- Author:
- rmollero <rochmollero@hotmail.com>
- Date:
- 2016-12-23 14:29:18+01:00
- Desc:
- Changed default values
- Permanent Source URI:
- https://models.cellml.org/workspace/44c/rawfile/da53741e15d2076dc46891c248cc6a6f9a5ce485/README.md
This model is a simplified "0D" version of the 3D electromechanical cardiac model developed at **Inria Sophia Antipolis - Asclepios Team**.
It describes the mechanical behaviour of a single ventricle of the heart, based on the Bestel-Clement-Sorine model of myocardial tissue and the Mooney-Rivlin equations for passive elasticity. Hemodynamics are represented through global values of pressures and flows in the cardiac chambers. The mechanical equations are coupled to the 3-element Windkessel for the after-load. Finally the cardiac pre-load is modeled by a (prescribed) varying atrial pressure with a "pressure bump" at the beginning of the cardiac cycle to account for atrial contraction.
Due to the difference of description language and procedural language, some features related to the heart valve dynamics rely currently on an unorthodox implementation of the equations. As a consequence, this CellMl code needs a specific configuration of OpenCOR to run. Namely, the solver has to be the **Euler (forward) solver** with a step of **1e-5**.
We recommend also the default configuration which simulate 3 heartbeats with the current parameters:
- **Ending point** : 2.4
- **Point Interval** : 0.001
And one also can display the following classic curves :
- **Volume curve in milliliters** : V_mL (Plot against variable of integration)
- **Ventricular, Atrial and Aortic Pressures curves** : P_v,P_at,P_ar (Plot against variable of integration)
- **PV Curve** : P_v (Plot against V_mL)
In particular both the SedMl file (HOD.sedml) and the COMBINE archive file (HOD.omex) contain exactly this configuration and can be readily exploited with OpenCOR 0.5 (available at http://www.opencor.ws/downloads).
**Contact**: Roch MOLLERO at rochmollero@hotmail.com
