- Author:
- izza.ismail <nism576@aucklanduni.ac.nz>
- Date:
- 2018-02-19 11:33:27+13:00
- Desc:
- Add cellml file
- Permanent Source URI:
- https://models.cellml.org/workspace/4fb/rawfile/09c04e80f2a94fce3a8b01e6e8f3556767e9a705/chan_SHP12004.cellml
<?xml version='1.0'?>
<model name="Chan2004_TCell_receptor_activation" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<units name="s">
<unit units="second"/>
</units>
<units name="micromolar">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="micromolar_per_second">
<unit units="micromolar"/>
<unit exponent="-1" units="s"/>
</units>
<units name="per_micromolar_per_second">
<unit exponent="-1" units="micromolar"/>
<unit exponent="-1" units="s"/>
</units>
<units name="per_second">
<unit exponent="-1" units="s"/>
</units>
<component name="environment">
<variable name="time" public_interface="out" units="s"/>
</component>
<component name="TCell_receptor_activation">
<variable name="time" public_interface="in" units="s"/>
<variable initial_value="0" name="lck_inactive" units="micromolar"/>
<variable initial_value="0" name="lck_active" units="micromolar"/>
<variable initial_value="0.6" name="phosphatase_inactive" units="micromolar"/>
<variable initial_value="0.6" name="phosphatase_active" units="micromolar"/>
<variable name="lck_total" units="micromolar"/>
<variable name="r_l" units="micromolar_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>r_l</ci>
<piecewise>
<piece>
<cn cellml:units="micromolar_per_second">1</cn>
<apply>
<and/>
<apply>
<gt/>
<ci>time</ci>
<cn cellml:units="s">9.8</cn>
</apply>
<apply>
<lt/>
<ci>time</ci>
<cn cellml:units="s">24.5</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="micromolar_per_second">0</cn>
</otherwise>
</piecewise>
</apply>
</math>
<variable initial_value="1" name="n1" units="per_micromolar_per_second"/>
<variable initial_value="0.01" name="k1" units="per_second"/>
<variable initial_value="1" name="m1" units="dimensionless"/>
<variable initial_value="0.15" name="d0" units="per_second"/>
<variable initial_value="0.15" name="d1" units="per_second"/>
<variable initial_value="0.01" name="k2" units="per_second"/>
<variable initial_value="1" name="m2" units="per_micromolar_per_second"/>
<variable initial_value="0.02" name="n2" units="per_second"/>
<variable initial_value="0" name="d2" units="per_second"/>
<variable initial_value="1.95" name="n" units="dimensionless"/>
<variable name="v1" units="micromolar_per_second"/>
<variable name="v2" units="micromolar_per_second"/>
<variable name="v3" units="micromolar_per_second"/>
<variable name="v4" units="micromolar_per_second"/>
<variable name="v5" units="micromolar_per_second"/>
<variable name="v6" units="micromolar_per_second"/>
<variable name="v7" units="micromolar_per_second"/>
<variable name="v8" units="micromolar_per_second"/>
<variable name="v9" units="micromolar_per_second"/>
<variable name="v10" units="micromolar_per_second"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>v10</ci>
<apply>
<times/>
<ci>d2</ci>
<ci>phosphatase_active</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v9</ci>
<apply>
<times/>
<ci>n2</ci>
<ci>phosphatase_active</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v8</ci>
<apply>
<times/>
<ci>m2</ci>
<ci>lck_active</ci>
<ci>phosphatase_inactive</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v7</ci>
<apply>
<times/>
<ci>k2</ci>
<ci>phosphatase_inactive</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v6</ci>
<apply>
<times/>
<ci>d1</ci>
<ci>lck_active</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v5</ci>
<apply>
<times/>
<ci>d0</ci>
<ci>lck_inactive</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v4</ci>
<apply>
<times/>
<ci>m1</ci>
<apply>
<power/>
<ci>lck_active</ci>
<ci>n</ci>
</apply>
<ci>lck_inactive</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v3</ci>
<apply>
<times/>
<ci>k1</ci>
<ci>lck_inactive</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v2</ci>
<apply>
<times/>
<ci>n1</ci>
<ci>lck_active</ci>
<ci>phosphatase_active</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>v1</ci>
<ci>r_l</ci>
</apply>
<apply>
<eq/>
<ci>lck_total</ci>
<apply>
<plus/>
<ci>lck_inactive</ci>
<ci>lck_active</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>phosphatase_active</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v10</ci>
</apply>
<ci>v9</ci>
</apply>
<ci>v8</ci>
<ci>v7</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>phosphatase_inactive</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>v9</ci>
<ci>v8</ci>
</apply>
<ci>v7</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>lck_active</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<minus/>
<ci>v6</ci>
</apply>
<ci>v4</ci>
<ci>v3</ci>
</apply>
<ci>v2</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>lck_inactive</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>v5</ci>
</apply>
<ci>v4</ci>
</apply>
<ci>v3</ci>
</apply>
<ci>v2</ci>
<ci>v1</ci>
</apply>
</apply>
</math>
</component>
<connection>
<map_components component_1="environment" component_2="TCell_receptor_activation"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
</model>
