- Author:
- Soroush <ssaf006@aucklanduni.ac.nz>
- Date:
- 2017-03-24 16:00:30+13:00
- Desc:
- adding adipose level
- Permanent Source URI:
- https://models.cellml.org/workspace/483/rawfile/272d946236ed831038e85b89e8503bdeb586e1f0/Hierarchical.cellml
<?xml version='1.0'?>
<model name="main1" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="Units.cellml">
<units name="l_per_kg" units_ref="l_per_kg"/>
<units name="per_s" units_ref="per_s"/>
<units name="s_kg_per_pmol" units_ref="s_kg_per_pmol"/>
<units name="mg" units_ref="mg"/>
<units name="per_mg" units_ref="per_mg"/>
<units name="mg_per_kg_s" units_ref="mg_per_kg_s"/>
<units name="mg_l_per_kg_s_pmol" units_ref="mg_l_per_kg_s_pmol"/>
<units name="mg_per_s_pmol" units_ref="mg_per_s_pmol"/>
<units name="mg_per_kg" units_ref="mg_per_kg"/>
<units name="pmol_l_per_kg_mg" units_ref="pmol_l_per_kg_mg"/>
<units name="pmol_l_per_kg_mg_s" units_ref="pmol_l_per_kg_mg_s"/>
<units name="pmol_per_kg" units_ref="pmol_per_kg"/>
<units name="pmol_per_l" units_ref="pmol_per_l"/>
<units name="mg_per_l" units_ref="mg_per_l"/>
<units name="pmol_per_kg_s" units_ref="pmol_per_kg_s"/>
<units name="l_per_mol_s" units_ref="l_per_mol_s"/>
<units name="mol_per_l" units_ref="mol_per_l"/>
</import>
<import xlink:href="Parameters.cellml">
<component component_ref="param1" name="param1"/>
</import>
<import xlink:href="Parameters.cellml">
<component component_ref="param2" name="param2"/>
</import>
<import xlink:href="Parameters.cellml">
<component component_ref="param3" name="param3"/>
</import>
<import xlink:href="1-WholeBodyLevel.cellml">
<component component_ref="state" name="WholeBodyLevel"/>
</import>
<import xlink:href="2-AdiposeTissueLevel.cellml">
<component component_ref="state" name="AdiposeTissueLevel"/>
</import>
<import xlink:href="3-InsulinBindingLevel.cellml">
<component component_ref="state" name="InsulinBindingLevel"/>
</import>
<component name="environment">
<variable name="time" public_interface="out" units="second"/>
</component>
<component name="WholeBody">
<variable name="INS" public_interface="in" units="pmol_per_l"/>
<variable name="G" public_interface="in" units="mg_per_l"/>
</component>
<component name="Tissue">
<variable name="vglucoseuptake" public_interface="in" units="mg_per_kg_s"/>
<variable name="IRS1" public_interface="in" units="dimensionless"/>
<variable name="IRS1iP" public_interface="in" units="dimensionless"/>
</component>
<connection>
<map_components component_1="WholeBodyLevel" component_2="AdiposeTissueLevel"/>
<map_variables variable_1="INS" variable_2="INS"/>
<map_variables variable_1="G_t" variable_2="G_t"/>
<map_variables variable_1="vglucoseuptake" variable_2="vglucoseuptake"/>
</connection>
<connection>
<map_components component_1="WholeBodyLevel" component_2="InsulinBindingLevel"/>
<map_variables variable_1="INS" variable_2="INS"/>
</connection>
<connection>
<map_components component_1="AdiposeTissueLevel" component_2="InsulinBindingLevel"/>
<map_variables variable_1="r1x2" variable_2="r1x2"/>
<map_variables variable_1="r11x2" variable_2="r11x2"/>
<map_variables variable_1="r1x22" variable_2="r1x22"/>
<map_variables variable_1="r1x22d" variable_2="r1x22d"/>
<map_variables variable_1="r11x22" variable_2="r11x22"/>
<map_variables variable_1="rendP" variable_2="rendP"/>
<map_variables variable_1="rPbasal" variable_2="rPbasal"/>
<map_variables variable_1="X_P" variable_2="X_P"/>
</connection>
<connection>
<map_components component_1="WholeBodyLevel" component_2="param1"/>
<map_variables variable_1="V_G" variable_2="V_G"/>
<map_variables variable_1="k_1" variable_2="k_1"/>
<map_variables variable_1="k_2" variable_2="k_2"/>
<map_variables variable_1="U_ii" variable_2="U_ii"/>
<map_variables variable_1="V_I" variable_2="V_I"/>
<map_variables variable_1="m_1" variable_2="m_1"/>
<map_variables variable_1="m_2" variable_2="m_2"/>
<map_variables variable_1="m_4" variable_2="m_4"/>
<map_variables variable_1="m_5" variable_2="m_5"/>
<map_variables variable_1="m_6" variable_2="m_6"/>
<map_variables variable_1="k_max" variable_2="k_max"/>
<map_variables variable_1="k_min" variable_2="k_min"/>
<map_variables variable_1="k_abs" variable_2="k_abs"/>
<map_variables variable_1="k_gri" variable_2="k_gri"/>
<map_variables variable_1="f" variable_2="f"/>
<map_variables variable_1="b" variable_2="b"/>
<map_variables variable_1="d" variable_2="d"/>
<map_variables variable_1="BW" variable_2="BW"/>
<map_variables variable_1="D" variable_2="D"/>
<map_variables variable_1="k_p1" variable_2="k_p1"/>
<map_variables variable_1="k_p2" variable_2="k_p2"/>
<map_variables variable_1="k_p3" variable_2="k_p3"/>
<map_variables variable_1="k_p4" variable_2="k_p4"/>
<map_variables variable_1="k_i" variable_2="k_i"/>
<map_variables variable_1="V_m0" variable_2="V_m0"/>
<map_variables variable_1="V_mX" variable_2="V_mX"/>
<map_variables variable_1="K_m0" variable_2="K_m0"/>
<map_variables variable_1="p_2U" variable_2="p_2U"/>
<map_variables variable_1="part" variable_2="part"/>
<map_variables variable_1="I_b" variable_2="I_b"/>
<map_variables variable_1="K" variable_2="K"/>
<map_variables variable_1="alpha" variable_2="alpha"/>
<map_variables variable_1="beta" variable_2="beta"/>
<map_variables variable_1="gamma" variable_2="gamma"/>
<map_variables variable_1="S_b" variable_2="S_b"/>
<map_variables variable_1="G_b" variable_2="G_b"/>
</connection>
<connection>
<map_components component_1="AdiposeTissueLevel" component_2="param2"/>
<map_variables variable_1="k21" variable_2="k21"/>
<map_variables variable_1="k22" variable_2="k22"/>
<map_variables variable_1="k23" variable_2="k23"/>
<map_variables variable_1="k24" variable_2="k24"/>
<map_variables variable_1="k2b" variable_2="k2b"/>
<map_variables variable_1="k3f" variable_2="k3f"/>
<map_variables variable_1="k3b" variable_2="k3b"/>
<map_variables variable_1="k4f" variable_2="k4f"/>
<map_variables variable_1="k4b" variable_2="k4b"/>
<map_variables variable_1="k5f" variable_2="k5f"/>
<map_variables variable_1="k5b" variable_2="k5b"/>
<map_variables variable_1="k6f" variable_2="k6f"/>
<map_variables variable_1="k6b" variable_2="k6b"/>
<map_variables variable_1="k7f" variable_2="k7f"/>
<map_variables variable_1="k7b" variable_2="k7b"/>
<map_variables variable_1="k8f" variable_2="k8f"/>
<map_variables variable_1="k8b" variable_2="k8b"/>
<map_variables variable_1="k91" variable_2="k91"/>
<map_variables variable_1="k9b" variable_2="k9b"/>
<map_variables variable_1="k92" variable_2="k92"/>
<map_variables variable_1="k5BasicWb" variable_2="k5BasicWb"/>
<map_variables variable_1="k_glut1" variable_2="k_glut1"/>
<map_variables variable_1="k_glut4" variable_2="k_glut4"/>
<map_variables variable_1="KmG1" variable_2="KmG1"/>
<map_variables variable_1="KmG4" variable_2="KmG4"/>
<map_variables variable_1="kbf" variable_2="kbf"/>
</connection>
<connection>
<map_components component_1="InsulinBindingLevel" component_2="param3"/>
<map_variables variable_1="a1" variable_2="a1"/>
<map_variables variable_1="a2" variable_2="a2"/>
<map_variables variable_1="d1" variable_2="d1"/>
<map_variables variable_1="d2" variable_2="d2"/>
<map_variables variable_1="K_cr" variable_2="K_cr"/>
<map_variables variable_1="K_ex" variable_2="K_ex"/>
<map_variables variable_1="K_end" variable_2="K_end"/>
<map_variables variable_1="K_dp" variable_2="K_dp"/>
<map_variables variable_1="K_cat" variable_2="K_cat"/>
<map_variables variable_1="K_m" variable_2="K_m"/>
<map_variables variable_1="kfbasal" variable_2="kfbasal"/>
<map_variables variable_1="krbasal" variable_2="krbasal"/>
<map_variables variable_1="K4" variable_2="K4"/>
<map_variables variable_1="K8" variable_2="K8"/>
</connection>
<connection>
<map_components component_1="environment" component_2="WholeBodyLevel"/>
<map_variables variable_1="time" variable_2="t"/>
</connection>
<connection>
<map_components component_1="environment" component_2="AdiposeTissueLevel"/>
<map_variables variable_1="time" variable_2="t"/>
</connection>
<connection>
<map_components component_1="environment" component_2="InsulinBindingLevel"/>
<map_variables variable_1="time" variable_2="t"/>
</connection>
<connection>
<map_components component_1="WholeBody" component_2="WholeBodyLevel"/>
<map_variables variable_1="INS" variable_2="INS"/>
<map_variables variable_1="G" variable_2="G"/>
</connection>
<connection>
<map_components component_1="Tissue" component_2="AdiposeTissueLevel"/>
<map_variables variable_1="vglucoseuptake" variable_2="vglucoseuptake"/>
</connection>
<connection>
<map_components component_1="Tissue" component_2="AdiposeTissueLevel"/>
<map_variables variable_1="IRS1" variable_2="IRS1"/>
<map_variables variable_1="IRS1iP" variable_2="IRS1iP"/>
</connection>
</model>
