- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2021-09-30 13:14:32+13:00
- Desc:
- fix the typos and tables in doc
- Permanent Source URI:
- https://models.cellml.org/workspace/6bb/rawfile/5766fc294ca1fb80e47e776c78d754cad7f5fc7f/Doc/Cai_experiment1.rst
Calcium concentration experiments
---------------------------------
In the `Calcium concentration experiment 1 <Experiments/Cai_experiment1.cellml/view>`_, the `Excitation-contraction unit <../Components/Unit_uSMC.cellml>`_ is configured and parameterised. The component ``Cai`` is defined to generate a :math:`Ca_i^{2+}` profile close to the measured values in Figure 9C.
In the `Calcium concentration experiment 2 <Experiments/Cai_experiment2.cellml>`_, the `Excitation-contraction unit <../Components/Unit_uSMC.cellml>`_ is configured and parameterised. The component ``Cai`` defines a piecewise linear function to construct the input :math:`Ca_i^{2+}` for Figure 10B.
You can bypass the parameters in the component ``model_parameters`` and ``initial_conditions`` and define your own parameters.
The simulation experiment can be obtained by loading the `corresponding SED-ML document Cai_experiment 1 <../Simulation/Cai_experiment1.sedml>`_ and `Cai_experiment 2 <../Simulation/Cai_experiment2.sedml>`_ into OpenCOR and executing the simulation.
MLC Phosphorylation and Stress Production by the Contracting Cell
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Figure [#]_ uses the settings in `Calcium concentration experiment 1 <Experiments/Cai_experiment1.cellml/view>`_.
.. [#]
.. figure:: ../Simulation/simFig9.png
:width: 75%
:align: center
:alt: simFig9
Simulation of MLC phosphorylation (A) and force production (B) in human nonpregnant myometrium in response to an increase in :math:`Ca_i^{2+}`.
Figure [#]_ uses the settings in `Calcium concentration experiment 2 <Experiments/Cai_experiment2.cellml>`_.
.. [#]
.. figure:: ../Simulation/simFig10.png
:width: 75%
:align: center
:alt: simFig10
Stress development and relaxation during stretch-induced phasic contraction of human myometrium.
