Location: Loewe-Lutz-Fabbri-Severi human sinus node cellular electrophysiology model @ e9e032fae07b / LoeweLutzFabbriSeveri.cellml

Author:
Axel Loewe <axel.loewe@kit.edu>
Date:
2021-11-24 16:32:50+01:00
Desc:
fix units
Permanent Source URI:
https://models.cellml.org/workspace/58f/rawfile/e9e032fae07bd09cdc50323406342a3657c1dc98/LoeweLutzFabbriSeveri.cellml

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    <unit units="second" exponent="-1.0"/>
    <unit units="mole" exponent="-2.0"/>
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    <unit units="kelvin" exponent="-1.0"/>
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    <unit units="second" exponent="-1.0"/>
    <unit units="mole"/>
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        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Cai</ci>
        </apply>
        <apply>
          <minus/>
          <apply>
            <divide/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">1.0</cn>
              <apply>
                <minus/>
                <apply>
                  <times/>
                  <ci>j_Ca_dif</ci>
                  <ci>V_sub</ci>
                </apply>
                <apply>
                  <times/>
                  <ci>j_up</ci>
                  <ci>V_nsr</ci>
                </apply>
              </apply>
            </apply>
            <ci>V_i</ci>
          </apply>
          <apply>
            <plus/>
            <apply>
              <plus/>
              <apply>
                <times/>
                <ci>CM_tot</ci>
                <ci>delta_fCMi</ci>
              </apply>
              <apply>
                <times/>
                <ci>TC_tot</ci>
                <ci>delta_fTC</ci>
              </apply>
            </apply>
            <apply>
              <times/>
              <ci>TMC_tot</ci>
              <ci>delta_fTMC</ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Ca_intracellular_fluxes">
    <variable name="ACh" units="mM" public_interface="in"/>
    <variable name="Ca_jsr" units="mM" public_interface="in"/>
    <variable name="Ca_nsr" units="mM" public_interface="in"/>
    <variable name="Ca_sub" units="mM" public_interface="in"/>
    <variable name="Cai" units="mM" public_interface="in"/>
    <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
    <variable name="K_up" units="mM" initial_value="2.86113000000000003e-04"/>
    <variable name="P_up" units="mol_per_m3_per_s"/>
    <variable name="P_up_basal" units="mol_per_m3_per_s" initial_value="5.0"/>
    <variable name="b_up" units="dimensionless"/>
    <variable name="j_Ca_dif" units="mol_per_m3_per_s" public_interface="out"/>
    <variable name="j_tr" units="mol_per_m3_per_s" public_interface="out"/>
    <variable name="j_up" units="mol_per_m3_per_s" public_interface="out"/>
    <variable name="slope_up" units="mM" initial_value="5e-05"/>
    <variable name="tau_dif_Ca" units="second" initial_value="5.469e-05"/>
    <variable name="tau_tr" units="second" initial_value="0.04"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>P_up</ci>
        <apply>
          <times/>
          <ci>P_up_basal</ci>
          <apply>
            <minus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <ci>b_up</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>b_up</ci>
        <piecewise>
          <piece>
            <apply>
              <minus/>
              <cn cellml:units="dimensionless">0.25</cn>
            </apply>
            <apply>
              <gt/>
              <ci>Iso_1_uM</ci>
              <cn cellml:units="dimensionless">0.0</cn>
            </apply>
          </piece>
          <piece>
            <apply>
              <divide/>
              <apply>
                <times/>
                <cn cellml:units="dimensionless">0.7</cn>
                <ci>ACh</ci>
              </apply>
              <apply>
                <plus/>
                <cn cellml:units="mM">9e-05</cn>
                <ci>ACh</ci>
              </apply>
            </apply>
            <apply>
              <gt/>
              <ci>ACh</ci>
              <cn cellml:units="mM">0.0</cn>
            </apply>
          </piece>
          <otherwise>
            <cn cellml:units="dimensionless">0.0</cn>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>j_Ca_dif</ci>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>Ca_sub</ci>
            <ci>Cai</ci>
          </apply>
          <ci>tau_dif_Ca</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>j_tr</ci>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>Ca_nsr</ci>
            <ci>Ca_jsr</ci>
          </apply>
          <ci>tau_tr</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>j_up</ci>
        <apply>
          <divide/>
          <ci>P_up</ci>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <plus/>
                  <apply>
                    <minus/>
                    <ci>Cai</ci>
                  </apply>
                  <ci>K_up</ci>
                </apply>
                <ci>slope_up</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Cell_parameters">
    <variable name="L_cell" units="um" initial_value="67.0"/>
    <variable name="L_sub" units="um" initial_value="0.02"/>
    <variable name="R_cell" units="um" initial_value="3.9"/>
    <variable name="V_cell" units="uL"/>
    <variable name="V_i" units="uL" public_interface="out"/>
    <variable name="V_i_part" units="dimensionless" initial_value="0.46"/>
    <variable name="V_jsr" units="uL" public_interface="out"/>
    <variable name="V_jsr_part" units="dimensionless" initial_value="0.0012"/>
    <variable name="V_nsr" units="uL" public_interface="out"/>
    <variable name="V_nsr_part" units="dimensionless" initial_value="0.0116"/>
    <variable name="V_sub" units="uL" public_interface="out"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>V_cell</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless_times_1e9">1e-09</cn>
              <cn cellml:units="dimensionless"> 3.14159265358979312e+00</cn>
            </apply>
            <apply>
              <power/>
              <ci>R_cell</ci>
              <cn cellml:units="dimensionless">2.0</cn>
            </apply>
          </apply>
          <ci>L_cell</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>V_i</ci>
        <apply>
          <minus/>
          <apply>
            <times/>
            <ci>V_i_part</ci>
            <ci>V_cell</ci>
          </apply>
          <ci>V_sub</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>V_jsr</ci>
        <apply>
          <times/>
          <ci>V_jsr_part</ci>
          <ci>V_cell</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>V_nsr</ci>
        <apply>
          <times/>
          <ci>V_nsr_part</ci>
          <ci>V_cell</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>V_sub</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <apply>
                <times/>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless_times_1e9">1e-09</cn>
                  <cn cellml:units="dimensionless">2.0</cn>
                </apply>
                <cn cellml:units="dimensionless"> 3.14159265358979312e+00</cn>
              </apply>
              <ci>L_sub</ci>
            </apply>
            <apply>
              <minus/>
              <ci>R_cell</ci>
              <apply>
                <divide/>
                <ci>L_sub</ci>
                <cn cellml:units="dimensionless">2.0</cn>
              </apply>
            </apply>
          </apply>
          <ci>L_cell</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Ionic_values">
    <variable name="Cao" units="mM" public_interface="out" initial_value="1.8"/>
    <variable name="E_K" units="mV" public_interface="out"/>
    <variable name="E_Na" units="mV" public_interface="out"/>
    <variable name="Ki" units="mM" public_interface="in"/>
    <variable name="Ko" units="mM" public_interface="out" initial_value="5.4"/>
    <variable name="Nai" units="mM" public_interface="in"/>
    <variable name="Nao" units="mM" public_interface="out" initial_value="140.0"/>
    <variable name="RTONF" units="mV" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>E_K</ci>
        <apply>
          <times/>
          <ci>RTONF</ci>
          <apply>
            <ln/>
            <apply>
              <divide/>
              <ci>Ko</ci>
              <ci>Ki</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>E_Na</ci>
        <apply>
          <times/>
          <ci>RTONF</ci>
          <apply>
            <ln/>
            <apply>
              <divide/>
              <ci>Nao</ci>
              <ci>Nai</ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Ki_concentration">
    <variable name="F" units="C_per_mol" public_interface="in"/>
    <variable name="Ki" units="mM" public_interface="out" initial_value="139.1382"/>
    <variable name="V_i" units="uL" public_interface="in"/>
    <variable name="V_sub" units="uL" public_interface="in"/>
    <variable name="i_Kr_i_Kr" units="nA" public_interface="in"/>
    <variable name="i_Ks_i_Ks" units="nA" public_interface="in"/>
    <variable name="i_Kur_i_Kur" units="nA" public_interface="in"/>
    <variable name="i_NaK_i_NaK" units="nA" public_interface="in"/>
    <variable name="i_SK_i_SK" units="nA" public_interface="in"/>
    <variable name="i_fK" units="nA" public_interface="in"/>
    <variable name="i_siK" units="nA" public_interface="in"/>
    <variable name="i_to_i_to" units="nA" public_interface="in"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Ki</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <times/>
            <apply>
              <minus/>
              <cn cellml:units="dimensionless_times_1e6">1.0</cn>
            </apply>
            <apply>
              <minus/>
              <apply>
                <plus/>
                <apply>
                  <plus/>
                  <apply>
                    <plus/>
                    <apply>
                      <plus/>
                      <apply>
                        <plus/>
                        <apply>
                          <plus/>
                          <ci>i_Kur_i_Kur</ci>
                          <ci>i_to_i_to</ci>
                        </apply>
                        <ci>i_Kr_i_Kr</ci>
                      </apply>
                      <ci>i_Ks_i_Ks</ci>
                    </apply>
                    <ci>i_fK</ci>
                  </apply>
                  <ci>i_siK</ci>
                </apply>
                <ci>i_SK_i_SK</ci>
              </apply>
              <apply>
                <times/>
                <cn cellml:units="dimensionless">2.0</cn>
                <ci>i_NaK_i_NaK</ci>
              </apply>
            </apply>
          </apply>
          <apply>
            <times/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless_times_1e6">1.0</cn>
              <apply>
                <plus/>
                <ci>V_i</ci>
                <ci>V_sub</ci>
              </apply>
            </apply>
            <ci>F</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Membrane">
    <variable name="C" units="uF" initial_value="5.7e-05"/>
    <variable name="F" units="C_per_mol" public_interface="out" initial_value="9.64853414999999950e+04"/>
    <variable name="R" units="mJ_per_mol_per_K" initial_value="8314.472"/>
    <variable name="RTONF" units="mV" public_interface="out"/>
    <variable name="T" units="kelvin" initial_value="310.0"/>
    <variable name="V" units="mV" public_interface="out"/>
    <variable name="V_ode" units="mV" initial_value="-4.61898999999999990e-02"/>
    <variable name="i_CaL_i_CaL" units="nA" public_interface="in"/>
    <variable name="i_CaT_i_CaT" units="nA" public_interface="in"/>
    <variable name="i_KACh_i_KACh" units="nA" public_interface="in"/>
    <variable name="i_Kr_i_Kr" units="nA" public_interface="in"/>
    <variable name="i_Ks_i_Ks" units="nA" public_interface="in"/>
    <variable name="i_Kur_i_Kur" units="nA" public_interface="in"/>
    <variable name="i_NaCa_i_NaCa" units="nA" public_interface="in"/>
    <variable name="i_NaK_i_NaK" units="nA" public_interface="in"/>
    <variable name="i_Na_i_Na" units="nA" public_interface="in"/>
    <variable name="i_SK_i_SK" units="nA" public_interface="in"/>
    <variable name="i_f_i_f" units="nA" public_interface="in"/>
    <variable name="i_to_i_to" units="nA" public_interface="in"/>
    <variable name="i_tot" units="nA"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>RTONF</ci>
        <apply>
          <divide/>
          <apply>
            <times/>
            <ci>R</ci>
            <ci>T</ci>
          </apply>
          <ci>F</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>V</ci>
        <ci>V_ode</ci>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>V_ode</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>i_tot</ci>
          </apply>
          <ci>C</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>i_tot</ci>
        <apply>
          <plus/>
          <apply>
            <plus/>
            <apply>
              <plus/>
              <apply>
                <plus/>
                <apply>
                  <plus/>
                  <apply>
                    <plus/>
                    <apply>
                      <plus/>
                      <apply>
                        <plus/>
                        <apply>
                          <plus/>
                          <apply>
                            <plus/>
                            <apply>
                              <plus/>
                              <ci>i_f_i_f</ci>
                              <ci>i_Kr_i_Kr</ci>
                            </apply>
                            <ci>i_Ks_i_Ks</ci>
                          </apply>
                          <ci>i_to_i_to</ci>
                        </apply>
                        <ci>i_NaK_i_NaK</ci>
                      </apply>
                      <ci>i_NaCa_i_NaCa</ci>
                    </apply>
                    <ci>i_Na_i_Na</ci>
                  </apply>
                  <ci>i_CaL_i_CaL</ci>
                </apply>
                <ci>i_CaT_i_CaT</ci>
              </apply>
              <ci>i_KACh_i_KACh</ci>
            </apply>
            <ci>i_Kur_i_Kur</ci>
          </apply>
          <ci>i_SK_i_SK</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Nai_concentration">
    <variable name="F" units="C_per_mol" public_interface="in"/>
    <variable name="Nai" units="mM" public_interface="out" initial_value="6.084085"/>
    <variable name="V_i" units="uL" public_interface="in"/>
    <variable name="V_sub" units="uL" public_interface="in"/>
    <variable name="i_NaCa_i_NaCa" units="nA" public_interface="in"/>
    <variable name="i_NaK_i_NaK" units="nA" public_interface="in"/>
    <variable name="i_Na_i_Na" units="nA" public_interface="in"/>
    <variable name="i_fNa" units="nA" public_interface="in"/>
    <variable name="i_siNa" units="nA" public_interface="in"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>Nai</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <times/>
            <apply>
              <minus/>
              <cn cellml:units="dimensionless_times_1e6">1.0</cn>
            </apply>
            <apply>
              <plus/>
              <apply>
                <plus/>
                <apply>
                  <plus/>
                  <apply>
                    <plus/>
                    <ci>i_Na_i_Na</ci>
                    <ci>i_fNa</ci>
                  </apply>
                  <ci>i_siNa</ci>
                </apply>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless">3.0</cn>
                  <ci>i_NaK_i_NaK</ci>
                </apply>
              </apply>
              <apply>
                <times/>
                <cn cellml:units="dimensionless">3.0</cn>
                <ci>i_NaCa_i_NaCa</ci>
              </apply>
            </apply>
          </apply>
          <apply>
            <times/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless_times_1e6">1.0</cn>
              <apply>
                <plus/>
                <ci>V_i</ci>
                <ci>V_sub</ci>
              </apply>
            </apply>
            <ci>F</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="Rate_modulation_experiments">
    <variable name="ACh" units="mM" public_interface="out" initial_value="0.0"/>
    <variable name="Iso_1_uM" units="dimensionless" public_interface="out" initial_value="0.0"/>
  </component>
  <component name="environment">
    <variable name="time" units="second" public_interface="out"/>
  </component>
  <component name="i_CaL">
    <variable name="ACh" units="mM" public_interface="in"/>
    <variable name="ACh_block" units="dimensionless"/>
    <variable name="Ca_sub" units="mM" public_interface="in"/>
    <variable name="Cao" units="mM" public_interface="in"/>
    <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
    <variable name="Iso_increase" units="dimensionless"/>
    <variable name="Ki" units="mM" public_interface="in"/>
    <variable name="Ko" units="mM" public_interface="in"/>
    <variable name="Nai" units="mM" public_interface="in"/>
    <variable name="Nao" units="mM" public_interface="in"/>
    <variable name="P_CaL" units="m3_A_per_mol_times_1e_minus_9" initial_value="0.5046812"/>
    <variable name="RTONF" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="dL" units="dimensionless" public_interface="in"/>
    <variable name="fCa" units="dimensionless" public_interface="in"/>
    <variable name="fL" units="dimensionless" public_interface="in"/>
    <variable name="i_CaL" units="nA" public_interface="out"/>
    <variable name="i_siCa" units="nA" public_interface="out"/>
    <variable name="i_siK" units="nA" public_interface="out"/>
    <variable name="i_siNa" units="nA" public_interface="out"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>ACh_block</ci>
        <apply>
          <divide/>
          <apply>
            <times/>
            <cn cellml:units="dimensionless">0.31</cn>
            <ci>ACh</ci>
          </apply>
          <apply>
            <plus/>
            <ci>ACh</ci>
            <cn cellml:units="mM">9e-05</cn>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>Iso_increase</ci>
        <piecewise>
          <piece>
            <cn cellml:units="dimensionless">1.23</cn>
            <apply>
              <gt/>
              <ci>Iso_1_uM</ci>
              <cn cellml:units="dimensionless">0.0</cn>
            </apply>
          </piece>
          <otherwise>
            <cn cellml:units="dimensionless">1.0</cn>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>i_CaL</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <apply>
                <plus/>
                <apply>
                  <plus/>
                  <ci>i_siCa</ci>
                  <ci>i_siK</ci>
                </apply>
                <ci>i_siNa</ci>
              </apply>
              <apply>
                <minus/>
                <cn cellml:units="dimensionless">1.0</cn>
                <ci>ACh_block</ci>
              </apply>
            </apply>
            <cn cellml:units="dimensionless">1.0</cn>
          </apply>
          <ci>Iso_increase</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>i_siCa</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <apply>
                <times/>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <apply>
                      <times/>
                      <cn cellml:units="dimensionless">2.0</cn>
                      <ci>P_CaL</ci>
                    </apply>
                    <apply>
                      <minus/>
                      <ci>V</ci>
                      <cn cellml:units="mV">0.0</cn>
                    </apply>
                  </apply>
                  <apply>
                    <times/>
                    <ci>RTONF</ci>
                    <apply>
                      <minus/>
                      <cn cellml:units="dimensionless">1.0</cn>
                      <apply>
                        <exp/>
                        <apply>
                          <divide/>
                          <apply>
                            <times/>
                            <apply>
                              <times/>
                              <apply>
                                <minus/>
                                <cn cellml:units="dimensionless">1.0</cn>
                              </apply>
                              <apply>
                                <minus/>
                                <ci>V</ci>
                                <cn cellml:units="mV">0.0</cn>
                              </apply>
                            </apply>
                            <cn cellml:units="dimensionless">2.0</cn>
                          </apply>
                          <ci>RTONF</ci>
                        </apply>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <minus/>
                  <ci>Ca_sub</ci>
                  <apply>
                    <times/>
                    <ci>Cao</ci>
                    <apply>
                      <exp/>
                      <apply>
                        <divide/>
                        <apply>
                          <times/>
                          <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">2.0</cn>
                          </apply>
                          <apply>
                            <minus/>
                            <ci>V</ci>
                            <cn cellml:units="mV">0.0</cn>
                          </apply>
                        </apply>
                        <ci>RTONF</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <ci>dL</ci>
            </apply>
            <ci>fL</ci>
          </apply>
          <ci>fCa</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>i_siK</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <apply>
                <times/>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <apply>
                      <times/>
                      <cn cellml:units="dimensionless">0.000365</cn>
                      <ci>P_CaL</ci>
                    </apply>
                    <apply>
                      <minus/>
                      <ci>V</ci>
                      <cn cellml:units="mV">0.0</cn>
                    </apply>
                  </apply>
                  <apply>
                    <times/>
                    <ci>RTONF</ci>
                    <apply>
                      <minus/>
                      <cn cellml:units="dimensionless">1.0</cn>
                      <apply>
                        <exp/>
                        <apply>
                          <divide/>
                          <apply>
                            <times/>
                            <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">1.0</cn>
                            </apply>
                            <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="mV">0.0</cn>
                            </apply>
                          </apply>
                          <ci>RTONF</ci>
                        </apply>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <minus/>
                  <ci>Ki</ci>
                  <apply>
                    <times/>
                    <ci>Ko</ci>
                    <apply>
                      <exp/>
                      <apply>
                        <divide/>
                        <apply>
                          <times/>
                          <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1.0</cn>
                          </apply>
                          <apply>
                            <minus/>
                            <ci>V</ci>
                            <cn cellml:units="mV">0.0</cn>
                          </apply>
                        </apply>
                        <ci>RTONF</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <ci>dL</ci>
            </apply>
            <ci>fL</ci>
          </apply>
          <ci>fCa</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>i_siNa</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <apply>
                <times/>
                <apply>
                  <divide/>
                  <apply>
                    <times/>
                    <apply>
                      <times/>
                      <cn cellml:units="dimensionless">1.85e-05</cn>
                      <ci>P_CaL</ci>
                    </apply>
                    <apply>
                      <minus/>
                      <ci>V</ci>
                      <cn cellml:units="mV">0.0</cn>
                    </apply>
                  </apply>
                  <apply>
                    <times/>
                    <ci>RTONF</ci>
                    <apply>
                      <minus/>
                      <cn cellml:units="dimensionless">1.0</cn>
                      <apply>
                        <exp/>
                        <apply>
                          <divide/>
                          <apply>
                            <times/>
                            <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">1.0</cn>
                            </apply>
                            <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="mV">0.0</cn>
                            </apply>
                          </apply>
                          <ci>RTONF</ci>
                        </apply>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <minus/>
                  <ci>Nai</ci>
                  <apply>
                    <times/>
                    <ci>Nao</ci>
                    <apply>
                      <exp/>
                      <apply>
                        <divide/>
                        <apply>
                          <times/>
                          <apply>
                            <minus/>
                            <cn cellml:units="dimensionless">1.0</cn>
                          </apply>
                          <apply>
                            <minus/>
                            <ci>V</ci>
                            <cn cellml:units="mV">0.0</cn>
                          </apply>
                        </apply>
                        <ci>RTONF</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <ci>dL</ci>
            </apply>
            <ci>fL</ci>
          </apply>
          <ci>fCa</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_CaL_dL_gate">
    <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
    <variable name="Iso_shift_dL" units="mV"/>
    <variable name="Iso_slope_dL" units="dimensionless"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="V_dL" units="mV"/>
    <variable name="adVm" units="mV"/>
    <variable name="alpha_dL" units="hertz"/>
    <variable name="bdVm" units="mV"/>
    <variable name="beta_dL" units="hertz"/>
    <variable name="dL" units="dimensionless" public_interface="out" initial_value="1.40229900000000008e-03"/>
    <variable name="dL_infinity" units="dimensionless"/>
    <variable name="k_dL" units="mV" initial_value="5.854"/>
    <variable name="tau_dL" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>Iso_shift_dL</ci>
        <piecewise>
          <piece>
            <apply>
              <minus/>
              <cn cellml:units="mV">8.0</cn>
            </apply>
            <apply>
              <gt/>
              <ci>Iso_1_uM</ci>
              <cn cellml:units="dimensionless">0.0</cn>
            </apply>
          </piece>
          <otherwise>
            <cn cellml:units="mV">0.0</cn>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>Iso_slope_dL</ci>
        <piecewise>
          <piece>
            <apply>
              <minus/>
              <cn cellml:units="dimensionless">27.0</cn>
            </apply>
            <apply>
              <gt/>
              <ci>Iso_1_uM</ci>
              <cn cellml:units="dimensionless">0.0</cn>
            </apply>
          </piece>
          <otherwise>
            <cn cellml:units="dimensionless">0.0</cn>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>V_dL</ci>
        <apply>
          <minus/>
          <cn cellml:units="dimensionless">7.7713</cn>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>adVm</ci>
        <piecewise>
          <piece>
            <apply>
              <minus/>
              <cn cellml:units="mV">41.80001</cn>
            </apply>
            <apply>
              <eq/>
              <ci>V</ci>
              <apply>
                <minus/>
                <cn cellml:units="mV">41.8</cn>
              </apply>
            </apply>
          </piece>
          <piece>
            <cn cellml:units="mV">0.0</cn>
            <apply>
              <eq/>
              <ci>V</ci>
              <cn cellml:units="mV">0.0</cn>
            </apply>
          </piece>
          <piece>
            <apply>
              <minus/>
              <cn cellml:units="mV">6.80001</cn>
            </apply>
            <apply>
              <eq/>
              <ci>V</ci>
              <apply>
                <minus/>
                <cn cellml:units="mV">6.8</cn>
              </apply>
            </apply>
          </piece>
          <otherwise>
            <ci>V</ci>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>alpha_dL</ci>
        <apply>
          <minus/>
          <apply>
            <divide/>
            <apply>
              <times/>
              <apply>
                <minus/>
                <cn cellml:units="s2_A_per_g_per_m2">0.02839</cn>
              </apply>
              <apply>
                <plus/>
                <ci>adVm</ci>
                <cn cellml:units="mV">41.8</cn>
              </apply>
            </apply>
            <apply>
              <minus/>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <apply>
                    <minus/>
                    <apply>
                      <plus/>
                      <ci>adVm</ci>
                      <cn cellml:units="mV">41.8</cn>
                    </apply>
                  </apply>
                  <cn cellml:units="mV">2.5</cn>
                </apply>
              </apply>
              <cn cellml:units="dimensionless">1.0</cn>
            </apply>
          </apply>
          <apply>
            <divide/>
            <apply>
              <times/>
              <cn cellml:units="s2_A_per_g_per_m2">0.0849</cn>
              <apply>
                <plus/>
                <ci>adVm</ci>
                <cn cellml:units="mV">6.8</cn>
              </apply>
            </apply>
            <apply>
              <minus/>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <apply>
                    <minus/>
                    <apply>
                      <plus/>
                      <ci>adVm</ci>
                      <cn cellml:units="mV">6.8</cn>
                    </apply>
                  </apply>
                  <cn cellml:units="mV">4.8</cn>
                </apply>
              </apply>
              <cn cellml:units="dimensionless">1.0</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>bdVm</ci>
        <piecewise>
          <piece>
            <apply>
              <minus/>
              <cn cellml:units="mV">1.80001</cn>
            </apply>
            <apply>
              <eq/>
              <ci>V</ci>
              <apply>
                <minus/>
                <cn cellml:units="mV">1.8</cn>
              </apply>
            </apply>
          </piece>
          <otherwise>
            <ci>V</ci>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>beta_dL</ci>
        <apply>
          <divide/>
          <apply>
            <times/>
            <cn cellml:units="s2_A_per_g_per_m2">0.01143</cn>
            <apply>
              <plus/>
              <ci>bdVm</ci>
              <cn cellml:units="mV">1.8</cn>
            </apply>
          </apply>
          <apply>
            <minus/>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <plus/>
                  <ci>bdVm</ci>
                  <cn cellml:units="mV">1.8</cn>
                </apply>
                <cn cellml:units="mV">2.5</cn>
              </apply>
            </apply>
            <cn cellml:units="dimensionless">1.0</cn>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>dL</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>dL_infinity</ci>
            <ci>dL</ci>
          </apply>
          <ci>tau_dL</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>dL_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <minus/>
                  <apply>
                    <minus/>
                    <apply>
                      <minus/>
                      <ci>V</ci>
                      <ci>V_dL</ci>
                    </apply>
                    <ci>Iso_shift_dL</ci>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <ci>k_dL</ci>
                  <apply>
                    <plus/>
                    <cn cellml:units="dimensionless">1.0</cn>
                    <apply>
                      <divide/>
                      <ci>Iso_slope_dL</ci>
                      <cn cellml:units="dimensionless">100.0</cn>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_dL</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">0.001</cn>
          <apply>
            <plus/>
            <ci>alpha_dL</ci>
            <ci>beta_dL</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_CaL_fCa_gate">
    <variable name="Ca_sub" units="mM" public_interface="in"/>
    <variable name="Km_fCa" units="mM" initial_value="0.000338"/>
    <variable name="alpha_fCa" units="hertz" initial_value="0.0075"/>
    <variable name="fCa" units="dimensionless" public_interface="out" initial_value="0.7820265"/>
    <variable name="fCa_infinity" units="dimensionless"/>
    <variable name="tau_fCa" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>fCa</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>fCa_infinity</ci>
            <ci>fCa</ci>
          </apply>
          <ci>tau_fCa</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>fCa_infinity</ci>
        <apply>
          <divide/>
          <ci>Km_fCa</ci>
          <apply>
            <plus/>
            <ci>Km_fCa</ci>
            <ci>Ca_sub</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_fCa</ci>
        <apply>
          <divide/>
          <apply>
            <times/>
            <cn cellml:units="dimensionless">0.001</cn>
            <ci>fCa_infinity</ci>
          </apply>
          <ci>alpha_fCa</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_CaL_fL_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="fL" units="dimensionless" public_interface="out" initial_value="0.9951828"/>
    <variable name="fL_infinity" units="dimensionless"/>
    <variable name="k_fL" units="mV" initial_value="5.1737"/>
    <variable name="shift_fL" units="mV" initial_value="0.0"/>
    <variable name="tau_fL" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>fL</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>fL_infinity</ci>
            <ci>fL</ci>
          </apply>
          <ci>tau_fL</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>fL_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <plus/>
                  <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">12.1847</cn>
                  </apply>
                  <ci>shift_fL</ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_fL</ci>
        <apply>
          <times/>
          <cn cellml:units="dimensionless">0.001</cn>
          <apply>
            <plus/>
            <cn cellml:units="second">44.3</cn>
            <apply>
              <times/>
              <cn cellml:units="second">230.0</cn>
              <apply>
                <exp/>
                <apply>
                  <minus/>
                  <apply>
                    <power/>
                    <apply>
                      <divide/>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">36.0</cn>
                      </apply>
                      <cn cellml:units="mV">10.0</cn>
                    </apply>
                    <cn cellml:units="dimensionless">2.0</cn>
                  </apply>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_CaT">
    <variable name="Ca_sub" units="mM" public_interface="in"/>
    <variable name="Cao" units="mM" public_interface="in"/>
    <variable name="P_CaT" units="m3_A_per_mol_times_1e_minus_9" initial_value="0.04132"/>
    <variable name="RTONF" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="dT" units="dimensionless" public_interface="in"/>
    <variable name="fT" units="dimensionless" public_interface="in"/>
    <variable name="i_CaT" units="nA" public_interface="out"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>i_CaT</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <apply>
                    <times/>
                    <cn cellml:units="dimensionless">2.0</cn>
                    <ci>P_CaT</ci>
                  </apply>
                  <ci>V</ci>
                </apply>
                <apply>
                  <times/>
                  <ci>RTONF</ci>
                  <apply>
                    <minus/>
                    <cn cellml:units="dimensionless">1.0</cn>
                    <apply>
                      <exp/>
                      <apply>
                        <divide/>
                        <apply>
                          <times/>
                          <apply>
                            <times/>
                            <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">1.0</cn>
                            </apply>
                            <ci>V</ci>
                          </apply>
                          <cn cellml:units="dimensionless">2.0</cn>
                        </apply>
                        <ci>RTONF</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <apply>
                <minus/>
                <ci>Ca_sub</ci>
                <apply>
                  <times/>
                  <ci>Cao</ci>
                  <apply>
                    <exp/>
                    <apply>
                      <divide/>
                      <apply>
                        <times/>
                        <apply>
                          <minus/>
                          <cn cellml:units="dimensionless">2.0</cn>
                        </apply>
                        <ci>V</ci>
                      </apply>
                      <ci>RTONF</ci>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <ci>dT</ci>
          </apply>
          <ci>fT</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_CaT_dT_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="dT" units="dimensionless" public_interface="out" initial_value="0.192108"/>
    <variable name="dT_infinity" units="dimensionless"/>
    <variable name="tau_dT" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>dT</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>dT_infinity</ci>
            <ci>dT</ci>
          </apply>
          <ci>tau_dT</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>dT_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <minus/>
                  <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">38.3</cn>
                  </apply>
                </apply>
                <cn cellml:units="mV">5.5</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_dT</ci>
        <apply>
          <divide/>
          <cn cellml:units="second">0.001</cn>
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">1.068</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">38.3</cn>
                  </apply>
                  <cn cellml:units="mV">30.0</cn>
                </apply>
              </apply>
            </apply>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">1.068</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <apply>
                    <minus/>
                    <apply>
                      <plus/>
                      <ci>V</ci>
                      <cn cellml:units="mV">38.3</cn>
                    </apply>
                  </apply>
                  <cn cellml:units="mV">30.0</cn>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_CaT_fT_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="fT" units="dimensionless" public_interface="out" initial_value="3.74674099999999996e-02"/>
    <variable name="fT_infinity" units="dimensionless"/>
    <variable name="offset_fT" units="second" initial_value="0.0"/>
    <variable name="tau_fT" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>fT</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>fT_infinity</ci>
            <ci>fT</ci>
          </apply>
          <ci>tau_fT</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>fT_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <plus/>
                  <ci>V</ci>
                  <cn cellml:units="mV">58.7</cn>
                </apply>
                <cn cellml:units="mV">3.8</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_fT</ci>
        <apply>
          <plus/>
          <apply>
            <divide/>
            <cn cellml:units="second">1.0</cn>
            <apply>
              <plus/>
              <apply>
                <times/>
                <cn cellml:units="dimensionless">16.67</cn>
                <apply>
                  <exp/>
                  <apply>
                    <divide/>
                    <apply>
                      <minus/>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">75.0</cn>
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                    <cn cellml:units="mV">83.3</cn>
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                </apply>
              </apply>
              <apply>
                <times/>
                <cn cellml:units="dimensionless">16.67</cn>
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                  <exp/>
                  <apply>
                    <divide/>
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                      <ci>V</ci>
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                    <cn cellml:units="mV">15.38</cn>
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                </apply>
              </apply>
            </apply>
          </apply>
          <ci>offset_fT</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_KACh">
    <variable name="ACh" units="mM" public_interface="in"/>
    <variable name="ACh_on" units="dimensionless" initial_value="0.0"/>
    <variable name="E_K" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="a" units="dimensionless" public_interface="in"/>
    <variable name="g_KACh" units="uS" initial_value="0.00345"/>
    <variable name="i_KACh" units="nA" public_interface="out"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>i_KACh</ci>
        <piecewise>
          <piece>
            <apply>
              <times/>
              <apply>
                <times/>
                <apply>
                  <times/>
                  <apply>
                    <times/>
                    <ci>ACh_on</ci>
                    <ci>g_KACh</ci>
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                  <apply>
                    <minus/>
                    <ci>V</ci>
                    <ci>E_K</ci>
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                </apply>
                <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1.0</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <divide/>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">20.0</cn>
                      </apply>
                      <cn cellml:units="mV">20.0</cn>
                    </apply>
                  </apply>
                </apply>
              </apply>
              <ci>a</ci>
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            <apply>
              <gt/>
              <ci>ACh</ci>
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            </apply>
          </piece>
          <otherwise>
            <cn cellml:units="nA">0.0</cn>
          </otherwise>
        </piecewise>
      </apply>
    </math>
  </component>
  <component name="i_KACh_a_gate">
    <variable name="ACh" units="mM" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="a" units="dimensionless" public_interface="out" initial_value="2.81845900000000016e-03"/>
    <variable name="a_infinity" units="dimensionless"/>
    <variable name="alpha_a" units="hertz"/>
    <variable name="beta_a" units="hertz"/>
    <variable name="tau_a" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>a</ci>
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        <apply>
          <divide/>
          <apply>
            <minus/>
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            <ci>a</ci>
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          <ci>tau_a</ci>
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      <apply>
        <eq/>
        <ci>a_infinity</ci>
        <apply>
          <divide/>
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            <plus/>
            <ci>alpha_a</ci>
            <ci>beta_a</ci>
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      <apply>
        <eq/>
        <ci>alpha_a</ci>
        <apply>
          <plus/>
          <apply>
            <divide/>
            <apply>
              <minus/>
              <cn cellml:units="hertz">3.5988</cn>
              <cn cellml:units="hertz">0.025641</cn>
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            <apply>
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              <cn cellml:units="dimensionless">1.0</cn>
              <apply>
                <divide/>
                <cn cellml:units="dimensionless"> 1.21550000000000005e-06</cn>
                <apply>
                  <power/>
                  <apply>
                    <times/>
                    <cn cellml:units="m3_per_mol">1.0</cn>
                    <ci>ACh</ci>
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                  <cn cellml:units="dimensionless">1.6951</cn>
                </apply>
              </apply>
            </apply>
          </apply>
          <cn cellml:units="hertz">0.025641</cn>
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      </apply>
      <apply>
        <eq/>
        <ci>beta_a</ci>
        <apply>
          <times/>
          <cn cellml:units="hertz">10.0</cn>
          <apply>
            <exp/>
            <apply>
              <times/>
              <cn cellml:units="per_mV">0.0133</cn>
              <apply>
                <plus/>
                <ci>V</ci>
                <cn cellml:units="mV">40.0</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_a</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <ci>alpha_a</ci>
            <ci>beta_a</ci>
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        </apply>
      </apply>
    </math>
  </component>
  <component name="i_Kr">
    <variable name="E_K" units="mV" public_interface="in"/>
    <variable name="Ko" units="mM" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="g_Kr" units="uS"/>
    <variable name="i_Kr" units="nA" public_interface="out"/>
    <variable name="paF" units="dimensionless" public_interface="in"/>
    <variable name="paS" units="dimensionless" public_interface="in"/>
    <variable name="piy" units="dimensionless" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>g_Kr</ci>
        <apply>
          <times/>
          <cn cellml:units="uS"> 4.98909900000000031e-03</cn>
          <apply>
            <root/>
            <apply>
              <divide/>
              <ci>Ko</ci>
              <cn cellml:units="mM">5.4</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>i_Kr</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <ci>g_Kr</ci>
              <apply>
                <minus/>
                <ci>V</ci>
                <ci>E_K</ci>
              </apply>
            </apply>
            <apply>
              <plus/>
              <apply>
                <times/>
                <cn cellml:units="dimensionless">0.9</cn>
                <ci>paF</ci>
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              <apply>
                <times/>
                <cn cellml:units="dimensionless">0.1</cn>
                <ci>paS</ci>
              </apply>
            </apply>
          </apply>
          <ci>piy</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_Kr_pa_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="paF" units="dimensionless" public_interface="out" initial_value="8.34449800000000054e-03"/>
    <variable name="paS" units="dimensionless" public_interface="out" initial_value="0.3450797"/>
    <variable name="pa_infinity" units="dimensionless"/>
    <variable name="tau_paF" units="second"/>
    <variable name="tau_paS" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
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          <ci>paF</ci>
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        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>pa_infinity</ci>
            <ci>paF</ci>
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          <ci>tau_paF</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
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          <ci>paS</ci>
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        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>pa_infinity</ci>
            <ci>paS</ci>
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          <ci>tau_paS</ci>
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      <apply>
        <eq/>
        <ci>pa_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <minus/>
                  <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">10.0144</cn>
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                </apply>
                <cn cellml:units="mV">7.6607</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_paF</ci>
        <apply>
          <divide/>
          <cn cellml:units="second">1.0</cn>
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">30.0</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn cellml:units="mV">10.0</cn>
                </apply>
              </apply>
            </apply>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <minus/>
                  <ci>V</ci>
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                <cn cellml:units="mV">12.0</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_paS</ci>
        <apply>
          <divide/>
          <cn cellml:units="second"> 8.46553540000000049e-01</cn>
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">4.2</cn>
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                <exp/>
                <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn cellml:units="mV">17.0</cn>
                </apply>
              </apply>
            </apply>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">0.15</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <apply>
                    <minus/>
                    <ci>V</ci>
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                  <cn cellml:units="mV">21.6</cn>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_Kr_pi_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="pi_infinity" units="dimensionless"/>
    <variable name="piy" units="dimensionless" public_interface="out" initial_value="0.7369347"/>
    <variable name="tau_pi" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>pi_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <plus/>
                  <ci>V</ci>
                  <cn cellml:units="mV">28.6</cn>
                </apply>
                <cn cellml:units="mV">17.1</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>piy</ci>
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        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>pi_infinity</ci>
            <ci>piy</ci>
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          <ci>tau_pi</ci>
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      <apply>
        <eq/>
        <ci>tau_pi</ci>
        <apply>
          <divide/>
          <cn cellml:units="second">1.0</cn>
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">100.0</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <apply>
                    <minus/>
                    <ci>V</ci>
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                  <cn cellml:units="mV">54.645</cn>
                </apply>
              </apply>
            </apply>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">656.0</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn cellml:units="mV">106.157</cn>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_Ks">
    <variable name="E_Ks" units="mV"/>
    <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
    <variable name="Ki" units="mM" public_interface="in"/>
    <variable name="Ko" units="mM" public_interface="in"/>
    <variable name="Nai" units="mM" public_interface="in"/>
    <variable name="Nao" units="mM" public_interface="in"/>
    <variable name="RTONF" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="g_Ks" units="uS"/>
    <variable name="g_Ks_" units="uS" initial_value="8.63714000000000018e-04"/>
    <variable name="i_Ks" units="nA" public_interface="out"/>
    <variable name="n" units="dimensionless" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>E_Ks</ci>
        <apply>
          <times/>
          <ci>RTONF</ci>
          <apply>
            <ln/>
            <apply>
              <divide/>
              <apply>
                <plus/>
                <ci>Ko</ci>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.12</cn>
                  <ci>Nao</ci>
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              </apply>
              <apply>
                <plus/>
                <ci>Ki</ci>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.12</cn>
                  <ci>Nai</ci>
                </apply>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>g_Ks</ci>
        <piecewise>
          <piece>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">1.2</cn>
              <ci>g_Ks_</ci>
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            <apply>
              <gt/>
              <ci>Iso_1_uM</ci>
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            </apply>
          </piece>
          <otherwise>
            <ci>g_Ks_</ci>
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        </piecewise>
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      <apply>
        <eq/>
        <ci>i_Ks</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <ci>g_Ks</ci>
            <apply>
              <minus/>
              <ci>V</ci>
              <ci>E_Ks</ci>
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          </apply>
          <apply>
            <power/>
            <ci>n</ci>
            <cn cellml:units="dimensionless">2.0</cn>
          </apply>
        </apply>
      </apply>
    </math>
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  <component name="i_Ks_n_gate">
    <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
    <variable name="Iso_shift" units="mV"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="alpha_n" units="hertz"/>
    <variable name="beta_n" units="hertz"/>
    <variable name="n" units="dimensionless" public_interface="out" initial_value="0.1057902"/>
    <variable name="n_infinity" units="dimensionless"/>
    <variable name="tau_n" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
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        <eq/>
        <ci>Iso_shift</ci>
        <piecewise>
          <piece>
            <apply>
              <minus/>
              <cn cellml:units="mV">14.0</cn>
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            <apply>
              <gt/>
              <ci>Iso_1_uM</ci>
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          </piece>
          <otherwise>
            <cn cellml:units="mV">0.0</cn>
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      <apply>
        <eq/>
        <ci>alpha_n</ci>
        <apply>
          <divide/>
          <cn cellml:units="hertz">28.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <minus/>
                  <apply>
                    <minus/>
                    <apply>
                      <minus/>
                      <ci>V</ci>
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                    <ci>Iso_shift</ci>
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                </apply>
                <cn cellml:units="mV">3.0</cn>
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          </apply>
        </apply>
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      <apply>
        <eq/>
        <ci>beta_n</ci>
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            <exp/>
            <apply>
              <divide/>
              <apply>
                <minus/>
                <apply>
                  <minus/>
                  <apply>
                    <minus/>
                    <ci>V</ci>
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                  <cn cellml:units="mV">5.0</cn>
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              </apply>
              <cn cellml:units="mV">25.0</cn>
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          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
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          <ci>n</ci>
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        <apply>
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          <ci>tau_n</ci>
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      <apply>
        <eq/>
        <ci>n_infinity</ci>
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          <root/>
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              <plus/>
              <cn cellml:units="dimensionless">1.0</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
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                    <minus/>
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                      <minus/>
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                        <plus/>
                        <ci>V</ci>
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                      <ci>Iso_shift</ci>
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                  <cn cellml:units="mV">10.7071</cn>
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              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_n</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <ci>alpha_n</ci>
            <ci>beta_n</ci>
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        </apply>
      </apply>
    </math>
  </component>
  <component name="i_Kur">
    <variable name="E_K" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="g_Kur" units="uS" initial_value="7.062e-05"/>
    <variable name="i_Kur" units="nA" public_interface="out"/>
    <variable name="r_Kur" units="dimensionless" public_interface="in"/>
    <variable name="s_Kur" units="dimensionless" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
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        <eq/>
        <ci>i_Kur</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <ci>g_Kur</ci>
              <ci>r_Kur</ci>
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            <ci>s_Kur</ci>
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          <apply>
            <minus/>
            <ci>V</ci>
            <ci>E_K</ci>
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        </apply>
      </apply>
    </math>
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  <component name="i_Kur_rKur_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="r_Kur" units="dimensionless" public_interface="out" initial_value="9.05902400000000059e-03"/>
    <variable name="r_Kur_infinity" units="dimensionless"/>
    <variable name="tau_r_Kur" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
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        <eq/>
        <apply>
          <diff/>
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            <ci>time</ci>
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          <ci>r_Kur</ci>
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        <apply>
          <divide/>
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            <minus/>
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            <ci>r_Kur</ci>
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          <ci>tau_r_Kur</ci>
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      <apply>
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          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
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            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
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              <exp/>
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                <apply>
                  <minus/>
                  <cn cellml:units="mV">8.6</cn>
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              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_r_Kur</ci>
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          <plus/>
          <apply>
            <divide/>
            <cn cellml:units="second">0.009</cn>
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              <plus/>
              <cn cellml:units="dimensionless">1.0</cn>
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                <exp/>
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                  <divide/>
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                    <plus/>
                    <ci>V</ci>
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                  <cn cellml:units="mV">12.0</cn>
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              </apply>
            </apply>
          </apply>
          <cn cellml:units="second">0.0005</cn>
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      </apply>
    </math>
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  <component name="i_Kur_sKur_gate">
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    <variable name="s_Kur" units="dimensionless" public_interface="out" initial_value="0.8655135"/>
    <variable name="s_Kur_infinity" units="dimensionless"/>
    <variable name="tau_s_Kur" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>s_Kur</ci>
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          <divide/>
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            <minus/>
            <ci>s_Kur_infinity</ci>
            <ci>s_Kur</ci>
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          <ci>tau_s_Kur</ci>
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      <apply>
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          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
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                <divide/>
                <apply>
                  <plus/>
                  <ci>V</ci>
                  <cn cellml:units="mV">7.5</cn>
                </apply>
                <cn cellml:units="mV">10.0</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_s_Kur</ci>
        <apply>
          <plus/>
          <apply>
            <divide/>
            <cn cellml:units="second">0.59</cn>
            <apply>
              <plus/>
              <cn cellml:units="dimensionless">1.0</cn>
              <apply>
                <exp/>
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                  <divide/>
                  <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">60.0</cn>
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                  <cn cellml:units="mV">10.0</cn>
                </apply>
              </apply>
            </apply>
          </apply>
          <cn cellml:units="second">3.05</cn>
        </apply>
      </apply>
    </math>
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  <component name="i_Na">
    <variable name="E_mh" units="mV"/>
    <variable name="Ki" units="mM" public_interface="in"/>
    <variable name="Ko" units="mM" public_interface="in"/>
    <variable name="Nai" units="mM" public_interface="in"/>
    <variable name="Nao" units="mM" public_interface="in"/>
    <variable name="RTONF" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="g_Na" units="uS" initial_value="0.0223"/>
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    <variable name="h" units="dimensionless" public_interface="in"/>
    <variable name="i_Na" units="nA" public_interface="out"/>
    <variable name="i_Na_" units="nA"/>
    <variable name="i_Na_L" units="nA"/>
    <variable name="m" units="dimensionless" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>E_mh</ci>
        <apply>
          <times/>
          <ci>RTONF</ci>
          <apply>
            <ln/>
            <apply>
              <divide/>
              <apply>
                <plus/>
                <ci>Nao</ci>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.12</cn>
                  <ci>Ko</ci>
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              <apply>
                <plus/>
                <ci>Nai</ci>
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                  <times/>
                  <cn cellml:units="dimensionless">0.12</cn>
                  <ci>Ki</ci>
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            </apply>
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      <apply>
        <eq/>
        <ci>i_Na</ci>
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          <plus/>
          <ci>i_Na_</ci>
          <ci>i_Na_L</ci>
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      <apply>
        <eq/>
        <ci>i_Na_</ci>
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          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <ci>g_Na</ci>
              <apply>
                <power/>
                <ci>m</ci>
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            <ci>h</ci>
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          <apply>
            <minus/>
            <ci>V</ci>
            <ci>E_mh</ci>
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        </apply>
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      <apply>
        <eq/>
        <ci>i_Na_L</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <ci>g_Na_L</ci>
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              <power/>
              <ci>m</ci>
              <cn cellml:units="dimensionless">3.0</cn>
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          </apply>
          <apply>
            <minus/>
            <ci>V</ci>
            <ci>E_mh</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_NaCa">
    <variable name="Ca_sub" units="mM" public_interface="in"/>
    <variable name="Cao" units="mM" public_interface="in"/>
    <variable name="K1ni" units="mM" initial_value="395.3"/>
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    <variable name="K2no" units="mM" initial_value="561.4"/>
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    <variable name="Kcni" units="mM" initial_value="26.44"/>
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    <variable name="Nao" units="mM" public_interface="in"/>
    <variable name="Qci" units="dimensionless" initial_value="0.1369"/>
    <variable name="Qco" units="dimensionless" initial_value="0.0"/>
    <variable name="Qn" units="dimensionless" initial_value="0.4315"/>
    <variable name="RTONF" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
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    <variable name="do" units="dimensionless"/>
    <variable name="i_NaCa" units="nA" public_interface="out"/>
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    <variable name="k14" units="dimensionless"/>
    <variable name="k21" units="dimensionless"/>
    <variable name="k23" units="dimensionless"/>
    <variable name="k32" units="dimensionless"/>
    <variable name="k34" units="dimensionless"/>
    <variable name="k41" units="dimensionless"/>
    <variable name="k43" units="dimensionless"/>
    <variable name="x1" units="dimensionless"/>
    <variable name="x2" units="dimensionless"/>
    <variable name="x3" units="dimensionless"/>
    <variable name="x4" units="dimensionless"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>di</ci>
        <apply>
          <plus/>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <times/>
              <apply>
                <divide/>
                <ci>Ca_sub</ci>
                <ci>Kci</ci>
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              <apply>
                <plus/>
                <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1.0</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <divide/>
                      <apply>
                        <times/>
                        <apply>
                          <minus/>
                          <ci>Qci</ci>
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                        <ci>V</ci>
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                      <ci>RTONF</ci>
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                </apply>
                <apply>
                  <divide/>
                  <ci>Nai</ci>
                  <ci>Kcni</ci>
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              </apply>
            </apply>
          </apply>
          <apply>
            <times/>
            <apply>
              <divide/>
              <ci>Nai</ci>
              <ci>K1ni</ci>
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              <plus/>
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              <apply>
                <times/>
                <apply>
                  <divide/>
                  <ci>Nai</ci>
                  <ci>K2ni</ci>
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                  <plus/>
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                    <divide/>
                    <ci>Nai</ci>
                    <ci>K3ni</ci>
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        <ci>do</ci>
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          <plus/>
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            <plus/>
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              <times/>
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                <ci>Cao</ci>
                <ci>Kco</ci>
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                  <exp/>
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                      <times/>
                      <ci>Qco</ci>
                      <ci>V</ci>
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                    <ci>RTONF</ci>
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            <times/>
            <apply>
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              <ci>Nao</ci>
              <ci>K1no</ci>
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                <times/>
                <apply>
                  <divide/>
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                    <ci>K3no</ci>
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      <apply>
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        <ci>i_NaCa</ci>
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          <divide/>
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            <ci>K_NaCa</ci>
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              <minus/>
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                <ci>x2</ci>
                <ci>k21</ci>
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                <ci>x1</ci>
                <ci>k12</ci>
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              <plus/>
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                <plus/>
                <ci>x1</ci>
                <ci>x2</ci>
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              <ci>x3</ci>
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            <ci>x4</ci>
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            <apply>
              <divide/>
              <ci>Ca_sub</ci>
              <ci>Kci</ci>
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                <apply>
                  <times/>
                  <apply>
                    <minus/>
                    <ci>Qci</ci>
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                  <ci>V</ci>
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                <ci>RTONF</ci>
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          <ci>di</ci>
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      <apply>
        <eq/>
        <ci>k14</ci>
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            <times/>
            <apply>
              <times/>
              <apply>
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                <ci>K2ni</ci>
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                  <ci>Nai</ci>
                  <ci>K3ni</ci>
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                <divide/>
                <apply>
                  <times/>
                  <ci>Qn</ci>
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                <apply>
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                  <ci>RTONF</ci>
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          <ci>di</ci>
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        <eq/>
        <ci>k21</ci>
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          <divide/>
          <apply>
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            <apply>
              <divide/>
              <ci>Cao</ci>
              <ci>Kco</ci>
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                  <ci>V</ci>
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                <ci>RTONF</ci>
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          <ci>do</ci>
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        <eq/>
        <ci>k23</ci>
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            <times/>
            <apply>
              <times/>
              <apply>
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                  <times/>
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                    <ci>K1no</ci>
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                  <ci>K3no</ci>
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                <divide/>
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                  <times/>
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                    <minus/>
                    <ci>Qn</ci>
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                  <ci>V</ci>
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                  <ci>RTONF</ci>
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          <ci>do</ci>
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      <apply>
        <eq/>
        <ci>k32</ci>
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          <exp/>
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            <divide/>
            <apply>
              <times/>
              <ci>Qn</ci>
              <ci>V</ci>
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              <ci>RTONF</ci>
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        <eq/>
        <ci>k34</ci>
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            <plus/>
            <ci>K3no</ci>
            <ci>Nao</ci>
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      <apply>
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          <exp/>
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            <divide/>
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              <times/>
              <apply>
                <minus/>
                <ci>Qn</ci>
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              <ci>V</ci>
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              <ci>RTONF</ci>
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        <ci>k43</ci>
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          <divide/>
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            <plus/>
            <ci>K3ni</ci>
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      <apply>
        <eq/>
        <ci>x1</ci>
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          <plus/>
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            <times/>
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              <times/>
              <ci>k41</ci>
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              <ci>k23</ci>
              <ci>k21</ci>
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              <times/>
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            <times/>
            <apply>
              <times/>
              <ci>k14</ci>
              <ci>k43</ci>
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              <ci>k23</ci>
              <ci>k21</ci>
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            <apply>
              <times/>
              <ci>k12</ci>
              <ci>k23</ci>
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              <ci>k43</ci>
              <ci>k41</ci>
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      <apply>
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        <ci>x4</ci>
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          <plus/>
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            <times/>
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              <times/>
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            <apply>
              <times/>
              <ci>k14</ci>
              <ci>k21</ci>
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            <apply>
              <plus/>
              <ci>k34</ci>
              <ci>k32</ci>
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          </apply>
        </apply>
      </apply>
    </math>
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    <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
    <variable name="Iso_increase" units="dimensionless"/>
    <variable name="Km_Kp" units="mM" initial_value="1.4"/>
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    <variable name="Ko" units="mM" public_interface="in"/>
    <variable name="Nai" units="mM" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="i_NaK" units="nA" public_interface="out"/>
    <variable name="i_NaK_max" units="nA" initial_value="0.137171"/>
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          <times/>
          <apply>
            <times/>
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              <times/>
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                <times/>
                <ci>Iso_increase</ci>
                <ci>i_NaK_max</ci>
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                <power/>
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                    <power/>
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                      <ci>Km_Kp</ci>
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                    <cn cellml:units="dimensionless">1.2</cn>
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                  <minus/>
                  <cn cellml:units="dimensionless">1.0</cn>
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              <power/>
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                <cn cellml:units="dimensionless">1.0</cn>
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                  <power/>
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                    <divide/>
                    <ci>Km_Nap</ci>
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                  <cn cellml:units="dimensionless">1.3</cn>
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                <minus/>
                <cn cellml:units="dimensionless">1.0</cn>
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            <power/>
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              <cn cellml:units="dimensionless">1.0</cn>
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                <exp/>
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                  <divide/>
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                    <minus/>
                    <apply>
                      <plus/>
                      <apply>
                        <minus/>
                        <ci>V</ci>
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                      <cn cellml:units="mV">110.0</cn>
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                  <cn cellml:units="mV">20.0</cn>
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            <apply>
              <minus/>
              <cn cellml:units="dimensionless">1.0</cn>
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          </apply>
        </apply>
      </apply>
    </math>
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    <variable name="alpha_h" units="hertz"/>
    <variable name="beta_h" units="hertz"/>
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    <variable name="h_infinity" units="dimensionless"/>
    <variable name="tau_h" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
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        <eq/>
        <ci>alpha_h</ci>
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          <times/>
          <cn cellml:units="hertz">20.0</cn>
          <apply>
            <exp/>
            <apply>
              <times/>
              <apply>
                <minus/>
                <cn cellml:units="per_mV">0.125</cn>
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              <apply>
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                <ci>V</ci>
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          </apply>
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      <apply>
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        <ci>beta_h</ci>
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          <divide/>
          <cn cellml:units="hertz">2000.0</cn>
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            <apply>
              <times/>
              <cn cellml:units="dimensionless">320.0</cn>
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                <apply>
                  <times/>
                  <apply>
                    <minus/>
                    <cn cellml:units="per_mV">0.1</cn>
                  </apply>
                  <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">75.0</cn>
                  </apply>
                </apply>
              </apply>
            </apply>
            <cn cellml:units="dimensionless">1.0</cn>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>h</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>h_infinity</ci>
            <ci>h</ci>
          </apply>
          <ci>tau_h</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>h_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <plus/>
                  <ci>V</ci>
                  <cn cellml:units="mV">69.804</cn>
                </apply>
                <cn cellml:units="mV">4.4565</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_h</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <ci>alpha_h</ci>
            <ci>beta_h</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_Na_m_gate">
    <variable name="E0_m" units="mV"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="alpha_m" units="hertz"/>
    <variable name="beta_m" units="hertz"/>
    <variable name="delta_m" units="mV" initial_value="1e-05"/>
    <variable name="m" units="dimensionless" public_interface="out" initial_value="0.3777047"/>
    <variable name="m_infinity" units="dimensionless"/>
    <variable name="tau_m" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>E0_m</ci>
        <apply>
          <plus/>
          <ci>V</ci>
          <cn cellml:units="mV">41.0</cn>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>alpha_m</ci>
        <piecewise>
          <piece>
            <cn cellml:units="hertz">2000.0</cn>
            <apply>
              <lt/>
              <apply>
                <abs/>
                <ci>E0_m</ci>
              </apply>
              <ci>delta_m</ci>
            </apply>
          </piece>
          <otherwise>
            <apply>
              <divide/>
              <apply>
                <times/>
                <cn cellml:units="s2_A_per_g_per_m2">200.0</cn>
                <ci>E0_m</ci>
              </apply>
              <apply>
                <minus/>
                <cn cellml:units="dimensionless">1.0</cn>
                <apply>
                  <exp/>
                  <apply>
                    <times/>
                    <apply>
                      <minus/>
                      <cn cellml:units="per_mV">0.1</cn>
                    </apply>
                    <ci>E0_m</ci>
                  </apply>
                </apply>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>beta_m</ci>
        <apply>
          <times/>
          <cn cellml:units="hertz">8000.0</cn>
          <apply>
            <exp/>
            <apply>
              <times/>
              <apply>
                <minus/>
                <cn cellml:units="per_mV">0.056</cn>
              </apply>
              <apply>
                <plus/>
                <ci>V</ci>
                <cn cellml:units="mV">66.0</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>m</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>m_infinity</ci>
            <ci>m</ci>
          </apply>
          <ci>tau_m</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>m_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <minus/>
                  <apply>
                    <plus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">42.0504</cn>
                  </apply>
                </apply>
                <cn cellml:units="mV">8.3106</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_m</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <ci>alpha_m</ci>
            <ci>beta_m</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_SK">
    <variable name="E_K" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="g_SK" units="uS" initial_value="0.000165"/>
    <variable name="i_SK" units="nA" public_interface="out"/>
    <variable name="x" units="dimensionless" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>i_SK</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <ci>g_SK</ci>
            <apply>
              <minus/>
              <ci>V</ci>
              <ci>E_K</ci>
            </apply>
          </apply>
          <ci>x</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_SK_x_gate">
    <variable name="Ca_sub" units="mM" public_interface="in"/>
    <variable name="EC50_SK" units="mM" initial_value="0.0007"/>
    <variable name="n_SK" units="dimensionless" initial_value="2.2"/>
    <variable name="tau_x" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <variable name="x" units="dimensionless" public_interface="out" initial_value="6.77693899999999988e-02"/>
    <variable name="x_infinity" units="dimensionless"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>tau_x</ci>
        <apply>
          <divide/>
          <cn cellml:units="second">0.001</cn>
          <apply>
            <plus/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">0.047</cn>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless">1000.0</cn>
                  <ci>Ca_sub</ci>
                </apply>
                <cn cellml:units="mM">1.0</cn>
              </apply>
            </apply>
            <apply>
              <divide/>
              <cn cellml:units="dimensionless">1.0</cn>
              <cn cellml:units="dimensionless">76.0</cn>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>x</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>x_infinity</ci>
            <ci>x</ci>
          </apply>
          <ci>tau_x</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>x_infinity</ci>
        <apply>
          <divide/>
          <apply>
            <times/>
            <cn cellml:units="dimensionless">0.81</cn>
            <apply>
              <power/>
              <apply>
                <ci>Ca_sub</ci>
                <cn cellml:units="mM">1.0</cn>
              </apply>
              <ci>n_SK</ci>
            </apply>
          </apply>
          <apply>
            <plus/>
            <apply>
              <power/>
              <apply>
                <divide/>
                <ci>Ca_sub</ci>
                <cn cellml:units="mM">1.0</cn>
              </apply>
              <ci>n_SK</ci>
            </apply>
            <apply>
              <power/>
              <apply>
                <divide/>
                <ci>EC50_SK</ci>
                <cn cellml:units="mM">1.0</cn>
              </apply>
              <ci>n_SK</ci>
            </apply>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_f">
    <variable name="E_K" units="mV" public_interface="in"/>
    <variable name="E_Na" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="g_f_K" units="uS" initial_value="0.0117"/>
    <variable name="g_f_Na" units="uS" initial_value="0.00696"/>
    <variable name="i_f" units="nA" public_interface="out"/>
    <variable name="i_fK" units="nA" public_interface="out"/>
    <variable name="i_fNa" units="nA" public_interface="out"/>
    <variable name="y" units="dimensionless" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>i_f</ci>
        <apply>
          <plus/>
          <ci>i_fNa</ci>
          <ci>i_fK</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>i_fK</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <ci>y</ci>
            <ci>g_f_K</ci>
          </apply>
          <apply>
            <minus/>
            <ci>V</ci>
            <ci>E_K</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>i_fNa</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <ci>y</ci>
            <ci>g_f_Na</ci>
          </apply>
          <apply>
            <minus/>
            <ci>V</ci>
            <ci>E_Na</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_f_y_gate">
    <variable name="ACh" units="mM" public_interface="in"/>
    <variable name="ACh_shift" units="mV"/>
    <variable name="Iso_1_uM" units="dimensionless" public_interface="in"/>
    <variable name="Iso_shift" units="mV"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="tau_y" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <variable name="y" units="dimensionless" public_interface="out" initial_value="0.0103301"/>
    <variable name="y_infinity" units="dimensionless"/>
    <variable name="y_shift" units="mV" initial_value="0.0"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>ACh_shift</ci>
        <piecewise>
          <piece>
            <apply>
              <minus/>
              <apply>
                <minus/>
                <cn cellml:units="mV">1.0</cn>
              </apply>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <cn cellml:units="mV">9.898</cn>
                  <apply>
                    <power/>
                    <apply>
                      <times/>
                      <cn cellml:units="m3_per_mol">1.0</cn>
                      <ci>ACh</ci>
                    </apply>
                    <cn cellml:units="dimensionless">0.618</cn>
                  </apply>
                </apply>
                <apply>
                  <plus/>
                  <apply>
                    <power/>
                    <apply>
                      <times/>
                      <cn cellml:units="m3_per_mol">1.0</cn>
                      <ci>ACh</ci>
                    </apply>
                    <cn cellml:units="dimensionless">0.618</cn>
                  </apply>
                  <cn cellml:units="dimensionless"> 1.22422999999999998e-03</cn>
                </apply>
              </apply>
            </apply>
            <apply>
              <gt/>
              <ci>ACh</ci>
              <cn cellml:units="mM">0.0</cn>
            </apply>
          </piece>
          <otherwise>
            <cn cellml:units="mV">0.0</cn>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>Iso_shift</ci>
        <piecewise>
          <piece>
            <cn cellml:units="mV">7.5</cn>
            <apply>
              <gt/>
              <ci>Iso_1_uM</ci>
              <cn cellml:units="dimensionless">0.0</cn>
            </apply>
          </piece>
          <otherwise>
            <cn cellml:units="mV">0.0</cn>
          </otherwise>
        </piecewise>
      </apply>
      <apply>
        <eq/>
        <ci>tau_y</ci>
        <apply>
          <minus/>
          <apply>
            <divide/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <plus/>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <cn cellml:units="s2_A_per_g_per_m2">0.36</cn>
                  <apply>
                    <minus/>
                    <apply>
                      <minus/>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">148.8</cn>
                      </apply>
                      <ci>ACh_shift</ci>
                    </apply>
                    <ci>Iso_shift</ci>
                  </apply>
                </apply>
                <apply>
                  <minus/>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <cn cellml:units="per_mV">0.066</cn>
                      <apply>
                        <minus/>
                        <apply>
                          <minus/>
                          <apply>
                            <plus/>
                            <ci>V</ci>
                            <cn cellml:units="mV">148.8</cn>
                          </apply>
                          <ci>ACh_shift</ci>
                        </apply>
                        <ci>Iso_shift</ci>
                      </apply>
                    </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1.0</cn>
                </apply>
              </apply>
              <apply>
                <divide/>
                <apply>
                  <times/>
                  <cn cellml:units="s2_A_per_g_per_m2">0.1</cn>
                  <apply>
                    <minus/>
                    <apply>
                      <minus/>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">87.3</cn>
                      </apply>
                      <ci>ACh_shift</ci>
                    </apply>
                    <ci>Iso_shift</ci>
                  </apply>
                </apply>
                <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1.0</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <apply>
                        <minus/>
                        <cn cellml:units="per_mV">0.2</cn>
                      </apply>
                      <apply>
                        <minus/>
                        <apply>
                          <minus/>
                          <apply>
                            <plus/>
                            <ci>V</ci>
                            <cn cellml:units="mV">87.3</cn>
                          </apply>
                          <ci>ACh_shift</ci>
                        </apply>
                        <ci>Iso_shift</ci>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
          </apply>
          <cn cellml:units="second">0.054</cn>
        </apply>
      </apply>
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>y</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>y_infinity</ci>
            <ci>y</ci>
          </apply>
          <ci>tau_y</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>y_infinity</ci>
        <piecewise>
          <piece>
            <apply>
              <plus/>
              <cn cellml:units="dimensionless">0.01329</cn>
              <apply>
                <divide/>
                <cn cellml:units="dimensionless">0.99921</cn>
                <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1.0</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <divide/>
                      <apply>
                        <minus/>
                        <apply>
                          <minus/>
                          <apply>
                            <minus/>
                            <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="mV">97.134</cn>
                            </apply>
                            <ci>ACh_shift</ci>
                          </apply>
                          <ci>Iso_shift</ci>
                        </apply>
                        <ci>y_shift</ci>
                      </apply>
                      <cn cellml:units="mV">8.1752</cn>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <apply>
              <lt/>
              <ci>V</ci>
              <apply>
                <minus/>
                <apply>
                  <minus/>
                  <apply>
                    <minus/>
                    <apply>
                      <minus/>
                      <cn cellml:units="mV">80.0</cn>
                      <ci>ACh_shift</ci>
                    </apply>
                    <ci>Iso_shift</ci>
                  </apply>
                  <ci>y_shift</ci>
                </apply>
              </apply>
            </apply>
          </piece>
          <otherwise>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">0.0002501</cn>
              <apply>
                <exp/>
                <apply>
                  <divide/>
                  <apply>
                    <minus/>
                    <apply>
                      <minus/>
                      <apply>
                        <minus/>
                        <apply>
                          <minus/>
                          <ci>V</ci>
                          <ci>ACh_shift</ci>
                        </apply>
                        <ci>Iso_shift</ci>
                      </apply>
                      <ci>y_shift</ci>
                    </apply>
                  </apply>
                  <cn cellml:units="mV">12.861</cn>
                </apply>
              </apply>
            </apply>
          </otherwise>
        </piecewise>
      </apply>
    </math>
  </component>
  <component name="i_to">
    <variable name="E_K" units="mV" public_interface="in"/>
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="g_to" units="uS" initial_value="1.67347999999999998e-03"/>
    <variable name="i_to" units="nA" public_interface="out"/>
    <variable name="q" units="dimensionless" public_interface="in"/>
    <variable name="r" units="dimensionless" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <ci>i_to</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <ci>g_to</ci>
              <apply>
                <minus/>
                <ci>V</ci>
                <ci>E_K</ci>
              </apply>
            </apply>
            <ci>q</ci>
          </apply>
          <ci>r</ci>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_to_q_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="q" units="dimensionless" public_interface="out" initial_value="0.4735559"/>
    <variable name="q_infinity" units="dimensionless"/>
    <variable name="tau_q" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>q</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>q_infinity</ci>
            <ci>q</ci>
          </apply>
          <ci>tau_q</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>q_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <plus/>
                  <ci>V</ci>
                  <cn cellml:units="mV">49.0</cn>
                </apply>
                <cn cellml:units="mV">13.0</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_q</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <cn cellml:units="dimensionless">0.001</cn>
            <cn cellml:units="dimensionless">0.6</cn>
          </apply>
          <apply>
            <plus/>
            <apply>
              <divide/>
              <cn cellml:units="dimensionless">65.17</cn>
              <apply>
                <plus/>
                <apply>
                  <times/>
                  <cn cellml:units="hertz">0.57</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <apply>
                        <minus/>
                        <cn cellml:units="per_mV">0.08</cn>
                      </apply>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">44.0</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <cn cellml:units="hertz">0.065</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <cn cellml:units="per_mV">0.1</cn>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">45.93</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <cn cellml:units="second">10.1</cn>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <component name="i_to_r_gate">
    <variable name="V" units="mV" public_interface="in"/>
    <variable name="r" units="dimensionless" public_interface="out" initial_value="1.24570600000000007e-02"/>
    <variable name="r_infinity" units="dimensionless"/>
    <variable name="tau_r" units="second"/>
    <variable name="time" units="second" public_interface="in"/>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq/>
        <apply>
          <diff/>
          <bvar>
            <ci>time</ci>
          </bvar>
          <ci>r</ci>
        </apply>
        <apply>
          <divide/>
          <apply>
            <minus/>
            <ci>r_infinity</ci>
            <ci>r</ci>
          </apply>
          <ci>tau_r</ci>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>r_infinity</ci>
        <apply>
          <divide/>
          <cn cellml:units="dimensionless">1.0</cn>
          <apply>
            <plus/>
            <cn cellml:units="dimensionless">1.0</cn>
            <apply>
              <exp/>
              <apply>
                <divide/>
                <apply>
                  <minus/>
                  <apply>
                    <minus/>
                    <ci>V</ci>
                    <cn cellml:units="mV">19.3</cn>
                  </apply>
                </apply>
                <cn cellml:units="mV">15.0</cn>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq/>
        <ci>tau_r</ci>
        <apply>
          <times/>
          <apply>
            <times/>
            <apply>
              <times/>
              <cn cellml:units="dimensionless">0.001</cn>
              <cn cellml:units="dimensionless">0.66</cn>
            </apply>
            <cn cellml:units="dimensionless">1.4</cn>
          </apply>
          <apply>
            <plus/>
            <apply>
              <divide/>
              <cn cellml:units="second">15.59</cn>
              <apply>
                <plus/>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless">1.037</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <cn cellml:units="per_mV">0.09</cn>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">30.61</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <times/>
                  <cn cellml:units="dimensionless">0.369</cn>
                  <apply>
                    <exp/>
                    <apply>
                      <times/>
                      <apply>
                        <minus/>
                        <cn cellml:units="per_mV">0.12</cn>
                      </apply>
                      <apply>
                        <plus/>
                        <ci>V</ci>
                        <cn cellml:units="mV">23.84</cn>
                      </apply>
                    </apply>
                  </apply>
                </apply>
              </apply>
            </apply>
            <cn cellml:units="second">2.98</cn>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
  <connection>
    <map_components component_1="Ca_SR_release" component_2="Ca_dynamics"/>
    <map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    <map_variables variable_1="j_SRCarel" variable_2="j_SRCarel"/>
  </connection>
  <connection>
    <map_components component_1="Ca_SR_release" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="Ca_buffering" component_2="Ca_dynamics"/>
    <map_variables variable_1="CM_tot" variable_2="CM_tot"/>
    <map_variables variable_1="CQ_tot" variable_2="CQ_tot"/>
    <map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    <map_variables variable_1="Cai" variable_2="Cai"/>
    <map_variables variable_1="TC_tot" variable_2="TC_tot"/>
    <map_variables variable_1="TMC_tot" variable_2="TMC_tot"/>
    <map_variables variable_1="delta_fCMi" variable_2="delta_fCMi"/>
    <map_variables variable_1="delta_fCMs" variable_2="delta_fCMs"/>
    <map_variables variable_1="delta_fCQ" variable_2="delta_fCQ"/>
    <map_variables variable_1="delta_fTC" variable_2="delta_fTC"/>
    <map_variables variable_1="delta_fTMC" variable_2="delta_fTMC"/>
  </connection>
  <connection>
    <map_components component_1="Ca_buffering" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="Ca_intracellular_fluxes"/>
    <map_variables variable_1="Ca_jsr" variable_2="Ca_jsr"/>
    <map_variables variable_1="Ca_nsr" variable_2="Ca_nsr"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    <map_variables variable_1="Cai" variable_2="Cai"/>
    <map_variables variable_1="j_Ca_dif" variable_2="j_Ca_dif"/>
    <map_variables variable_1="j_tr" variable_2="j_tr"/>
    <map_variables variable_1="j_up" variable_2="j_up"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="Cell_parameters"/>
    <map_variables variable_1="V_i" variable_2="V_i"/>
    <map_variables variable_1="V_jsr" variable_2="V_jsr"/>
    <map_variables variable_1="V_nsr" variable_2="V_nsr"/>
    <map_variables variable_1="V_sub" variable_2="V_sub"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="Membrane"/>
    <map_variables variable_1="F" variable_2="F"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="i_CaL"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    <map_variables variable_1="i_siCa" variable_2="i_siCa"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="i_CaL_fCa_gate"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="i_CaT"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    <map_variables variable_1="i_CaT_i_CaT" variable_2="i_CaT"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="i_NaCa"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
    <map_variables variable_1="i_NaCa_i_NaCa" variable_2="i_NaCa"/>
  </connection>
  <connection>
    <map_components component_1="Ca_dynamics" component_2="i_SK_x_gate"/>
    <map_variables variable_1="Ca_sub" variable_2="Ca_sub"/>
  </connection>
  <connection>
    <map_components component_1="Ca_intracellular_fluxes" component_2="Rate_modulation_experiments"/>
    <map_variables variable_1="ACh" variable_2="ACh"/>
    <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
  </connection>
  <connection>
    <map_components component_1="Cell_parameters" component_2="Ki_concentration"/>
    <map_variables variable_1="V_i" variable_2="V_i"/>
    <map_variables variable_1="V_sub" variable_2="V_sub"/>
  </connection>
  <connection>
    <map_components component_1="Cell_parameters" component_2="Nai_concentration"/>
    <map_variables variable_1="V_i" variable_2="V_i"/>
    <map_variables variable_1="V_sub" variable_2="V_sub"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="Ki_concentration"/>
    <map_variables variable_1="Ki" variable_2="Ki"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="Membrane"/>
    <map_variables variable_1="RTONF" variable_2="RTONF"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="Nai_concentration"/>
    <map_variables variable_1="Nai" variable_2="Nai"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_CaL"/>
    <map_variables variable_1="Cao" variable_2="Cao"/>
    <map_variables variable_1="Ko" variable_2="Ko"/>
    <map_variables variable_1="Nao" variable_2="Nao"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_CaT"/>
    <map_variables variable_1="Cao" variable_2="Cao"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_KACh"/>
    <map_variables variable_1="E_K" variable_2="E_K"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_Kr"/>
    <map_variables variable_1="E_K" variable_2="E_K"/>
    <map_variables variable_1="Ko" variable_2="Ko"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_Ks"/>
    <map_variables variable_1="Ko" variable_2="Ko"/>
    <map_variables variable_1="Nao" variable_2="Nao"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_Kur"/>
    <map_variables variable_1="E_K" variable_2="E_K"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_Na"/>
    <map_variables variable_1="Ko" variable_2="Ko"/>
    <map_variables variable_1="Nao" variable_2="Nao"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_NaCa"/>
    <map_variables variable_1="Cao" variable_2="Cao"/>
    <map_variables variable_1="Nao" variable_2="Nao"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_NaK"/>
    <map_variables variable_1="E_Na" variable_2="E_Na"/>
    <map_variables variable_1="Ko" variable_2="Ko"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_SK"/>
    <map_variables variable_1="E_K" variable_2="E_K"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_f"/>
    <map_variables variable_1="E_K" variable_2="E_K"/>
    <map_variables variable_1="E_Na" variable_2="E_Na"/>
  </connection>
  <connection>
    <map_components component_1="Ionic_values" component_2="i_to"/>
    <map_variables variable_1="E_K" variable_2="E_K"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="Membrane"/>
    <map_variables variable_1="F" variable_2="F"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_CaL"/>
    <map_variables variable_1="Ki" variable_2="Ki"/>
    <map_variables variable_1="i_siK" variable_2="i_siK"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_Kr"/>
    <map_variables variable_1="i_Kr_i_Kr" variable_2="i_Kr"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_Ks"/>
    <map_variables variable_1="Ki" variable_2="Ki"/>
    <map_variables variable_1="i_Ks_i_Ks" variable_2="i_Ks"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_Kur"/>
    <map_variables variable_1="i_Kur_i_Kur" variable_2="i_Kur"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_Na"/>
    <map_variables variable_1="Ki" variable_2="Ki"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_NaK"/>
    <map_variables variable_1="i_NaK_i_NaK" variable_2="i_NaK"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_SK"/>
    <map_variables variable_1="i_SK_i_SK" variable_2="i_SK"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_f"/>
    <map_variables variable_1="i_fK" variable_2="i_fK"/>
  </connection>
  <connection>
    <map_components component_1="Ki_concentration" component_2="i_to"/>
    <map_variables variable_1="i_to_i_to" variable_2="i_to"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="Nai_concentration"/>
    <map_variables variable_1="F" variable_2="F"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_CaL"/>
    <map_variables variable_1="RTONF" variable_2="RTONF"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_CaL_i_CaL" variable_2="i_CaL"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_CaL_dL_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_CaL_fL_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_CaT"/>
    <map_variables variable_1="RTONF" variable_2="RTONF"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_CaT_i_CaT" variable_2="i_CaT"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_CaT_dT_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_CaT_fT_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_KACh"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_KACh_i_KACh" variable_2="i_KACh"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_KACh_a_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Kr"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_Kr_i_Kr" variable_2="i_Kr"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Kr_pa_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Kr_pi_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Ks"/>
    <map_variables variable_1="RTONF" variable_2="RTONF"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_Ks_i_Ks" variable_2="i_Ks"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Ks_n_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Kur"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_Kur_i_Kur" variable_2="i_Kur"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Kur_rKur_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Kur_sKur_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Na"/>
    <map_variables variable_1="RTONF" variable_2="RTONF"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_Na_i_Na" variable_2="i_Na"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_NaCa"/>
    <map_variables variable_1="RTONF" variable_2="RTONF"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_NaCa_i_NaCa" variable_2="i_NaCa"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_NaK"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_NaK_i_NaK" variable_2="i_NaK"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Na_h_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_Na_m_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_SK"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_SK_i_SK" variable_2="i_SK"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_f"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_f_i_f" variable_2="i_f"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_f_y_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_to"/>
    <map_variables variable_1="V" variable_2="V"/>
    <map_variables variable_1="i_to_i_to" variable_2="i_to"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_to_q_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Membrane" component_2="i_to_r_gate"/>
    <map_variables variable_1="V" variable_2="V"/>
  </connection>
  <connection>
    <map_components component_1="Nai_concentration" component_2="environment"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="Nai_concentration" component_2="i_CaL"/>
    <map_variables variable_1="Nai" variable_2="Nai"/>
    <map_variables variable_1="i_siNa" variable_2="i_siNa"/>
  </connection>
  <connection>
    <map_components component_1="Nai_concentration" component_2="i_Ks"/>
    <map_variables variable_1="Nai" variable_2="Nai"/>
  </connection>
  <connection>
    <map_components component_1="Nai_concentration" component_2="i_Na"/>
    <map_variables variable_1="Nai" variable_2="Nai"/>
    <map_variables variable_1="i_Na_i_Na" variable_2="i_Na"/>
  </connection>
  <connection>
    <map_components component_1="Nai_concentration" component_2="i_NaCa"/>
    <map_variables variable_1="Nai" variable_2="Nai"/>
    <map_variables variable_1="i_NaCa_i_NaCa" variable_2="i_NaCa"/>
  </connection>
  <connection>
    <map_components component_1="Nai_concentration" component_2="i_NaK"/>
    <map_variables variable_1="Nai" variable_2="Nai"/>
    <map_variables variable_1="i_NaK_i_NaK" variable_2="i_NaK"/>
  </connection>
  <connection>
    <map_components component_1="Nai_concentration" component_2="i_f"/>
    <map_variables variable_1="i_fNa" variable_2="i_fNa"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_CaL"/>
    <map_variables variable_1="ACh" variable_2="ACh"/>
    <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_CaL_dL_gate"/>
    <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_KACh"/>
    <map_variables variable_1="ACh" variable_2="ACh"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_KACh_a_gate"/>
    <map_variables variable_1="ACh" variable_2="ACh"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_Ks"/>
    <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_Ks_n_gate"/>
    <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_NaK"/>
    <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
  </connection>
  <connection>
    <map_components component_1="Rate_modulation_experiments" component_2="i_f_y_gate"/>
    <map_variables variable_1="ACh" variable_2="ACh"/>
    <map_variables variable_1="Iso_1_uM" variable_2="Iso_1_uM"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_CaL_dL_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_CaL_fCa_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_CaL_fL_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_CaT_dT_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_CaT_fT_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_KACh_a_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_Kr_pa_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_Kr_pi_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_Ks_n_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_Kur_rKur_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_Kur_sKur_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_Na_h_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_Na_m_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_SK_x_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_f_y_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_to_q_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="environment" component_2="i_to_r_gate"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  <connection>
    <map_components component_1="i_CaL" component_2="i_CaL_dL_gate"/>
    <map_variables variable_1="dL" variable_2="dL"/>
  </connection>
  <connection>
    <map_components component_1="i_CaL" component_2="i_CaL_fCa_gate"/>
    <map_variables variable_1="fCa" variable_2="fCa"/>
  </connection>
  <connection>
    <map_components component_1="i_CaL" component_2="i_CaL_fL_gate"/>
    <map_variables variable_1="fL" variable_2="fL"/>
  </connection>
  <connection>
    <map_components component_1="i_CaT" component_2="i_CaT_dT_gate"/>
    <map_variables variable_1="dT" variable_2="dT"/>
  </connection>
  <connection>
    <map_components component_1="i_CaT" component_2="i_CaT_fT_gate"/>
    <map_variables variable_1="fT" variable_2="fT"/>
  </connection>
  <connection>
    <map_components component_1="i_KACh" component_2="i_KACh_a_gate"/>
    <map_variables variable_1="a" variable_2="a"/>
  </connection>
  <connection>
    <map_components component_1="i_Kr" component_2="i_Kr_pa_gate"/>
    <map_variables variable_1="paF" variable_2="paF"/>
    <map_variables variable_1="paS" variable_2="paS"/>
  </connection>
  <connection>
    <map_components component_1="i_Kr" component_2="i_Kr_pi_gate"/>
    <map_variables variable_1="piy" variable_2="piy"/>
  </connection>
  <connection>
    <map_components component_1="i_Ks" component_2="i_Ks_n_gate"/>
    <map_variables variable_1="n" variable_2="n"/>
  </connection>
  <connection>
    <map_components component_1="i_Kur" component_2="i_Kur_rKur_gate"/>
    <map_variables variable_1="r_Kur" variable_2="r_Kur"/>
  </connection>
  <connection>
    <map_components component_1="i_Kur" component_2="i_Kur_sKur_gate"/>
    <map_variables variable_1="s_Kur" variable_2="s_Kur"/>
  </connection>
  <connection>
    <map_components component_1="i_Na" component_2="i_Na_h_gate"/>
    <map_variables variable_1="h" variable_2="h"/>
  </connection>
  <connection>
    <map_components component_1="i_Na" component_2="i_Na_m_gate"/>
    <map_variables variable_1="m" variable_2="m"/>
  </connection>
  <connection>
    <map_components component_1="i_SK" component_2="i_SK_x_gate"/>
    <map_variables variable_1="x" variable_2="x"/>
  </connection>
  <connection>
    <map_components component_1="i_f" component_2="i_f_y_gate"/>
    <map_variables variable_1="y" variable_2="y"/>
  </connection>
  <connection>
    <map_components component_1="i_to" component_2="i_to_q_gate"/>
    <map_variables variable_1="q" variable_2="q"/>
  </connection>
  <connection>
    <map_components component_1="i_to" component_2="i_to_r_gate"/>
    <map_variables variable_1="r" variable_2="r"/>
  </connection>
</model>