- Author:
- Michael Clerx <michael.clerx@nottingham.ac.uk>
- Date:
- 2021-04-29 14:50:10+01:00
- Desc:
- Removed duplicate +C2 from ical C1 equation
- Permanent Source URI:
- https://models.cellml.org/workspace/650/rawfile/4dad3d8d14e2bb3b938294f1173dea13e8b6cb9f/wang_sobie_2008.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model cmeta:id="wang_model_2008" name="wang_model_2008" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="millisecond">
<unit prefix="milli" units="second"/>
</units>
<units name="per_millisecond">
<unit exponent="-1" prefix="milli" units="second"/>
</units>
<units name="micromolar_per_millisecond">
<unit units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="per_micromolar_millisecond">
<unit exponent="-1" units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="micromolar3_per_millisecond">
<unit exponent="-3" units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="micromolar4_per_millisecond">
<unit exponent="-4" units="micromolar"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="millivolt">
<unit prefix="milli" units="volt"/>
</units>
<units name="per_millivolt">
<unit exponent="-1" prefix="milli" units="volt"/>
</units>
<units name="millivolt2">
<unit exponent="2" prefix="milli" units="volt"/>
</units>
<units name="per_millivolt_millisecond">
<unit exponent="-1" units="millivolt"/>
<unit exponent="-1" units="millisecond"/>
</units>
<units name="milliS_per_microF">
<unit prefix="milli" units="siemens"/>
<unit exponent="-1" prefix="micro" units="farad"/>
</units>
<units name="picoF">
<unit prefix="pico" units="farad"/>
</units>
<units name="per_picoF">
<unit exponent="-1" units="picoF"/>
</units>
<units name="microF_per_cm2">
<unit prefix="micro" units="farad"/>
<unit exponent="-2" prefix="centi" units="metre"/>
</units>
<units name="picoA_per_picoF">
<unit prefix="pico" units="ampere"/>
<unit exponent="-1" prefix="pico" units="farad"/>
</units>
<units name="micromolar">
<unit prefix="micro" units="mole"/>
<unit exponent="-1" units="litre"/>
</units>
<units name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit exponent="-1" units="mole"/>
<unit exponent="-1" units="kelvin"/>
</units>
<units name="coulomb_per_millimole">
<unit units="coulomb"/>
<unit exponent="-1" prefix="milli" units="mole"/>
</units>
<units name="cm2">
<unit exponent="2" prefix="centi" units="metre"/>
</units>
<units name="cm2_per_microF">
<unit exponent="2" prefix="centi" units="metre"/>
<unit exponent="-1" prefix="micro" units="farad"/>
</units>
<units name="cm_per_second">
<unit prefix="centi" units="metre"/>
<unit exponent="-1" units="second"/>
</units>
<units name="microlitre">
<unit prefix="micro" units="litre"/>
</units>
<component name="environment">
<variable cmeta:id="environment_time" name="time" public_interface="out" units="millisecond"/>
</component>
<component name="membrane">
<variable initial_value="-80.6475" name="V" public_interface="out" units="millivolt"/>
<variable initial_value="1" name="Cm" public_interface="out" units="microF_per_cm2"/>
<variable initial_value="2.2826e-6" name="Vmyo" public_interface="out" units="microlitre"/>
<variable initial_value="0.12e-8" name="VJSR" public_interface="out" units="microlitre"/>
<variable initial_value="2.098e-7" name="VNSR" public_interface="out" units="microlitre"/>
<variable initial_value="3.0734e-8" name="Vss" public_interface="out" units="microlitre"/>
<variable initial_value="1.5410e-5" name="Acap" public_interface="out" units="cm2"/>
<variable initial_value="5400" name="Ko" public_interface="out" units="micromolar"/>
<variable initial_value="140000" name="Nao" public_interface="out" units="micromolar"/>
<variable initial_value="1000" name="Cao" public_interface="out" units="micromolar"/>
<variable initial_value="132000" name="Clo" public_interface="out" units="micromolar"/>
<variable initial_value="30000" name="Cli" public_interface="out" units="micromolar"/>
<variable initial_value="8.314" name="R" public_interface="out" units="joule_per_mole_kelvin"/>
<variable initial_value="298" name="T" public_interface="out" units="kelvin"/>
<variable initial_value="96.5" name="F" public_interface="out" units="coulomb_per_millimole"/>
<variable name="i_stim" units="picoA_per_picoF"/>
<variable initial_value="20" name="stim_start" units="millisecond"/>
<variable initial_value="500000" name="stim_end" units="millisecond"/>
<variable initial_value="2000.0" name="stim_period" units="millisecond"/>
<variable initial_value="0.5" name="stim_duration" units="millisecond"/>
<variable initial_value="-80" name="stim_amplitude" units="picoA_per_picoF"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_CaT" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_pCa" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Cab" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Na" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Nab" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Kto_f" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_K1" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Ks" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Kur" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Kss" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_ClCa" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Kr" public_interface="in" units="picoA_per_picoF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<leq/>
<ci>time</ci>
<ci>stim_end</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<apply>
<minus/>
<ci>time</ci>
<ci>stim_start</ci>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_duration</ci>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="picoA_per_picoF">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_CaL</ci>
<ci>i_CaT</ci>
<ci>i_pCa</ci>
<ci>i_NaCa</ci>
<ci>i_Cab</ci>
<ci>i_Na</ci>
<ci>i_Nab</ci>
<ci>i_NaK</ci>
<ci>i_Kto_f</ci>
<ci>i_K1</ci>
<ci>i_Ks</ci>
<ci>i_Kur</ci>
<ci>i_Kss</ci>
<ci>i_Kr</ci>
<ci>i_ClCa</ci>
<ci>i_stim</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_concentration">
<variable initial_value="0.2049" name="Cai" public_interface="out" units="micromolar"/>
<variable initial_value="0.1867" name="Cass" public_interface="out" units="micromolar"/>
<variable initial_value="705.5417" name="CaJSR" public_interface="out" units="micromolar"/>
<variable initial_value="703.3063" name="CaNSR" public_interface="out" units="micromolar"/>
<variable name="Bi" units="dimensionless"/>
<variable name="Bss" units="dimensionless"/>
<variable name="BJSR" units="dimensionless"/>
<variable cmeta:id="calcium_concentration_CMDN_tot" initial_value="25" name="CMDN_tot" units="micromolar"/>
<variable cmeta:id="calcium_concentration_CSQN_tot" initial_value="15000" name="CSQN_tot" units="micromolar"/>
<variable initial_value="0.238" name="Km_CMDN" units="micromolar"/>
<variable initial_value="800" name="Km_CSQN" units="micromolar"/>
<variable name="Acap" public_interface="in" units="cm2"/>
<variable name="Vmyo" public_interface="in" units="microlitre"/>
<variable name="VJSR" public_interface="in" units="microlitre"/>
<variable name="Vss" public_interface="in" units="microlitre"/>
<variable name="VNSR" public_interface="in" units="microlitre"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="Cm" public_interface="in" units="microF_per_cm2"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="i_Cab" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_CaT" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_pCa" public_interface="in" units="picoA_per_picoF"/>
<variable name="J_leak" public_interface="in" units="micromolar_per_millisecond"/>
<variable name="J_rel" public_interface="in" units="micromolar_per_millisecond"/>
<variable name="J_up" public_interface="in" units="micromolar_per_millisecond"/>
<variable name="J_tr" public_interface="in" units="micromolar_per_millisecond"/>
<variable name="J_trpn" public_interface="in" units="micromolar_per_millisecond"/>
<variable name="J_xfer" public_interface="in" units="micromolar_per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<ci>Bi</ci>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_leak</ci>
<ci>J_xfer</ci>
</apply>
<apply>
<plus/>
<ci>J_up</ci>
<ci>J_trpn</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cass</ci>
</apply>
<apply>
<times/>
<ci>Bss</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_rel</ci>
<ci>VJSR</ci>
</apply>
<ci>Vss</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_xfer</ci>
<ci>Vmyo</ci>
</apply>
<ci>Vss</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_CaL</ci>
<ci>i_Cab</ci>
<ci>i_pCa</ci>
<ci>i_CaT</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vss</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaJSR</ci>
</apply>
<apply>
<times/>
<ci>BJSR</ci>
<apply>
<minus/>
<ci>J_xfer</ci>
<ci>J_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaNSR</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>J_up</ci>
<ci>J_leak</ci>
</apply>
<ci>Vmyo</ci>
</apply>
<ci>VNSR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_tr</ci>
<ci>VJSR</ci>
</apply>
<ci>VNSR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Bi</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>Km_CMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Km_CMDN</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Bss</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CMDN_tot</ci>
<ci>Km_CMDN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Km_CMDN</ci>
<ci>Cass</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>BJSR</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN_tot</ci>
<ci>Km_CSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Km_CSQN</ci>
<ci>CaJSR</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_fluxes">
<variable cmeta:id="calcium_fluxes_J_leak" name="J_leak" public_interface="out" units="micromolar_per_millisecond"/>
<variable cmeta:id="calcium_fluxes_J_rel" name="J_rel" public_interface="out" units="micromolar_per_millisecond"/>
<variable cmeta:id="calcium_fluxes_J_up" name="J_up" public_interface="out" units="micromolar_per_millisecond"/>
<variable cmeta:id="calcium_fluxes_J_tr" name="J_tr" public_interface="out" units="micromolar_per_millisecond"/>
<variable name="J_trpn" public_interface="out" units="micromolar_per_millisecond"/>
<variable name="J_xfer" public_interface="out" units="micromolar_per_millisecond"/>
<variable initial_value="0.00237" name="k_plus_htrpn" public_interface="out" units="per_micromolar_millisecond"/>
<variable initial_value="3.2e-5" name="k_minus_htrpn" public_interface="out" units="per_millisecond"/>
<variable initial_value="0.0327" name="k_plus_ltrpn" public_interface="out" units="per_micromolar_millisecond"/>
<variable initial_value="0.0196" name="k_minus_ltrpn" public_interface="out" units="per_millisecond"/>
<variable initial_value="2.8603e-14" name="P_RyR" units="dimensionless"/>
<variable initial_value="0.45" name="v1" units="per_millisecond"/>
<variable initial_value="20" name="tau_tr" units="millisecond"/>
<variable initial_value="2.088e-5" name="v2" units="per_millisecond"/>
<variable initial_value="8" name="tau_xfer" units="millisecond"/>
<variable initial_value="0.09" name="v3" units="micromolar_per_millisecond"/>
<variable initial_value="0.5" name="Km_up" units="micromolar"/>
<variable name="LTRPN_tot" public_interface="in" units="micromolar"/>
<variable name="HTRPN_tot" public_interface="in" units="micromolar"/>
<variable name="LTRPN_Ca" public_interface="in" units="micromolar"/>
<variable name="HTRPN_Ca" public_interface="in" units="micromolar"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="i_CaL_max" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_CaL" public_interface="in" units="picoA_per_picoF"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="Cass" public_interface="in" units="micromolar"/>
<variable name="CaJSR" public_interface="in" units="micromolar"/>
<variable name="CaNSR" public_interface="in" units="micromolar"/>
<variable name="P_O1" public_interface="in" units="dimensionless"/>
<variable name="P_O2" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<ci>CaJSR</ci>
<ci>Cass</ci>
</apply>
<ci>P_RyR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>CaJSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_xfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cass</ci>
<ci>Cai</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_leak</ci>
<apply>
<times/>
<ci>v2</ci>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_up</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>v3</ci>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Km_up</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_trpn</ci>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>k_plus_htrpn</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>HTRPN_tot</ci>
<ci>HTRPN_Ca</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_plus_ltrpn</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>LTRPN_tot</ci>
<ci>LTRPN_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>k_minus_htrpn</ci>
<ci>HTRPN_Ca</ci>
</apply>
<apply>
<times/>
<ci>k_minus_ltrpn</ci>
<ci>LTRPN_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_RyR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millisecond">0.04</cn>
</apply>
<ci>P_RyR</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.1</cn>
<ci>i_CaL</ci>
</apply>
<ci>i_CaL_max</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt2">648</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_buffering">
<variable cmeta:id="calcium_buffering_LTRPN_tot" initial_value="35" name="LTRPN_tot" public_interface="out" units="micromolar"/>
<variable initial_value="70" name="HTRPN_tot" public_interface="out" units="micromolar"/>
<variable initial_value="8.9220" name="LTRPN_Ca" public_interface="out" units="micromolar"/>
<variable initial_value="66.0407" name="HTRPN_Ca" public_interface="out" units="micromolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="k_plus_htrpn" public_interface="in" units="per_micromolar_millisecond"/>
<variable name="k_minus_htrpn" public_interface="in" units="per_millisecond"/>
<variable name="k_plus_ltrpn" public_interface="in" units="per_micromolar_millisecond"/>
<variable name="k_minus_ltrpn" public_interface="in" units="per_millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>LTRPN_Ca</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_plus_ltrpn</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>LTRPN_tot</ci>
<ci>LTRPN_Ca</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_minus_ltrpn</ci>
<ci>LTRPN_Ca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>HTRPN_Ca</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_plus_htrpn</ci>
<ci>Cai</ci>
<apply>
<minus/>
<ci>HTRPN_tot</ci>
<ci>HTRPN_Ca</ci>
</apply>
</apply>
<apply>
<times/>
<ci>k_minus_htrpn</ci>
<ci>HTRPN_Ca</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ryanodine_receptors">
<variable initial_value="1.1e-3" name="P_O1" public_interface="out" units="dimensionless"/>
<variable initial_value="2.9799e-8" name="P_O2" public_interface="out" units="dimensionless"/>
<variable name="P_C1" public_interface="out" units="dimensionless"/>
<variable initial_value="0.1003" name="P_C2" public_interface="out" units="dimensionless"/>
<variable initial_value="0.00608" name="k_plus_a" units="micromolar4_per_millisecond"/>
<variable initial_value="0.07125" name="k_minus_a" units="per_millisecond"/>
<variable initial_value="0.00405" name="k_plus_b" units="micromolar3_per_millisecond"/>
<variable initial_value="0.965" name="k_minus_b" units="per_millisecond"/>
<variable initial_value="0.009" name="k_plus_c" units="per_millisecond"/>
<variable initial_value="0.0008" name="k_minus_c" units="per_millisecond"/>
<variable initial_value="3" name="m" units="dimensionless"/>
<variable initial_value="4" name="n" units="dimensionless"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="Cass" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>k_plus_a</ci>
<apply>
<power/>
<ci>Cass</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<times/>
<ci>k_minus_b</ci>
<ci>P_O2</ci>
</apply>
<apply>
<times/>
<ci>k_minus_c</ci>
<ci>P_C2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>k_minus_a</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_plus_b</ci>
<apply>
<power/>
<ci>Cass</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_plus_c</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_C1</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>P_C2</ci>
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_plus_b</ci>
<apply>
<power/>
<ci>Cass</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_minus_b</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_plus_c</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_minus_c</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_calcium_current">
<variable cmeta:id="L_type_calcium_current_i_CaL" name="i_CaL" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="7" name="i_CaL_max" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="63" name="E_CaL" public_interface="out" units="millivolt"/>
<variable initial_value="0.19019" name="g_CaL" units="milliS_per_microF"/>
<variable initial_value="4.4776e-12" name="O" units="dimensionless"/>
<variable name="C1" units="dimensionless"/>
<variable initial_value="1.6996e-4" name="C2" units="dimensionless"/>
<variable initial_value="1.1754e-8" name="C3" units="dimensionless"/>
<variable initial_value="6.1239e-10" name="C4" units="dimensionless"/>
<variable initial_value="1.5450e-9" name="I1" units="dimensionless"/>
<variable initial_value="6.4226e-8" name="I2" units="dimensionless"/>
<variable initial_value="6.5201e-7" name="I3" units="dimensionless"/>
<variable name="alpha" units="per_millisecond"/>
<variable name="beta" units="per_millisecond"/>
<variable name="gamma" units="per_millisecond"/>
<variable name="Kpcf" units="per_millisecond"/>
<variable initial_value="0.0005" name="Kpcb" units="per_millisecond"/>
<variable initial_value="0.23324" name="Kpc_max" units="per_millisecond"/>
<variable initial_value="20" name="Kpc_half" units="micromolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="Cass" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaL</ci>
<apply>
<times/>
<ci>g_CaL</ci>
<ci>O</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_CaL</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<ci>Kpcb</ci>
<ci>I1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>I2</ci>
</apply>
<apply>
<times/>
<ci>Kpcf</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C1</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>O</ci>
<ci>C2</ci>
<ci>C3</ci>
<ci>C4</ci>
<ci>I1</ci>
<ci>I2</ci>
<ci>I3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>alpha</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
<ci>C3</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>C2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C3</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>alpha</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
<ci>C4</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>beta</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>C3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C4</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>alpha</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<cn cellml:units="millisecond">0.01</cn>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>Kpcb</ci>
<ci>beta</ci>
<ci>I1</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>gamma</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.002</cn>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>I2</ci>
</apply>
<apply>
<times/>
<ci>Kpcf</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="millisecond">4</cn>
<ci>beta</ci>
<ci>Kpcb</ci>
<ci>I3</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>beta</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>gamma</ci>
<ci>Kpcf</ci>
<ci>C4</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>gamma</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>I3</ci>
</apply>
<apply>
<times/>
<ci>Kpcf</ci>
<ci>I1</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="millisecond">0.01</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha</ci>
<ci>gamma</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>Kpcf</ci>
<ci>I1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Kpcb</ci>
<ci>I1</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>Kpcf</ci>
<ci>O</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>I2</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>Kpcb</ci>
<ci>I3</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.002</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>Kpcf</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">4</cn>
<ci>beta</ci>
<ci>I2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>I2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I3</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.001</cn>
<apply>
<minus/>
<apply>
<times/>
<ci>Kpcf</ci>
<ci>I1</ci>
</apply>
<apply>
<times/>
<ci>alpha</ci>
<ci>I3</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<ci>gamma</ci>
<ci>I2</ci>
</apply>
<apply>
<times/>
<cn cellml:units="millisecond">1</cn>
<ci>gamma</ci>
<ci>Kpcf</ci>
<ci>C4</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">4</cn>
<ci>beta</ci>
<ci>Kpcb</ci>
<ci>I3</ci>
</apply>
<apply>
<times/>
<ci>Kpcb</ci>
<ci>I3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.4</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">12</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.7</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt2">10</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.75</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">20</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt2">400</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.12</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">12</cn>
</apply>
<cn cellml:units="millivolt">10</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.05</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
<cn cellml:units="millivolt">13</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>Kpc_max</ci>
<ci>Cass</ci>
</apply>
<apply>
<plus/>
<ci>Kpc_half</ci>
<ci>Cass</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Kpcf</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">13</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">14.5</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt2">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_calcium_current">
<variable cmeta:id="T_type_calcium_current_i_CaT" name="i_CaT" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="50" name="E_CaT" units="millivolt"/>
<variable initial_value="0.055" name="g_CaT" units="milliS_per_microF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="b" private_interface="in" units="dimensionless"/>
<variable name="g" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_CaT</ci>
<apply>
<times/>
<ci>g_CaT</ci>
<ci>b</ci>
<ci>g</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_CaT</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="T_type_calcium_current_b_gate">
<variable initial_value="0.0047" name="b" public_interface="out" units="dimensionless"/>
<variable name="b_infinity" units="dimensionless"/>
<variable name="tau_b" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>b_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">48</cn>
</apply>
</apply>
<cn cellml:units="millivolt">6.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_b</ci>
<apply>
<plus/>
<cn cellml:units="millisecond">0.1</cn>
<apply>
<divide/>
<cn cellml:units="millisecond">5.4</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">100</cn>
</apply>
<cn cellml:units="millivolt">6.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>b</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>b_infinity</ci>
<ci>b</ci>
</apply>
<ci>tau_b</ci>
</apply>
</apply>
</math>
</component>
<component name="T_type_calcium_current_g_gate">
<variable initial_value="0.9020" name="g" public_interface="out" units="dimensionless"/>
<variable name="g_infinity" units="dimensionless"/>
<variable name="tau_g" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>g_infinity</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">66</cn>
</apply>
<cn cellml:units="millivolt">6.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_g</ci>
<apply>
<plus/>
<cn cellml:units="millisecond">8</cn>
<apply>
<divide/>
<cn cellml:units="millisecond">32</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">65</cn>
</apply>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>g</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>g_infinity</ci>
<ci>g</ci>
</apply>
<ci>tau_g</ci>
</apply>
</apply>
</math>
</component>
<component name="calcium_pump_current">
<variable cmeta:id="calcium_pump_current_i_pCa" name="i_pCa" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="0.2" name="i_pCa_max" units="picoA_per_picoF"/>
<variable initial_value="0.5" name="Km_pCa" units="micromolar"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_pCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_pCa_max</ci>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Km_pCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchange_current">
<variable cmeta:id="sodium_calcium_exchange_current_i_NaCa" name="i_NaCa" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="907.68" name="k_NaCa" units="picoA_per_picoF"/>
<variable initial_value="87500" name="K_mNa" units="micromolar"/>
<variable initial_value="1380" name="K_mCa" units="micromolar"/>
<variable initial_value="0.1" name="k_sat" units="dimensionless"/>
<variable initial_value="0.35" name="eta" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Nai" public_interface="in" units="micromolar"/>
<variable name="Nao" public_interface="in" units="micromolar"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="Cao" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaCa</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable cmeta:id="calcium_background_current_i_Cab" name="i_Cab" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="0.00025" name="g_Cab" units="milliS_per_microF"/>
<variable name="E_CaN" units="millivolt"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Cai" public_interface="in" units="micromolar"/>
<variable name="Cao" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<times/>
<ci>g_Cab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_CaN</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_CaN</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_concentration">
<variable initial_value="2.1747e4" name="Nai" public_interface="out" units="micromolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Vmyo" public_interface="in" units="microlitre"/>
<variable name="Cm" public_interface="in" units="microF_per_cm2"/>
<variable name="Acap" public_interface="in" units="cm2"/>
<variable name="i_Na" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_NaCa" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Nab" public_interface="in" units="picoA_per_picoF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Nab</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current">
<variable cmeta:id="fast_sodium_current_i_Na" name="i_Na" public_interface="out" units="picoA_per_picoF"/>
<variable name="E_Na" public_interface="out" units="millivolt"/>
<variable initial_value="10" name="g_Na" units="milliS_per_microF"/>
<variable name="time" private_interface="out" public_interface="in" units="millisecond"/>
<variable name="V" private_interface="out" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Nao" public_interface="in" units="micromolar"/>
<variable name="Nai" public_interface="in" units="micromolar"/>
<variable name="m" private_interface="in" units="dimensionless"/>
<variable name="h" private_interface="in" units="dimensionless"/>
<variable name="j" private_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<apply>
<power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>h</ci>
<ci>j</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Nao</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_m_gate">
<variable initial_value="0.0032" name="m" public_interface="out" units="dimensionless"/>
<variable name="alpha_m" units="per_millisecond"/>
<variable name="beta_m" units="per_millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.32</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_m</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.08</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">11</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<apply>
<minus/>
<ci>alpha_m</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_m</ci>
<ci>beta_m</ci>
</apply>
<ci>m</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_h_gate">
<variable initial_value="0.9606" name="h" public_interface="out" units="dimensionless"/>
<variable name="alpha_h" units="per_millisecond"/>
<variable name="beta_h" units="per_millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_h</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.135</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<cn cellml:units="millivolt">80</cn>
<ci>V</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">6.8</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_h</ci>
<piecewise>
<piece>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millisecond">3.56</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.079</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millisecond">310000</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.35</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.13</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">10.66</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="millivolt">11.1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>h</ci>
</apply>
<apply>
<minus/>
<ci>alpha_h</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_h</ci>
<ci>beta_h</ci>
</apply>
<ci>h</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current_j_gate">
<variable initial_value="0.9744" name="j" public_interface="out" units="dimensionless"/>
<variable name="alpha_j" units="per_millisecond"/>
<variable name="beta_j" units="per_millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>alpha_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">127140</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.2444</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond" type="e-notation">3.474<sep/>-5</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.04391</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">37.78</cn>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.311</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">79.23</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="per_millisecond">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<ci>beta_j</ci>
<piecewise>
<piece>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.1212</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.01052</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1378</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">40.14</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<lt/>
<ci>V</ci>
<apply>
<minus/>
<cn cellml:units="millivolt">40</cn>
</apply>
</apply>
</piece>
<otherwise>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt" type="e-notation">2.535<sep/>-7</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.1</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">32</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>j</ci>
</apply>
<apply>
<minus/>
<ci>alpha_j</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>alpha_j</ci>
<ci>beta_j</ci>
</apply>
<ci>j</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable cmeta:id="sodium_background_current_i_Nab" name="i_Nab" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="0.0026" name="g_Nab" units="milliS_per_microF"/>
<variable name="E_Na" public_interface="in" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Nab</ci>
<apply>
<times/>
<ci>g_Nab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="potassium_concentration">
<variable initial_value="1.3645e5" name="Ki" public_interface="out" units="micromolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Vmyo" public_interface="in" units="microlitre"/>
<variable name="Cm" public_interface="in" units="microF_per_cm2"/>
<variable name="Acap" public_interface="in" units="cm2"/>
<variable name="i_Kto_f" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_K1" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Ks" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Kss" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Kur" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_Kr" public_interface="in" units="picoA_per_picoF"/>
<variable name="i_NaK" public_interface="in" units="picoA_per_picoF"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Kto_f</ci>
<ci>i_K1</ci>
<ci>i_Ks</ci>
<ci>i_Kss</ci>
<ci>i_Kur</ci>
<ci>i_Kr</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
</apply>
</apply>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_transient_outward_potassium_current">
<variable cmeta:id="fast_transient_outward_potassium_current_i_Kto_f" name="i_Kto_f" public_interface="out" units="picoA_per_picoF"/>
<variable name="E_K" public_interface="out" units="millivolt"/>
<variable initial_value="0.1017" name="g_Kto_f" units="milliS_per_microF"/>
<variable initial_value="0.0032" name="ato_f" units="dimensionless"/>
<variable initial_value="0.7530" name="ito_f" units="dimensionless"/>
<variable name="ito_f_infinity" units="dimensionless"/>
<variable name="tau_ito_f" units="millisecond"/>
<variable name="alpha_a" units="per_millisecond"/>
<variable name="beta_a" units="per_millisecond"/>
<variable name="alpha_i" units="per_millisecond"/>
<variable name="beta_i" units="per_millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Ki" public_interface="in" units="micromolar"/>
<variable name="Ko" public_interface="in" units="micromolar"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kto_f</ci>
<apply>
<times/>
<ci>g_Kto_f</ci>
<apply>
<power/>
<ci>ato_f</ci>
<cn cellml:units="dimensionless">6.5</cn>
</apply>
<ci>ito_f</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ato_f</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_a</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>ato_f</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_a</ci>
<ci>ato_f</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ito_f</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ito_f_infinity</ci>
<ci>ito_f</ci>
</apply>
<ci>tau_ito_f</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ito_f_infinity</ci>
<apply>
<divide/>
<ci>alpha_i</ci>
<apply>
<plus/>
<ci>alpha_i</ci>
<ci>beta_i</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_ito_f</ci>
<apply>
<divide/>
<cn cellml:units="millisecond">1</cn>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.000152</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">13.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.067083</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.00095</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.051335</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">33.5</cn>
</apply>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_a</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.18064</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.03577</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_a</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.3956</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.06237</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.000152</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">3.81</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15.75</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0067083</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">132.05</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15.75</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.00095</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">132.05</cn>
</apply>
<cn cellml:units="millivolt">15.75</cn>
</apply>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.051335</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">132.05</cn>
</apply>
<cn cellml:units="millivolt">15.75</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ultra_rapidly_activating_delayed_rectifier_potassium_current">
<variable cmeta:id="ultra_rapidly_activating_delayed_rectifier_potassium_current_i_Kur" name="i_Kur" public_interface="out" units="picoA_per_picoF"/>
<variable name="ass" public_interface="out" units="dimensionless"/>
<variable initial_value="0.0048" name="g_Kur" units="milliS_per_microF"/>
<variable initial_value="5.2471e-4" name="aur" units="dimensionless"/>
<variable initial_value="0.9866" name="iur" units="dimensionless"/>
<variable name="tau_aur" units="millisecond"/>
<variable name="tau_iur" units="millisecond"/>
<variable name="iss" units="dimensionless"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kur</ci>
<apply>
<times/>
<ci>g_Kur</ci>
<ci>aur</ci>
<ci>iur</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>aur</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ass</ci>
<ci>aur</ci>
</apply>
<ci>tau_aur</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>iur</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>iss</ci>
<ci>iur</ci>
</apply>
<ci>tau_iur</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ass</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">22.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">7.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_aur</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">0.493</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.0629</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">2.058</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>iss</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.2</cn>
</apply>
<cn cellml:units="millivolt">5.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_iur</ci>
<apply>
<minus/>
<cn cellml:units="millisecond">1200</cn>
<apply>
<divide/>
<cn cellml:units="millisecond">170</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.2</cn>
</apply>
<cn cellml:units="millivolt">5.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="non_inactivating_steady_state_potassium_current">
<variable cmeta:id="non_inactivating_steady_state_potassium_current_i_Kss" name="i_Kss" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="0.015" name="g_Kss" units="milliS_per_microF"/>
<variable initial_value="0.8500" name="aKss" units="dimensionless"/>
<variable name="tau_Kss" units="millisecond"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="ass" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kss</ci>
<apply>
<times/>
<ci>g_Kss</ci>
<ci>aKss</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>aKss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ass</ci>
<ci>aKss</ci>
</apply>
<ci>tau_Kss</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_Kss</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">39.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.0862</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">13.17</cn>
</apply>
</apply>
</math>
</component>
<component name="time_independent_potassium_current">
<variable cmeta:id="time_independent_potassium_current_i_K1" name="i_K1" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="0.235" name="g_K1" units="milliS_per_microF"/>
<variable name="Ko" public_interface="in" units="micromolar"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<cn cellml:units="micromolar">210</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0896</cn>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="slow_delayed_rectifier_potassium_current">
<variable cmeta:id="slow_delayed_rectifier_potassium_current_i_Ks" name="i_Ks" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="0.046" name="g_Ks" units="milliS_per_microF"/>
<variable initial_value="0.0026" name="nKs" units="dimensionless"/>
<variable name="alpha_n" units="per_millisecond"/>
<variable name="beta_n" units="per_millisecond"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="time" public_interface="in" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<power/>
<ci>nKs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>nKs</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_n</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nKs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_n</ci>
<ci>nKs</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_n</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.00000481333</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.5</cn>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.128</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_n</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.0000953333</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.038</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_potassium_current">
<variable cmeta:id="rapid_delayed_rectifier_potassium_current_i_Kr" name="i_Kr" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="01.17" name="g_Kr" units="milliS_per_microF"/>
<variable initial_value="2.1e-3" name="O_K" units="dimensionless"/>
<variable initial_value="1.1e-3" name="C_K1" units="dimensionless"/>
<variable initial_value="8.3641e-4" name="C_K2" units="dimensionless"/>
<variable name="C_K0" units="dimensionless"/>
<variable initial_value="4.3522e-4" name="I_K" units="dimensionless"/>
<variable name="alpha_a0" units="per_millisecond"/>
<variable name="beta_a0" units="per_millisecond"/>
<variable initial_value="0.036778" name="kb" units="per_millisecond"/>
<variable initial_value="0.023761" name="kf" units="per_millisecond"/>
<variable name="alpha_a1" units="per_millisecond"/>
<variable name="beta_a1" units="per_millisecond"/>
<variable name="alpha_i" units="per_millisecond"/>
<variable name="beta_i" units="per_millisecond"/>
<variable name="time" public_interface="in" units="millisecond"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="E_K" public_interface="in" units="millivolt"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<ci>O_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C_K0</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>C_K1</ci>
<ci>C_K2</ci>
<ci>O_K</ci>
<ci>I_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_K2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kf</ci>
<ci>C_K1</ci>
</apply>
<apply>
<times/>
<ci>beta_a1</ci>
<ci>O_K</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>kb</ci>
<ci>C_K2</ci>
</apply>
<apply>
<times/>
<ci>alpha_a1</ci>
<ci>C_K2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_K1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_a0</ci>
<ci>C_K0</ci>
</apply>
<apply>
<times/>
<ci>kb</ci>
<ci>C_K2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_a0</ci>
<ci>C_K1</ci>
</apply>
<apply>
<times/>
<ci>kf</ci>
<ci>C_K1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O_K</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_a1</ci>
<ci>C_K2</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<ci>I_K</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_a1</ci>
<ci>O_K</ci>
</apply>
<apply>
<times/>
<ci>alpha_i</ci>
<ci>O_K</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I_K</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_i</ci>
<ci>O_K</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<ci>I_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_a0</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.022348</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.01176</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_a0</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.047002</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.0631</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_a1</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.013733</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.038198</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_a1</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.0000689</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.04178</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.090821</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.023391</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.006497</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.03268</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump_current">
<variable cmeta:id="sodium_potassium_pump_current_i_NaK" name="i_NaK" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="0.88" name="i_NaK_max" units="picoA_per_picoF"/>
<variable initial_value="21000" name="Km_Nai" units="micromolar"/>
<variable initial_value="1500" name="Km_Ko" units="micromolar"/>
<variable name="f_NaK" units="dimensionless"/>
<variable name="sigma" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Nai" public_interface="in" units="micromolar"/>
<variable name="Nao" public_interface="in" units="micromolar"/>
<variable name="Ko" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<ci>f_NaK</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="micromolar">67300</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_activated_chloride_current">
<variable cmeta:id="calcium_activated_chloride_current_i_ClCa" name="i_ClCa" public_interface="out" units="picoA_per_picoF"/>
<variable initial_value="2.74e-7" name="P_ClCa" units="cm_per_second"/>
<variable name="f_ClCa" units="dimensionless"/>
<variable initial_value="4" name="Km_Cl" units="micromolar"/>
<variable initial_value="3" name="n_ClCa" units="dimensionless"/>
<variable name="V" public_interface="in" units="millivolt"/>
<variable name="R" public_interface="in" units="joule_per_mole_kelvin"/>
<variable name="T" public_interface="in" units="kelvin"/>
<variable name="F" public_interface="in" units="coulomb_per_millimole"/>
<variable name="Cli" public_interface="in" units="micromolar"/>
<variable name="Clo" public_interface="in" units="micromolar"/>
<variable name="Cass" public_interface="in" units="micromolar"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>f_ClCa</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>Cass</ci>
<apply>
<plus/>
<ci>Km_Cl</ci>
<ci>Cass</ci>
</apply>
</apply>
<ci>n_ClCa</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_ClCa</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="cm2_per_microF">1</cn>
<ci>P_ClCa</ci>
<ci>f_ClCa</ci>
<ci>V</ci>
<apply>
<power/>
<ci>F</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Clo</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<ci>Cli</ci>
</apply>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="fast_sodium_current">
<component_ref component="fast_sodium_current_m_gate"/>
<component_ref component="fast_sodium_current_h_gate"/>
<component_ref component="fast_sodium_current_j_gate"/>
</component_ref>
<component_ref component="T_type_calcium_current">
<component_ref component="T_type_calcium_current_b_gate"/>
<component_ref component="T_type_calcium_current_g_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_buffering" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ryanodine_receptors" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_calcium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="T_type_calcium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ultra_rapidly_activating_delayed_rectifier_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="non_inactivating_steady_state_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_potassium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_calcium_current"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="T_type_calcium_current"/>
<map_variables variable_1="i_CaT" variable_2="i_CaT"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_pump_current"/>
<map_variables variable_1="i_pCa" variable_2="i_pCa"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_calcium_exchange_current"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current"/>
<map_variables variable_1="i_Nab" variable_2="i_Nab"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump_current"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_transient_outward_potassium_current"/>
<map_variables variable_1="i_Kto_f" variable_2="i_Kto_f"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_potassium_current"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ultra_rapidly_activating_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_inactivating_steady_state_potassium_current"/>
<map_variables variable_1="i_Kss" variable_2="i_Kss"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_activated_chloride_current"/>
<map_variables variable_1="i_ClCa" variable_2="i_ClCa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Clo" variable_2="Clo"/>
<map_variables variable_1="Cli" variable_2="Cli"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_concentration"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="VNSR" variable_2="VNSR"/>
<map_variables variable_1="VJSR" variable_2="VJSR"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_fluxes"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_concentration"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="potassium_concentration"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_fluxes"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
<map_variables variable_1="CaJSR" variable_2="CaJSR"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="CaNSR" variable_2="CaNSR"/>
<map_variables variable_1="J_rel" variable_2="J_rel"/>
<map_variables variable_1="J_tr" variable_2="J_tr"/>
<map_variables variable_1="J_xfer" variable_2="J_xfer"/>
<map_variables variable_1="J_leak" variable_2="J_leak"/>
<map_variables variable_1="J_up" variable_2="J_up"/>
<map_variables variable_1="J_trpn" variable_2="J_trpn"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_buffering"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="ryanodine_receptors"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="L_type_calcium_current"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="T_type_calcium_current"/>
<map_variables variable_1="i_CaT" variable_2="i_CaT"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_pump_current"/>
<map_variables variable_1="i_pCa" variable_2="i_pCa"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="sodium_calcium_exchange_current"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_background_current"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_activated_chloride_current"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes" component_2="calcium_buffering"/>
<map_variables variable_1="LTRPN_tot" variable_2="LTRPN_tot"/>
<map_variables variable_1="HTRPN_tot" variable_2="HTRPN_tot"/>
<map_variables variable_1="LTRPN_Ca" variable_2="LTRPN_Ca"/>
<map_variables variable_1="HTRPN_Ca" variable_2="HTRPN_Ca"/>
<map_variables variable_1="k_plus_htrpn" variable_2="k_plus_htrpn"/>
<map_variables variable_1="k_minus_htrpn" variable_2="k_minus_htrpn"/>
<map_variables variable_1="k_plus_ltrpn" variable_2="k_plus_ltrpn"/>
<map_variables variable_1="k_minus_ltrpn" variable_2="k_minus_ltrpn"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes" component_2="L_type_calcium_current"/>
<map_variables variable_1="i_CaL_max" variable_2="i_CaL_max"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes" component_2="ryanodine_receptors"/>
<map_variables variable_1="P_O1" variable_2="P_O1"/>
<map_variables variable_1="P_O2" variable_2="P_O2"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="fast_sodium_current"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="sodium_background_current"/>
<map_variables variable_1="i_Nab" variable_2="i_Nab"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="sodium_calcium_exchange_current"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="sodium_potassium_pump_current"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="fast_transient_outward_potassium_current"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_Kto_f" variable_2="i_Kto_f"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="time_independent_potassium_current"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="ultra_rapidly_activating_delayed_rectifier_potassium_current"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="sodium_potassium_pump_current"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="ultra_rapidly_activating_delayed_rectifier_potassium_current" component_2="non_inactivating_steady_state_potassium_current"/>
<map_variables variable_1="ass" variable_2="ass"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="non_inactivating_steady_state_potassium_current"/>
<map_variables variable_1="i_Kss" variable_2="i_Kss"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_potassium_current" component_2="time_independent_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_potassium_current" component_2="slow_delayed_rectifier_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_potassium_current" component_2="ultra_rapidly_activating_delayed_rectifier_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_potassium_current" component_2="non_inactivating_steady_state_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_potassium_current" component_2="rapid_delayed_rectifier_potassium_current"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_m_gate"/>
<map_variables variable_1="m" variable_2="m"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_h_gate"/>
<map_variables variable_1="h" variable_2="h"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="fast_sodium_current_j_gate"/>
<map_variables variable_1="j" variable_2="j"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_b_gate"/>
<map_variables variable_1="b" variable_2="b"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="T_type_calcium_current" component_2="T_type_calcium_current_g_gate"/>
<map_variables variable_1="g" variable_2="g"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<documentation xmlns="http://cellml.org/tmp-documentation">
<article xmlns="http://cellml.org/tmp-documentation">
<articleinfo xmlns="http://cellml.org/tmp-documentation">
<title xmlns="http://cellml.org/tmp-documentation">Mathematical model of the neonatal mouse ventricular action potential</title>
<author xmlns="http://cellml.org/tmp-documentation">
<firstname xmlns="http://cellml.org/tmp-documentation">Catherine</firstname>
<surname xmlns="http://cellml.org/tmp-documentation">Lloyd</surname>
<affiliation xmlns="http://cellml.org/tmp-documentation">
<shortaffil xmlns="http://cellml.org/tmp-documentation">ABI</shortaffil>
</affiliation>
</author>
</articleinfo>
<section xmlns="http://cellml.org/tmp-documentation" id="sec_status">
<title xmlns="http://cellml.org/tmp-documentation">Model Status</title>
<para xmlns="http://cellml.org/tmp-documentation">
This CellML model is known to run in OpenCell and COR to recreate the published results. The units have been checked and are consistent.
</para>
</section>
<sect1 xmlns="http://cellml.org/tmp-documentation" id="sec_structure">
<title xmlns="http://cellml.org/tmp-documentation">Model Structure</title>
<para xmlns="http://cellml.org/tmp-documentation">
ABSTRACT: Therapies for heart disease are based largely on our understanding of the adult myocardium. The dramatic differences in action potential (AP) shape between neonatal and adult cardiac myocytes, however, indicate that a different set of molecular interactions in neonatal myocytes necessitates different treatment for newborns. Computational modeling is useful for synthesizing data to determine how interactions between components lead to systems-level behavior, but this technique has not been used extensively to study neonatal heart cell function. We created a mathematical model of the neonatal (day 1) mouse myocyte by modifying, on the basis of experimental data, the densities and/or formulations of ion transport mechanisms in an adult cell model. The new model reproduces the characteristic AP shape of neonatal cells, with a brief plateau phase and longer duration than the adult (action potential duration at 80% repolarization = 60.1 vs. 12.6 ms). The simulation results are consistent with experimental data, including 1) decreased density and altered inactivation of transient outward K+ currents, 2) increased delayed rectifier K+ currents, 3) Ca2+ entry through T-type as well as L-type Ca2+ channels, 4) increased Ca2+ influx through Na+/Ca2+ exchange, and 5) Ca2+ transients resulting from transmembrane Ca2+ entry rather than release from the sarcoplasmic reticulum (SR). Simulations performed with the model generated novel predictions, including increased SR Ca2+ leak and elevated intracellular Na+ concentration in neonatal compared with adult myocytes. This new model can therefore be used for testing hypotheses and obtaining a better quantitative understanding of differences between neonatal and adult physiology.
</para>
<para xmlns="http://cellml.org/tmp-documentation">
The original paper reference is cited below:
</para>
<para xmlns="http://cellml.org/tmp-documentation">
Mathematical model of the neonatal mouse ventricular action potential, Linda J. Wang and Eric A. Sobie, 2008,<emphasis xmlns="http://cellml.org/tmp-documentation">American Journal of Physiology: Heart and Circulatory Physiology</emphasis>, 294, H2565-H2575. <ulink xmlns="http://cellml.org/tmp-documentation" url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=18408122&amp;dopt=Abstract">PubMed ID: 18408122</ulink>
</para>
<informalfigure xmlns="http://cellml.org/tmp-documentation" float="0" id="fig_cell_diagram">
<mediaobject xmlns="http://cellml.org/tmp-documentation">
<imageobject xmlns="http://cellml.org/tmp-documentation">
<objectinfo xmlns="http://cellml.org/tmp-documentation">
<title xmlns="http://cellml.org/tmp-documentation">cell diagram</title>
</objectinfo>
<imagedata xmlns="http://cellml.org/tmp-documentation" fileref="wang_2008.png"/>
</imageobject>
</mediaobject>
<caption xmlns="http://cellml.org/tmp-documentation">Schematic diagram of the neonatal mouse model.</caption>
</informalfigure>
</sect1>
</article>
</documentation>
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="#wang_model_2008">
<simulation xmlns="http://www.cellml.org/metadata/simulation/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n1"/>
</simulation>
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#09c152f3-5f44-41ce-bad8-175e6f27bf86"/>
</cmeta:comment>
<reference xmlns="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d0769982-0d4d-4d65-a54e-462d65917001"/>
</reference>
<reference xmlns="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n2"/>
</reference>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#af27a0fa-7d17-43df-a49b-7e01d8a1c114">
<W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">2008-04-11 00:00</W3CDTF>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8ea3fb69-ae8b-4e35-80e4-372ce3abed38">
<Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Wang</Family>
<Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">J</Other>
<Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Linda</Given>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#caf953e9-03ae-44e2-a1f3-5edbd2d3c6c7">
<ORG xmlns="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#632aec73-3b6c-4e1c-a245-49a7b52af31d"/>
</ORG>
<EMAIL xmlns="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d25fefba-6be1-4fc9-80ef-ade4d3798d48"/>
</EMAIL>
<N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7cd164da-489d-43b3-ac26-575850200ade"/>
</N>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n3">
<rdf:rest xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#nil"/>
</rdf:rest>
<rdf:first xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n4"/>
</rdf:first>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#50781470-62a2-46f6-a423-b72a35b34587">
<creator xmlns="http://purl.org/dc/elements/1.1/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6c03d419-e71e-403d-9074-48fa3afe93de"/>
</creator>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">This CellML model is known to run in PCEnv and COR to recreate the published results. The units have been checked and are consistent.</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#19e7066e-d983-4408-b59a-bd31a1ef5189">
<N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7d52f800-28d5-464b-9904-191c0468798c"/>
</N>
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://www.cellml.org/bqs/1.0#Person"/>
</rdf:type>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n1">
<boundIntervals xmlns="http://www.cellml.org/metadata/simulation/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n3"/>
</boundIntervals>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4d0294d5-dd3e-4677-88c1-b641f2d1d3a8">
<W3CDTF xmlns="http://purl.org/dc/terms/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">2009-03-02T00:00:00+00:00</W3CDTF>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d77fcb00-54a6-4792-b702-dde28a037fd5">
<FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d25fefba-6be1-4fc9-80ef-ade4d3798d48">
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">c.lloyd@auckland.ac.nz</rdf:value>
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://imc.org/vCard/3.0#internet"/>
</rdf:type>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7d52f800-28d5-464b-9904-191c0468798c">
<Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Sobie</Family>
<Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">A</Other>
<Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Eric</Given>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="">
<creator xmlns="http://purl.org/dc/elements/1.1/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#caf953e9-03ae-44e2-a1f3-5edbd2d3c6c7"/>
</creator>
<created xmlns="http://purl.org/dc/terms/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#4d0294d5-dd3e-4677-88c1-b641f2d1d3a8"/>
</created>
<publisher xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace"/>
<cmeta:comment xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#50781470-62a2-46f6-a423-b72a35b34587"/>
</cmeta:comment>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9f4e73fd-4d59-471e-a9d5-4efb22972e41">
<title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Mathematical model of the neonatal mouse ventricular action potential</title>
<Journal xmlns="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1c62e8db-6d60-4a8b-828d-016d4b882233"/>
</Journal>
<creator xmlns="http://purl.org/dc/elements/1.1/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0b6e6fb8-9e67-4163-8f2a-125b2973d05e"/>
</creator>
<last_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">H2575</last_page>
<volume xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">294</volume>
<issued xmlns="http://purl.org/dc/terms/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#af27a0fa-7d17-43df-a49b-7e01d8a1c114"/>
</issued>
<first_page xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">H2565</first_page>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#0b6e6fb8-9e67-4163-8f2a-125b2973d05e">
<rdf:_2 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#19e7066e-d983-4408-b59a-bd31a1ef5189"/>
</rdf:_2>
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Seq"/>
</rdf:type>
<rdf:_1 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6685a93f-c980-4fa3-b78e-cd112c11390e"/>
</rdf:_1>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d0769982-0d4d-4d65-a54e-462d65917001">
<Pubmed_id xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">18408122</Pubmed_id>
<JournalArticle xmlns="http://www.cellml.org/bqs/1.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#9f4e73fd-4d59-471e-a9d5-4efb22972e41"/>
</JournalArticle>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#1c62e8db-6d60-4a8b-828d-016d4b882233">
<title xmlns="http://purl.org/dc/elements/1.1/" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">American Journal of Physiology Heart and Circulatory Physiology</title>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#09c152f3-5f44-41ce-bad8-175e6f27bf86">
<creator xmlns="http://purl.org/dc/elements/1.1/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#d77fcb00-54a6-4792-b702-dde28a037fd5"/>
</creator>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace"/>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n2">
<subject xmlns="http://purl.org/dc/elements/1.1/">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n5"/>
</subject>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n4">
<maximumStepSize xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">0.1</maximumStepSize>
<endingValue xmlns="http://www.cellml.org/metadata/simulation/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">120</endingValue>
<pointDensity xmlns="http://www.cellml.org/metadata/simulation/1.0#nonstandard-" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">10000</pointDensity>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6c03d419-e71e-403d-9074-48fa3afe93de">
<FN xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Catherine Lloyd</FN>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#6685a93f-c980-4fa3-b78e-cd112c11390e">
<N xmlns="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#8ea3fb69-ae8b-4e35-80e4-372ce3abed38"/>
</N>
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://www.cellml.org/bqs/1.0#Person"/>
</rdf:type>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#632aec73-3b6c-4e1c-a245-49a7b52af31d">
<Orgunit xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Auckland Bioengineering Institute</Orgunit>
<Orgname xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">The University of Auckland</Orgname>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n6">
<rdf:_2 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">calcium dynamics</rdf:_2>
<rdf:_3 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">myocyte</rdf:_3>
<rdf:_4 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">mouse</rdf:_4>
<rdf:type xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="http://www.w3.org/1999/02/22-rdf-syntax-ns#Bag"/>
</rdf:type>
<rdf:_1 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">electrophysiology</rdf:_1>
<rdf:_5 xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">myocardium</rdf:_5>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n5">
<subject_type xmlns="http://www.cellml.org/bqs/1.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">keyword</subject_type>
<rdf:value xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:nodeID="n6"/>
</rdf:value>
</rdf:Description>
<rdf:Description xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:about="rdf:#7cd164da-489d-43b3-ac26-575850200ade">
<Family xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Lloyd</Family>
<Other xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">May</Other>
<Given xmlns="http://www.w3.org/2001/vcard-rdf/3.0#" xml:lang="en" xmlns:xml="http://www.w3.org/XML/1998/namespace">Catherine</Given>
</rdf:Description>
</rdf:RDF>
</model>
