Location: Model of Human Jejunal Smooth Muscle Cell Electrophysiology @ d5a44a9d9492 / Components / ICaL.cellml

Author:
WeiweiAi <wai484@aucklanduni.ac.nz>
Date:
2021-06-02 14:40:15+12:00
Desc:
Add E_Nernst to instantiate Nernst potential for Ca, Na and K and modify relevant models to accommodate the change. Add experiment of Periodic_stimulation, which can run.
Permanent Source URI:
https://models.cellml.org/workspace/692/rawfile/d5a44a9d949275dfd1b2e46aeaa827571356cd68/Components/ICaL.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="ICaL" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="ms" units_ref="ms"/>
        <units name="pA" units_ref="pA"/>
        <units name="mV" units_ref="mV"/>
        <units name="nS" units_ref="nS"/>
    </import>
    <import xlink:href="Ionic_currents.cellml">
        <component component_ref="Ionic_currents" name="Ionic_currents"/>
    </import>
    <import xlink:href="E_Nernst.cellml">
        <component component_ref="E_Ca" name="E_Ca"/>
    </import>
    <import xlink:href="ICaL_channel_states.cellml">
        <component component_ref="ICaL_channel_states" name="ICaL_channel_states"/>
    </import>
    <component name="ICaL">
        <variable name="time" private_interface="out" public_interface="in" units="ms"/>
        <variable name="P_CaL" private_interface="in" public_interface="out" units="dimensionless"/>
        <variable name="I_CaL" private_interface="in" public_interface="out" units="pA"/>
        <variable name="V" private_interface="out" public_interface="in" units="mV"/>
        <variable name="g_CaL" private_interface="out" public_interface="in" units="nS"/>
        <variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
        <variable name="T0Ca" private_interface="out" public_interface="in" units="kelvin"/>
        <variable name="Q10Ca" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="Cao" private_interface="out" public_interface="in" units="mM"/>
        <variable name="Cai" private_interface="out" public_interface="in" units="mM"/>
        <variable name="C0_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="C1_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="C2_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="C3_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="C0Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="C1Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="C2Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="C3Ca_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="ICa_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="IVs_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="IVf_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="IVfCa_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="IVsCa_init" private_interface="out" public_interface="in" units="dimensionless"/>
        <variable name="O_CaL_init" private_interface="out" public_interface="in" units="dimensionless"/>
    </component>
    <group>
        <relationship_ref relationship="encapsulation"/>
        <component_ref component="ICaL">
            <component_ref component="Ionic_currents"/>
            <component_ref component="E_Ca"/>
            <component_ref component="ICaL_channel_states"/>
        </component_ref>
    </group>
    <connection>
        <map_components component_1="ICaL" component_2="Ionic_currents"/>
        <map_variables variable_1="I_CaL" variable_2="I"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="g_CaL" variable_2="g_max"/>
    </connection>
    <connection>
        <map_components component_1="ICaL" component_2="E_Ca"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
        <map_variables variable_1="Cao" variable_2="Cao"/>
    </connection>
    <connection>
        <map_components component_1="E_Ca" component_2="Ionic_currents"/>
        <map_variables variable_1="E_Ca" variable_2="E"/>
    </connection>
    <connection>
        <map_components component_1="ICaL_channel_states" component_2="Ionic_currents"/>
        <map_variables variable_1="O_CaL" variable_2="PO"/>
    </connection>
    <connection>
        <map_components component_1="ICaL" component_2="ICaL_channel_states"/>
        <map_variables variable_1="time" variable_2="time"/>
        <map_variables variable_1="P_CaL" variable_2="O_CaL"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="Cai" variable_2="Cai"/>
        <map_variables variable_1="T0Ca" variable_2="T0"/>
        <map_variables variable_1="Q10Ca" variable_2="Q10Ca"/>
        <map_variables variable_1="C0_init" variable_2="C0_init"/>
        <map_variables variable_1="C1_init" variable_2="C1_init"/>
        <map_variables variable_1="C2_init" variable_2="C2_init"/>
        <map_variables variable_1="C3_init" variable_2="C3_init"/>
        <map_variables variable_1="C0Ca_init" variable_2="C0Ca_init"/>
        <map_variables variable_1="C1Ca_init" variable_2="C1Ca_init"/>
        <map_variables variable_1="C2Ca_init" variable_2="C2Ca_init"/>
        <map_variables variable_1="C3Ca_init" variable_2="C3Ca_init"/>
        <map_variables variable_1="ICa_init" variable_2="ICa_init"/>
        <map_variables variable_1="IVs_init" variable_2="IVs_init"/>
        <map_variables variable_1="IVf_init" variable_2="IVf_init"/>
        <map_variables variable_1="IVfCa_init" variable_2="IVfCa_init"/>
        <map_variables variable_1="IVsCa_init" variable_2="IVsCa_init"/>
        <map_variables variable_1="O_CaL_init" variable_2="O_CaL_init"/>
    </connection>
</model>