- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-03-31 10:48:40+13:00
- Desc:
- Add open channel IV of HH models; Add simulation and plot python scripts
- Permanent Source URI:
- https://models.cellml.org/workspace/64f/rawfile/ab2962b8796666ad9938a2577611c954f006b5fd/components/gate_initials.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="gate_initials" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<!-- Compute initial values of m, n and h based on initial value of V and temperature T (T does not affect the computation)-->
<import xlink:href="../cellLib/Components/units.cellml">
<units name="mV" units_ref="mV"/>
<units name="per_ms" units_ref="per_ms"/>
</import>
<import xlink:href="../cellLib/Components/gate_steady.cellml">
<component component_ref="gate_steady" name="m_gate_steady"/>
</import>
<import xlink:href="../cellLib/Components/gate_steady.cellml">
<component component_ref="gate_steady" name="n_gate_steady"/>
</import>
<import xlink:href="../cellLib/Components/gate_steady.cellml">
<component component_ref="gate_steady" name="h_gate_steady"/>
</import>
<import xlink:href="INa-gating-rates.cellml">
<component component_ref="alpha_m" name="alpha_m"/>
<component component_ref="beta_m" name="beta_m"/>
<component component_ref="alpha_h" name="alpha_h"/>
<component component_ref="beta_h" name="beta_h"/>
</import>
<import xlink:href="IK-gating-rates.cellml">
<component component_ref="alpha_n" name="alpha_n"/>
<component component_ref="beta_n" name="beta_n"/>
</import>
<component name="gate_initials">
<variable name="V_b" private_interface="out" public_interface="in" units="mV"/>
<variable name="m_initial" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="n_initial" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="h_initial" private_interface="in" public_interface="out" units="dimensionless"/>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="gate_initials">
<component_ref component="alpha_m"/>
<component_ref component="beta_m"/>
<component_ref component="alpha_n"/>
<component_ref component="beta_n"/>
<component_ref component="alpha_h"/>
<component_ref component="beta_h"/>
<component_ref component="m_gate_steady"/>
<component_ref component="n_gate_steady"/>
<component_ref component="h_gate_steady"/>
</component_ref>
</group>
<connection>
<map_components component_1="gate_initials" component_2="alpha_m"/>
<map_variables variable_1="V_b" variable_2="V"/>
</connection>
<connection>
<map_components component_1="gate_initials" component_2="beta_m"/>
<map_variables variable_1="V_b" variable_2="V"/>
</connection>
<connection>
<map_components component_1="gate_initials" component_2="alpha_n"/>
<map_variables variable_1="V_b" variable_2="V"/>
</connection>
<connection>
<map_components component_1="gate_initials" component_2="beta_n"/>
<map_variables variable_1="V_b" variable_2="V"/>
</connection>
<connection>
<map_components component_1="gate_initials" component_2="alpha_h"/>
<map_variables variable_1="V_b" variable_2="V"/>
</connection>
<connection>
<map_components component_1="gate_initials" component_2="beta_h"/>
<map_variables variable_1="V_b" variable_2="V"/>
</connection>
<connection>
<map_components component_1="m_gate_steady" component_2="alpha_m"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="n_gate_steady" component_2="alpha_n"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="h_gate_steady" component_2="alpha_h"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="m_gate_steady" component_2="beta_m"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
<connection>
<map_components component_1="n_gate_steady" component_2="beta_n"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
<connection>
<map_components component_1="h_gate_steady" component_2="beta_h"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
<connection>
<map_components component_1="m_gate_steady" component_2="gate_initials"/>
<map_variables variable_1="X_s" variable_2="m_initial"/>
</connection>
<connection>
<map_components component_1="n_gate_steady" component_2="gate_initials"/>
<map_variables variable_1="X_s" variable_2="n_initial"/>
</connection>
<connection>
<map_components component_1="h_gate_steady" component_2="gate_initials"/>
<map_variables variable_1="X_s" variable_2="h_initial"/>
</connection>
</model>
