- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-09 17:59:55+12:00
- Desc:
- Update figure titles and documentation;
- Permanent Source URI:
- https://models.cellml.org/workspace/692/rawfile/4de8d2594e8e71c62b4f118f49fde8a277df70d7/Doc/Patch_clampXi_experiment.rst
Voltage clamp experiment
------------------------
In the `Voltage clamp experiment <../Experiments/Patch_clampXi_experiment.cellml>`_, the `Clamped current component <../Components/Clamped_current_Xi.cellml/view>`_ is configured and parameterised with an applied `Patch clamp protocol <../Experiments/Patch_clamp_protocol.cellml>`_.
You can change the clamping parameters in the component ``Clamp_parameters``.
You can also bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters.
The simulation experiment can be obtained by loading the `corresponding SED-ML document <../Simulation/Patch_clampXi_experiment.sedml>`__ into OpenCOR and executing the simulation.
Clamped :math:`I_{CaL}`
-------------------------
Figure [#]_ shows normalized L-type calcium channels peak I–V plot for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig2.png
:width: 85%
:align: center
:alt: simFig2
Clamped :math:`I_{CaT}`
-------------------------
Figure [#]_ shows normalized T-type calcium channels peak I–V plot for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig3.png
:width: 85%
:align: center
:alt: simFig3
Clamped :math:`I_{Kv}`
-------------------------
Figure [#]_ shows normalized I–V plot of whole cell voltage-activated potassium currents for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig4.png
:width: 85%
:align: center
:alt: simFig4
Clamped :math:`P_{BK}`
-------------------------
Figure [#]_ shows Open probability of BK channel versus clamping voltage (@ various :math:`Ca_i^{2+}`) for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig5.png
:width: 85%
:align: center
:alt: simFig5
Clamped :math:`I_{Na}`
-------------------------
Figure [#]_ shows normalized :math:`Na_^{+}` channel peak I–V plot for simulated data derived from the publication(dots) and the current CellML model (solid line).
.. [#]
.. figure:: ../Simulation/simFig6.png
:width: 85%
:align: center
:alt: simFig6
