- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2016-07-20 19:01:57+12:00
- Desc:
- update units
- Permanent Source URI:
- https://models.cellml.org/workspace/295/rawfile/7e78f196f310d93e60aeaf88c034209fb8a9a56e/Ostby_2009_NBC.cellml
<?xml version='1.0'?>
<!-- This CellML file was generated from:
Ostby, Ivar, et al. "Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space." PLoS Comput Biol 5.1 (2009): e1000272.-->
<model cmeta:id="Ostby_2009_NBC" name="Ostby_2009_NBC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units/Units.cellml">
<units name="mV" units_ref="mV"/>
<units name="mM" units_ref="mM"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="mJ_per_mol_per_kelvin" units_ref="mJ_per_mol_per_kelvin"/>
<units name="umol_per_s_per_cm2" units_ref="umol_per_s_per_cm2"/>
<units name="mS_per_cm2" units_ref="mS_per_cm2"/>
</import>
<component name="NBC">
<variable name="V_m" public_interface="in" units="mV"/>
<variable name="Na_int" public_interface="in" units="mM"/>
<variable name="Na_ext" public_interface="in" units="mM"/>
<variable name="HCO3_int" public_interface="in" units="mM"/>
<variable name="HCO3_ext" public_interface="in" units="mM"/>
<variable initial_value="0.08" name="g_NBC" public_interface="out" units="mS_per_cm2"/>
<variable initial_value="96485" name="F" units="C_per_mol"/>
<variable initial_value="8314.41" name="R" units="mJ_per_mol_per_kelvin"/>
<variable initial_value="300" name="T" units="kelvin"/>
<variable initial_value="2" name="n" units="dimensionless"/>
<variable initial_value="1e-15" name="eps" units="mM"/>
<variable name="E_NBC" public_interface="out" units="mV"/>
<variable name="J_NBC_Na" public_interface="out" units="umol_per_s_per_cm2"/>
<variable name="J_NBC_HCO3" public_interface="out" units="umol_per_s_per_cm2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_NBC</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>n</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<plus/>
<ci>Na_ext</ci>
<ci>eps</ci>
</apply>
<apply>
<plus/>
<ci>Na_int</ci>
<ci>eps</ci>
</apply>
</apply>
<apply>
<power/>
<apply>
<divide/>
<apply>
<plus/>
<ci>HCO3_ext</ci>
<ci>eps</ci>
</apply>
<apply>
<plus/>
<ci>HCO3_int</ci>
<ci>eps</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_NBC</ci>
<apply>
<minus/>
<ci>E_NBC</ci>
<ci>V_m</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_HCO3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>J_NBC_Na</ci>
</apply>
</apply>
</math>
</component>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A kinetically defined Na+/HCO3- cotransporter (NBC) within a mathematical model of the brain.</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Ostby_2009_NBC">
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Bag xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">protein module</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
<dc:title xmlns:dc="http://purl.org/dc/elements/1.1/">A kinetic model of Na+/HCO3- cotransporter (NBC)</dc:title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#Oyehaug_2009_NBC">
<bqs:reference xmlns:bqs="http://www.cellml.org/bqs/1.0#" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<dc:subject xmlns:dc="http://purl.org/dc/elements/1.1/" rdf:parseType="Resource" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<bqs:subject_type xmlns:bqs="http://www.cellml.org/bqs/1.0#">keyword</bqs:subject_type>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Bag xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:li xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">protein module</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
</model>
