- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2017-11-30 15:35:25+13:00
- Desc:
- rename variables to valid CellML identifiers
- Permanent Source URI:
- https://models.cellml.org/workspace/4e3/rawfile/05b3384ebffa15c5270486a6b9249a3360e34ebf/Kapela_VSM.cellml
<?xml version="1.0" encoding="UTF-8"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:semsim="http://www.bhi.washington.edu/SemSim#" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" name="Kapela_VSM">
<units name="amp">
<unit units="ampere"/>
</units>
<units name="nanosiemens_picofarad">
<unit units="siemens" prefix="nano"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="cm3__s">
<unit units="metre" prefix="centi" exponent="3"/>
<unit units="second" prefix="-1"/>
</units>
<units name="per__mol">
<unit units="mole" exponent="-1"/>
</units>
<units name="mol">
<unit units="mole"/>
</units>
<units name="J_s_cm2">
<unit units="joule"/>
<unit units="second"/>
<unit units="metre" prefix="centi" exponen="2"/>
</units>
<units name="mol2__per__J_s_cm2">
<unit units="mole" exponent="2"/>
<unit units="J_s_cm2" exponent="-1"/>
</units>
<units name="mM_per_ms">
<unit units="mM"/>
<unit units="ms" exponent="-1"/>
</units>
<units name="per__mol_picoliter">
<unit units="mole" exponent="-1"/>
<unit units="litre" prefix="pico" exponent="-1"/>
</units>
<units name="degK">
<unit units="kelvin"/>
</units>
<units name="per__ms_mM2">
<unit units="ms" exponent="-1"/>
<unit units="mM" exponent="-2"/>
</units>
<units name="K">
<unit units="kelvin"/>
</units>
<units name="picofarad__cm2">
<unit units="farad" prefix="pico"/>
<unit units="cm" exponent="-2"/>
</units>
<units name="per__msec">
<unit units="ms" exponent="-1"/>
</units>
<units name="picoampere_per_picofarad">
<unit units="ampere" prefix="pico"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="coulomb_mV__per__K_mol">
<unit units="coulomb"/>
<unit units="mV"/>
<unit units="K" exponent="-1"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="mM__per__ms__per__msec">
<unit units="mM"/>
<unit units="msec"/>
<unit units="ms" exponent="-1"/>
</units>
<units name="mV__per__msec">
<unit units="mV"/>
<unit units="msec" exponent="-1"/>
</units>
<units name="coulomb__per__mol">
<unit units="coulomb"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="per__ms">
<unit units="ms" exponent="-1"/>
</units>
<units name="per__cm2">
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units name="mM__per__msec">
<unit units="mM"/>
<unit units="msec" exponent="-1"/>
</units>
<units name="uM">
<unit units="mole" prefix="micro"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="coulomb_mV__per__mol">
<unit units="coulomb"/>
<unit units="mV"/>
<unit units="mole" exponent="-1"/>
</units>
<units name="mM2__">
<unit units="mM" exponent="2"/>
</units>
<units name="msec">
<unit units="second" prefix="milli"/>
</units>
<units name="per__mV">
<unit units="mV" exponent="-1"/>
</units>
<units name="per_ms__per_mol__picoliter__mM">
<unit units="ms" exponent="-1"/>
<unit units="mole" exponent="-1"/>
<unit units="litre" prefix="pico"/>
<unit units="mM"/>
</units>
<units name="mV">
<unit units="volt" prefix="milli"/>
</units>
<units name="cm__per__s">
<unit units="metre" prefix="centi"/>
<unit units="second" exponent="-1"/>
</units>
<units name="nanosiemens">
<unit units="siemens" prefix="nano"/>
</units>
<units name="ms">
<unit units="second" prefix="milli"/>
</units>
<units name="per__ms_mM">
<unit units="ms" exponent="-1"/>
<unit units="mM" exponent="-1"/>
</units>
<units name="m">
<unit units="metre"/>
</units>
<units name="mM">
<unit units="mole" prefix="milli"/>
<unit units="litre" prefix="" exponent="-1"/>
</units>
<units name="picoliter">
<unit units="litre" prefix="pico"/>
</units>
<units name="picoampere">
<unit units="ampere" prefix="pico"/>
</units>
<units name="kg">
<unit units="kilogram"/>
</units>
<units name="cm2__">
<unit units="metre" prefix="centi" exponent="2"/>
</units>
<units name="sec">
<unit units="second"/>
</units>
<units name="picofarad">
<unit units="farad" prefix="pico"/>
</units>
<component name="component_0">
<variable cmeta:id="I_VOCC" name="I_VOCC" units="picoampere" />
<variable cmeta:id="K_i0" name="K_i0" units="mM" />
<variable cmeta:id="p_K0" name="p_K0" units="dimensionless" />
<variable cmeta:id="p_s:time" name="p_s__time" units="per__msec" />
<variable cmeta:id="I_ClCa" name="I_ClCa" units="picoampere" />
<variable cmeta:id="k_m2sGC" name="k_m2sGC" units="per__ms" />
<variable cmeta:id="I_NCX" name="I_NCX" units="picoampere" />
<variable cmeta:id="k_DsGC" name="k_DsGC" units="per__ms" />
<variable cmeta:id="R_supSG:time" name="R_supSG__time" units="per__msec" />
<variable cmeta:id="tau_fL" name="tau_fL" units="ms" />
<variable cmeta:id="V_cGMP" initial_value="V_cGMP0" name="V_cGMP" units="mM_per_ms" />
<variable cmeta:id="tau_tr" name="tau_tr" units="ms" />
<variable cmeta:id="d_L" initial_value="d_L0" name="d_L" units="dimensionless" />
<variable cmeta:id="P_BKCa" name="P_BKCa" units="cm3__s" />
<variable cmeta:id="tau_SOC" name="tau_SOC" units="ms" />
<variable cmeta:id="R_110" name="R_110" units="dimensionless" />
<variable cmeta:id="I_Kv" name="I_Kv" units="picoampere" />
<variable cmeta:id="Vol_SRu" name="Vol_SRu" units="picoliter" />
<variable cmeta:id="h_IP3:time" name="h_IP3__time" units="per__msec" />
<variable cmeta:id="n_ClCa" name="n_ClCa" units="dimensionless" />
<variable cmeta:id="dbar_L" name="dbar_L" units="dimensionless" />
<variable cmeta:id="I_NSC" name="I_NSC" units="picoampere" />
<variable cmeta:id="Vol_SRr" name="Vol_SRr" units="picoliter" />
<variable cmeta:id="NO_0" name="NO_0" units="mM" />
<variable cmeta:id="R_10" initial_value="R_100" name="R_10" units="dimensionless" />
<variable cmeta:id="IK_NaKCl" name="IK_NaKCl" units="picoampere" />
<variable cmeta:id="R_11" initial_value="R_110" name="R_11" units="dimensionless" />
<variable cmeta:id="time.delta" name="time.delta" units="msec" />
<variable cmeta:id="R_cGMP" name="R_cGMP" units="dimensionless" />
<variable cmeta:id="I_PMCA" name="I_PMCA" units="picoampere" />
<variable cmeta:id="V_cGMP0" name="V_cGMP0" units="mM_per_ms" />
<variable cmeta:id="N_BKCa" name="N_BKCa" units="per__cm2" />
<variable cmeta:id="R_supSPG0" name="R_supSPG0" units="dimensionless" />
<variable cmeta:id="CSQNbar" name="CSQNbar" units="mM" />
<variable cmeta:id="ICa_NSC" name="ICa_NSC" units="picoampere" />
<variable cmeta:id="ICa_totm" name="ICa_totm" units="picoampere" />
<variable cmeta:id="p_K:time" name="p_K__time" units="per__msec" />
<variable cmeta:id="Na_dNai" name="Na_dNai" units="mM" />
<variable cmeta:id="z_Na" name="z_Na" units="dimensionless" />
<variable cmeta:id="K_ClCacGMP" name="K_ClCacGMP" units="mM" />
<variable cmeta:id="R_00" name="R_00" units="dimensionless" />
<variable cmeta:id="fbar_L" name="fbar_L" units="dimensionless" />
<variable cmeta:id="Pbar_SOC" name="Pbar_SOC" units="dimensionless" />
<variable cmeta:id="R_01" initial_value="R_010" name="R_01" units="dimensionless" />
<variable cmeta:id="V_50KCa" name="V_50KCa" units="mV" />
<variable cmeta:id="K_i" initial_value="K_i0" name="K_i" units="mM" />
<variable cmeta:id="NE" name="NE" units="mM" />
<variable cmeta:id="gamma_G" name="gamma_G" units="per__mol_picoliter" />
<variable cmeta:id="Na_i" initial_value="Na_i0" name="Na_i" units="mM" />
<variable cmeta:id="r_hG" name="r_hG" units="per__ms" />
<variable cmeta:id="C_m" name="C_m" units="picofarad" />
<variable cmeta:id="K_e" name="K_e" units="mM" />
<variable cmeta:id="P_SOC" initial_value="0" name="P_SOC" units="dimensionless" />
<variable cmeta:id="Na_e" name="Na_e" units="mM" />
<variable cmeta:id="K_mpde" name="K_mpde" units="mM" />
<variable cmeta:id="V_m:time" name="V_m__time" units="mV__per__msec" />
<variable cmeta:id="Ca_u0" name="Ca_u0" units="mM" />
<variable cmeta:id="R_010" name="R_010" units="dimensionless" />
<variable cmeta:id="Ibar_NaK" name="Ibar_NaK" units="picoampere_per_picofarad" />
<variable cmeta:id="DAG" name="DAG" units="mM" />
<variable cmeta:id="Ca_i" initial_value="Ca_i0" name="Ca_i" units="mM" />
<variable cmeta:id="n_HKe" name="n_HKe" units="dimensionless" />
<variable cmeta:id="n_ClcGMP" name="n_ClcGMP" units="dimensionless" />
<variable cmeta:id="f_L0" name="f_L0" units="dimensionless" />
<variable cmeta:id="NO" name="NO" units="mM" />
<variable cmeta:id="R_supSPG" initial_value="R_supSPG0" name="R_supSPG" units="dimensionless" />
<variable cmeta:id="Ca_r" initial_value="Ca_r0" name="Ca_r" units="mM" />
<variable cmeta:id="I_SOC" name="I_SOC" units="picoampere" />
<variable cmeta:id="B5_sGC" name="B5_sGC" units="mM" />
<variable cmeta:id="Ca_u" initial_value="Ca_u0" name="Ca_u" units="mM" />
<variable cmeta:id="alpha_Cl" name="alpha_Cl" units="dimensionless" />
<variable cmeta:id="Ibar_PMCA" name="Ibar_PMCA" units="picoampere" />
<variable cmeta:id="K_mup" name="K_mup" units="mM" />
<variable cmeta:id="E_K" name="E_K" units="mV" />
<variable cmeta:id="dV_50KCacGMP" name="dV_50KCacGMP" units="mV" />
<variable cmeta:id="P_Cl" name="P_Cl" units="dimensionless" />
<variable cmeta:id="R_supSPG:time" name="R_supSPG__time" units="per__msec" />
<variable cmeta:id="INa_SOC" name="INa_SOC" units="picoampere" />
<variable cmeta:id="Ca_e" name="Ca_e" units="mM" />
<variable cmeta:id="k_pdecGMP" name="k_pdecGMP" units="per__ms" />
<variable cmeta:id="V_m" initial_value="V_m0" name="V_m" units="mV" />
<variable cmeta:id="k_2sGC" name="k_2sGC" units="per__ms" />
<variable cmeta:id="K_2G" name="K_2G" units="mM" />
<variable cmeta:id="Cl_i0" name="Cl_i0" units="mM" />
<variable cmeta:id="R_11:time" name="R_11__time" units="per__msec" />
<variable cmeta:id="qbar" name="qbar" units="dimensionless" />
<variable cmeta:id="Q_10" name="Q_10" units="dimensionless" />
<variable cmeta:id="R_NO" name="R_NO" units="dimensionless" />
<variable cmeta:id="K_dB" name="K_dB" units="mM" />
<variable cmeta:id="Vol_Ca" name="Vol_Ca" units="picoliter" />
<variable cmeta:id="E_Ca" name="E_Ca" units="mV" />
<variable cmeta:id="q_2:time" name="q_2__time" units="per__msec" />
<variable cmeta:id="K_cG" name="K_cG" units="mM" />
<variable cmeta:id="f_L" initial_value="f_L0" name="f_L" units="dimensionless" />
<variable cmeta:id="INa_NaKCl" name="INa_NaKCl" units="picoampere" />
<variable cmeta:id="r_hG0" name="r_hG0" units="per_ms__per_mol__picoliter__mM" />
<variable cmeta:id="E_Cl" name="E_Cl" units="mV" />
<variable cmeta:id="I_rel" name="I_rel" units="picoampere" />
<variable cmeta:id="R_NO0" name="R_NO0" units="dimensionless" />
<variable cmeta:id="V_50KCa0" name="V_50KCa0" units="mV" />
<variable cmeta:id="k_m1sGC" name="k_m1sGC" units="per__ms" />
<variable cmeta:id="IK_totm" name="IK_totm" units="picoampere" />
<variable cmeta:id="K_1G" name="K_1G" units="mM" />
<variable cmeta:id="V_cGMP:time" name="V_cGMP__time" units="mM__per__ms__per__msec" />
<variable cmeta:id="PIP2:time" name="PIP2__time" units="per__msec" />
<variable cmeta:id="Ibar_SERCA" name="Ibar_SERCA" units="picoampere" />
<variable cmeta:id="R_leak" name="R_leak" units="dimensionless" />
<variable cmeta:id="INa_NSC" name="INa_NSC" units="picoampere" />
<variable cmeta:id="k_pG" name="k_pG" units="per__ms" />
<variable cmeta:id="I_BKCa" name="I_BKCa" units="picoampere" />
<variable cmeta:id="FRT" name="FRT" units="per__mV" />
<variable cmeta:id="ICl_totm" name="ICl_totm" units="picoampere" />
<variable cmeta:id="K_i:time" name="K_i__time" units="mM__per__msec" />
<variable cmeta:id="k_DrsGC" name="k_DrsGC" units="per__ms" />
<variable cmeta:id="time.max" name="time.max" units="msec" />
<variable cmeta:id="K_IP3" name="K_IP3" units="mM" />
<variable cmeta:id="p_s0" name="p_s0" units="dimensionless" />
<variable cmeta:id="I_NaK" name="I_NaK" units="picoampere" />
<variable cmeta:id="p_f:time" name="p_f__time" units="per__msec" />
<variable cmeta:id="k_3sGC" name="k_3sGC" units="per__ms_mM" />
<variable cmeta:id="Cl_i:time" name="Cl_i__time" units="mM__per__msec" />
<variable cmeta:id="z_Ca" name="z_Ca" units="dimensionless" />
<variable cmeta:id="RT" name="RT" units="coulomb_mV__per__mol" />
<variable cmeta:id="k_aG" name="k_aG" units="per__ms" />
<variable cmeta:id="INa_totm" name="INa_totm" units="picoampere" />
<variable cmeta:id="K_r2" name="K_r2" units="per__ms_mM" />
<variable cmeta:id="g_Kv" name="g_Kv" units="nanosiemens" />
<variable cmeta:id="g_ClCa" name="g_ClCa" units="nanosiemens_picofarad" />
<variable cmeta:id="K_dCM" name="K_dCM" units="mM" />
<variable cmeta:id="cGMP_i:time" name="cGMP_i__time" units="mM__per__msec" />
<variable cmeta:id="Ca_i0" name="Ca_i0" units="mM" />
<variable cmeta:id="K_r1" name="K_r1" units="per__ms_mM2" />
<variable cmeta:id="A1_sGC" name="A1_sGC" units="mM" />
<variable cmeta:id="I_SERCA" name="I_SERCA" units="picoampere" />
<variable cmeta:id="p_f" initial_value="p_f0" name="p_f" units="dimensionless" />
<variable cmeta:id="K_inhIP3" name="K_inhIP3" units="mM" />
<variable cmeta:id="cGMP_i" initial_value="cGMP_i0" name="cGMP_i" units="mM" />
<variable cmeta:id="k_rG" name="k_rG" units="per__ms" />
<variable cmeta:id="P_KCa" name="P_KCa" units="dimensionless" />
<variable cmeta:id="cGMP_i0" name="cGMP_i0" units="mM" />
<variable cmeta:id="f_L:time" name="f_L__time" units="per__msec" />
<variable cmeta:id="z_Cl" name="z_Cl" units="dimensionless" />
<variable cmeta:id="PK_NSC" name="PK_NSC" units="cm__per__s" />
<variable cmeta:id="I_Kleak" name="I_Kleak" units="picoampere" />
<variable cmeta:id="deltaG_0" name="deltaG_0" units="dimensionless" />
<variable cmeta:id="PIP2_T" name="PIP2_T" units="dimensionless" />
<variable cmeta:id="IP3:time" name="IP3__time" units="mM__per__msec" />
<variable cmeta:id="pbar_K" name="pbar_K" units="dimensionless" />
<variable cmeta:id="Sbar_CM" name="Sbar_CM" units="mM" />
<variable cmeta:id="p_K" initial_value="p_K0" name="p_K" units="dimensionless" />
<variable cmeta:id="xi_G" name="xi_G" units="dimensionless" />
<variable cmeta:id="L_NaKCl" name="L_NaKCl" units="mol2__per__J_s_cm2" />
<variable cmeta:id="G_0" name="G_0" units="dimensionless" />
<variable cmeta:id="K_mr1" name="K_mr1" units="per__ms" />
<variable cmeta:id="K_mr2" name="K_mr2" units="per__ms" />
<variable cmeta:id="gCa_SOC" name="gCa_SOC" units="nanosiemens" />
<variable cmeta:id="T" name="T" units="K" />
<variable cmeta:id="R" name="R" units="coulomb_mV__per__K_mol" />
<variable cmeta:id="Vol_i" name="Vol_i" units="picoliter" />
<variable cmeta:id="Q" name="Q" units="dimensionless" />
<variable cmeta:id="Vbar_cGMP" name="Vbar_cGMP" units="mM_per_ms" />
<variable cmeta:id="K_NSC" name="K_NSC" units="mM" />
<variable cmeta:id="F" name="F" units="coulomb__per__mol" />
<variable cmeta:id="G" initial_value="G_0" name="G" units="dimensionless" />
<variable cmeta:id="pbar_o" name="pbar_o" units="dimensionless" />
<variable cmeta:id="Cl_e" name="Cl_e" units="mM" />
<variable cmeta:id="I_tr" name="I_tr" units="picoampere" />
<variable cmeta:id="Cl_i" initial_value="Cl_i0" name="Cl_i" units="mM" />
<variable cmeta:id="R_NCXcGMP" name="R_NCXcGMP" units="dimensionless" />
<variable cmeta:id="k_1sGC" name="k_1sGC" units="per__ms_mM" />
<variable cmeta:id="dV_50KCaNO" name="dV_50KCaNO" units="mV" />
<variable cmeta:id="tau_q1" name="tau_q1" units="ms" />
<variable cmeta:id="P_SOC0" name="P_SOC0" units="dimensionless" />
<variable cmeta:id="k_degG" name="k_degG" units="per__ms" />
<variable cmeta:id="q_10" name="q_10" units="dimensionless" />
<variable cmeta:id="tau_pK" name="tau_pK" units="ms" />
<variable cmeta:id="k_dG" name="k_dG" units="per__ms" />
<variable cmeta:id="d_NCX" name="d_NCX" units="dimensionless" />
<variable cmeta:id="Bbar_F" name="Bbar_F" units="mM" />
<variable cmeta:id="h_IP30" name="h_IP30" units="dimensionless" />
<variable cmeta:id="E_Na" name="E_Na" units="mV" />
<variable cmeta:id="p_f0" name="p_f0" units="dimensionless" />
<variable cmeta:id="N_Avo" name="N_Avo" units="per__mol" />
<variable cmeta:id="Ibar_IP3" name="Ibar_IP3" units="per__ms" />
<variable cmeta:id="Na_i:time" name="Na_i__time" units="mM__per__msec" />
<variable cmeta:id="tau_q2" name="tau_q2" units="ms" />
<variable cmeta:id="q_1:time" name="q_1__time" units="per__msec" />
<variable cmeta:id="q_20" name="q_20" units="dimensionless" />
<variable cmeta:id="R_01:time" name="R_01__time" units="per__msec" />
<variable cmeta:id="K_SOC" name="K_SOC" units="mM" />
<variable cmeta:id="k_eG" name="k_eG" units="per__ms" />
<variable cmeta:id="time" name="time" units="msec" />
<variable cmeta:id="P_SOC:time" name="P_SOC__time" units="per__msec" />
<variable cmeta:id="p_s" initial_value="p_s0" name="p_s" units="dimensionless" />
<variable cmeta:id="tau_sGC" name="tau_sGC" units="ms" />
<variable cmeta:id="PCa_NSC" name="PCa_NSC" units="cm__per__s" />
<variable cmeta:id="tau_rel" name="tau_rel" units="ms" />
<variable cmeta:id="Ca_i:time" name="Ca_i__time" units="mM__per__msec" />
<variable cmeta:id="Ca_u:time" name="Ca_u__time" units="mM__per__msec" />
<variable cmeta:id="V_m0" name="V_m0" units="mV" />
<variable cmeta:id="d_L:time" name="d_L__time" units="per__msec" />
<variable cmeta:id="PIP2_0" name="PIP2_0" units="dimensionless" />
<variable cmeta:id="k_onIP3" name="k_onIP3" units="per__ms_mM" />
<variable cmeta:id="Ca_r0" name="Ca_r0" units="mM" />
<variable cmeta:id="ICa_SOC" name="ICa_SOC" units="picoampere" />
<variable cmeta:id="z_K" name="z_K" units="dimensionless" />
<variable cmeta:id="gamma_NCX" name="gamma_NCX" units="dimensionless" />
<variable cmeta:id="g_Kleak" name="g_Kleak" units="nanosiemens" />
<variable cmeta:id="IK_NSC" name="IK_NSC" units="picoampere" />
<variable cmeta:id="P_VOCC" name="P_VOCC" units="cm__per__s" />
<variable cmeta:id="rho_rG" name="rho_rG" units="dimensionless" />
<variable cmeta:id="ICl_NaKCl" name="ICl_NaKCl" units="picoampere" />
<variable cmeta:id="g_NCX" name="g_NCX" units="picoampere" />
<variable cmeta:id="A0_sGC" name="A0_sGC" units="mM2__" />
<variable cmeta:id="K_CSQN" name="K_CSQN" units="mM" />
<variable cmeta:id="R_10:time" name="R_10__time" units="per__msec" />
<variable cmeta:id="r_rG" name="r_rG" units="per__ms" />
<variable cmeta:id="IP3_0" name="IP3_0" units="mM" />
<variable cmeta:id="phi_R" name="phi_R" units="dimensionless" />
<variable cmeta:id="V_cGMPmax" name="V_cGMPmax" units="mM_per_ms" />
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<variable cmeta:id="K_mPMCA" name="K_mPMCA" units="mM" />
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<variable cmeta:id="n_HNai" name="n_HNai" units="dimensionless" />
<variable cmeta:id="K_ClcGMP" name="K_ClcGMP" units="uM" />
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<variable cmeta:id="K_ClCa" name="K_ClCa" units="mM" />
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<variable cmeta:id="alpha_G" name="alpha_G" units="per__ms" />
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<variable cmeta:id="I_IP3" name="I_IP3" units="picoampere" />
<variable cmeta:id="i_KCa" name="i_KCa" units="picoampere" />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<cn>1E-12</cn>
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<minus />
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<plus />
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<plus />
<ci>ICa_SOC</ci>
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<minus />
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<ci>alpha_Cl</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">4E-4</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<minus />
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<minus />
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<minus />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<apply>
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<plus />
<apply>
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<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
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<ci>I_BKCa</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>.66</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>.9955</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>2.3083</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci>IP3</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<apply>
<divide />
<apply>
<divide />
<apply>
<minus />
<apply>
<minus />
<apply>
<plus />
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<ci>I_SERCA</ci>
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<apply>
<times />
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<plus />
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<plus />
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<apply>
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<ci>K_dCM</ci>
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<power />
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<ci>Ca_i</ci>
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<divide />
<apply>
<times />
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<ci>K_dB</ci>
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<power />
<apply>
<plus />
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<ci>Ca_i</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>3.3</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
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<apply>
<plus />
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<apply>
<exp />
<apply>
<divide />
<apply>
<plus />
<ci>V_m0</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">42</cn>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">9.1</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
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<minus />
<apply>
<divide />
<apply>
<times />
<ci>k_pG</ci>
<ci>R_supSG</ci>
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<plus />
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<divide />
<apply>
<times />
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<ci>R_supSPG</ci>
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<plus />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
<apply>
<divide />
<apply>
<minus />
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<ci>I_rel</ci>
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<apply>
<times />
<apply>
<times />
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<ci>F</ci>
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<plus />
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<divide />
<apply>
<times />
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<ci>K_CSQN</ci>
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<power />
<apply>
<plus />
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<ci>Ca_r</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus />
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<ci>ICa_SOC</ci>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide />
<ci>k_2sGC</ci>
<ci>k_3sGC</ci>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide />
<apply>
<minus />
<apply>
<minus />
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<ci>I_tr</ci>
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<times />
<apply>
<times />
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<ci>F</ci>
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<ci>Vol_SRu</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
<apply>
<power />
<apply>
<divide />
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<apply>
<plus />
<apply>
<power />
<apply>
<divide />
<ci>cGMP_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">1</cn>
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<apply>
<power />
<apply>
<times />
<apply>
<divide />
<ci>K_ClcGMP</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>.001</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<apply>
<divide />
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<apply>
<times />
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<ci>FRT</ci>
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<log />
<apply>
<divide />
<ci>K_e</ci>
<ci>K_i</ci>
</apply>
</apply>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>76</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<plus />
<apply>
<times />
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<divide />
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">1</cn>
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<plus />
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<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">1</cn>
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<apply>
<power />
<apply>
<divide />
<ci>K_ClCa</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">1</cn>
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<ci>n_ClCa</ci>
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</apply>
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<apply>
<times />
<ci>alpha_Cl</ci>
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<divide />
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">1</cn>
</apply>
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<plus />
<apply>
<power />
<apply>
<divide />
<ci>Ca_i</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mM">1</cn>
</apply>
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<apply>
<power />
<apply>
<divide />
<ci>K_ClCacGMP</ci>
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</apply>
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</apply>
</apply>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
<ci>NE</ci>
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<minus />
<apply>
<divide />
<apply>
<times />
<ci>k_pG</ci>
<ci>R_supSG</ci>
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<apply>
<plus />
<ci>K_1G</ci>
<ci>NE</ci>
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<divide />
<apply>
<times />
<ci>k_eG</ci>
<ci>R_supSPG</ci>
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<plus />
<ci>K_2G</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
<apply>
<times />
<ci>gNa_SOC</ci>
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<apply>
<minus />
<ci>V_m</ci>
<ci>E_Na</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>2</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>6.95E-5</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
<apply>
<divide />
<cn>1</cn>
<ci>C_m</ci>
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<plus />
<apply>
<times />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
<ci>I_VOCC</ci>
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<cn>59.4</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<plus />
<apply>
<minus />
<apply>
<times />
<apply>
<times />
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<times />
<apply>
<plus />
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<apply>
<times />
<ci>K_r1</ci>
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<ci>Ca_i</ci>
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<apply>
<plus />
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">14</cn>
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<plus />
<ci>NO</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<apply>
<divide />
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<log />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
<apply>
<minus />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
<apply>
<minus />
<ci>fbar_L</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<ci>ICl_NaKCl</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
<apply>
<times />
<apply>
<times />
<ci>k_degG</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<apply>
<divide />
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<log />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<apply>
<times />
<apply>
<times />
<apply>
<plus />
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<power />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
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<plus />
<ci>NO_0</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<minus />
<apply>
<minus />
<apply>
<minus />
<apply>
<times />
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<log />
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<ci>Ca_i0</ci>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">128.2</cn>
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<times />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<minus />
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<plus />
<apply>
<plus />
<apply>
<plus />
<apply>
<plus />
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<ci>I_NaK</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
<apply>
<minus />
<ci>Vbar_cGMP</ci>
<ci>V_cGMP</ci>
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<ci>tau_sGC</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<plus />
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<minus />
<apply>
<times />
<apply>
<times />
<apply>
<plus />
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<ci>r_rG</ci>
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<apply>
<times />
<apply>
<times />
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<times />
<ci>r_rG</ci>
<ci>PIP2_T</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>1.07E-5</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>A_m</ci>
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<plus />
<apply>
<divide />
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<plus />
<ci>DAG</ci>
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<ci>d_NSCmin</ci>
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<ci>PNa_NSC</ci>
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<ci>V_m</ci>
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<ci>Na_i</ci>
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<apply>
<times />
<ci>V_m</ci>
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<minus />
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<exp />
<apply>
<times />
<ci>V_m</ci>
<ci>FRT</ci>
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</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>1E-4</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<apply>
<times />
<apply>
<times />
<ci>A_m</ci>
<ci>N_BKCa</ci>
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<ci>P_KCa</ci>
</apply>
<ci>i_KCa</ci>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide />
<ci>F</ci>
<ci>RT</ci>
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<ci>d_L</ci>
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<ci>tau_dL</ci>
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<ci>E_Ca</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>.067</cn>
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<times />
<apply>
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<apply>
<times />
<apply>
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<apply>
<times />
<apply>
<times />
<apply>
<times />
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<plus />
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<divide />
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<plus />
<ci>DAG</ci>
<ci>K_NSC</ci>
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<ci>K_i</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>1.88E-5</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
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<times />
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<ci>R_supSG</ci>
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<times />
<apply>
<times />
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<apply>
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<times />
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<ci>K_e</ci>
<ci>K_i</ci>
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<divide />
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<ci>Cl_i</ci>
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<cn>-1E9</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>4.87E-4</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<divide />
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<plus />
<apply>
<times />
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<ci>k_2sGC</ci>
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<ci>k_m2sGC</ci>
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<ci>k_3sGC</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<plus />
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<minus />
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<times />
<apply>
<times />
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<ci>R_11</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>1.26E-7</cn>
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<ci>xi_G</ci>
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<minus />
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<apply>
<times />
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<divide />
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<divide />
<apply>
<minus />
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<times />
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<ci>K_CSQN</ci>
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<power />
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<cn>35.9</cn>
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<cn>5.11E-7</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<plus />
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<minus />
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<times />
<apply>
<times />
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<times />
<apply>
<times />
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<cn>.0132</cn>
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<cn>.0575</cn>
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<cn>8.4</cn>
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<cn>.0244</cn>
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<cn>3.65E-4</cn>
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<plus />
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<times />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="ms">2.5</cn>
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<ci>V_m</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<minus />
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<minus />
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<times />
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<ci>NE</ci>
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<ci>R_supSPG</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<ci>cGMP_i</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<minus />
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<times />
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<ci>IP3</ci>
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<ci>C_m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="picofarad__cm2">1E6</cn>
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<cn>1.6</cn>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<plus />
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<plus />
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<divide />
<apply>
<minus />
<ci>V_m</ci>
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">47.12</cn>
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<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mV">24.24</cn>
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</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide />
<apply>
<power />
<ci>cGMP_i0</ci>
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<plus />
<apply>
<power />
<ci>cGMP_i0</ci>
<cn>2</cn>
</apply>
<apply>
<times />
<apply>
<power />
<cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="uM">5.5E-4</cn>
<cn>2</cn>
</apply>
<cn>1E-6</cn>
</apply>
</apply>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>1E5</cn>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<cn>2.781E-8</cn>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide />
<apply>
<minus />
<ci>qbar</ci>
<ci>q_2</ci>
</apply>
<ci>tau_q2</ci>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<divide />
<apply>
<minus />
<ci>qbar</ci>
<ci>q_1</ci>
</apply>
<ci>tau_q1</ci>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus />
<apply>
<times />
<apply>
<times />
<ci>k_aG</ci>
<apply>
<plus />
<ci>deltaG_0</ci>
<ci>rho_rG</ci>
</apply>
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<apply>
<minus />
<ci>G_TG</ci>
<ci>G</ci>
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<apply>
<times />
<ci>k_dG</ci>
<ci>G</ci>
</apply>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
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<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>Ibar_IP3</ci>
<ci>z_Ca</ci>
</apply>
<ci>Vol_Ca</ci>
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<ci>F</ci>
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<power />
<apply>
<times />
<apply>
<times />
<apply>
<divide />
<ci>IP3</ci>
<apply>
<plus />
<ci>IP3</ci>
<ci>K_IP3</ci>
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<apply>
<divide />
<ci>Ca_i</ci>
<apply>
<plus />
<ci>Ca_i</ci>
<ci>K_actIP3</ci>
</apply>
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</apply>
<ci>h_IP3</ci>
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<apply>
<minus />
<ci>Ca_u</ci>
<ci>Ca_i</ci>
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<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times />
<apply>
<divide />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<apply>
<times />
<ci>P_BKCa</ci>
<ci>V_m</ci>
</apply>
<ci>F</ci>
</apply>
<ci>FRT</ci>
</apply>
<apply>
<minus />
<ci>K_e</ci>
<apply>
<times />
<ci>K_i</ci>
<apply>
<exp />
<apply>
<times />
<ci>V_m</ci>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus />
<cn>1</cn>
<apply>
<exp />
<apply>
<times />
<ci>V_m</ci>
<ci>FRT</ci>
</apply>
</apply>
</apply>
</apply>
<cn>1E6</cn>
</apply>
</math>
</component>
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<rdf:Description rdf:about="#Ibar_SERCA">
<dcterms:description>Total cell sarcoplasmic/endoplasmic reticulum calcium ATPase maximal current</dcterms:description>
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<dcterms:description>Rate of change of IP3 receptor activation gate open probability</dcterms:description>
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<dcterms:description>Rate of change of number of phosporylated alpha adrenoreceptors</dcterms:description>
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<dcterms:description>L-type calcium channel inactivation gate open probability</dcterms:description>
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<dcterms:description>Initial voltage gated potassium channel slow activation gate open probability</dcterms:description>
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<dcterms:description>Sodium-calcium exchanger sensitivity factor</dcterms:description>
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<rdf:Description rdf:about="#cGMP_i0">
<dcterms:description>Initial intracellular cGMP concentration</dcterms:description>
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<rdf:Description rdf:about="#R_leak">
<dcterms:description>Ryanodine receptor calcium leak factor</dcterms:description>
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<rdf:Description rdf:about="#k_3sGC">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation rate constant</dcterms:description>
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<rdf:Description rdf:about="#R_NCXcGMP">
<dcterms:description>Sodium/calcium exchanger cyclic GMP sensitivity</dcterms:description>
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<rdf:Description rdf:about="#K_ClcGMP">
<dcterms:description>Calcium activated chloride channel cyclic GMP activation effective concentration at 50% maximal response</dcterms:description>
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<dcterms:description>F over RT coefficient</dcterms:description>
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<semsim:name>Portion of the cytosol available to calcium</semsim:name>
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<dcterms:description>Cytosolic volume available to calcium</dcterms:description>
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<dcterms:description>Large conductance calcium activated potassium channel slow activation gate open probability</dcterms:description>
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<dcterms:description>Total cell plasma membrane potassium current</dcterms:description>
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<dcterms:description>Initial voltage gated potassium channel fast activation gate open probability</dcterms:description>
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<dcterms:description>Total cell plasma membrane chloride current</dcterms:description>
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<dcterms:description>Nernst potential for sodium</dcterms:description>
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<semsim:physicalPropertyOf>
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<dcterms:description>Voltage gated potassium channel fast activation gate open probability</dcterms:description>
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<dcterms:description>Total cytosolic volume</dcterms:description>
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<rdf:Description rdf:about="#R_ClcGMPmin">
<dcterms:description>Calcium activated chloride channel cyclic GMP independent factor</dcterms:description>
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<rdf:Description rdf:about="#pbar_o">
<dcterms:description>Voltage gated potassium channel fast and slow activation gate steady state open probability</dcterms:description>
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29103" />
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular potassium concentration</dcterms:description>
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<rdf:Description rdf:about="#R">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01705" />
<dcterms:description>Ideal gas constant</dcterms:description>
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<dcterms:description>Calcium activated chloride channel cyclic GMP sensitivity parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#r_hG">
<dcterms:description>Inositol trisphosphate and PIP2 baseline production rate factor</dcterms:description>
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<rdf:Description rdf:about="#time.max">
<dcterms:description>Simulation end time</dcterms:description>
</rdf:Description>
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<dcterms:description>Initial number of active G proteins</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_100">
<dcterms:description>Initial ryanodine receptor state with calcium bound to the activation site</dcterms:description>
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<rdf:Description rdf:about="#k_aG">
<dcterms:description>G protein activation rate</dcterms:description>
</rdf:Description>
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<dcterms:description>Rate of change of intracellular potassium concentration</dcterms:description>
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<rdf:Description rdf:about="#gCa_SOC">
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<rdf:Description rdf:about="#property_41">
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<rdf:Description rdf:about="#entity_37">
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<semsim:name>Store operated cation channel</semsim:name>
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<dcterms:description>Store operated cation channel maximal calcium conductance</dcterms:description>
</rdf:Description>
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<dcterms:description>Rate of change of number of active G proteins</dcterms:description>
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<rdf:Description rdf:about="#R_cGMP">
<dcterms:description>Large conductance calcium activated potassium channel cyclic GMP sensitivity factor</dcterms:description>
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<rdf:Description rdf:about="#k_m2sGC">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation rate constant</dcterms:description>
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<rdf:Description rdf:about="#Pbar_SOC">
<dcterms:description>Store operated cation channel activation gate steady state open probability</dcterms:description>
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<dcterms:description>Total cell potassium leak channel current</dcterms:description>
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<rdf:Description rdf:about="#Vol_SRu">
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<dcterms:description>Sarcoplasmic reticulum volume associated with the SERCA uptake</dcterms:description>
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<rdf:Description rdf:about="#tau_SOC">
<dcterms:description>Store operated cation channel activaton gate time constant</dcterms:description>
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<dcterms:description>Sarcoplasmic reticulum release space calcium concentration</dcterms:description>
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</rdf:Description>
<rdf:Description rdf:about="#n_HNai">
<dcterms:description>Sodium/potassium ATPase intracellular sodium Hill coefficient</dcterms:description>
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<rdf:Description rdf:about="#V_cGMP">
<dcterms:description>Reaction velocity of cyclic GMP formation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_Cl">
<dcterms:description>Calcium activated chloride channel activation gate open probability</dcterms:description>
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<rdf:Description rdf:about="#q_2:time">
<dcterms:description>Rate of change of voltage gated potassium channel slow activation gate open probability</dcterms:description>
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<rdf:Description rdf:about="#K_r1">
<dcterms:description>Sarcoplasmic reticulum ryanodine receptor rate of calcium binding to activation site</dcterms:description>
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<rdf:Description rdf:about="#K_CSQN">
<dcterms:description>Binding affinity of calsequestrin in sarcoplasmic reticulum</dcterms:description>
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01581" />
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<dcterms:description>Nernst potential for calcium</dcterms:description>
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<rdf:Description rdf:about="#P_BKCa">
<dcterms:description>Large conductance calcium activated potassium channel permeability surface area product</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP2_0">
<dcterms:description>Initial number of cytosolic phosphatidylinositol 4,5-bisphosphate molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_rG">
<dcterms:description>Alpha adrenoceptor recycling rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_fL">
<dcterms:description>L-type calcium channel f_L gate time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ibar_NaK">
<dcterms:description>Total cell sodium/potassium ATPase maximal current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_dL">
<dcterms:description>L-type calcium channel d_L gate time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cGMP_i:time">
<dcterms:description>Rate of change of intracellular cGMP concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_NO0">
<dcterms:description>Initial large conductance calcium activated potassium channel nitric oxide sensitivity</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_i0">
<dcterms:description>Initial intracellular calcium concentraion</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_SOC0">
<dcterms:description>Initial store operated cation channel activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_01:time">
<dcterms:description>Rate of change of ryanodine receptor state with calcium bound to the inactivation site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_r2">
<dcterms:description>Sarcoplasmic reticulum ryanodine receptor rate of calcium binding to inactivation site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_NSC">
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<rdf:Description rdf:about="#property_5">
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</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_6" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_8">
<ro:part_of rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29101" />
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<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_5" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_3" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_7" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference>
<rdf:Description rdf:about="#entity_9">
<ro:part_of rdf:resource="#entity_23" />
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29103" />
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<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_6" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_7" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_5" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_0" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell nonselective cation channel current comprised of the calcium, potassium and sodium currents</dcterms:description>
<semsim:name>Total nonselective cation channel current</semsim:name>
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</semsim:isComputationalComponentFor>
<dcterms:description>Total cell nonselective cation channel current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#INa_NSC">
<dcterms:description>Total cell nonselective cation channel maximal sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#q_1:time">
<dcterms:description>Rate of change of voltage gated potassium channel fast activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#A1_sGC">
<dcterms:description>cGMP production rate term</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#qbar">
<dcterms:description>Voltage gated potassium channel fast and slow activation gate steady state open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phi_R">
<dcterms:description>Sodium/calcium exchanger reverse reaction rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#CSQNbar">
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<rdf:Description rdf:about="#property_10">
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<ro:part_of rdf:resource="#entity_2" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.org/sig/ont/fma/fma72448" />
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</ro:part_of>
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/PR_000005057" />
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Average sarcoplasmic reticulum calsequestrin concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_i">
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<rdf:Description rdf:about="#property_14">
<semsim:physicalPropertyOf rdf:resource="#entity_9" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
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</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular potassium concentration</dcterms:description>
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<rdf:Description rdf:about="#process_12">
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<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_17" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_34" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell transfer from SR matrix to SR cisternae calcium current</dcterms:description>
<semsim:name>Internal SR calcium current</semsim:name>
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<dcterms:description>Total cell transfer from SR matrix to SR cisternae calcium current</dcterms:description>
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<rdf:Description rdf:about="#K_inhIP3">
<dcterms:description>IP3 receptor calcium inhibition dissociation constant</dcterms:description>
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<rdf:Description rdf:about="#V_m0">
<dcterms:description>Initial vascular smooth muscle cell plasma membrane potential</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_010">
<dcterms:description>Initial ryanodine receptor state with calcium bound to the inactivation site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_01">
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<rdf:Description rdf:about="#property_13">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_19">
<ro:part_of rdf:resource="#entity_12" />
<semsim:name>Ryanodine receptor 2 with calcium bound to inactivation site</semsim:name>
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01298" />
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<dcterms:description>Ryanodine receptor state with calcium bound to the inactivation site</dcterms:description>
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<rdf:Description rdf:about="#PIP2:time">
<dcterms:description>Rate of change of number of cytosolic phosphatidylinositol 4,5-bisphosphate molecules</dcterms:description>
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<rdf:Description rdf:about="#tau_pf">
<dcterms:description>Large conductance calcium activated potassium channel fast activaton gate time constant</dcterms:description>
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<rdf:Description rdf:about="#k_DrsGC">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_dG">
<dcterms:description>G protein deactivation rate</dcterms:description>
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<rdf:Description rdf:about="#I_BKCa">
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<rdf:Description rdf:about="#property_33">
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<rdf:Description rdf:about="#process_9">
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<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_13" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total large conductance calcium activated potassium channel current</dcterms:description>
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<dcterms:description>Total cell large conductance calcium activated potassium channel current</dcterms:description>
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<rdf:Description rdf:about="#NE">
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<rdf:Description rdf:about="#entity_20">
<ro:part_of rdf:resource="#entity_4" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:33569" />
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<dcterms:description>Extracellular norepinephrine concentration</dcterms:description>
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<rdf:Description rdf:about="#IP3">
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<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:25450" />
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<dcterms:description>Intracellular inositol trisphosphate concentration</dcterms:description>
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<dcterms:description>IP3 receptor IP3 dissociation constant</dcterms:description>
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<rdf:Description rdf:about="#R_00">
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<rdf:Description rdf:about="#property_12">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_18">
<ro:part_of rdf:resource="#entity_12" />
<semsim:name>Ryanodine receptor 2 with no calcium bound</semsim:name>
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<dcterms:description>Ryanodine receptor state with no active site or inactive site calcium bond</dcterms:description>
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<rdf:Description rdf:about="#Ca_i">
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<rdf:Description rdf:about="#property_21">
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<dcterms:description>Intracellular calcium concentration</dcterms:description>
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<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00506" />
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<dcterms:description>Vascular smooth muscle cell plasma membrane potential</dcterms:description>
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<rdf:Description rdf:about="#I_ClCa">
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<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_1" semsim:hasMultiplier="1.0">
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<dcterms:description>Calicum activated chloride channel current</dcterms:description>
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<dcterms:description>Total cell calcium activated chloride channel current</dcterms:description>
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<dcterms:description>Avogadros number</dcterms:description>
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<dcterms:description>Ryanodine receptor calcium release time constant</dcterms:description>
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<rdf:Description rdf:about="#entity_15">
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<semsim:name>Ryanodine receptor 2 with calcium bound to both the activation and inactivation sites</semsim:name>
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<dcterms:description>Ryanodine receptor state with calcium bound to both the activation and inactivation sites</dcterms:description>
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<rdf:Description rdf:about="#I_NCX">
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<semsim:hasSinkParticipant>
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<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_3" semsim:hasMultiplier="3.0">
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<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_2" semsim:hasMultiplier="1.0">
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<dcterms:description>Rate of change of sarcoplasmic reticulum release space calcium concentration</dcterms:description>
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<dcterms:description>Large conductance calcium activated potassium channel maximal NO independent voltage shift at 50% response</dcterms:description>
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<dcterms:description>Sarcoplasmic/endoplasmic reticulum calcium ATPase Michaelis constant</dcterms:description>
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<rdf:Description rdf:about="#k_eG">
<dcterms:description>Alpha adrenoceptor endocytosis rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#DAG">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_20">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_22">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:18035" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Diacylglycerol concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_stim">
<dcterms:description>Input applied stimulation current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#N_BKCa">
<dcterms:description>Large conductance calcium activated potassium channel density per unit cell surface area</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Cl_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_47">
<semsim:physicalPropertyOf rdf:resource="#entity_5" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular chloride concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_10">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_7">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_14">
<ro:part_of rdf:resource="#entity_12" />
<semsim:name>Ryanodine receptor 2 with calcium bound to the activation site</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01298" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Ryanodine receptor state with calcium bound to the activation site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G_TG">
<dcterms:description>Total number of G proteins</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#INa_SOC">
<dcterms:description>Total cell store operated cation channel maximal sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Bbar_F">
<dcterms:description>Concentration of other Ca buffers</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#deltaG_0">
<dcterms:description>Alpha adrentoceptor tatio of activated unbound ligand</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_tr">
<dcterms:description>Sarcoplasmic reticulum internal rate of diffusion of calcium between uptake an release compartments</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#A_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_53">
<semsim:physicalPropertyOf rdf:resource="#entity_21" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01043" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Surface area of the smooth muscle cell</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_ClCa">
<dcterms:description>Calcium activated chloride channel calcium activation effective concentration at 50% maximal response</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#h_IP3">
<dcterms:description>IP3 receptor activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PNa_NSC">
<dcterms:description>Nonselective cation channel whole cell sodium permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_VOCC">
<dcterms:description>L-type calcium channel maximal calcium permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_SOC">
<dcterms:description>Store operated cation channel activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ICa_totm">
<dcterms:description>Total cell plasma membrane calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_supSPG">
<dcterms:description>Number of phosporylated alpha adrenoreceptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#dbar_L">
<dcterms:description>Voltage operated calcium channel d gate steady state open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_NO">
<dcterms:description>Large conductance calcium activated potassium channel nitric oxide sensitivity</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Q_10">
<dcterms:description>Sodium/calcium exchanger temperature correction multiplier</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Cl_i0">
<dcterms:description>Initial intracellular chloride concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_27">
<semsim:physicalPropertyOf rdf:resource="#entity_3" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular Ca concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_KCa">
<dcterms:description>Large conductance calcium activated potassium channel total open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_i:time">
<dcterms:description>Rate of change of intracellular calcium concentration with time</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_pK">
<dcterms:description>Voltage gated potassium channel activaton gate time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#IK_NSC">
<dcterms:description>Total cell nonselective cation channel maximal potassium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#r_rG">
<dcterms:description>PIP2 baseline production rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#p_K0">
<dcterms:description>Initial voltage gated potassium channel activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#time" dcterms:description="Time">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01023" />
</rdf:Description>
<rdf:Description rdf:about="#NO_0">
<dcterms:description>Initial intracellular nitric oxide concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_pdecGMP">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#pbar_K">
<dcterms:description>Voltage gated potassium channel activation gate steady state open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_onIP3">
<dcterms:description>IP3 receptor rate of calcium binding to inhibition site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#RT">
<dcterms:description>Product of ideal gas number and temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_u:time">
<dcterms:description>Rate of change of sarcoplasmic reticulum uptake space calcium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Cl_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_45">
<semsim:physicalPropertyOf rdf:resource="#entity_6" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular chloride concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_m1sGC">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#p_s:time">
<dcterms:description>Rate of change of large conductance calcium activated potassium channel slow activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_SOC">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_24">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_7">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_11" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_10" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_3" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_11" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_7" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_10" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_0" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell store operated cation channel current</dcterms:description>
<semsim:name>Store operated cation channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total cell store operated cation channel current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_supSG">
<dcterms:description>Number of unphosporylated alpha adrenoreceptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#fbar_L">
<dcterms:description>Steady state L-type calcium channel inactivation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#p_f">
<dcterms:description>Large conductance calcium activated potassium channel fast activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#g_Kleak">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_49">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_40">
<ro:part_of rdf:resource="#entity_21" />
<semsim:name>Potassium leak channel</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00015" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Potassium leak channel maximal conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#r_hG0">
<dcterms:description>Iniital inositol trisphosphate and PIP2 baseline production rate factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#i_KCa">
<dcterms:description>Single channel large conductance calcium activated potassium channel current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_degG">
<dcterms:description>IP3 degradation rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#d_L0">
<dcterms:description>Initial L-type calcium channel activation gate probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#n_HKe">
<dcterms:description>Sodium/potassium ATPase extracellular potassium Hill coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_sGC">
<dcterms:description>cyclic GMP rate of the reaction velocity time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_supSG0">
<dcterms:description>Initial number of unphosporylated alpha adrenoreceptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_mpde">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_mr2">
<dcterms:description>Sarcoplasmic reticulum ryanodine receptor rate of calcium unbinding from inactivation site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_NaK">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_34">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_10">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_15" semsim:hasMultiplier="2.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_14" semsim:hasMultiplier="3.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_8" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_15" semsim:hasMultiplier="2.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasSourceParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_14" semsim:hasMultiplier="3.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_7" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell sodium/potassium ATPase current</dcterms:description>
<semsim:name>Sodium/potassium ATPase current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total cell sodium/potassium ATPase current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_dB">
<dcterms:description>Nonspecific calcium buffer dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_DsGC">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Ca_r0">
<dcterms:description>Intitial sarcoplasmic reticulum release space calcium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_2sGC">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gNa_SOC">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_51">
<semsim:physicalPropertyOf rdf:resource="#entity_37" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00015" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Store operated cation channel maximal sodium conductance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_mr1">
<dcterms:description>Sarcoplasmic reticulum ryanodine receptor rate of calcium unbinding from activation site</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#NO">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_22">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_24">
<ro:part_of rdf:resource="#entity_23" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:16480" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular nitric oxide concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#V_cGMP0">
<dcterms:description>Initial reaction velocity of cyclic GMP formation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_cGMP0">
<dcterms:description>Large conductance calcium activated potassium channel cyclic GMP regulatory factor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#V_50KCa0">
<dcterms:description>Initial large conductance calcium activated potassium channel voltage at 50% maximal response</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_PMCA">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_9">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_5">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_8" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_3" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_8" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_0" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell plasma membrane calcium ATPase current</dcterms:description>
<semsim:name>Plasma membrane calcium ATPase current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total cell plasma membrane calcium ATPase current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#B5_sGC">
<dcterms:description>cGMP porduction rate NO sensitivity term</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#C_m">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_17">
<semsim:physicalPropertyOf rdf:resource="#entity_21" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00446" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total membrane capacitance</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#n_ClcGMP">
<dcterms:description>Calcium activated chloride channel cyclic GMP sensitivity Hill coefficient</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Sbar_CM">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_40">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_36">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://purl.obolibrary.org/obo/PR_P62158" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Average cytosolic calmodulin concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_i0">
<dcterms:description>Initial intracellular sodium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#phi_F">
<dcterms:description>Sodium/calcium exchanger forward reaction rate</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_SERCA">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_37">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_11">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_16" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_0" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_16" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_34" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell sarcoplasmic/endoplamic reticulum calcium APTase current</dcterms:description>
<semsim:name>Sarcoplasmic/endoplamic reticulum calcium APTase current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total cell sarcoplasmic/endoplamic reticulum calcium APTase current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#d_NSCmin">
<dcterms:description>Minimal NSC channel activation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_Kv">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_3">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_3">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_4" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_10" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_4" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_9" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell voltage gated potassium channel current</dcterms:description>
<semsim:name>Voltage gated potassium channel current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total cell voltage gated potassium channel current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#INa_NaKCl">
<dcterms:description>Total cell sodium/potassium/chloride cotransporter sodium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#d_L">
<dcterms:description>L-type calcium channel activation gate probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#z_Cl">
<dcterms:description>Valence of chloride</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#gamma_NCX">
<dcterms:description>Sodium/calcium exchanger parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_dCM">
<dcterms:description>Calmoduling-calcium dissociation constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#z_Na">
<dcterms:description>Valence of sodium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_supSPG0">
<dcterms:description>Initial number of phosporylated alpha adrenoreceptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_q2">
<dcterms:description>Voltage gated potassium channel slow inactivaton gate time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#k_1sGC">
<dcterms:description>Soluble guanylate cyclase activation and cyclic GMP formation rate constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#P_SOC:time">
<dcterms:description>Rate of change of store operated cation channel activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_q1">
<dcterms:description>Voltage gated potassium channel fast inactivaton gate time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Po_NSC">
<dcterms:description>Nonselective cation channel activation gate steady state open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#z_K">
<dcterms:description>Valence of potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#d_L:time">
<dcterms:description>Rate of change of L-type calcium channel activation gate probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#V_cGMP:time">
<dcterms:description>Rate of change of reaction velocity of cyclic GMP formation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_mPMCA">
<dcterms:description>Plasma membrane calcium ATPase Michaelis constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PIP2">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_50">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_41">
<ro:part_of rdf:resource="#entity_1" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:37328" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01001" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Number of cytosolic phosphatidylinositol 4,5-bisphosphate molecules</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#K_i0">
<dcterms:description>Initial intracellular potassium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#p_K">
<dcterms:description>Voltage gated potassium channel activation gate open probability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#ICa_NSC">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_11">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_6">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_9" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_3" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_9" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_0" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell nonselective cation channel calcium current</dcterms:description>
<semsim:name>Nonselective cation channel calcium current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total cell nonselective cation channel calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#cGMP_i">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_38">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_35">
<ro:part_of rdf:resource="#entity_23" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:16356" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Intracellular cGMP concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#Na_e">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_19">
<semsim:physicalPropertyOf rdf:resource="#entity_8" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00340" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Extracellular sodium concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#I_rel">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_32">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#process_8">
<semsim:hasSinkParticipant>
<rdf:Description rdf:about="#sink_12" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_0" />
</rdf:Description>
</semsim:hasSinkParticipant>
<semsim:hasSourceParticipant>
<rdf:Description rdf:about="#source_12" semsim:hasMultiplier="1.0">
<semsim:hasPhysicalEntityReference rdf:resource="#entity_31" />
</rdf:Description>
</semsim:hasSourceParticipant>
<dcterms:description>Total cell ryanodine receptor calcium current</dcterms:description>
<semsim:name>Ryanodine receptor calcium current</semsim:name>
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00318" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Total cell ryanodine receptor calcium current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#F">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_00089" />
<dcterms:description>Faraday constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#alpha_Cl">
<dcterms:description>Ca-act Cl channel cGMP sensitivity term</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#alpha_G">
<dcterms:description>Alpha adrenoceptor G protein effective signal gain parameter</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#V_cGMPmax">
<dcterms:description>Maximal reaction velocity of cyclic GMP formation</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#PK_NSC">
<dcterms:description>Nonselective cation channel whole cell potasium permeability</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#G">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_44">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_38">
<ro:part_of rdf:resource="#entity_21" />
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:16235" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01001" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Number of active G proteins</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#E_K">
<semsim:isComputationalComponentFor>
<rdf:Description rdf:about="#property_26">
<semsim:physicalPropertyOf>
<rdf:Description rdf:about="#entity_27">
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/chebi/CHEBI:29103" />
</rdf:Description>
</semsim:physicalPropertyOf>
<semsim:hasPhysicalDefinition rdf:resource="http://identifiers.org/opb/OPB_01581" />
</rdf:Description>
</semsim:isComputationalComponentFor>
<dcterms:description>Nernst potential for potassium</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#tau_ps">
<dcterms:description>Large conductance calcium activated potassium channel slow activaton gate time constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="#R_NaKClcGMP">
<dcterms:description>Sodium/potassium/chloride cotransporter cyclic GMP sensitivity</dcterms:description>
</rdf:Description>
</rdf:RDF>
</model>
