- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-02 14:40:15+12:00
- Desc:
- Add E_Nernst to instantiate Nernst potential for Ca, Na and K and modify relevant models to accommodate the change.
Add experiment of Periodic_stimulation, which can run.
- Permanent Source URI:
- https://models.cellml.org/workspace/692/rawfile/d5a44a9d949275dfd1b2e46aeaa827571356cd68/Components/IBK.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="IBK" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units.cellml">
<units name="mM" units_ref="mM"/>
<units name="ms" units_ref="ms"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="pA" units_ref="pA"/>
<units name="mV" units_ref="mV"/>
<units name="nS" units_ref="nS"/>
</import>
<import xlink:href="Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="Ionic_currents"/>
</import>
<import xlink:href="E_Nernst.cellml">
<component component_ref="E_K" name="E_K"/>
</import>
<import xlink:href="IBK_channel_states.cellml">
<component component_ref="IBK_channel_states" name="IBK_channel_states"/>
</import>
<component name="IBK">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="P_BK" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="I_BK" private_interface="in" public_interface="out" units="pA"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_BK" private_interface="out" public_interface="in" units="nS"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Ko" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ki" private_interface="out" public_interface="in" units="mM"/>
<variable name="Cai" private_interface="out" public_interface="in" units="mM"/>
<variable name="BK_C0_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="BK_C1_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="BK_C2_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="BK_C3_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="BK_C4_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="O0_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="O1_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="O2_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="O3_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="O4_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="k_on" private_interface="out" public_interface="in" units="per_ms"/>
<variable name="k_off_C" private_interface="out" public_interface="in" units="per_ms"/>
<variable name="k_off_O" private_interface="out" public_interface="in" units="per_ms"/>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="IBK">
<component_ref component="Ionic_currents"/>
<component_ref component="E_K"/>
<component_ref component="IBK_channel_states"/>
</component_ref>
</group>
<connection>
<map_components component_1="IBK" component_2="Ionic_currents"/>
<map_variables variable_1="I_BK" variable_2="I"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="g_BK" variable_2="g_max"/>
</connection>
<connection>
<map_components component_1="IBK" component_2="E_K"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="E_K" component_2="Ionic_currents"/>
<map_variables variable_1="E_K" variable_2="E"/>
</connection>
<connection>
<map_components component_1="IBK_channel_states" component_2="Ionic_currents"/>
<map_variables variable_1="O4" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="IBK" component_2="IBK_channel_states"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="P_BK" variable_2="O4"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="BK_C0_init" variable_2="BK_C0_init"/>
<map_variables variable_1="BK_C1_init" variable_2="BK_C1_init"/>
<map_variables variable_1="BK_C2_init" variable_2="BK_C2_init"/>
<map_variables variable_1="BK_C3_init" variable_2="BK_C3_init"/>
<map_variables variable_1="BK_C4_init" variable_2="BK_C4_init"/>
<map_variables variable_1="O0_init" variable_2="O0_init"/>
<map_variables variable_1="O1_init" variable_2="O1_init"/>
<map_variables variable_1="O2_init" variable_2="O2_init"/>
<map_variables variable_1="O3_init" variable_2="O3_init"/>
<map_variables variable_1="O4_init" variable_2="O4_init"/>
<map_variables variable_1="k_on" variable_2="k_on"/>
<map_variables variable_1="k_off_C" variable_2="k_off_C"/>
<map_variables variable_1="k_off_O" variable_2="k_off_O"/>
</connection>
</model>
