- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 08:02:32+12:00
- Desc:
- committing version01 of bertram_previte_sherman_kinard_satin_2000
- Permanent Source URI:
- https://models.cellml.org/workspace/2e0/rawfile/97c9fcf2702501d9812a705d768e9bd21e352b90/bertram_previte_sherman_kinard_satin_2000.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : bertram_model_2000.xml
CREATED : 10th April 2002
LAST MODIFIED : 9th April 2003
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/01/2002 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Bertram et al's
2000 phantom burster model for pancreatic beta-cells.
CHANGES:
18/07/2002 - CML - Added more metadata.
09/04/2003 - AAC - Added publication date information.
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="bertram_previte_sherman_kinard_satin_2000_version01" name="bertram_previte_sherman_kinard_satin_2000_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>The Phantom Burster Model For Pancreatic Beta-Cells</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This is the original unchecked version of the model imported from the previous
CellML model repository, 24-Jan-2006.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
Pancreatic beta-cells have been the subject of both experimental and theoretical studies for several decades. One reason for this interest has been the essential role beta-cells play in glucose homeostasis - they are the only source of insulin that most cells require in order to take up and metabolise glucose, and impairment of beta-cell function contributes to diabetes. A major focus of theoretical work has been beta-cell dynamics, especially in the form of bursting electrical activity. The bursts consist of active phases of Ca<superscript>2+</superscript>-carrying action potentials alternating with silent phases of repolarisation and are accompanied by oscillations in cytosolic Ca<superscript>2+</superscript>, which drive pulses of insulin secretion.
</para>
<para>
Experimentally, electrical activity in beta-cells is studied in two distinct preparations: islets of Langerhans, which are microorgans containing thousands of endocrine cells, and isolated cells. Pancreatic beta-cells exhibit bursting oscillations with a wide range of periods. Whereas periods in isolated cells are generally either a few seconds or a few minutes, in intact islets of Langerhans they are intermediate (10-60 seconds). In their 2000 publication, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard and Leslie S. Satin develop a mathematical model for beta-cell electrical activity capable of generating this wide range of bursting oscillations. Unlike previously published models, bursting is driven by the interaction of two slow processes (I<subscript>s1</subscript> and I<subscript>s2</subscript> in <xref linkend="fig_cell_diagram"/> below), one with a relatively small time constant (1-5 seconds) and the other with a much larger time constant (1-2 minutes). Bursting on the intermediate time scale is generated without the need for a slow process having an intermediate time constant, hence phantom bursting. This mathematical model has been translated into a CellML description which can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>.
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.biophysj.org/cgi/content/abstract/79/6/2880">The Phantom Burster Model for Pancreatic beta-Cells</ulink>, Richard Bertram, Joseph Previte, Arthur Sherman, Tracie A. Kinard and Leslie S. Satin, 2000, <ulink url="http://www.biophysj.org/">
<emphasis>Biophysical Journal</emphasis>
</ulink>, 79, 2880-2892. (<ulink url="http://www.biophysj.org/cgi/content/full/79/6/2880">Full text</ulink> and <ulink url="http://www.biophysj.org/cgi/reprint/79/6/2880.pdf">PDF</ulink> versions of the article are available for Journal Members on the Biophysical Journal website.) <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11106596&dopt=Abstract">PubMed ID: 11106596</ulink>
</para>
<informalfigure float="0" id="fig_cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>cell schematic for the model</title>
</objectinfo>
<imagedata fileref="cell_diagram.gif"/>
</imageobject>
</mediaobject>
<caption>Schematic diagram of the pancreatic beta-cell plasma membrane showing the ionic currents captured by the phantom burster model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<!--
Below, we define some additional units for association with variables and
constants within the model. The identifiers are fairly self-explanatory.
-->
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-->
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<dc:title>
The Bertram et al 2000 phantom burster model for pancreatic beta-cells.
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The Phantom Burster Model for Pancreatic Beta Cells
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