Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This CellML version of the model has been checked in COR and OpenCell. The units are consistent and the model runs to recreate the published results. This is the tissue version of the model - to use this model embedded within tissue, set the initial value of the variable tissue in component Environment to 1.
Model Structure
In the paper described here, Thomas Hund and Yoram Rudy present a detailed, and physiologically realistic, mathematical model of a canine ventricular cell. Model simulations are able to recreate the rate-dependent phenomena associated with ion-channel kinetics, action potential properties, and calcium ion handling. The model is based on an epicardial myocyte because these cells contain the largest transient outward potassium current (when compared with endocardial or midmyocardial myocytes). The calcium/calmodulin-dependent protein kinase (CaMKII) regulatory pathway was embedded within the electrophysiological model, incorporating calcium-release formulation, calcium subspace, and dynamic chloride handling. Results from the model simulations revealed CaMKII is an important determinant of the rate dependence of the calcium transient, but not of the action potential duration, which depends instead on the ion-channel kinetics.
The complete original paper reference is cited below:
Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model, Thomas J. Hund and Yoram Rudy, 2004,Circulation,
110, 3168-3174. PubMed ID: 15505083
James Lawson
Yoram
Rudy
Penny
Noble
J
Oxford University
Dept of Physiology, Anatomy & Genetics
2007-09-11T00:00:00+00:00
Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model (Tissue Model)
Oxford University
keyword
electrophysiology
cardiac electrophysiology
ventricular
myocyte
ventricular
penny.noble@dpag.ox.ac.uk
15505083
10000
10000
0.01
bdf15
Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model
110(20)
3168
3174
Circulation
Thomas
Hund
J
This file is known to run in COR and PCEnv and reproduces the published results.
2004-11-16 00:00
This file is a CellML description of Hund & Rudy's canine cardiac ventricular model from the paper "Rate Dependence and Regulation of Action Potential and Calcium Transient in a Canine Cardiac Ventricular Cell Model"
James Lawson