Location: Hodgkin & Huxley (1952) model @ 01b5e3d2e6dd / experiments / voltage_clamp_protocol.cellml

Author:

WeiweiAi <wai484@aucklanduni.ac.nz>

Date:

2021-04-27 14:28:37+12:00

Desc:

Change .xml to cellml; Add temperature_factor.cellml and corresponding modification to include tempeature in the model; Add clamped_current.cellml, voltage_clamp_protocol.cellml and voltage_clamp_experiment.cellml to simulate membrance current during voltage clamp ( there is an issue at -10 mV but works fine at other voltage conditions); Add propagated_AP.cellml and AP_propagation_experiment.cellml to simulate propagated action potential (issue: the AP doesn't fall); Add data derived from the figures in the original paper using Engauge Digitizer;

Permanent Source URI:

https://models.cellml.org/workspace/64f/rawfile/01b5e3d2e6dd9987f71682214516c78e4dd76916/experiments/voltage_clamp_protocol.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="voltage_clamp_protocol" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <!-- clamp the voltage for the experiments-->
    <import xlink:href="../components/units.cellml">
        <units name="ms" units_ref="ms"/>
        <units name="mV" units_ref="mV"/>
    </import>
    <component name="voltage_clamp_protocol">
        <variable name="V" public_interface="out" units="mV"/>
        <variable name="time" public_interface="in" units="ms"/>
        <variable name="t_start" public_interface="in" units="ms"/>
        <variable name="t_end" public_interface="in" units="ms"/>
        <variable name="V_clamp" public_interface="in" units="mV"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply id="voltage_clamp_calculation">
                <eq/>
                <ci>V</ci>
                <piecewise>
                    <piece>
                        <ci>V_clamp</ci>
                        <apply>
                            <and/>
                            <apply>
                                <gt/>
                                <ci>time</ci>
                                <ci>t_start</ci>
                            </apply>
                            <apply>
                                <lt/>
                                <ci>time</ci>
                                <ci>t_end</ci>
                            </apply>
                        </apply>
                    </piece>
                    <otherwise>
                        <cn cellml:units="mV">0.0</cn>
                    </otherwise>
                </piecewise>
            </apply>
        </math>
    </component>
</model>