- Author:
- pmr2.import <nobody@models.cellml.org>
- Date:
- 2006-07-09 07:32:28+12:00
- Desc:
- committing version01 of ciliberto_novak_tyson_2003
- Permanent Source URI:
- https://models.cellml.org/workspace/36c/rawfile/d561090e23220f85f69afc38bcb5b6c9b90e9f0f/ciliberto_novak_tyson_2003.cellml
<?xml version='1.0' encoding='utf-8'?>
<!-- FILE : ciliberto_model_II_2003.xml
CREATED : 5th January 2004
LAST MODIFIED : 5th January 2004
AUTHOR : Catherine Lloyd
Bioengineering Institute
The University of Auckland
MODEL STATUS : This model conforms to the CellML 1.0 Specification released on
10th August 2001, and the 16/1/02 CellML Metadata 1.0 Specification.
DESCRIPTION : This file contains a CellML description of Ciliberto et al.'s 2003 mathematical model of the morphogenesis checkpoint in the budding yeast cell cycle.
CHANGES:
--><model xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" cmeta:id="ciliberto_novak_tyson_2003_version01" name="ciliberto_novak_tyson_2003_version01">
<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<articleinfo>
<title>Modelling the Morphogenesis Checkpoint in the Budding Yeast Cell Cycle</title>
<author>
<firstname>Catherine</firstname>
<surname>Lloyd</surname>
<affiliation>
<shortaffil>Bioengineering Institute, University of Auckland</shortaffil>
</affiliation>
</author>
</articleinfo>
<section id="sec_status">
<title>Model Status</title>
<para>
This model is currently producing inaccuracies and is not able to reproduce the published results.
</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>
During mitotic cell division, eukaryotic cells will replicate their DNA during the S-phase of the cell cycle, and then divide during the M-phase. S and M phases are temporally separated by gaps, G1 and G2 phases. These discrete phases of the cell cycle are carefully regulated by specific proteins (see <xref linkend="fig_reaction_diagram1"/> below for an illustration of the molecular mechanisms underlying the cell-cycle):
</para>
<itemizedlist>
<listitem>
<para>In order to ensure that DNA replication only occurs once per cell cycle, cyclin-dependent protein kinases (CDKs) control the activity of licensing factors, which in turn bind to the DNA and prime the origins of replication. The CDKs ensure that this only occurs once per cycle.</para>
</listitem>
<listitem>
<para>It is also important that the cell doesn't begin to divide until DNA replication is complete. Chromosome alignment during the early M phase is required for the activation of the anaphase-promoting complex (APC). In turn, this initiates the degradation of an inhibitor of chromatid separation. APC also mediates the break down of mitotic cyclins, thereby destroying CDK activities and allowing licensing factors to accumulate and origins to be primed for replication.</para>
</listitem>
<listitem>
<para>Thirdly, the cell must coordinate its DNA replication and division cycle with cell growth. In order to maintain a certain cell size, the cell must reach a critical mass before it divides.</para>
</listitem>
</itemizedlist>
<para>
The main transitions of the cell cycle, namely the onset of DNA replication (Start), entry into mitosis (G2-M transition), and exit from mitosis, are controlled by checkpoint mechanisms. The morphogenesis checkpoint in budding yeast arrests the cell cycle at the G2-M transition when bud formation is impaired (perhaps due to environmental stimuli such as heat or osmotic shock). This delay effectively prevents the formation of dinucleated cells, which are less viable than mononucleated cells. However, the arrest in the cycle is not complete; after several hours, the cell cycle will continue and unbudded cells will undergo mitosis and dinucleate cells will be formed.
</para>
<para>
The model has been described here in CellML (the raw CellML description of the Ciliberto <emphasis>et al.</emphasis> 2003 model can be downloaded in various formats as described in <xref linkend="sec_download_this_model"/>).
</para>
<para>
The complete original paper reference is cited below:
</para>
<para>
<ulink url="http://www.jcb.org/cgi/content/abstract/163/6/1243">Mathematical model of the morphogenesis checkpoint in budding yeast</ulink>, Andrea Ciliberto, Bela Novak, and John J. Tyson, 2003, <ulink url="http://www.jcb.org/">
<emphasis>The Journal of Cell Biology</emphasis>
</ulink>, 163, 1243-1254. (<ulink url="http://www.jcb.org/cgi/content/full/163/6/1243">Full text (HTML)</ulink> and <ulink url="http://www.jcb.org/cgi/reprint/163/6/1243">PDF</ulink> versions of the article are available on the <emphasis>The Journal of Cell Biology</emphasis> website.) <ulink url="http://www.ncbi.nlm.nih.gov/pubmed/14691135">PubMed ID: 14691135</ulink>
</para>
<informalfigure float="0" id="fig_reaction_diagram1">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction diagram1</title>
</objectinfo>
<imagedata fileref="ciliberto_2003a.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the molecular mechanisms underlying the regulation of the cell cycle in budding yeast.</caption>
</informalfigure>
<informalfigure float="0" id="fig_reaction_diagram2">
<mediaobject>
<imageobject>
<objectinfo>
<title>reaction diagram2</title>
</objectinfo>
<imagedata fileref="ciliberto_2003b.png"/>
</imageobject>
</mediaobject>
<caption>A schematic diagram of the Swe1 box - a process which is central to the morphogenesis checkpoint in budding yeast.</caption>
</informalfigure>
<para>
The model simulations support the idea that the morphogenesis checkpoint increases the cell size threshold for progression from one phase of the cell cycle to the next.
</para>
</sect1>
</article>
</documentation>
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<variable units="minute" public_interface="in" name="time"/>
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<ci> Cdc20_ </ci>
</apply>
</apply>
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<apply>
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</apply>
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</apply>
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</math>
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<component name="PClb2">
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<variable units="first_order_rate_constant" public_interface="in" name="kd_clb_2"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_clb_3"/>
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<apply>
<divide/>
<apply>
<times/>
<ci> Vi_mih </ci>
<ci> Mih1_ </ci>
</apply>
<apply>
<plus/>
<ci> Ji_mih </ci>
<ci> Mih1_ </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Va_mih </ci>
<ci> Clb2 </ci>
<ci> Mih1 </ci>
</apply>
<apply>
<plus/>
<ci> Ja_mih </ci>
<ci> Mih1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="IE_">
<variable units="concentration" public_interface="out" name="IE_" initial_value="0.522"/>
<variable units="dimensionless" name="Ji_ie" initial_value="0.01"/>
<variable units="dimensionless" name="Ja_ie" initial_value="0.01"/>
<variable units="first_order_rate_constant" name="ki_ie" initial_value="0.04"/>
<variable units="first_order_rate_constant" name="ka_ie" initial_value="0.1"/>
<variable units="concentration" public_interface="in" name="IE"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IE_</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ki_ie </ci>
<ci> IE_ </ci>
</apply>
<apply>
<plus/>
<ci> Ji_ie </ci>
<ci> IE_ </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ka_ie </ci>
<ci> Clb2 </ci>
<ci> IE </ci>
</apply>
<apply>
<plus/>
<ci> Ja_ie </ci>
<ci> IE </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20_">
<variable units="concentration" public_interface="out" name="Cdc20_" initial_value="1.438"/>
<variable units="dimensionless" public_interface="in" name="Ji_cdc20"/>
<variable units="dimensionless" public_interface="in" name="Ja_cdc20"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_cdc20"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_cdc20"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_cdc20"/>
<variable units="concentration" public_interface="in" name="Cdc20"/>
<variable units="concentration" public_interface="in" name="IE_"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20_</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ka_cdc20 </ci>
<ci> IE_ </ci>
<ci> Cdc20 </ci>
</apply>
<apply>
<plus/>
<ci> Ja_cdc20 </ci>
<ci> Cdc20 </ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ki_cdc20 </ci>
<ci> Cdc20_ </ci>
</apply>
<apply>
<plus/>
<ci> Ji_cdc20 </ci>
<ci> Cdc20_ </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_cdc20 </ci>
<ci> Cdc20_ </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdc20">
<variable units="concentration" public_interface="out" name="Cdc20" initial_value="1.172"/>
<variable units="first_order_rate_constant" name="ks_cdc20_1" initial_value="0.005"/>
<variable units="first_order_rate_constant" name="ks_cdc20_2" initial_value="0.3"/>
<variable units="dimensionless" name="Js_cdc20" initial_value="0.3"/>
<variable units="dimensionless" public_interface="in" name="Ji_cdc20"/>
<variable units="dimensionless" public_interface="in" name="Ja_cdc20"/>
<variable units="first_order_rate_constant" public_interface="in" name="ki_cdc20"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_cdc20"/>
<variable units="first_order_rate_constant" public_interface="in" name="ka_cdc20"/>
<variable units="concentration" public_interface="in" name="Cdc20_"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<variable units="concentration" public_interface="in" name="IE_"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdc20</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci> ks_cdc20_1 </ci>
<apply>
<times/>
<ci> ks_cdc20_2 </ci>
<apply>
<divide/>
<apply>
<power/>
<ci> Clb2 </ci>
<cn cellml:units="dimensionless"> 4.0 </cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci> Js_cdc20 </ci>
<cn cellml:units="dimensionless"> 4.0 </cn>
</apply>
<apply>
<power/>
<ci> Clb2 </ci>
<cn cellml:units="dimensionless"> 4.0 </cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> ki_cdc20 </ci>
<ci> Cdc20_ </ci>
</apply>
<apply>
<plus/>
<ci> Ji_cdc20 </ci>
<ci> Cdc20_ </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci> ka_cdc20 </ci>
<ci> IE_ </ci>
<ci> Cdc20 </ci>
</apply>
<apply>
<plus/>
<ci> Ja_cdc20 </ci>
<ci> Cdc20 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_cdc20 </ci>
<ci> Cdc20 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cdh1_">
<variable units="concentration" public_interface="out" name="Cdh1_" initial_value="0.993"/>
<variable units="dimensionless" name="Ji_cdh" initial_value="0.01"/>
<variable units="dimensionless" name="Ja_cdh" initial_value="0.01"/>
<variable units="first_order_rate_constant" name="ki_cdh" initial_value="35.0"/>
<variable units="first_order_rate_constant" name="ka_cdh_1" initial_value="1.0"/>
<variable units="first_order_rate_constant" name="ki_cdh_1" initial_value="2.0"/>
<variable units="first_order_rate_constant" name="ka_cdh_2" initial_value="10.0"/>
<variable units="concentration" public_interface="in" name="Cln"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<variable units="concentration" public_interface="in" name="Cdh1"/>
<variable units="concentration" public_interface="in" name="Cdc20_"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cdh1_</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> ki_cdh </ci>
<ci> Clb2 </ci>
</apply>
<apply>
<times/>
<ci> ki_cdh </ci>
<ci> Cln </ci>
</apply>
</apply>
<ci> Cdh1_ </ci>
</apply>
<apply>
<plus/>
<ci> Ji_cdh </ci>
<ci> Cdh1_ </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci> ka_cdh_1 </ci>
<apply>
<times/>
<ci> ka_cdh_2 </ci>
<ci> Cdc20_ </ci>
</apply>
</apply>
<ci> Cdh1 </ci>
</apply>
<apply>
<plus/>
<ci> Ja_cdh </ci>
<ci> Cdh1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Cln">
<variable units="concentration" public_interface="out" name="Cln" initial_value="0.054"/>
<variable units="first_order_rate_constant" name="ks_cln" initial_value="0.1"/>
<variable units="first_order_rate_constant" name="kd_cln" initial_value="0.1"/>
<variable units="concentration" public_interface="in" name="SBF_"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cln</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> ks_cln </ci>
<ci> SBF_ </ci>
</apply>
<apply>
<times/>
<ci> kd_cln </ci>
<ci> Cln </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="SBF_">
<variable units="concentration" public_interface="out" name="SBF_" initial_value="0.124"/>
<variable units="dimensionless" name="Ji_sbf" initial_value="0.01"/>
<variable units="dimensionless" name="Ja_sbf" initial_value="0.01"/>
<variable units="first_order_rate_constant" name="ki_sbf_1" initial_value="1.0"/>
<variable units="first_order_rate_constant" name="ka_sbf_1" initial_value="1.0"/>
<variable units="first_order_rate_constant" name="ki_sbf_2" initial_value="2.0"/>
<variable units="first_order_rate_constant" name="ka_sbf_2" initial_value="0.0"/>
<variable units="concentration" public_interface="in" name="Cln"/>
<variable units="concentration" public_interface="in" name="M"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<variable units="concentration" public_interface="in" name="SBF"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>SBF_</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<ci> ki_sbf_1 </ci>
<apply>
<times/>
<ci> ki_sbf_2 </ci>
<ci> Clb2 </ci>
</apply>
</apply>
<ci> SBF_ </ci>
</apply>
<apply>
<plus/>
<ci> Ji_sbf </ci>
<ci> SBF_ </ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci> ka_sbf_1 </ci>
<ci> M </ci>
</apply>
<apply>
<times/>
<ci> ka_sbf_2 </ci>
<ci> Cln </ci>
</apply>
</apply>
<ci> SBF </ci>
</apply>
<apply>
<plus/>
<ci> Ja_sbf </ci>
<ci> SBF </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swe1">
<variable units="concentration" public_interface="out" name="Swe1" initial_value="0.0"/>
<variable units="first_order_rate_constant" name="ks_swe" initial_value="0.0025"/>
<variable units="first_order_rate_constant" name="ks_sweC" initial_value="0.0"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1r"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swe_1"/>
<variable units="dimensionless" public_interface="in" name="Ji_wee"/>
<variable units="dimensionless" public_interface="in" name="Ja_wee"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vi_wee"/>
<variable units="first_order_rate_constant" public_interface="in" name="Va_wee"/>
<variable units="concentration" public_interface="in" name="SBF_"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<variable units="concentration" public_interface="in" name="BUD"/>
<variable units="concentration" public_interface="in" name="PSwe1"/>
<variable units="concentration" public_interface="in" name="Swe1M"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swe1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> ks_swe </ci>
<ci> SBF_ </ci>
</apply>
<ci> ks_sweC </ci>
<apply>
<times/>
<ci> khsl1r </ci>
<ci> Swe1M </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Va_wee </ci>
<ci> PSwe1 </ci>
</apply>
<apply>
<plus/>
<ci> Ja_wee </ci>
<ci> PSwe1 </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> khsl1 </ci>
<ci> BUD </ci>
<ci> Swe1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Vi_wee </ci>
<ci> Clb2 </ci>
<ci> Swe1 </ci>
</apply>
<apply>
<plus/>
<ci> Ji_wee </ci>
<ci> Swe1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_swe_1 </ci>
<ci> Swe1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PSwe1">
<variable units="concentration" public_interface="out" name="PSwe1" initial_value="0.0"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1r"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swe_1"/>
<variable units="dimensionless" public_interface="in" name="Ja_wee"/>
<variable units="first_order_rate_constant" public_interface="in" name="Va_wee"/>
<variable units="concentration" public_interface="in" name="BUD"/>
<variable units="concentration" public_interface="in" name="PSwe1M"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PSwe1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> khsl1r </ci>
<ci> PSwe1M </ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> khsl1 </ci>
<ci> BUD </ci>
<ci> PSwe1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Va_wee </ci>
<ci> PSwe1 </ci>
</apply>
<apply>
<plus/>
<ci> Ja_wee </ci>
<ci> PSwe1 </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_swe_1 </ci>
<ci> PSwe1 </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="Swe1M">
<variable units="concentration" public_interface="out" name="Swe1M" initial_value="0.018"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1r"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swe_1"/>
<variable units="dimensionless" public_interface="in" name="Ji_wee"/>
<variable units="dimensionless" public_interface="in" name="Ja_wee"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vi_wee"/>
<variable units="first_order_rate_constant" public_interface="in" name="Va_wee"/>
<variable units="concentration" public_interface="in" name="Swe1"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<variable units="concentration" public_interface="in" name="BUD"/>
<variable units="concentration" public_interface="in" name="PSwe1M"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Swe1M</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> khsl1 </ci>
<ci> BUD </ci>
<ci> Swe1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Va_wee </ci>
<ci> PSwe1M </ci>
</apply>
<apply>
<plus/>
<ci> Ja_wee </ci>
<ci> PSwe1M </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> khsl1r </ci>
<ci> Swe1M </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Vi_wee </ci>
<ci> Clb2 </ci>
<ci> Swe1M </ci>
</apply>
<apply>
<plus/>
<ci> Ji_wee </ci>
<ci> Swe1M </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_swe_1 </ci>
<ci> Swe1M </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="PSwe1M">
<variable units="concentration" public_interface="out" name="PSwe1M" initial_value="0.013"/>
<variable units="first_order_rate_constant" name="kd_swe_2" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="in" name="kd_swe_1"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1"/>
<variable units="first_order_rate_constant" public_interface="in" name="khsl1r"/>
<variable units="dimensionless" public_interface="in" name="Ji_wee"/>
<variable units="dimensionless" public_interface="in" name="Ja_wee"/>
<variable units="first_order_rate_constant" public_interface="in" name="Vi_wee"/>
<variable units="first_order_rate_constant" public_interface="in" name="Va_wee"/>
<variable units="concentration" public_interface="in" name="Swe1M"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<variable units="concentration" public_interface="in" name="BUD"/>
<variable units="concentration" public_interface="in" name="PSwe1"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>PSwe1M</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci> khsl1 </ci>
<ci> BUD </ci>
<ci> PSwe1 </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Vi_wee </ci>
<ci> Clb2 </ci>
<ci> Swe1M </ci>
</apply>
<apply>
<plus/>
<ci> Ji_wee </ci>
<ci> Swe1M </ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci> khsl1r </ci>
<ci> PSwe1M </ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci> Va_wee </ci>
<ci> PSwe1M </ci>
</apply>
<apply>
<plus/>
<ci> Ja_wee </ci>
<ci> PSwe1M </ci>
</apply>
</apply>
<apply>
<times/>
<ci> kd_swe_2 </ci>
<ci> PSwe1M </ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="BE">
<variable units="concentration" public_interface="out" name="BE" initial_value="0.0"/>
<variable units="first_order_rate_constant" name="ks_bud" initial_value="0.1"/>
<variable units="first_order_rate_constant" name="kd_bud" initial_value="0.1"/>
<variable units="concentration" public_interface="in" name="Cln"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>BE</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci> ks_bud </ci>
<ci> Cln </ci>
</apply>
<apply>
<times/>
<ci> kd_bud </ci>
<ci> BE </ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="M">
<variable units="concentration" public_interface="out" name="M" initial_value="0.802"/>
<variable units="first_order_rate_constant" name="mu" initial_value="0.005"/>
<variable units="minute" public_interface="in" name="time"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>M</ci>
</apply>
<apply>
<times/>
<ci> mu </ci>
<ci> M </ci>
</apply>
</apply>
</math>
</component>
<component name="IE">
<variable units="concentration" public_interface="out" name="IE"/>
<variable units="concentration" name="IE_total" initial_value="1.0"/>
<variable units="concentration" public_interface="in" name="IE_"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>IE</ci>
<apply>
<minus/>
<ci> IE_total </ci>
<ci> IE_ </ci>
</apply>
</apply>
</math>
</component>
<component name="Cdh1">
<variable units="concentration" public_interface="out" name="Cdh1"/>
<variable units="concentration" name="Cdh1_total" initial_value="1.0"/>
<variable units="concentration" public_interface="in" name="Cdh1_"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Cdh1</ci>
<apply>
<minus/>
<ci> Cdh1_total </ci>
<ci> Cdh1_ </ci>
</apply>
</apply>
</math>
</component>
<component name="Mih1">
<variable units="concentration" public_interface="out" name="Mih1"/>
<variable units="concentration" name="Mih1_total" initial_value="1.0"/>
<variable units="concentration" public_interface="in" name="Mih1_"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Mih1</ci>
<apply>
<minus/>
<ci> Mih1_total </ci>
<ci> Mih1_ </ci>
</apply>
</apply>
</math>
</component>
<component name="Mcm">
<variable units="concentration" public_interface="out" name="Mcm"/>
<variable units="concentration" name="Mcm_total" initial_value="1.0"/>
<variable units="concentration" public_interface="in" name="Mcm_"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Mcm</ci>
<apply>
<minus/>
<ci> Mcm_total </ci>
<ci> Mcm_ </ci>
</apply>
</apply>
</math>
</component>
<component name="SBF">
<variable units="concentration" public_interface="out" name="SBF"/>
<variable units="concentration" name="SBF_total" initial_value="1.0"/>
<variable units="concentration" public_interface="in" name="SBF_"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>SBF</ci>
<apply>
<minus/>
<ci> SBF_total </ci>
<ci> SBF_ </ci>
</apply>
</apply>
</math>
</component>
<component name="Swe1_total">
<variable units="concentration" public_interface="out" name="Swe1_total"/>
<variable units="concentration" public_interface="in" name="Swe1"/>
<variable units="concentration" public_interface="in" name="PSwe1"/>
<variable units="concentration" public_interface="in" name="Swe1M"/>
<variable units="concentration" public_interface="in" name="PSwe1M"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Swe1_total</ci>
<apply>
<plus/>
<ci> Swe1 </ci>
<ci> PSwe1 </ci>
<ci> Swe1M </ci>
<ci> PSwe1M </ci>
</apply>
</apply>
</math>
</component>
<component name="BUD">
<variable units="concentration" public_interface="out" name="BUD"/>
<variable units="concentration" public_interface="in" name="BE"/>
<variable units="concentration" public_interface="in" name="Clb2"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>BUD</ci>
<piecewise>
<piece>
<cn cellml:units="concentration"> 0.0 </cn>
<apply>
<lt/>
<ci> BE </ci>
<cn cellml:units="concentration"> 0.6 </cn>
</apply>
</piece>
<piece>
<cn cellml:units="concentration"> 1.0 </cn>
<apply>
<lt/>
<ci> Clb2 </ci>
<cn cellml:units="concentration"> 0.2 </cn>
</apply>
</piece>
</piecewise>
</apply>
</math>
</component>
<component name="kinetic_parameters">
<variable units="dimensionless" public_interface="out" name="Ji_cdc20" initial_value="0.001"/>
<variable units="dimensionless" public_interface="out" name="Ja_cdc20" initial_value="0.001"/>
<variable units="first_order_rate_constant" public_interface="out" name="ki_cdc20" initial_value="0.25"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_cdc20" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="ka_cdc20" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="khsl1" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="khsl1r" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_swe_1" initial_value="0.007"/>
<variable units="dimensionless" public_interface="out" name="Ji_wee" initial_value="0.05"/>
<variable units="dimensionless" public_interface="out" name="Ja_wee" initial_value="0.05"/>
<variable units="first_order_rate_constant" public_interface="out" name="Vi_wee" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="Va_wee" initial_value="0.3"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_clb_1" initial_value="0.015"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_clb_2" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_clb_3" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kswe"/>
<variable units="first_order_rate_constant" public_interface="out" name="kmih"/>
<variable units="first_order_rate_constant" public_interface="out" name="kass" initial_value="300.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kdiss" initial_value="0.1"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_sic" initial_value="0.01"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_sic_1" initial_value="1.0"/>
<variable units="first_order_rate_constant" public_interface="out" name="kd_sic_2" initial_value="3.0"/>
<variable units="first_order_rate_constant" name="kswe_1" initial_value="2.0"/>
<variable units="first_order_rate_constant" name="kswe_2" initial_value="0.01"/>
<variable units="first_order_rate_constant" name="kswe_3" initial_value="0.2"/>
<variable units="first_order_rate_constant" name="kmih_1" initial_value="5.0"/>
<variable units="first_order_rate_constant" name="kmih_2" initial_value="0.5"/>
<variable units="concentration" public_interface="in" name="Mih1_"/>
<variable units="concentration" public_interface="in" name="Mih1"/>
<variable units="concentration" public_interface="in" name="Swe1"/>
<variable units="concentration" public_interface="in" name="Swe1M"/>
<variable units="concentration" public_interface="in" name="PSwe1"/>
<variable units="concentration" public_interface="in" name="PSwe1M"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>kmih</ci>
<apply>
<plus/>
<apply>
<times/>
<ci> kmih_1 </ci>
<ci> Mih1_ </ci>
</apply>
<apply>
<times/>
<ci> kmih_2 </ci>
<ci> Mih1 </ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>kswe</ci>
<apply>
<plus/>
<apply>
<times/>
<ci> kswe_1 </ci>
<ci> Swe1 </ci>
</apply>
<apply>
<times/>
<ci> kswe_2 </ci>
<ci> Swe1M </ci>
</apply>
<apply>
<times/>
<ci> kswe_3 </ci>
<ci> PSwe1 </ci>
</apply>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_2="environment" component_1="Clb2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="PClb2"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Trim"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="PTrim"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Mcm_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Sic1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Mih1_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="IE_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc20_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdc20"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cdh1_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Cln"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="SBF_"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Swe1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="PSwe1"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="Swe1M"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="PSwe1M"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="BE"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="environment" component_1="M"/>
<map_variables variable_2="time" variable_1="time"/>
</connection>
<connection>
<map_components component_2="M" component_1="Clb2"/>
<map_variables variable_2="M" variable_1="M"/>
</connection>
<connection>
<map_components component_2="Cdh1_" component_1="Clb2"/>
<map_variables variable_2="Cdh1_" variable_1="Cdh1_"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cdc20_" component_1="Clb2"/>
<map_variables variable_2="Cdc20_" variable_1="Cdc20_"/>
</connection>
<connection>
<map_components component_2="Mcm_" component_1="Clb2"/>
<map_variables variable_2="Mcm_" variable_1="Mcm_"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="PClb2" component_1="Clb2"/>
<map_variables variable_2="PClb2" variable_1="PClb2"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Clb2"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Trim" component_1="Clb2"/>
<map_variables variable_2="Trim" variable_1="Trim"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cln" component_1="Clb2"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="Cdh1_" component_1="PClb2"/>
<map_variables variable_2="Cdh1_" variable_1="Cdh1_"/>
</connection>
<connection>
<map_components component_2="Cdc20_" component_1="PClb2"/>
<map_variables variable_2="Cdc20_" variable_1="Cdc20_"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="PClb2"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="PClb2" variable_1="PClb2"/>
</connection>
<connection>
<map_components component_2="PTrim" component_1="PClb2"/>
<map_variables variable_2="PTrim" variable_1="PTrim"/>
<map_variables variable_2="PClb2" variable_1="PClb2"/>
</connection>
<connection>
<map_components component_2="Cln" component_1="PClb2"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="Trim"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="Trim" variable_1="Trim"/>
</connection>
<connection>
<map_components component_2="Cln" component_1="Trim"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="Cdh1_" component_1="Trim"/>
<map_variables variable_2="Cdh1_" variable_1="Cdh1_"/>
</connection>
<connection>
<map_components component_2="Cdc20_" component_1="Trim"/>
<map_variables variable_2="Cdc20_" variable_1="Cdc20_"/>
</connection>
<connection>
<map_components component_2="PTrim" component_1="Trim"/>
<map_variables variable_2="PTrim" variable_1="PTrim"/>
<map_variables variable_2="Trim" variable_1="Trim"/>
</connection>
<connection>
<map_components component_2="Sic1" component_1="PTrim"/>
<map_variables variable_2="Sic1" variable_1="Sic1"/>
<map_variables variable_2="PTrim" variable_1="PTrim"/>
</connection>
<connection>
<map_components component_2="Cln" component_1="PTrim"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="PTrim"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cdh1_" component_1="PTrim"/>
<map_variables variable_2="Cdh1_" variable_1="Cdh1_"/>
</connection>
<connection>
<map_components component_2="Cdc20_" component_1="PTrim"/>
<map_variables variable_2="Cdc20_" variable_1="Cdc20_"/>
</connection>
<connection>
<map_components component_2="Mcm" component_1="Mcm_"/>
<map_variables variable_2="Mcm" variable_1="Mcm"/>
<map_variables variable_2="Mcm_" variable_1="Mcm_"/>
</connection>
<connection>
<map_components component_2="Cln" component_1="Sic1"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="Cdh1_" component_1="Sic1"/>
<map_variables variable_2="Cdh1_" variable_1="Cdh1_"/>
</connection>
<connection>
<map_components component_2="Cdc20_" component_1="Sic1"/>
<map_variables variable_2="Cdc20_" variable_1="Cdc20_"/>
</connection>
<connection>
<map_components component_2="Mih1" component_1="Mih1_"/>
<map_variables variable_2="Mih1" variable_1="Mih1"/>
<map_variables variable_2="Mih1_" variable_1="Mih1_"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Mih1_"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="IE" component_1="IE_"/>
<map_variables variable_2="IE" variable_1="IE"/>
<map_variables variable_2="IE_" variable_1="IE_"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="IE_"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="IE_" component_1="Cdc20_"/>
<map_variables variable_2="IE_" variable_1="IE_"/>
</connection>
<connection>
<map_components component_2="Cdc20" component_1="Cdc20_"/>
<map_variables variable_2="Cdc20" variable_1="Cdc20"/>
<map_variables variable_2="Cdc20_" variable_1="Cdc20_"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Cdc20"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="IE_" component_1="Cdc20"/>
<map_variables variable_2="IE_" variable_1="IE_"/>
</connection>
<connection>
<map_components component_2="Cln" component_1="Cdh1_"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="Cdc20_" component_1="Cdh1_"/>
<map_variables variable_2="Cdc20_" variable_1="Cdc20_"/>
</connection>
<connection>
<map_components component_2="Cdh1" component_1="Cdh1_"/>
<map_variables variable_2="Cdh1" variable_1="Cdh1"/>
<map_variables variable_2="Cdh1_" variable_1="Cdh1_"/>
</connection>
<connection>
<map_components component_2="SBF_" component_1="Cln"/>
<map_variables variable_2="SBF_" variable_1="SBF_"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="SBF" component_1="SBF_"/>
<map_variables variable_2="SBF" variable_1="SBF"/>
<map_variables variable_2="SBF_" variable_1="SBF_"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="SBF_"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="M" component_1="SBF_"/>
<map_variables variable_2="M" variable_1="M"/>
</connection>
<connection>
<map_components component_2="SBF_" component_1="Swe1"/>
<map_variables variable_2="SBF_" variable_1="SBF_"/>
</connection>
<connection>
<map_components component_2="BUD" component_1="Swe1"/>
<map_variables variable_2="BUD" variable_1="BUD"/>
</connection>
<connection>
<map_components component_2="Swe1M" component_1="Swe1"/>
<map_variables variable_2="Swe1M" variable_1="Swe1M"/>
<map_variables variable_2="Swe1" variable_1="Swe1"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Swe1"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="PSwe1" component_1="Swe1"/>
<map_variables variable_2="PSwe1" variable_1="PSwe1"/>
</connection>
<connection>
<map_components component_2="BUD" component_1="PSwe1"/>
<map_variables variable_2="BUD" variable_1="BUD"/>
</connection>
<connection>
<map_components component_2="PSwe1M" component_1="PSwe1"/>
<map_variables variable_2="PSwe1M" variable_1="PSwe1M"/>
<map_variables variable_2="PSwe1" variable_1="PSwe1"/>
</connection>
<connection>
<map_components component_2="BUD" component_1="Swe1M"/>
<map_variables variable_2="BUD" variable_1="BUD"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="Swe1M"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="PSwe1M" component_1="Swe1M"/>
<map_variables variable_2="PSwe1M" variable_1="PSwe1M"/>
<map_variables variable_2="Swe1M" variable_1="Swe1M"/>
</connection>
<connection>
<map_components component_2="BUD" component_1="PSwe1M"/>
<map_variables variable_2="BUD" variable_1="BUD"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="PSwe1M"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="Cln" component_1="BE"/>
<map_variables variable_2="Cln" variable_1="Cln"/>
</connection>
<connection>
<map_components component_2="Swe1" component_1="Swe1_total"/>
<map_variables variable_2="Swe1" variable_1="Swe1"/>
</connection>
<connection>
<map_components component_2="PSwe1" component_1="Swe1_total"/>
<map_variables variable_2="PSwe1" variable_1="PSwe1"/>
</connection>
<connection>
<map_components component_2="Swe1M" component_1="Swe1_total"/>
<map_variables variable_2="Swe1M" variable_1="Swe1M"/>
</connection>
<connection>
<map_components component_2="PSwe1M" component_1="Swe1_total"/>
<map_variables variable_2="PSwe1M" variable_1="PSwe1M"/>
</connection>
<connection>
<map_components component_2="BE" component_1="BUD"/>
<map_variables variable_2="BE" variable_1="BE"/>
</connection>
<connection>
<map_components component_2="Clb2" component_1="BUD"/>
<map_variables variable_2="Clb2" variable_1="Clb2"/>
</connection>
<connection>
<map_components component_2="kinetic_parameters" component_1="Clb2"/>
<map_variables variable_2="kd_clb_1" variable_1="kd_clb_1"/>
<map_variables variable_2="kd_clb_2" variable_1="kd_clb_2"/>
<map_variables variable_2="kd_clb_3" variable_1="kd_clb_3"/>
<map_variables variable_2="kswe" variable_1="kswe"/>
<map_variables variable_2="kmih" variable_1="kmih"/>
<map_variables variable_2="kass" variable_1="kass"/>
<map_variables variable_2="kdiss" variable_1="kdiss"/>
<map_variables variable_2="kd_sic" variable_1="kd_sic"/>
<map_variables variable_2="kd_sic_1" variable_1="kd_sic_1"/>
<map_variables variable_2="kd_sic_2" variable_1="kd_sic_2"/>
</connection>
<connection>
<map_components component_2="kinetic_parameters" component_1="PClb2"/>
<map_variables variable_2="kd_clb_1" variable_1="kd_clb_1"/>
<map_variables variable_2="kd_clb_2" variable_1="kd_clb_2"/>
<map_variables variable_2="kd_clb_3" variable_1="kd_clb_3"/>
<map_variables variable_2="kswe" variable_1="kswe"/>
<map_variables variable_2="kmih" variable_1="kmih"/>
<map_variables variable_2="kass" variable_1="kass"/>
<map_variables variable_2="kdiss" variable_1="kdiss"/>
<map_variables variable_2="kd_sic" variable_1="kd_sic"/>
<map_variables variable_2="kd_sic_1" variable_1="kd_sic_1"/>
<map_variables variable_2="kd_sic_2" variable_1="kd_sic_2"/>
</connection>
<connection>
<map_components component_2="kinetic_parameters" component_1="Trim"/>
<map_variables variable_2="kd_clb_1" variable_1="kd_clb_1"/>
<map_variables variable_2="kd_clb_2" variable_1="kd_clb_2"/>
<map_variables variable_2="kd_clb_3" variable_1="kd_clb_3"/>
<map_variables variable_2="kswe" variable_1="kswe"/>
<map_variables variable_2="kmih" variable_1="kmih"/>
<map_variables variable_2="kass" variable_1="kass"/>
<map_variables variable_2="kdiss" variable_1="kdiss"/>
<map_variables variable_2="kd_sic" variable_1="kd_sic"/>
<map_variables variable_2="kd_sic_1" variable_1="kd_sic_1"/>
<map_variables variable_2="kd_sic_2" variable_1="kd_sic_2"/>
</connection>
<connection>
<map_components component_2="kinetic_parameters" component_1="PTrim"/>
<map_variables variable_2="kd_clb_1" variable_1="kd_clb_1"/>
<map_variables variable_2="kd_clb_2" variable_1="kd_clb_2"/>
<map_variables variable_2="kd_clb_3" variable_1="kd_clb_3"/>
<map_variables variable_2="kswe" variable_1="kswe"/>
<map_variables variable_2="kmih" variable_1="kmih"/>
<map_variables variable_2="kass" variable_1="kass"/>
<map_variables variable_2="kdiss" variable_1="kdiss"/>
<map_variables variable_2="kd_sic" variable_1="kd_sic"/>
<map_variables variable_2="kd_sic_1" variable_1="kd_sic_1"/>
<map_variables variable_2="kd_sic_2" variable_1="kd_sic_2"/>
</connection>
<connection>
<map_components component_2="kinetic_parameters" component_1="Sic1"/>
<map_variables variable_2="kd_clb_1" variable_1="kd_clb_1"/>
<map_variables variable_2="kd_clb_2" variable_1="kd_clb_2"/>
<map_variables variable_2="kd_clb_3" variable_1="kd_clb_3"/>
<map_variables variable_2="kass" variable_1="kass"/>
<map_variables variable_2="kdiss" variable_1="kdiss"/>
<map_variables variable_2="kd_sic" variable_1="kd_sic"/>
<map_variables variable_2="kd_sic_1" variable_1="kd_sic_1"/>
<map_variables variable_2="kd_sic_2" variable_1="kd_sic_2"/>
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Mathematical Model of the Morphogenesis Checkpoint in Budding Yeast
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Ciliberto et al.'s 2003 mathematical model of the morphogenesis
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