Location: Model of Human Jejunal Smooth Muscle Cell Electrophysiology @ d5a44a9d9492 / Components / INS_K.cellml

Author:
WeiweiAi <wai484@aucklanduni.ac.nz>
Date:
2021-06-02 14:40:15+12:00
Desc:
Add E_Nernst to instantiate Nernst potential for Ca, Na and K and modify relevant models to accommodate the change. Add experiment of Periodic_stimulation, which can run.
Permanent Source URI:
https://models.cellml.org/workspace/692/rawfile/d5a44a9d949275dfd1b2e46aeaa827571356cd68/Components/INS_K.cellml

<?xml version='1.0' encoding='UTF-8'?>
<model name="INS_K" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
    <import xlink:href="units.cellml">
        <units name="mM" units_ref="mM"/>
        <units name="pA" units_ref="pA"/>
        <units name="mV" units_ref="mV"/>
        <units name="nS" units_ref="nS"/>
        <units name="J_per_K_mol" units_ref="J_per_K_mol"/>
        <units name="C_per_mmol" units_ref="C_per_mmol"/>
    </import>
    <import xlink:href="Ionic_currents.cellml">
        <component component_ref="Ionic_currents" name="Ionic_currents"/>
    </import>
    <import xlink:href="E_Nernst.cellml">
        <component component_ref="E_K" name="E_K"/>
    </import>
    <component name="INS_K">
        <variable name="I_NsK" private_interface="in" public_interface="out" units="pA"/>
        <variable name="V" private_interface="out" public_interface="in" units="mV"/>
        <variable name="g_NsK" private_interface="out" public_interface="in" units="nS"/>
        <variable name="T" private_interface="out" public_interface="in" units="kelvin"/>
        <variable name="Ko" private_interface="out" public_interface="in" units="mM"/>
        <variable name="Ki" private_interface="out" public_interface="in" units="mM"/>
        <variable initial_value="1" name="PO" private_interface="out" units="dimensionless"/>
    </component>
    <group>
        <relationship_ref relationship="encapsulation"/>
        <component_ref component="INS_K">
            <component_ref component="Ionic_currents"/>
            <component_ref component="E_K"/>
        </component_ref>
    </group>
    <connection>
        <map_components component_1="INS_K" component_2="Ionic_currents"/>
        <map_variables variable_1="I_NsK" variable_2="I"/>
        <map_variables variable_1="V" variable_2="V"/>
        <map_variables variable_1="g_NsK" variable_2="g_max"/>
        <map_variables variable_1="PO" variable_2="PO"/>
    </connection>
    <connection>
        <map_components component_1="INS_K" component_2="E_K"/>
        <map_variables variable_1="T" variable_2="T"/>
        <map_variables variable_1="Ki" variable_2="Ki"/>
        <map_variables variable_1="Ko" variable_2="Ko"/>
    </connection>
    <connection>
        <map_components component_1="E_K" component_2="Ionic_currents"/>
        <map_variables variable_1="E_K" variable_2="E"/>
    </connection>
</model>