- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-03-31 10:48:40+13:00
- Desc:
- Add open channel IV of HH models; Add simulation and plot python scripts
- Permanent Source URI:
- https://models.cellml.org/workspace/64f/rawfile/ab2962b8796666ad9938a2577611c954f006b5fd/components/IK.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="IK" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../cellLib/Components/units.cellml">
<units name="ms" units_ref="ms"/>
<units name="mV" units_ref="mV"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="per_ms_mV" units_ref="per_ms_mV"/>
<units name="uA_per_cmsq" units_ref="uA_per_cmsq"/>
<units name="mS_per_cmsq" units_ref="mS_per_cmsq"/>
</import>
<import xlink:href="../cellLib/Components/gating-variable.cellml">
<component component_ref="hh_gating_variable" name="n_gate"/>
</import>
<import xlink:href="IK-gating-rates.cellml">
<component component_ref="alpha_n" name="alpha_n"/>
<component component_ref="beta_n" name="beta_n"/>
</import>
<component name="IK">
<variable name="IK" private_interface="out" public_interface="out" units="uA_per_cmsq"/>
<variable name="n_initial" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="n" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="VK" private_interface="out" public_interface="in" units="mV"/>
<variable name="gK" private_interface="out" public_interface="out" units="mS_per_cmsq"/>
<variable name="gK_max" private_interface="out" public_interface="in" units="mS_per_cmsq"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0K" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10K" private_interface="out" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="IK_calculation">
<eq/>
<ci>IK</ci>
<apply>
<times/>
<ci>gK</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>VK</ci>
</apply>
</apply>
</apply>
<apply id="gK_calculation">
<eq/>
<ci>gK</ci>
<apply>
<times/>
<ci>gK_max</ci>
<apply>
<power/>
<ci>n</ci>
<cn cellml:units="dimensionless">4.0</cn>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="IK">
<component_ref component="alpha_n"/>
<component_ref component="beta_n"/>
<component_ref component="n_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="IK" component_2="n_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="n_initial" variable_2="X_initial"/>
<map_variables variable_1="n" variable_2="X"/>
<map_variables variable_1="T0K" variable_2="T_0"/>
<map_variables variable_1="Q10K" variable_2="Q_10"/>
<map_variables variable_1="T" variable_2="T"/>
</connection>
<connection>
<map_components component_1="IK" component_2="alpha_n"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IK" component_2="beta_n"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="n_gate" component_2="alpha_n"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="n_gate" component_2="beta_n"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
</model>
