- Author:
- Glucose Uptake <nafs080@aucklanduni.ac.nz>
- Date:
- 2018-03-29 11:47:30+13:00
- Desc:
- Modular Version of Glucose Uptake in CellML
- Permanent Source URI:
- https://models.cellml.org/workspace/572/rawfile/fad507f47193ac8be8dee23ffa9448938603f792/Parameters.cellml
<?xml version='1.0'?>
<!-- // Data from: Thorsen, K., Drengstig, T., & Ruoff, P. (2014). Transepithelial glucose transport and Na+/K+ homeostasis in enterocytes: an integrative model. American Journal of Physiology-Cell Physiology, 307(4), C320-C337.-->
<model name="Parameters" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="parameters">
<variable initial_value="-1" name="z_Cl" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="z_Na" public_interface="out" units="dimensionless"/>
<variable initial_value="1" name="z_k" public_interface="out" units="dimensionless"/>
<variable initial_value="96485" name="F" public_interface="out" units="C_per_mol"/>
<variable initial_value="8.314" name="R" public_interface="out" units="J_per_K_per_mol"/>
<variable initial_value="310" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="1e-5" name="capacitance" public_interface="out" units="uF"/>
<variable initial_value="8.4e-10" name="A_Apical" public_interface="out" units="m2"/>
<variable initial_value="5e-10" name="A_Basol" public_interface="out" units="m2"/>
<variable initial_value="5e-16" name="v_cell" public_interface="out" units="m3"/>
<variable initial_value="4.5e-8" name="P_P_Na" public_interface="out" units="m_per_s"/>
<variable initial_value="1e-6" name="P_P_k" public_interface="out" units="m_per_s"/>
<variable initial_value="3e-8" name="P_P_Cl" public_interface="out" units="m_per_s"/>
<!--SGLT1 parameters are from 6 states model
Original Paper: Xing-Zhen Chen, Michael J Coady, Francis Jackson, Alfred Berteloot, and Jean-Yves Lapointe. Thermodynamic determination of the Na+: glucose coupling ratio for the human sglt1 cotransporter. -->
<variable initial_value="14000" name="k0_12" public_interface="out" units="per_M2_per_second"/>
<variable initial_value="300" name="k0_21" public_interface="out" units="per_second"/>
<variable initial_value="15000" name="k0_23" public_interface="out" units="per_M_per_second"/>
<variable initial_value="20" name="k0_32" public_interface="out" units="per_second"/>
<variable initial_value="0.1" name="k0_25" public_interface="out" units="per_second"/>
<variable initial_value="0.01" name="k0_52" public_interface="out" units="per_second"/>
<variable initial_value="50" name="k0_34" public_interface="out" units="per_second"/>
<variable initial_value="50" name="k0_43" public_interface="out" units="per_second"/>
<variable initial_value="6" name="k0_45" public_interface="out" units="per_second"/>
<variable initial_value="450" name="k0_54" public_interface="out" units="per_M_per_second"/>
<variable initial_value="10" name="k0_56" public_interface="out" units="per_second"/>
<variable initial_value="2000" name="k0_65" public_interface="out" units="per_M2_per_second"/>
<variable initial_value="25" name="k0_61" public_interface="out" units="per_second"/>
<variable initial_value="600" name="k0_16" public_interface="out" units="per_second"/>
<variable initial_value="0.7" name="delta" public_interface="out" units="dimensionless"/>
<variable initial_value="0.3" name="alpha_p" public_interface="out" units="dimensionless"/>
<variable initial_value="0" name="alpha_pp" public_interface="out" units="dimensionless"/>
<variable initial_value="2" name="n" public_interface="out" units="dimensionless"/>
<variable initial_value="-2" name="z_c" public_interface="out" units="dimensionless"/>
<variable name="v_mc" public_interface="in" units="volt"/>
<variable name="mu" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>mu</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>v_mc</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</math>
</component>
</model>
