Location: Core Domains Principled Model Example @ e8b0e5d10f56 / index.html

Author:

Michael Cooling <mcoo001@UoA.auckland.ac.nz>

Date:

2016-04-11 11:48:36+12:00

Desc:

Initial Commit

Permanent Source URI:

https://models.cellml.org/workspace/2c5/rawfile/e8b0e5d10f563c9a997626435bace472ab5f7f34/index.html

Model Overview

This is the model for the Core Domains Example as described in ....

Biological schematic of the Core Domains Model. The membrane is depolarized at t=50 (voltage graph shown, scale is mV), resulting in calcium influx (trace shown in µM) through L-type calcium channels (electrophysiology). The channels are sensitive to pH and [ATP], both of which are influenced by myosin ATPase reaction (metabolism). Calcium activates calmodulin and calcineurin (trace of ratio of active calcineurin-calmodulin complex shown), leading to NFAT cycling (signaling). NFAT (trace shown in nM) is a transcription factor for a sample ‘device’ (synthetic biology) resulting in mRNA production that is translated outside the nucleus to form a GFP signal (trace shown in nM), which increases as the membrane is depolarized.