
<variable cmeta:id="model_parameters.time" name="time" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="0.1">
<ci type="integer">t</ci>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="0.2">
<apply>
<eq />
<ci>t</ci>
<ci>time</ci>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML" id="0.3">
<apply>
<eq />
<ci>delta_t</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="minute">1.0</cn>
</apply>
</math>
</component>
<component name="R_A" cmeta:id="R_A">
<variable cmeta:id="R_A.R_A" name="R_A" public_interface="out" units="mmHg_minute_per_nanoL" />
<variable cmeta:id="R_A.H_A" initial_value="0.5" name="H_A" units="dimensionless" />
<variable cmeta:id="R_A.gamma" initial_value="3.3" name="gamma" units="dimensionless" />
<variable cmeta:id="R_A.epsilon" name="epsilon" public_interface="in" units="mmHg_minute_per_nanoL" />
<variable cmeta:id="R_A.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="R_A.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="1">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">R_A</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<selector />
<ci type="vector">epsilon</ci>
<ci>t</ci>
</apply>
<apply>
<exp />
<apply>
<times />
<ci>gamma</ci>
<ci>H_A</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="P_G" cmeta:id="P_G">
<variable cmeta:id="P_G.P_G" name="P_G" public_interface="out" units="mmHg" />
<variable cmeta:id="P_G.P_A" initial_value="108.5" name="P_A" units="mmHg" />
<variable cmeta:id="P_G.P_V" initial_value="5.0" name="P_V" units="mmHg" />
<variable cmeta:id="P_G.R_E" initial_value="0.0298" name="R_E" units="mmHg_minute_per_nanoL" />
<variable cmeta:id="P_G.C_A" name="C_A" public_interface="in" units="g_per_L" />
<variable cmeta:id="P_G.C_E" name="C_E" public_interface="in" units="g_per_L" />
<variable cmeta:id="P_G.R_A" name="R_A" public_interface="in" units="mmHg_minute_per_nanoL" />
<variable cmeta:id="P_G.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="P_G.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="2">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">P_G</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<plus />
<ci>P_V</ci>
<apply>
<times />
<ci>P_A</ci>
<apply>
<divide />
<apply>
<selector />
<ci type="vector">R_E</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">R_A</ci>
<ci>t</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<selector />
<ci type="vector">C_A</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">C_E</ci>
<ci>t</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times />
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<apply>
<selector />
<ci type="vector">R_E</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">R_A</ci>
<ci>t</ci>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<selector />
<ci type="vector">C_A</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">C_E</ci>
<ci>t</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="phi" cmeta:id="phi">
<variable cmeta:id="phi.phi" name="phi" public_interface="out" units="dimensionless" />
<variable cmeta:id="phi.epsilon_max" initial_value="0.057" name="epsilon_max" units="mmHg_minute_per_nanoL" />
<variable cmeta:id="phi.psi" initial_value="0.02" name="psi" units="mmHg_minute_per_nanoL" />
<variable cmeta:id="phi.kappa" initial_value="33.6" name="kappa" units="nanoL_per_minute_cm" />
<variable cmeta:id="phi.D_TGF" initial_value="0.1" name="D_TGF" units="minute" />
<variable cmeta:id="phi.Na_half" initial_value="44.0" name="Na_half" units="millimolar" />
<variable cmeta:id="phi.Na_M" name="Na_M" public_interface="in" units="g_per_L" />
<variable cmeta:id="phi.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="phi.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="3">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">phi</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<minus />
<ci>epsilon_max</ci>
<apply>
<divide />
<ci>psi</ci>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<exp />
<apply>
<minus />
<apply>
<times />
<ci>kappa</ci>
<apply>
<selector />
<ci type="vector">Na_M</ci>
<apply>
<minus />
<ci>t</ci>
<ci>D_TGF</ci>
</apply>
</apply>
</apply>
<ci>Na_half</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="epsilon" cmeta:id="epsilon">
<variable cmeta:id="epsilon.epsilon" name="epsilon" public_interface="out" units="mmHg_minute_per_nanoL" />
<variable cmeta:id="epsilon.omega" initial_value="0.2" name="omega" units="radian_per_second" />
<variable cmeta:id="epsilon.delta" initial_value="1" name="delta" units="dimensionless" />
<variable cmeta:id="epsilon.zeta" initial_value="0.9" name="zeta" units="dimensionless" />
<variable cmeta:id="epsilon.phi" name="phi" public_interface="in" units="dimensionless" />
<variable cmeta:id="epsilon.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="epsilon.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="4">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">epsilon</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<divide />
<apply>
<minus />
<apply>
<plus />
<apply>
<selector />
<ci type="vector">phi</ci>
<ci>t</ci>
</apply>
<apply>
<times />
<apply>
<selector />
<ci type="vector">epsilon</ci>
<ci>t</ci>
</apply>
<apply>
<plus />
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>zeta</ci>
</apply>
<apply>
<times />
<ci>omega</ci>
<ci>delta</ci>
</apply>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<apply>
<power />
<apply>
<times />
<ci>omega</ci>
<ci>delta</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide />
<apply>
<times />
<apply>
<selector />
<ci type="vector">epsilon</ci>
<apply>
<minus />
<ci>t</ci>
<ci>delta</ci>
</apply>
</apply>
</apply>
<apply>
<power />
<apply>
<times />
<ci>omega</ci>
<ci>delta</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
<apply>
<plus />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<divide />
<apply>
<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
<ci>zeta</ci>
</apply>
<apply>
<times />
<ci>omega</ci>
<ci>delta</ci>
</apply>
</apply>
<apply>
<divide />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">1.0</cn>
<apply>
<power />
<apply>
<times />
<ci>omega</ci>
<ci>delta</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="pi_G" cmeta:id="pi_G">
<variable cmeta:id="pi_G.pi_G" name="pi_G" public_interface="out" units="mmHg" />
<variable cmeta:id="pi_G.pi" name="pi" public_interface="in" units="mmHg" />
<variable cmeta:id="pi_G.C_A" name="C_A" public_interface="in" units="g_per_L" />
<variable cmeta:id="pi_G.C_E" name="C_E" public_interface="in" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="5">
<apply>
<eq />
<ci>pi_G</ci>
<apply>
<times />
<ci>pi</ci>
<apply>
<divide />
<apply>
<plus />
<ci>C_A</ci>
<ci>C_E</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="g_per_L">2.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="pi" cmeta:id="pi">
<variable cmeta:id="pi.pi" name="pi" public_interface="out" units="mmHg" />
<variable cmeta:id="pi.a" initial_value="0.1631" name="a" units="mmHg_L_per_gram" />
<variable cmeta:id="pi.b" initial_value="0.00294" name="b" units="mmHg_L2_per_gram2" />
<variable cmeta:id="pi.C" initial_value="58.0" name="C" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="6">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">pi</ci>
<ci>C</ci>
</apply>
<apply>
<plus />
<apply>
<times />
<ci>a</ci>
<ci>C</ci>
</apply>
<apply>
<times />
<ci>b</ci>
<apply>
<power />
<ci>C</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SNGFR" cmeta:id="SNGFR">
<variable cmeta:id="SNGFR.SNGFR" name="SNGFR" public_interface="out" units="nanoL_per_minute" />
<variable cmeta:id="SNGFR.Kf" initial_value="2.5" name="Kf" units="nanoL_per_minute_mmHg" />
<variable cmeta:id="SNGFR.P_BC" initial_value="1.0" name="P_BC" units="mmHg" />
<variable cmeta:id="SNGFR.P_G" name="P_G" public_interface="in" units="mmHg" />
<variable cmeta:id="SNGFR.pi_G" name="pi_G" public_interface="in" units="mmHg" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="7">
<apply>
<eq />
<ci>SNGFR</ci>
<apply>
<times />
<ci>Kf</ci>
<apply>
<minus />
<ci>P_G</ci>
<apply>
<plus />
<ci>P_BC</ci>
<ci>pi_G</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_I" cmeta:id="Na_I">
<variable cmeta:id="Na_I.Na_I" name="Na_I" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_I.Na_R" name="Na_R" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_I.t" name="t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="8">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">Na_I</ci>
<ci>t</ci>
</apply>
<apply>
<divide />
<apply>
<selector />
<ci type="vector">Na_R</ci>
<ci>t</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.67</cn>
</apply>
</apply>
</math>
</component>
<component name="H2O_I" cmeta:id="H2O_I">
<variable cmeta:id="H2O_I.H2O_I" name="H2O_I" public_interface="out" units="dimensionless" />
<variable cmeta:id="H2O_I.H2O_R" name="H2O_R" public_interface="in" units="dimensionless" />
<variable cmeta:id="H2O_I.t" name="t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="9">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">H2O_I</ci>
<ci>t</ci>
</apply>
<apply>
<divide />
<apply>
<selector />
<ci type="vector">H2O_R</ci>
<ci>t</ci>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">0.67</cn>
</apply>
</apply>
</math>
</component>
<component name="H2O_D_M" cmeta:id="H2O_D_M">
<variable cmeta:id="H2O_D_M.H2O_D_M" name="H2O_D_M" public_interface="out" units="dimensionless" />
<variable cmeta:id="H2O_D_M.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="H2O_D_M.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="10">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">H2O_D_M</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">H2O_D_M</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_D_M" cmeta:id="Na_D_M">
<variable cmeta:id="Na_D_M.Na_D_M" name="Na_D_M" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_D_M.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="Na_D_M.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="11">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">Na_D_M</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">Na_D_M</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_D" cmeta:id="Na_D">
<variable cmeta:id="Na_D.Na_D" name="Na_D" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_D.H2O_D" name="H2O_D" public_interface="in" units="dimensionless" />
<variable cmeta:id="Na_D.H2O_M" name="H2O_M" public_interface="in" units="dimensionless" />
<variable cmeta:id="Na_D.Na_M" name="Na_M" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_D.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="Na_D.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="12">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">Na_D</ci>
<ci>t</ci>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<selector />
<ci type="vector">Na_M</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">H2O_M</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
</apply>
<apply>
<selector />
<ci type="vector">H2O_D</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_M" cmeta:id="Na_M">
<variable cmeta:id="Na_M.Na_M" name="Na_M" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_M.H2O_M" name="H2O_M" public_interface="in" units="dimensionless" />
<variable cmeta:id="Na_M.H2O_A" name="H2O_A" public_interface="in" units="dimensionless" />
<variable cmeta:id="Na_M.Na_G" name="Na_G" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_M.Na_A" name="Na_A" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_M.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="Na_M.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="12a">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">Na_M</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<selector />
<ci type="vector">H2O_M</ci>
<ci>t</ci>
</apply>
<apply>
<plus />
<apply>
<divide />
<apply>
<selector />
<ci type="vector">Na_A</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<selector />
<ci type="vector">H2O_A</ci>
<ci>t</ci>
</apply>
</apply>
<ci>Na_G</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H2O_D" cmeta:id="H2O_D">
<variable cmeta:id="H2O_D.H2O_D" name="H2O_D" public_interface="out" units="dimensionless" />
<variable cmeta:id="H2O_D.Na_D" name="Na_D" public_interface="in" units="g_per_L" />
<variable cmeta:id="H2O_D.Na_D_M" name="Na_D_M" public_interface="in" units="g_per_L" />
<variable cmeta:id="H2O_D.H2O_D_M" name="H2O_D_M" public_interface="in" units="dimensionless" />
<variable cmeta:id="H2O_D.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="H2O_D.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="13">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">H2O_D</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<selector />
<ci type="vector">Na_D</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">Na_D_M</ci>
<ci>t</ci>
</apply>
</apply>
<apply>
<selector />
<ci type="vector">H2O_D_M</ci>
<ci>t</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="H2O_M" cmeta:id="H2O_M">
<variable cmeta:id="H2O_M.H2O_M" name="H2O_M" public_interface="out" units="dimensionless" />
<variable cmeta:id="H2O_M.Na_M" name="Na_M" public_interface="in" units="g_per_L" />
<variable cmeta:id="H2O_M.Na_D_M" name="Na_D_M" public_interface="in" units="g_per_L" />
<variable cmeta:id="H2O_M.H2O_D_M" name="H2O_D_M" public_interface="in" units="dimensionless" />
<variable cmeta:id="H2O_M.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="H2O_M.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="14">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">H2O_M</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<selector />
<ci type="vector">Na_M</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">Na_D_M</ci>
<ci>t</ci>
</apply>
</apply>
<apply>
<selector />
<ci type="vector">H2O_D_M</ci>
<ci>t</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_A" cmeta:id="Na_A">
<variable cmeta:id="Na_A.Na_A" name="Na_A" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_A.H2O_A" name="H2O_A" public_interface="in" units="dimensionless" />
<variable cmeta:id="Na_A.H2O_M" name="H2O_M" public_interface="in" units="dimensionless" />
<variable cmeta:id="Na_A.H2O_M_A" name="H2O_M_A" public_interface="in" units="dimensionless" />
<variable cmeta:id="Na_A.Na_M_A" name="Na_M_A" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_A.Na_G" name="Na_G" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_A.t" name="t" public_interface="in" units="minute" />
<variable cmeta:id="Na_A.delta_t" name="delta_t" public_interface="in" units="minute" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="15">
<apply>
<eq />
<apply>
<selector />
<ci type="vector">Na_A</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
<apply>
<times />
<apply>
<divide />
<apply>
<selector />
<ci type="vector">H2O_A</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">H2O_M_A</ci>
<apply>
<plus />
<ci>t</ci>
<ci>delta_t</ci>
</apply>
</apply>
</apply>
<apply>
<minus />
<apply>
<selector />
<ci type="vector">Na_M_A</ci>
<ci>t</ci>
</apply>
<apply>
<times />
<apply>
<selector />
<ci type="vector">Na_G</ci>
<ci>t</ci>
</apply>
<apply>
<selector />
<ci type="vector">H2O_M</ci>
<ci>t</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_G" cmeta:id="Na_G">
<variable cmeta:id="Na_G.Na_G" name="Na_G" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_G.Na_M" name="Na_M" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_G.Na_A" name="Na_A" public_interface="in" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="15a">
<apply>
<eq />
<ci>Na_G</ci>
<apply>
<minus />
<ci>Na_M</ci>
<ci>Na_A</ci>
</apply>
</apply>
</math>
</component>
<component name="H2O_A" cmeta:id="H2O_A">
<variable cmeta:id="H2O_A.H2O_A" initial_value="100.0" name="H2O_A" public_interface="out" units="dimensionless" />
</component>
<component name="H2O_I_IF" cmeta:id="H2O_I_IF">
<variable cmeta:id="H2O_I_IF.H2O_I_IF" initial_value="100.0" name="H2O_I_IF" public_interface="out" units="dimensionless" />
</component>
<component name="Na_I_IF" cmeta:id="Na_I_IF">
<variable cmeta:id="Na_I_IF.Na_I_IF" initial_value="100.0" name="Na_I_IF" public_interface="out" units="g_per_L" />
</component>
<component name="Na_M_A" cmeta:id="Na_M_A">
<variable cmeta:id="Na_M_A.Na_M_A" name="Na_M_A" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_M_A.Na_M" name="Na_M" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_M_A.Na_A" name="Na_A" public_interface="in" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="15b">
<apply>
<eq />
<ci>Na_M_A</ci>
<apply>
<plus />
<ci>Na_M</ci>
<ci>Na_A</ci>
</apply>
</apply>
</math>
</component>
<component name="H2O_M_A" cmeta:id="H2O_M_A">
<variable cmeta:id="H2O_M_A.H2O_M_A" name="H2O_M_A" public_interface="out" units="dimensionless" />
<variable cmeta:id="H2O_M_A.H2O_M" name="H2O_M" public_interface="in" units="dimensionless" />
<variable cmeta:id="H2O_M_A.H2O_A" name="H2O_A" public_interface="in" units="dimensionless" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="15c">
<apply>
<eq />
<ci>H2O_M_A</ci>
<apply>
<plus />
<ci>H2O_M</ci>
<ci>H2O_A</ci>
</apply>
</apply>
</math>
</component>
<component name="R_ADH" cmeta:id="R_ADH">
<variable cmeta:id="R_ADH.R_ADH" name="R_ADH" public_interface="out" units="g_per_L" />
<variable cmeta:id="R_ADH.ADH_I" initial_value="100.0" name="ADH_I" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="16">
<apply>
<eq />
<ci>R_ADH</ci>
<apply>
<divide />
<apply>
<log />
<apply>
<times />
<ci>ADH_I</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">
1
<sep />
12
</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">2.0</cn>
</apply>
</apply>
</math>
</component>
<component name="R_ALD" cmeta:id="R_ALD">
<variable cmeta:id="R_ALD.R_ALD" name="R_ALD" public_interface="out" units="g_per_L" />
<variable cmeta:id="R_ALD.ALD_I" initial_value="100.0" name="ALD_I" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="17">
<apply>
<eq />
<ci>R_ALD</ci>
<apply>
<divide />
<apply>
<log />
<apply>
<times />
<ci>ALD_I</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" type="e-notation" cellml:units="dimensionless">
1
<sep />
11
</cn>
</apply>
</apply>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.0#" cellml:units="dimensionless">3.0</cn>
</apply>
</apply>
</math>
</component>
<component name="H2O_R" cmeta:id="H2O_R">
<variable cmeta:id="H2O_R.H2O_R" name="H2O_R" public_interface="out" units="dimensionless" />
<variable cmeta:id="H2O_R.R_ADH" name="R_ADH" public_interface="in" units="g_per_L" />
<variable cmeta:id="H2O_R.H2O_I" name="H2O_I" public_interface="in" units="dimensionless" />
<variable cmeta:id="H2O_R.H2O_I_IF" name="H2O_I_IF" public_interface="in" units="dimensionless" />
<variable cmeta:id="H2O_R.Na_I" name="Na_I" public_interface="in" units="g_per_L" />
<variable cmeta:id="H2O_R.Na_I_IF" name="Na_I_IF" public_interface="in" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="18">
<apply>
<eq />
<ci>H2O_R</ci>
<apply>
<times />
<ci>R_ADH</ci>
<apply>
<minus />
<ci>H2O_I</ci>
<apply>
<times />
<ci>Na_I</ci>
<apply>
<divide />
<ci>H2O_I_IF</ci>
<ci>Na_I_IF</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Na_R" cmeta:id="Na_R">
<variable cmeta:id="Na_R.Na_R" name="Na_R" public_interface="out" units="g_per_L" />
<variable cmeta:id="Na_R.Na_max" initial_value="100.0" name="Na_max" units="g_per_L" />
<variable cmeta:id="Na_R.R_ALD" name="R_ALD" public_interface="in" units="g_per_L" />
<variable cmeta:id="Na_R.Na_I" name="Na_I" public_interface="in" units="g_per_L" />
<math xmlns="http://www.w3.org/1998/Math/MathML" id="19">
<apply>
<eq />
<ci>Na_R</ci>
<apply>
<times />
<ci>R_ALD</ci>
<ci>Na_max</ci>
<ci>Na_I</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="Na_A" component_2="Na_M_A" />
<map_variables variable_1="Na_A" variable_2="Na_A" />
</connection>
<connection>
<map_components component_1="R_ADH" component_2="H2O_R" />
<map_variables variable_1="R_ADH" variable_2="R_ADH" />
</connection>
<connection>
<map_components component_1="H2O_I" component_2="H2O_R" />
<map_variables variable_1="H2O_I" variable_2="H2O_I" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="epsilon" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="Na_M" component_2="H2O_M" />
<map_variables variable_1="Na_M" variable_2="Na_M" />
</connection>
<connection>
<map_components component_1="Na_I" component_2="H2O_R" />
<map_variables variable_1="Na_I" variable_2="Na_I" />
</connection>
<connection>
<map_components component_1="Na_M" component_2="phi" />
<map_variables variable_1="Na_M" variable_2="Na_M" />
</connection>
<connection>
<map_components component_1="pi" component_2="pi_G" />
<map_variables variable_1="pi" variable_2="pi" />
</connection>
<connection>
<map_components component_1="Na_M" component_2="Na_M_A" />
<map_variables variable_1="Na_M" variable_2="Na_M" />
</connection>
<connection>
<map_components component_1="Na_I_IF" component_2="H2O_R" />
<map_variables variable_1="Na_I_IF" variable_2="Na_I_IF" />
</connection>
<connection>
<map_components component_1="Na_D_M" component_2="H2O_D" />
<map_variables variable_1="Na_D_M" variable_2="Na_D_M" />
</connection>
<connection>
<map_components component_1="P_G" component_2="SNGFR" />
<map_variables variable_1="P_G" variable_2="P_G" />
</connection>
<connection>
<map_components component_1="pi_G" component_2="SNGFR" />
<map_variables variable_1="pi_G" variable_2="pi_G" />
</connection>
<connection>
<map_components component_1="H2O_D_M" component_2="H2O_M" />
<map_variables variable_1="H2O_D_M" variable_2="H2O_D_M" />
</connection>
<connection>
<map_components component_1="H2O_M_A" component_2="Na_A" />
<map_variables variable_1="H2O_M_A" variable_2="H2O_M_A" />
</connection>
<connection>
<map_components component_1="H2O_D_M" component_2="H2O_D" />
<map_variables variable_1="H2O_D_M" variable_2="H2O_D_M" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="phi" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="R_A" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="Na_D" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="Na_D" component_2="H2O_D" />
<map_variables variable_1="Na_D" variable_2="Na_D" />
</connection>
<connection>
<map_components component_1="H2O_M" component_2="Na_A" />
<map_variables variable_1="H2O_M" variable_2="H2O_M" />
</connection>
<connection>
<map_components component_1="environment" component_2="model_parameters" />
<map_variables variable_1="time" variable_2="time" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="Na_A" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="Na_A" component_2="Na_G" />
<map_variables variable_1="Na_A" variable_2="Na_A" />
</connection>
<connection>
<map_components component_1="Na_M" component_2="Na_G" />
<map_variables variable_1="Na_M" variable_2="Na_M" />
</connection>
<connection>
<map_components component_1="H2O_M" component_2="H2O_M_A" />
<map_variables variable_1="H2O_M" variable_2="H2O_M" />
</connection>
<connection>
<map_components component_1="R_A" component_2="P_G" />
<map_variables variable_1="R_A" variable_2="R_A" />
</connection>
<connection>
<map_components component_1="Na_A" component_2="Na_M" />
<map_variables variable_1="Na_A" variable_2="Na_A" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="H2O_M" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="H2O_A" component_2="H2O_M_A" />
<map_variables variable_1="H2O_A" variable_2="H2O_A" />
</connection>
<connection>
<map_components component_1="Na_M_A" component_2="Na_A" />
<map_variables variable_1="Na_M_A" variable_2="Na_M_A" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="Na_D_M" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="H2O_R" component_2="H2O_I" />
<map_variables variable_1="H2O_R" variable_2="H2O_R" />
</connection>
<connection>
<map_components component_1="H2O_D" component_2="Na_D" />
<map_variables variable_1="H2O_D" variable_2="H2O_D" />
</connection>
<connection>
<map_components component_1="R_ALD" component_2="Na_R" />
<map_variables variable_1="R_ALD" variable_2="R_ALD" />
</connection>
<connection>
<map_components component_1="Na_D_M" component_2="H2O_M" />
<map_variables variable_1="Na_D_M" variable_2="Na_D_M" />
</connection>
<connection>
<map_components component_1="Na_R" component_2="Na_I" />
<map_variables variable_1="Na_R" variable_2="Na_R" />
</connection>
<connection>
<map_components component_1="Na_G" component_2="Na_A" />
<map_variables variable_1="Na_G" variable_2="Na_G" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="H2O_I" />
<map_variables variable_1="t" variable_2="t" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="H2O_D_M" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="phi" component_2="epsilon" />
<map_variables variable_1="phi" variable_2="phi" />
</connection>
<connection>
<map_components component_1="H2O_I_IF" component_2="H2O_R" />
<map_variables variable_1="H2O_I_IF" variable_2="H2O_I_IF" />
</connection>
<connection>
<map_components component_1="epsilon" component_2="R_A" />
<map_variables variable_1="epsilon" variable_2="epsilon" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="Na_M" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="H2O_D" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
</connection>
<connection>
<map_components component_1="Na_G" component_2="Na_M" />
<map_variables variable_1="Na_G" variable_2="Na_G" />
</connection>
<connection>
<map_components component_1="H2O_A" component_2="Na_A" />
<map_variables variable_1="H2O_A" variable_2="H2O_A" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="pi_G" />
<map_variables variable_1="C_E" variable_2="C_E" />
<map_variables variable_1="C_A" variable_2="C_A" />
</connection>
<connection>
<map_components component_1="H2O_A" component_2="Na_M" />
<map_variables variable_1="H2O_A" variable_2="H2O_A" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="P_G" />
<map_variables variable_1="t" variable_2="t" />
<map_variables variable_1="C_E" variable_2="C_E" />
<map_variables variable_1="delta_t" variable_2="delta_t" />
<map_variables variable_1="C_A" variable_2="C_A" />
</connection>
<connection>
<map_components component_1="model_parameters" component_2="Na_I" />
<map_variables variable_1="t" variable_2="t" />
</connection>
<connection>
<map_components component_1="Na_M" component_2="Na_D" />
<map_variables variable_1="Na_M" variable_2="Na_M" />
</connection>
<connection>
<map_components component_1="Na_I" component_2="Na_R" />
<map_variables variable_1="Na_I" variable_2="Na_I" />
</connection>
<connection>
<map_components component_1="H2O_M" component_2="Na_D" />
<map_variables variable_1="H2O_M" variable_2="H2O_M" />
</connection>
<connection>
<map_components component_1="H2O_M" component_2="Na_M" />
<map_variables variable_1="H2O_M" variable_2="H2O_M" />
</connection>
<rdf:RDF xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:opb="http://bhi.washington.edu/OPB#" xmlns:foaf="http://xmlns.com/foaf/0.1/">
<rdf:Description rdf:about="#Na_A.Na_G">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_35">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_24">
<ro:part_of>
<rdf:Description rdf:about="#entity_25">
<ro:part_of>
<rdf:Description rdf:about="#entity_23">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_17717" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_9673" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26708" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration gradient between the interstitial fluid and the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_I.H2O_I">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_10">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_13">
<ro:part_of>
<rdf:Description rdf:about="#entity_12">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_17693" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15377" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water filtrate in the proximal tubule</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_M_A.H2O_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_45">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_22">
<ro:part_of rdf:resource="#entity_23" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15377" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_M.Na_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_6">
<ro:part_of>
<rdf:Description rdf:about="#entity_7">
<ro:part_of>
<rdf:Description rdf:about="#entity_8">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_17698" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_9673" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26708" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_M_A.Na_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_41">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_I.Na_I">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_11">
<ro:part_of rdf:resource="#entity_12" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26708" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium filtrate in the proximal tubule</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_R.H2O_I">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_49">
<semsim:physicalPropertyOf rdf:resource="#entity_13" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water filtrate in the proximal tubule</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_M.Na_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Protein">
<dcterms:description>Moss network model</dcterms:description>
<ro:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/PR_000015165" />
</rdf:Description>
<rdf:Description rdf:about="#Na_A.H2O_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_32">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_21">
<ro:part_of rdf:resource="#entity_7" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15377" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Keyword" dcterms:description="kidney">
<dcterms:description>emergent dynamics</dcterms:description>
<dcterms:description>nephron models</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_D.H2O_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_15">
<semsim:physicalPropertyOf rdf:resource="#entity_21" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_ALD.R_ALD">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_47">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_30">
<ro:part_of>
<rdf:Description rdf:about="#entity_29">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/GO_0072068" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_27584" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of aldosterone in the late distal tubule</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#SNGFR.P_BC">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_8">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_9">
<ro:part_of>
<rdf:Description rdf:about="#entity_10">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_17721" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/GO_0008217" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00509" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>pressure in the distal tubule ("at the start of the tubule" is mentioned in the paper, I assume distal tubule!)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_G.Na_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_37">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_M_A.Na_M_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_40">
<semsim:physicalPropertyOf rdf:resource="#entity_24" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid and the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_D.H2O_D_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_25">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14">
<ro:part_of>
<rdf:Description rdf:about="#entity_15">
<ro:part_of>
<rdf:Description rdf:about="#entity_16">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_9673" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_17705" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15377" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water conservation (quantity) in the descending limb and interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_M.H2O_D_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_29">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water conservation (quantity) in the descending limb and interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DOI">
<bqmodel:isDescribedBy rdf:resource="http://identifiers.org/doi/10.1098/rsta.2008.0313" />
</rdf:Description>
<rdf:Description rdf:about="#Author">
<vCard:FN>Robert Moss</vCard:FN>
<vCard:FN>ED Kazmierczak</vCard:FN>
<vCard:FN>Michel Kirley</vCard:FN>
<vCard:FN>Peter Harris</vCard:FN>
</rdf:Description>
<rdf:Description rdf:about="#Abstract">
<dcterms:description>In this paper, concepts from network automata are adapted and extended to model complex biological systems. Specifically, systems of nephrons, the operational units of the kidney, are modelled and the dynamics of such systems are explored. Nephron behaviour can fluctuate widely and, under certain conditions, become chaotic. However, the behaviour of the whole kidney remains remarkably stable and blood solute levels are maintained under a wide range of conditions even when many nephrons are damaged or lost. A network model is used to investigate the stability of systems of nephrons and interactions between nephrons. More sophisticated dynamics are explored including the observed oscillations in single nephron filtration rates and the development of stable ionic and osmotic gradients in the inner medulla which contribute to the countercurrent exchange mechanism. We have used the model to explore the effects of changes in input parameters including hydrostatic and osmotic pressures and concentrations of ions, such as sodium and chloride. The intrinsic nephron control, tubuloglomerular feedback, is included and the effects of coupling between nephrons are explored in two-, eight- and 72-nephron models.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_D.Na_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_16">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#model_parameters.C_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_0">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_0">
<ro:part_of>
<rdf:Description rdf:about="#entity_1">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_77042" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_66843" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein (blood plasma) in the afferent arteriole (?? "plasma membrane protein" from FMA??)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_D.Na_D_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_17">
<ro:part_of rdf:resource="#entity_15" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26708" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in the descending limb and interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#model_parameters.time" dcterms:description="Time">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Na_A.Na_M_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_34">
<semsim:physicalPropertyOf rdf:resource="#entity_24" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid and the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_A.Na_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_30">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_26">
<ro:part_of rdf:resource="#entity_23" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26708" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_ADH.R_ADH">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_46">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_28">
<ro:part_of rdf:resource="#entity_29" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_9937" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of antidiuretic hormone (ADH) in the distal tubule (ADH is also known as vasopressin)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_R.R_ADH">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_48">
<semsim:physicalPropertyOf rdf:resource="#entity_28" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of antidiuretic hormone (ADH) in the distal tubule (ADH is also known as vasopressin)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phi.Na_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_5">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Title">
<dcterms:description>A computational model for emergent dynamics in the kidney</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_G.C_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_2">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein (blood plasma) in the afferent arteriole (?? "plasma membrane protein" from FMA??)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_M.H2O_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#entity_22" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Compartment" dcterms:description="compartment1">
<dcterms:description>compartment2</dcterms:description>
<dcterms:description>compartment3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_D_M.H2O_D_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf rdf:resource="#entity_14" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water conservation (quantity) in the descending limb and interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pi_G.C_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_6">
<semsim:physicalPropertyOf rdf:resource="#entity_0" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein (blood plasma) in the afferent arteriole (?? "plasma membrane protein" from FMA??)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_D.H2O_D">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_20">
<ro:part_of>
<rdf:Description rdf:about="#entity_19">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_17705" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15377" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the descending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_D_M.Na_D_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf rdf:resource="#entity_17" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in the descending limb and interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_R.R_ALD">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_51">
<semsim:physicalPropertyOf rdf:resource="#entity_30" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of aldosterone in the late distal tubule</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phi.Na_half">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_4">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_4">
<ro:part_of>
<rdf:Description rdf:about="#entity_5">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_15624" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26708" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium delivery in the glomerulus for which the TGF response is half maximal</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_A.H2O_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_31">
<semsim:physicalPropertyOf rdf:resource="#entity_22" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Species" dcterms:description="Species" />
<rdf:Description rdf:about="#H2O_M_A.H2O_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:physicalPropertyOf rdf:resource="#entity_21" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_M.H2O_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:physicalPropertyOf rdf:resource="#entity_21" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_D.Na_D">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_23">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_18">
<ro:part_of rdf:resource="#entity_19" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_26708" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the descending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_M_A.Na_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_42">
<semsim:physicalPropertyOf rdf:resource="#entity_26" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_G.Na_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:physicalPropertyOf rdf:resource="#entity_26" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_D.Na_D">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf rdf:resource="#entity_18" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the descending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_M.Na_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_21">
<semsim:physicalPropertyOf rdf:resource="#entity_26" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#environment.time" dcterms:description="Time">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#Na_M.Na_G">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf rdf:resource="#entity_24" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration gradient between the interstitial fluid and the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#moss_2009" bqmodel:isDescribedBy="19414449" semsim:modelName="moss_2009" />
<rdf:Description rdf:about="#H2O_M_A.H2O_M_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_43">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_27">
<ro:part_of rdf:resource="#entity_25" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/CHEBI_15377" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the interstitial fluid and the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_R.Na_I">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_52">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium filtrate in the proximal tubule</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#model_parameters.C_E">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_1">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_2">
<ro:part_of>
<rdf:Description rdf:about="#entity_3">
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_77043" />
</rdf:Description>
</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/FMA_66843" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein (bloood pasma) in the efferent arteriole (?? "plasma membrane protein" from FMA??)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_D.H2O_D">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#entity_20" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the descending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#moss_2009">
<ro:located_in rdf:resource="http://purl.obolibrary.org/obo/FMA_7203" />
</rdf:Description>
<rdf:Description rdf:about="#H2O_R.Na_I">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_50">
<semsim:physicalPropertyOf rdf:resource="#entity_11" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium filtrate in the proximal tubule</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_M.Na_D_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_28">
<semsim:physicalPropertyOf rdf:resource="#entity_17" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of sodium in the descending limb and interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_M.H2O_M">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_18">
<semsim:physicalPropertyOf rdf:resource="#entity_21" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the interstitial fluid of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_G.Na_G">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_36">
<semsim:physicalPropertyOf rdf:resource="#entity_24" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>sodium concentration gradient between the interstitial fluid and the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_G.C_E">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein (bloood pasma) in the efferent arteriole (?? "plasma membrane protein" from FMA??)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#H2O_A.H2O_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_39">
<semsim:physicalPropertyOf rdf:resource="#entity_22" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#SNGFR.SNGFR">
<bqbiol:is rdf:resource="http://purl.bioontology.org/ontology/SNOMEDCT/80274001" />
<dcterms:description>single nephron glomerular filtration rate (SNGFR)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pi_G.C_E">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:physicalPropertyOf rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>concentration of protein (bloood pasma) in the efferent arteriole (?? "plasma membrane protein" from FMA??)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_A.H2O_M_A">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_33">
<semsim:physicalPropertyOf rdf:resource="#entity_27" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00154" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>water in the interstitial fluid and the ascending limb of the loop of Henle</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Gene" dcterms:description="Gene" />
</rdf:RDF>
</model>
