- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-03-31 10:48:40+13:00
- Desc:
- Add open channel IV of HH models; Add simulation and plot python scripts
- Permanent Source URI:
- https://models.cellml.org/workspace/64f/rawfile/ab2962b8796666ad9938a2577611c954f006b5fd/BG/IK_BG.cellml
<?xml version='1.0' encoding='UTF-8'?>
<!-- The BG of K channel model that combines channel current and gating modules. -->
<model name="IK_BG" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/BG/units_BG.cellml">
<units name="per_fmol" units_ref="per_fmol"/>
<units name="fmol" units_ref="fmol"/>
<units name="fmol_per_sec" units_ref="fmol_per_sec"/>
<units name="fA" units_ref="fA"/>
</import>
<import xlink:href="../cellLib/BG/IX_BG.cellml">
<component component_ref="IX_BG" name="IX_BG"/>
</import>
<import xlink:href="channelK_BG.cellml">
<component component_ref="channelK_BG" name="channelK_BG"/>
</import>
<import xlink:href="../cellLib/BG/gate_n4_BG.cellml">
<component component_ref="gate_n4_BG" name="gate_n4_BG"/>
</import>
<component name="IK_BG">
<!--Parameters-->
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="kappa_K" private_interface="out" public_interface="in" units="fmol_per_sec"/>
<variable name="z_K" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="K_i_K" private_interface="out" public_interface="in" units="per_fmol"/>
<variable name="q_i_K_init" private_interface="out" public_interface="in" units="fmol"/>
<variable name="K_e_K" private_interface="out" public_interface="in" units="per_fmol"/>
<variable name="q_e_K_init" private_interface="out" public_interface="in" units="fmol"/>
<variable name="q_S0_init" private_interface="out" public_interface="in" units="fmol"/>
<variable name="q_S1_init" private_interface="out" public_interface="in" units="fmol"/>
<variable name="q_S2_init" private_interface="out" public_interface="in" units="fmol"/>
<variable name="q_S3_init" private_interface="out" public_interface="in" units="fmol"/>
<variable name="q_S4_init" private_interface="out" public_interface="in" units="fmol"/>
<variable name="K_S0" private_interface="out" public_interface="in" units="per_fmol"/>
<variable name="K_S1" private_interface="out" public_interface="in" units="per_fmol"/>
<variable name="K_S2" private_interface="out" public_interface="in" units="per_fmol"/>
<variable name="K_S3" private_interface="out" public_interface="in" units="per_fmol"/>
<variable name="K_S4" private_interface="out" public_interface="in" units="per_fmol"/>
<variable name="kappa_n1" private_interface="out" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_n2" private_interface="out" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_n3" private_interface="out" public_interface="in" units="fmol_per_sec"/>
<variable name="kappa_n4" private_interface="out" public_interface="in" units="fmol_per_sec"/>
<variable name="z_n_f" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="z_n_r" private_interface="out" public_interface="in" units="dimensionless"/>
<!--Inputs-->
<variable name="t" private_interface="out" public_interface="in" units="second"/>
<variable name="V_m" private_interface="out" public_interface="in" units="volt"/>
<!--Outputs-->
<variable name="I_K" private_interface="in" public_interface="out" units="fA"/>
<variable name="A_g_K" private_interface="in" public_interface="out" units="J_per_mol"/>
<variable name="q_S0" private_interface="in" public_interface="out" units="fmol"/>
<variable name="q_S1" private_interface="in" public_interface="out" units="fmol"/>
<variable name="q_S2" private_interface="in" public_interface="out" units="fmol"/>
<variable name="q_S3" private_interface="in" public_interface="out" units="fmol"/>
<variable name="q_S4" private_interface="in" public_interface="out" units="fmol"/>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="IK_BG">
<component_ref component="IX_BG"/>
<component_ref component="channelK_BG"/>
<component_ref component="gate_n4_BG"/>
</component_ref>
</group>
<connection>
<map_components component_1="IK_BG" component_2="channelK_BG"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="kappa_K" variable_2="kappa_K"/>
<map_variables variable_1="z_K" variable_2="z_K"/>
<map_variables variable_1="K_i_K" variable_2="K_i_K"/>
<map_variables variable_1="q_i_K_init" variable_2="q_i_K_init"/>
<map_variables variable_1="K_e_K" variable_2="K_e_K"/>
<map_variables variable_1="q_e_K_init" variable_2="q_e_K_init"/>
</connection>
<connection>
<map_components component_1="IK_BG" component_2="gate_n4_BG"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="t" variable_2="t"/>
<map_variables variable_1="q_S0_init" variable_2="q_S0_init"/>
<map_variables variable_1="q_S1_init" variable_2="q_S1_init"/>
<map_variables variable_1="q_S2_init" variable_2="q_S2_init"/>
<map_variables variable_1="q_S3_init" variable_2="q_S3_init"/>
<map_variables variable_1="q_S4_init" variable_2="q_S4_init"/>
<map_variables variable_1="K_S0" variable_2="K_S0"/>
<map_variables variable_1="K_S1" variable_2="K_S1"/>
<map_variables variable_1="K_S2" variable_2="K_S2"/>
<map_variables variable_1="K_S3" variable_2="K_S3"/>
<map_variables variable_1="K_S4" variable_2="K_S4"/>
<map_variables variable_1="kappa_n1" variable_2="kappa_n1"/>
<map_variables variable_1="kappa_n2" variable_2="kappa_n2"/>
<map_variables variable_1="kappa_n3" variable_2="kappa_n3"/>
<map_variables variable_1="kappa_n4" variable_2="kappa_n4"/>
<map_variables variable_1="z_n_f" variable_2="z_n_f"/>
<map_variables variable_1="z_n_r" variable_2="z_n_r"/>
<map_variables variable_1="q_S0" variable_2="q_S0"/>
<map_variables variable_1="q_S1" variable_2="q_S1"/>
<map_variables variable_1="q_S2" variable_2="q_S2"/>
<map_variables variable_1="q_S3" variable_2="q_S3"/>
<map_variables variable_1="q_S4" variable_2="q_S4"/>
<map_variables variable_1="A_g_K" variable_2="A_g_K"/>
</connection>
<connection>
<map_components component_1="IK_BG" component_2="IX_BG"/>
<map_variables variable_1="V_m" variable_2="V_m"/>
<map_variables variable_1="I_K" variable_2="I_X"/>
</connection>
<connection>
<map_components component_1="IX_BG" component_2="gate_n4_BG"/>
<map_variables variable_1="mu_p" variable_2="mu_p"/>
<map_variables variable_1="v_g_X" variable_2="v_n_K"/>
</connection>
<connection>
<map_components component_1="IX_BG" component_2="channelK_BG"/>
<map_variables variable_1="mu_p" variable_2="mu_p"/>
<map_variables variable_1="v_p_X" variable_2="v_p_K"/>
</connection>
<connection>
<map_components component_1="channelK_BG" component_2="gate_n4_BG"/>
<map_variables variable_1="A_g_K" variable_2="A_g_K"/>
</connection>
</model>
