- Author:
- Mabelle Lin <mlin865@aucklanduni.ac.nz>
- Date:
- 2021-11-25 09:40:07+13:00
- Desc:
- Adding Y5Q1 of human colon scaffold
- Permanent Source URI:
- https://models.cellml.org/workspace/614/rawfile/70042cfa11349f601a91bf34e9bbbf1384d2bc40/README.rst
In this workspace we have the mapping tool provenance data file needed to produce the generic human colon scaffold for the `SPARC <https://commonfund.nih.gov/sparc>`_ project. The mapping tool will be accessible from the release download page on the `SPARC Portal <https://sparc.science>`_.
.. image:: humanColon_thumbnail.jpeg
:width: 50%
:alt: Rendering of the generic human colon scaffold.
The colon scaffold is designed topologically as a tube defined by a central line which follows the path of a colon traced from an image, which could be obtained from photography, CT or MRI. The scaffold captures the haustral sacs appearance due to presence of three tenia coli. The colon scaffold's haustra are currently very regular, and are representative rather than matching any individual. The ability to control dimensions such as colon diameter, wall thickness, and tenia coli properties, as well as variations of these properties throughout the entire length of the colon allows the scaffold to be configurable for different center paths and sizes to support different species and individuals.
The human colon scaffold is created based on average dimensions and images obtained from literature.
In this release, four wall layers (mucosa, submucosa, circular muscle, and longitudinal muscle) are added to the human colon scaffold. The outer surface of the scaffold is annotated as the serosa. The human colon scaffold now also has a material coordinate field called colon coordinates. This coordinate field will be used for the data embedding step in the scaffold mapping process.
Please see the `SPARC Portal <https://sparc.science>`_ for more details about the SPARC project.
