- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-05-11 17:42:05+12:00
- Desc:
- Add readme.rst at the top level to resolve the relative path issue.
- Permanent Source URI:
- https://models.cellml.org/workspace/64f/rawfile/b05905c1739d98b1712b1a644d615c6fc0b4a59a/doc/voltage_clamp_experiment.rst
Voltage clamp experiment
----------------------------------------
In the `voltage clamp experiment <../components/voltage_clamp_experiment.cellml>`_, the `membrane current model <../components/clamped_current.cellml/view>`_ is configured and parameterised to simulate the behaviour during a `voltage clamp <../experiments/voltage_clamp_protocol.cellml>`_.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../sed-ml/voltage_clamp_experiment.sedml>`__ into OpenCOR and executing the simulation.
You can change the parameters of voltage clamp, such as start/end time and amplitude in the component ``voltage_clamp_protocol_params``.
You can also modify the parameters of temperature :math:`T` and boundary condition of the potential :math:`V_b`, in the component ``parameters`` and ``boundary_conditions`` respectively.
The `gate_initials.cellml <../components/gate_initials.cellml>`_ computes the initial values of m, n and h based on the value of membrane potential :math:`V_b`, while the `gate_steady.cellml <../components/gate_steady.cellml>`_ defines `the equation of steady state values <../components/gate_steady.cellml/cellml_math>`_ of m, n and h gates.
Membrane currents during a voltage clamp
-----------------------------------------
Figure :numref:`fig-11` shows the membrane current during a voltage clamp.
.. _fig-11:
.. figure:: ../sed-ml/originalFig11.png
:width: 85%
:align: center
:alt: originalFig11
Membrane current during voltage clamp at 4 :math:`^{\circ} C`
