- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-06-02 14:40:15+12:00
- Desc:
- Add E_Nernst to instantiate Nernst potential for Ca, Na and K and modify relevant models to accommodate the change.
Add experiment of Periodic_stimulation, which can run.
- Permanent Source URI:
- https://models.cellml.org/workspace/692/rawfile/d5a44a9d949275dfd1b2e46aeaa827571356cd68/Components/IKv.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="IKv" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="units.cellml">
<units name="mM" units_ref="mM"/>
<units name="ms" units_ref="ms"/>
<units name="pA" units_ref="pA"/>
<units name="mV" units_ref="mV"/>
<units name="nS" units_ref="nS"/>
</import>
<import xlink:href="Ionic_currents.cellml">
<component component_ref="Ionic_currents" name="Ionic_currents"/>
</import>
<import xlink:href="E_Nernst.cellml">
<component component_ref="E_K" name="E_K"/>
</import>
<import xlink:href="gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="x_gate"/>
</import>
<import xlink:href="gating_kinetics.cellml">
<component component_ref="gating_kinetics" name="y_gate"/>
</import>
<import xlink:href="IKv_gating_inf.cellml">
<component component_ref="x_inf" name="x_inf"/>
<component component_ref="y_inf" name="y_inf"/>
</import>
<component name="IKv">
<variable name="time" private_interface="out" public_interface="in" units="ms"/>
<variable name="I_Kv" private_interface="in" public_interface="out" units="pA"/>
<variable name="V" private_interface="out" public_interface="in" units="mV"/>
<variable name="g_Kv" private_interface="out" public_interface="in" units="nS"/>
<variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="T0K" private_interface="out" public_interface="in" units="kelvin"/>
<variable name="Q10K" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="Ko" private_interface="out" public_interface="in" units="mM"/>
<variable name="Ki" private_interface="out" public_interface="in" units="mM"/>
<variable name="x_Kv_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="x_Kv" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="y_Kv_init" private_interface="out" public_interface="in" units="dimensionless"/>
<variable name="y_Kv" private_interface="in" public_interface="out" units="dimensionless"/>
<variable name="tau_xKv" private_interface="out" public_interface="in" units="ms"/>
<variable name="tau_yKv" private_interface="out" public_interface="in" units="ms"/>
<variable name="P_Kv" private_interface="out" public_interface="out" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>P_Kv</ci>
<apply>
<times/>
<ci>x_Kv</ci>
<ci>y_Kv</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="IKv">
<component_ref component="Ionic_currents"/>
<component_ref component="E_K"/>
<component_ref component="x_gate"/>
<component_ref component="y_gate"/>
<component_ref component="x_inf"/>
<component_ref component="y_inf"/>
</component_ref>
</group>
<connection>
<map_components component_1="IKv" component_2="x_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IKv" component_2="y_inf"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="IKv" component_2="x_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10K" variable_2="Q10"/>
<map_variables variable_1="T0K" variable_2="T0"/>
<map_variables variable_1="x_Kv_init" variable_2="X_initial"/>
<map_variables variable_1="x_Kv" variable_2="X"/>
<map_variables variable_1="tau_xKv" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="IKv" component_2="y_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10K" variable_2="Q10"/>
<map_variables variable_1="T0K" variable_2="T0"/>
<map_variables variable_1="y_Kv_init" variable_2="X_initial"/>
<map_variables variable_1="y_Kv" variable_2="X"/>
<map_variables variable_1="tau_yKv" variable_2="tau_X"/>
</connection>
<connection>
<map_components component_1="x_inf" component_2="x_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="y_inf" component_2="y_gate"/>
<map_variables variable_1="X_inf" variable_2="X_inf"/>
</connection>
<connection>
<map_components component_1="IKv" component_2="Ionic_currents"/>
<map_variables variable_1="I_Kv" variable_2="I"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="g_Kv" variable_2="g_max"/>
<map_variables variable_1="P_Kv" variable_2="PO"/>
</connection>
<connection>
<map_components component_1="IKv" component_2="E_K"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="E_K" component_2="Ionic_currents"/>
<map_variables variable_1="E_K" variable_2="E"/>
</connection>
</model>
