$\frac{d \mathrm{Ca\_actn}}{d \mathrm{time}}=\mathrm{time}\mathrm{Ca\_max}$
$T=\frac{\mathrm{Ca\_max}\mathrm{Ca\_actn}^{h}}{\mathrm{Ca\_actn}^{h}+\mathrm{c50}^{h}}\mathrm{T\_ref}(1.0+\mathrm{beta}(\mathrm{lambda}-1.0))$
2003-12-08
Nickerson
David
d.nickerson@auckland.ac.nz
The University of Auckland
The Bioengineering Institute
This is a CellML version of the steady-state length-tension-calcium
relationship described by Martyn Nash in his thesis.
We'll use this component as the "interface" to the model, all
other components are hidden via encapsulation in this component.
With this model, we expect the extension ratio to be
controlled externally for non-isometric simulations.
A dummy equation that we simply use to make grabbing the
value in CMISS much easier.
We need a dummy ODE to establish time as the bound variable to
get things to work properly with CMISS.
The component which defines the kinetics of the active
tension development.
The kinetics of the active tension development using the
steady-state description from the Nash model.
Here we define the calcium activation transient which simply
goes from 0 to 1 and back to 0 over a period of 2ms.