- Author:
- Michael Cooling <mcoo001@UoA.auckland.ac.nz>
- Date:
- 2016-04-11 11:48:36+12:00
- Desc:
- Initial Commit
- Permanent Source URI:
- https://models.cellml.org/workspace/2c5/rawfile/e8b0e5d10f563c9a997626435bace472ab5f7f34/CaN_to_DNAReady_NFAT.cellml
<?xml version="1.0" encoding="utf-8"?>
<model xmlns:xlink="http://www.w3.org/1999/xlink" name="CaN_to_DNAReady_NFAT" cmeta:id="CaN_to_DNAReady_NFAT"
xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Principled_Base/Time.cellml">
<component name="Time" component_ref="Time"/>
</import>
<component name="CaN_to_DNAReady_NFAT_Parameters">
<variable name="Ca" units="nM" initial_value="6400" public_interface="out"/>
</component>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Calcineurin_Activation.cellml">
<component name="Calcineurin_Activation_Parameters" component_ref="Calcineurin_Activation_Parameters"/>
</import>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="NFAT_Cycling.cellml">
<component name="NFAT_Cycling_Parameters" component_ref="NFAT_Cycling_Parameters"/>
</import>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="CaN_to_DNAReady_NFAT">
<component_ref component="Calcineurin_Activation"/>
<component_ref component="NFAT_Cycling"/>
</component_ref>
</group>
<component name="CaN_to_DNAReady_NFAT">
<variable name="time" units="second" public_interface="in" private_interface="out"/>
<variable name="Ca" units="nM" public_interface="in" private_interface="out"/>
<variable name="M" units="nM" public_interface="in" private_interface="out"/>
<variable name="K_mN" units="nM" public_interface="in" private_interface="out"/>
<variable name="n" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="K_dN" units="nM" public_interface="in" private_interface="out"/>
<variable name="Ccn" units="dimensionless" public_interface="in" private_interface="out"/>
<variable name="Ntot" units="nM" public_interface="in" private_interface="out"/>
<variable name="k_f1" units="per_nM_per_s" public_interface="in" private_interface="out"/>
<variable name="k_r1" units="per_s" public_interface="in" private_interface="out"/>
<variable name="k_f2" units="per_s" public_interface="in" private_interface="out"/>
<variable name="k_f3" units="per_s" public_interface="in" private_interface="out"/>
<variable name="k_r3" units="per_nM_per_s" public_interface="in" private_interface="out"/>
<variable name="k_f4" units="per_s" public_interface="in" private_interface="out"/>
<variable name="NFATp_c_init" units="nM" private_interface="out" public_interface="in"/>
<variable name="NFATN_c_init" units="nM" private_interface="out" public_interface="in"/>
<variable name="NFATN_n_init" units="nM" private_interface="out" public_interface="in"/>
<variable name="NFATp_n_init" units="nM" private_interface="out" public_interface="in"/>
<variable name="J_NFATp_c_External" units="nM_per_s" private_interface="out" public_interface="in"/>
<variable name="J_NFATN_c_External" units="nM_per_s" private_interface="out" public_interface="in"/>
<variable name="J_NFATN_n_External" units="nM_per_s" private_interface="out" public_interface="in"/>
<variable name="J_NFATp_n_External" units="nM_per_s" private_interface="out" public_interface="in"/>
<variable name="N_active_ratio" units="dimensionless" private_interface="in" public_interface="out"/>
<variable name="NFATp_c" units="nM" private_interface="in" public_interface="out"/>
<variable name="NFATN_c" units="nM" private_interface="in" public_interface="out"/>
<variable name="NFATN_n" units="nM" private_interface="in" public_interface="out"/>
<variable name="NFATp_n" units="nM" private_interface="in" public_interface="out"/>
<variable name="J_NFATp_c" units="nM_per_s" private_interface="in" public_interface="out"/>
<variable name="J_NFATN_c" units="nM_per_s" private_interface="in" public_interface="out"/>
<variable name="J_NFATN_n" units="nM_per_s" private_interface="in" public_interface="out"/>
<variable name="J_NFATp_n" units="nM_per_s" private_interface="in" public_interface="out"/>
</component>
<connection>
<map_components component_1="CaN_to_DNAReady_NFAT" component_2="Time"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="CaN_to_DNAReady_NFAT" component_2="CaN_to_DNAReady_NFAT_Parameters"/>
<map_variables variable_1="Ca" variable_2="Ca"/>
</connection>
<connection>
<map_components component_1="CaN_to_DNAReady_NFAT" component_2="Calcineurin_Activation_Parameters"/>
<map_variables variable_1="M" variable_2="M"/>
<map_variables variable_1="K_mN" variable_2="K_mN"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="K_dN" variable_2="K_dN"/>
</connection>
<connection>
<map_components component_1="CaN_to_DNAReady_NFAT" component_2="NFAT_Cycling_Parameters"/>
<map_variables variable_1="Ccn" variable_2="Ccn" />
<map_variables variable_1="Ntot" variable_2="Ntot" />
<map_variables variable_1="k_f1" variable_2="k_f1" />
<map_variables variable_1="k_r1" variable_2="k_r1" />
<map_variables variable_1="k_f2" variable_2="k_f2" />
<map_variables variable_1="k_f3" variable_2="k_f3" />
<map_variables variable_1="k_r3" variable_2="k_r3" />
<map_variables variable_1="k_f4" variable_2="k_f4" />
<map_variables variable_1="NFATp_c_init" variable_2="NFATp_c_init" />
<map_variables variable_1="NFATN_c_init" variable_2="NFATN_c_init" />
<map_variables variable_1="NFATN_n_init" variable_2="NFATN_n_init" />
<map_variables variable_1="NFATp_n_init" variable_2="NFATp_n_init" />
<map_variables variable_1="J_NFATp_c_External" variable_2="J_NFATp_c_External" />
<map_variables variable_1="J_NFATN_c_External" variable_2="J_NFATN_c_External" />
<map_variables variable_1="J_NFATN_n_External" variable_2="J_NFATN_n_External" />
<map_variables variable_1="J_NFATp_n_External" variable_2="J_NFATp_n_External" />
</connection>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="Calcineurin_Activation.cellml">
<component name="Calcineurin_Activation" component_ref="Calcineurin_Activation"/>
</import>
<connection>
<map_components component_1="CaN_to_DNAReady_NFAT" component_2="Calcineurin_Activation"/>
<map_variables variable_1="M" variable_2="M"/>
<map_variables variable_1="K_mN" variable_2="K_mN"/>
<map_variables variable_1="n" variable_2="n"/>
<map_variables variable_1="K_dN" variable_2="K_dN"/>
<map_variables variable_1="Ca" variable_2="Ca"/>
<map_variables variable_1="N_active_ratio" variable_2="act_N"/>
</connection>
<import xmlns="http://www.cellml.org/cellml/1.1#" xlink:href="NFAT_Cycling.cellml">
<units name="per_s" units_ref="per_s"/>
<units name="nM" units_ref="nM"/>
<units name="nM_per_s" units_ref="nM_per_s"/>
<units name="per_nM_per_s" units_ref="per_nM_per_s"/>
<component name="NFAT_Cycling" component_ref="NFAT_Cycling"/>
</import>
<connection>
<map_components component_1="CaN_to_DNAReady_NFAT" component_2="NFAT_Cycling"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Ccn" variable_2="Ccn"/>
<map_variables variable_1="Ntot" variable_2="Ntot"/>
<map_variables variable_1="k_f1" variable_2="k_f1" />
<map_variables variable_1="k_r1" variable_2="k_r1" />
<map_variables variable_1="k_f2" variable_2="k_f2" />
<map_variables variable_1="k_f3" variable_2="k_f3" />
<map_variables variable_1="k_r3" variable_2="k_r3" />
<map_variables variable_1="k_f4" variable_2="k_f4" />
<map_variables variable_1="NFATp_c_init" variable_2="NFATp_c_init" />
<map_variables variable_1="NFATN_c_init" variable_2="NFATN_c_init" />
<map_variables variable_1="NFATN_n_init" variable_2="NFATN_n_init" />
<map_variables variable_1="NFATp_n_init" variable_2="NFATp_n_init" />
<map_variables variable_1="J_NFATp_c_External" variable_2="J_NFATp_c_External" />
<map_variables variable_1="J_NFATN_c_External" variable_2="J_NFATN_c_External" />
<map_variables variable_1="J_NFATN_n_External" variable_2="J_NFATN_n_External" />
<map_variables variable_1="J_NFATp_n_External" variable_2="J_NFATp_n_External" />
<map_variables variable_1="NFATp_c" variable_2="NFATp_c" />
<map_variables variable_1="NFATN_c" variable_2="NFATN_c"/>
<map_variables variable_1="NFATN_n" variable_2="NFATN_n" />
<map_variables variable_1="NFATp_n" variable_2="NFATp_n"/>
<map_variables variable_1="J_NFATp_c" variable_2="J_NFATp_c"/>
<map_variables variable_1="J_NFATN_c" variable_2="J_NFATN_c"/>
<map_variables variable_1="J_NFATN_n" variable_2="J_NFATN_n"/>
<map_variables variable_1="J_NFATp_n" variable_2="J_NFATp_n"/>
</connection>
<connection>
<map_components component_1="Calcineurin_Activation" component_2="NFAT_Cycling"/>
<map_variables variable_1="act_N" variable_2="act_N"/>
</connection>
</model>
