Location: Vasalou and Henson 2010 @ 96f3a7c9e9c9 / vasalou_2010.rdf

Author:
AnandR <a.rampadarath@auckland.ac.nz>
Date:
2019-09-09 14:29:53+12:00
Desc:
curated model with annotation
Permanent Source URI:
https://models.cellml.org/workspace/54c/rawfile/96f3a7c9e9c909c0a984dd882f64946815d62739/vasalou_2010.rdf
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<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
    xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
    xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" > 
  <rdf:Description rdf:about="./vasalou_2010.cellml#BC.MB">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_38"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of corresponding mRNA of BMAL1</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BCP_BCP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_24"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phosphorylated BMAL1 protein in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCNP.PCN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of nuclear form of of unphosphorylated Per-Cry complex.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_4">
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:226054"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CB_CB">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of CREB</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCN_PCN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of nuclear form of of unphosphorylated Per-Cry complex.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#source_5">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_16"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.MP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_25"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Transcription of Per (Per1, per2 and Per3 gene) into the corresponding mRNA.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCN.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#process_4">
    <semsim:name>Excitatory postsynaptic currents in response to the glutamate neurotransmitter.</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCC.CC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_28"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated CRY (lumped CRY1 and CRY2) protein in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCP_PCP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_40"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phoshorylated PER (Lumped Per1, per2 and per3) in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#sink_1">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_16"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#IN.PCN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of nuclear form of of unphosphorylated Per-Cry complex.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_12">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_13"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29101"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BN.BNP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phosphorylated BMAL1 protein in the suprachiasmatic Nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_24">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_23"/>
    <bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/PR_000004305"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.CC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_28"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated CRY (lumped CRY1 and CRY2) protein in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_36">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_37"/>
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67122"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCN.PCNP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phosphorylated nuclear form of Per-Cry complex</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.i_ex">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_4"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>Contributions of excitatory postsynaptic currents (EPSCs) in response to the glutamate neurotransmitter.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#mediator_2">
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_19"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CC.MC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_36"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of corresponding mRNA of CRY (CRY1 and CRY2 lumped).</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCC.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.CC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_28"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated CRY (lumped CRY1 and CRY2) protein in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.i_KCa">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>Calcium-activated potassium current.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.g_ex">
    <dcterms:description>Conductance of the excitatory current</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCNP_PCNP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phosphorylated nuclear form of Per-Cry complex</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_3">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_4"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29101"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.BC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_24"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated, cytosolic BMAL1 protein.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#process_5">
    <semsim:hasMediatorParticipant rdf:resource="./vasalou_2010.cellml#mediator_4"/>
    <semsim:name>Inhibitory postsynaptic current (IPSCs)</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCC.PCN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of nuclear form of of unphosphorylated Per-Cry complex.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BC.BN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of BMAL1 in the suprachiasmatic nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BCP.BC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_24"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated, cytosolic BMAL1 protein.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#IN_IN">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Inactive complex between PER�CRY and CLOCK�BMAL1 in nucleus</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BC.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_40">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_4"/>
    <semsim:name>Lumped Per1, per2 and per3</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.Ca_store">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_29"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>IP3 and ryanodine dependent Calcium stores.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCN.IN">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Inactive complex between PER�CRY and CLOCK�BMAL1 in nucleus</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.v0">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_1"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Influx of Calcium into the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_41">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_4"/>
    <bqbiol:is rdf:resource="http://identifiers.org/go/GO:1990512"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#MP.BN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of BMAL1 in the suprachiasmatic nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.Cl_in">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_11"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Intracellular Cl- concentration.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BC_BC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_24"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated, cytosolic BMAL1 protein.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#sink_0">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_6"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.i_inhib">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_5"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>Inhibitory postsynaptic currents (IPSCs), conveyed by the
GABA neurotransmitter and its GABA A receptor.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_13">
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:70022"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.Na_in">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_3"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of sodium in the cytosol</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_25">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_26"/>
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67122"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_37">
    <semsim:name>Lumped CRY1 and CRY2 proteins</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#VIP.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.CB">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of CREB</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#IN.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CB.V_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Intracellular protein kinase concentration.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BN_BN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of BMAL1 in the suprachiasmatic nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#mediator_1">
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_17"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCCP.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PC.PCC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_41"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosophorylated Per-Cry complex in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.i_Na">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>Sodium current across membrane</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.E_Na">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_6"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01581"/>
    <dcterms:description>Nernst potential for Sodium.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.g_Ca">
    <dcterms:description>Conductance of Ca2+ channels</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PC.PCP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_40"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phoshorylated PER (Lumped Per1, per2 and per3) in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.g_K">
    <dcterms:description>COnductance of potassium channels</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#process_6">
    <semsim:hasMediatorParticipant rdf:resource="./vasalou_2010.cellml#mediator_5"/>
    <semsim:hasSinkParticipant rdf:resource="./vasalou_2010.cellml#sink_3"/>
    <semsim:hasSourceParticipant rdf:resource="./vasalou_2010.cellml#source_3"/>
    <semsim:name>Ca(2+) transport from the cytosol to the ryanodine stores</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#MC.BN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of BMAL1 in the suprachiasmatic nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_30">
    <semsim:name>IP3 and Ryanodine stores</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_42">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_23"/>
    <semsim:name>Phosphorylated lumped CRY1 and CRY2</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#sink_3">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_31"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BNP.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PC.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCC.PC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_40"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of mRNA translated to cyctolic, unphosphorylated Per</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#MC_MC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_36"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of corresponding mRNA of CRY (CRY1 and CRY2 lumped).</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_14">
    <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005272"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_26">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_10"/>
    <semsim:name>Lumped Per1, per2 and per3</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_6">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29101"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_38">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_39"/>
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:67122"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCC.PCCP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_41"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phosphorylated Per-Cry complex in the cytosol of a neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BN.BC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_24"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated, cytosolic BMAL1 protein.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.g_KCa">
    <dcterms:description>Conductance of Calcium-activated potassium channels</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#mediator_0">
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_14"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.GABA">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_9"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of gamma-aminobutyric acid in the neuron</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CC.PC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_40"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of mRNA translated to cyctolic, unphosphorylated Per</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.Ca_in">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_22"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of intracellular calcium in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#source_0">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_12"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.i_Ca">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_1"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>Calcium current through the membrane of the SCN neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#process_7">
    <semsim:hasMediatorParticipant rdf:resource="./vasalou_2010.cellml#mediator_6"/>
    <semsim:hasSinkParticipant rdf:resource="./vasalou_2010.cellml#sink_4"/>
    <semsim:hasSourceParticipant rdf:resource="./vasalou_2010.cellml#source_4"/>
    <semsim:name>Ca(2+) transport from ryanodine stores to the cytosol of the neuron.</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CCP.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CCP_CCP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_42"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phoshorylated CRY (lumped CRY1 and CRY2) protein in the cytosol of the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCN.PCC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_41"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosophorylated Per-Cry complex in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BNP_BNP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phosphorylated BMAL1 protein in the suprachiasmatic Nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CC.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_31">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_32"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#sink_2">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_8"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_43">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_35"/>
    <bqbiol:is rdf:resource="http://identifiers.org/go/GO:1990512"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CC.CCP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_42"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phoshorylated CRY (lumped CRY1 and CRY2) protein in the cytosol of the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BN.PCN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_43"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of nuclear form of of unphosphorylated Per-Cry complex.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.i_L">
    <dcterms:description>Leakage current across membrane.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCN.BN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of BMAL1 in the suprachiasmatic nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_15">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_13"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_27">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_2"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:80331"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_39">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_4"/>
    <bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/PR_000004305"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_5">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_4"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29103"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BN.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#MP_MP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_25"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Transcription of Per (Per1, per2 and Per3 gene) into the corresponding mRNA.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#process_0">
    <semsim:hasMediatorParticipant rdf:resource="./vasalou_2010.cellml#mediator_0"/>
    <semsim:hasSinkParticipant rdf:resource="./vasalou_2010.cellml#sink_0"/>
    <semsim:hasSourceParticipant rdf:resource="./vasalou_2010.cellml#source_0"/>
    <semsim:name>Na+ flow across membrane</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PC.MP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_25"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Transcription of Per (Per1, per2 and Per3 gene) into the corresponding mRNA.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_0">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/fma/FMA:30322"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#IN.BN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of BMAL1 in the suprachiasmatic nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#mediator_7">
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_17"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.k">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_8"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00592"/>
    <dcterms:description>Calcium efflux out of the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#source_1">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_15"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#process_8">
    <semsim:hasMediatorParticipant rdf:resource="./vasalou_2010.cellml#mediator_7"/>
    <semsim:hasSinkParticipant rdf:resource="./vasalou_2010.cellml#sink_5"/>
    <semsim:hasSourceParticipant rdf:resource="./vasalou_2010.cellml#source_5"/>
    <semsim:name>Ca2+ flux out of neuron.</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#MB.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#MP.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CB.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_20">
    <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0015269"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_32">
    <semsim:name>ryanodine stores</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.V_K">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Intracellular protein kinase concentration.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.VIP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_27"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of intracellular Vasoactive intestinal peptide.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCC_PCC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_41"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosophorylated Per-Cry complex in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.v3">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
    <dcterms:description>Release of Calcium from the stores into the cytosol</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.E_Ca">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_7"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01581"/>
    <dcterms:description>Calcium reverse membrane potential.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.i_K">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#process_2"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00318"/>
    <dcterms:description>Potassium current through the membrane of the SCN neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_16">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_4"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_28">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_4"/>
    <semsim:name>Lumped CRY1 and CRY2 proteins</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_8">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29103"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BNP.BN">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_34"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of BMAL1 in the suprachiasmatic nucleus.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#mediator_6">
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_33"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.V_rest">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_0"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00378"/>
    <dcterms:description>Membrane resting potential</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#source_2">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_18"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CC_CC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_28"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated CRY (lumped CRY1 and CRY2) protein in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#environment.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PCCP_PCCP">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_41"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of phosphorylated Per-Cry complex in the cytosol of a neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#PC.CC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_28"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosphorylated CRY (lumped CRY1 and CRY2) protein in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#process_1">
    <semsim:hasMediatorParticipant rdf:resource="./vasalou_2010.cellml#mediator_1"/>
    <semsim:hasSinkParticipant rdf:resource="./vasalou_2010.cellml#sink_1"/>
    <semsim:hasSourceParticipant rdf:resource="./vasalou_2010.cellml#source_1"/>
    <semsim:name>Ca(2+) influx into the cytosol.</semsim:name>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#sink_5">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_15"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BCP.time">
    <bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#sink_4">
    <semsim:hasMultiplier>1.0</semsim:hasMultiplier>
    <semsim:hasPhysicalEntityReference rdf:resource="./vasalou_2010.cellml#entity_16"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_21">
    <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0004890"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_33">
    <bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/PR_Q15413"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_17">
    <bqbiol:is rdf:resource="http://identifiers.org/go/GO:0005262"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_29">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_30"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#Ca_in.Ca_in">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_22"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of intracellular calcium in the neuron.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#entity_7">
    <bqbiol:isPartOf rdf:resource="./vasalou_2010.cellml#entity_1"/>
    <bqbiol:is rdf:resource="http://identifiers.org/chebi/CHEBI:29108"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#CC.PCC">
    <bqbiol:isPropertyOf rdf:resource="./vasalou_2010.cellml#entity_41"/>
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Concentration of unphosophorylated Per-Cry complex in the cytosol.</dcterms:description>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#membrane.E_inhib">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01581"/>
  </rdf:Description>
  <rdf:Description rdf:about="./vasalou_2010.cellml#BN.IN">
    <bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
    <dcterms:description>Inactive complex between PER�CRY and CLOCK�BMAL1 in nucleus</dcterms:description>
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      &lt;title&gt;A multiscale model to investigate circadian rhythmicity of pacemaker neurons in the suprachiasmatic nucleus&lt;/title&gt;&#xD;
      &lt;author&gt;&#xD;
        &lt;firstname&gt;Catherine&lt;/firstname&gt;&#xD;
        &lt;surname&gt;Lloyd&lt;/surname&gt;&#xD;
        &lt;affiliation&gt;&#xD;
          &lt;shortaffil&gt;Auckland Bioengineering Institute, The University of Auckland&lt;/shortaffil&gt;&#xD;
        &lt;/affiliation&gt;&#xD;
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    &lt;section id="sec_status"&gt;&#xD;
      &lt;title&gt;Model Status&lt;/title&gt;&#xD;
      &lt;para&gt;This model runs in both OpenCell and COR to replicate the published results (figure 2). This CellML model translation is based on the curated SBML model in the BioModels database (BIOMD0000000246.xml) which in turn was based on the original author's Matlab code. Note that in order to replicate figure 2 the model has to be run for at least 200 hours to allow the oscillations to stabilise (and for 500 hours to clearly see the stablisation).&lt;/para&gt;&#xD;
    &lt;/section&gt;&#xD;
    &lt;sect1 id="sec_structure"&gt;&#xD;
      &lt;title&gt;Model Structure&lt;/title&gt;&#xD;
      &lt;para&gt;ABSTRACT: The suprachiasmatic nucleus (SCN) of the hypothalamus is a multicellular system that drives daily rhythms in mammalian behavior and physiology. Although the gene regulatory network that produces daily oscillations within individual neurons is well characterized, less is known about the electrophysiology of the SCN cells and how firing rate correlates with circadian gene expression. We developed a firing rate code model to incorporate known electrophysiological properties of SCN pacemaker cells, including circadian dependent changes in membrane voltage and ion conductances. Calcium dynamics were included in the model as the putative link between electrical firing and gene expression. Individual ion currents exhibited oscillatory patterns matching experimental data both in current levels and phase relationships. VIP and GABA neurotransmitters, which encode synaptic signals across the SCN, were found to play critical roles in daily oscillations of membrane excitability and gene expression. Blocking various mechanisms of intracellular calcium accumulation by simulated pharmacological agents (nimodipine, IP3- and ryanodine-blockers) reproduced experimentally observed trends in firing rate dynamics and core-clock gene transcription. The intracellular calcium concentration was shown to regulate diverse circadian processes such as firing frequency, gene expression and system periodicity. The model predicted a direct relationship between firing frequency and gene expression amplitudes, demonstrated the importance of intracellular pathways for single cell behavior and provided a novel multiscale framework which captured characteristics of the SCN at both the electrophysiological and gene regulatory levels.&lt;/para&gt;&#xD;
      &lt;para&gt;The original paper reference is cited below:&lt;/para&gt;&#xD;
      &lt;para&gt;&#xD;
        A multiscale model to investigate circadian rhythmicity of pacemaker neurons in the suprachiasmatic nucleus, Vasalou C, Henson MA, 2010,&#xD;
        &lt;emphasis&gt;PLoS Computational Biology&lt;/emphasis&gt;&#xD;
        , 6, e1000706.&#xD;
        &lt;ulink url="http://www.ncbi.nlm.nih.gov/pubmed/20300645"&gt;PubMed ID: 20300645&lt;/ulink&gt;&#xD;
      &lt;/para&gt;&#xD;
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        &lt;caption&gt;Schematic representation of the SCN neuron model&lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
      &lt;informalfigure float="0" id="fig_cell_diagram1"&gt;&#xD;
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            &lt;imagedata fileref="leloup_2003.png" /&gt;&#xD;
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        &lt;caption&gt;&#xD;
          Leloup and Goldbeter 2003 model for circadian oscillations in mammals involving interlocked negative and positive regulations of&#xD;
          &lt;emphasis&gt;Per&lt;/emphasis&gt;&#xD;
          ,&#xD;
          &lt;emphasis&gt;Cry&lt;/emphasis&gt;&#xD;
          ,&#xD;
          &lt;emphasis&gt;Bmal1&lt;/emphasis&gt;&#xD;
          , and&#xD;
          &lt;emphasis&gt;Rev-Erb&lt;/emphasis&gt;&#xD;
          genes by their protein products.&#xD;
        &lt;/caption&gt;&#xD;
      &lt;/informalfigure&gt;&#xD;
    &lt;/sect1&gt;&#xD;
  &lt;/article&gt;&#xD;
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